β-adrenergic stimulation controls the expression of a thioesterase specific for very-long-chain fatty acids in perfused hearts

Autores
Neuman, Maria Isabel; Maloberti, Paula Mariana; Lisdero, Constanza; Colonna, Cecilia; Peralta, Jorge; Poderoso, Juan José; Podestá, Ernesto J.
Año de publicación
2002
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Arachidonic acid is not freely stored in the cells. A number of different pathways for the mobilization of this compound have been proposed, including a novel mechanism that involves the release of arachidonic acid from arachidonoyl-CoA by a thioesterase with substrate specificity for very-long-chain fatty acids. In rat heart, the acyl-CoA thioesterase activity can be regulated by a mechanism that involves β-adrenoceptors. In this paper we demonstrate that β-adrenergic agonists also regulate the acyl-CoA thioesterase mRNA levels. Isoproterenol (10-7) a concentration known to exert physiological responses - increases in a time-dependent manner the acyl-CoA thioesterase mRNA levels, an effect blocked by a specific β-adrenoceptor antagonist. In addition, our results show that cAMP is involved in this process. The acyl-CoA thioesterase mRNA levels are also increased by fasting, but not by di(2-ethylhexyl)phthalate, a peroxisome proliferator. These results may suggest the existence of a β-adrenoceptor-activated regulatory pathway for arachidonic acid release in cardiac tissue. © 2002 Elsevier Science (USA). All rights reserved.
Fil: Neuman, Maria Isabel. Universidad de Buenos Aires; Argentina
Fil: Maloberti, Paula Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
Fil: Lisdero, Constanza. Universidad de Buenos Aires; Argentina
Fil: Colonna, Cecilia. Universidad de Buenos Aires; Argentina
Fil: Peralta, Jorge. Universidad de Buenos Aires; Argentina
Fil: Poderoso, Juan José. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Podestá, Ernesto J.. Universidad de Buenos Aires; Argentina
Materia
ACYL-COA THIOESTERASE
ARACHIDONIC ACID
CARDIAC TISSUE
HEART PERFUSION
ISOPROTERENOL
MRNA LEVELS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/171931
Acceder
id CONICETDig_1969e38b79636713a8a4783a8e4654f2
oai_identifier_str oai:ri.conicet.gov.ar:11336/171931
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling β-adrenergic stimulation controls the expression of a thioesterase specific for very-long-chain fatty acids in perfused heartsNeuman, Maria IsabelMaloberti, Paula MarianaLisdero, ConstanzaColonna, CeciliaPeralta, JorgePoderoso, Juan JoséPodestá, Ernesto J.ACYL-COA THIOESTERASEARACHIDONIC ACIDCARDIAC TISSUEHEART PERFUSIONISOPROTERENOLMRNA LEVELShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Arachidonic acid is not freely stored in the cells. A number of different pathways for the mobilization of this compound have been proposed, including a novel mechanism that involves the release of arachidonic acid from arachidonoyl-CoA by a thioesterase with substrate specificity for very-long-chain fatty acids. In rat heart, the acyl-CoA thioesterase activity can be regulated by a mechanism that involves β-adrenoceptors. In this paper we demonstrate that β-adrenergic agonists also regulate the acyl-CoA thioesterase mRNA levels. Isoproterenol (10-7) a concentration known to exert physiological responses - increases in a time-dependent manner the acyl-CoA thioesterase mRNA levels, an effect blocked by a specific β-adrenoceptor antagonist. In addition, our results show that cAMP is involved in this process. The acyl-CoA thioesterase mRNA levels are also increased by fasting, but not by di(2-ethylhexyl)phthalate, a peroxisome proliferator. These results may suggest the existence of a β-adrenoceptor-activated regulatory pathway for arachidonic acid release in cardiac tissue. © 2002 Elsevier Science (USA). All rights reserved.Fil: Neuman, Maria Isabel. Universidad de Buenos Aires; ArgentinaFil: Maloberti, Paula Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; ArgentinaFil: Lisdero, Constanza. Universidad de Buenos Aires; ArgentinaFil: Colonna, Cecilia. Universidad de Buenos Aires; ArgentinaFil: Peralta, Jorge. Universidad de Buenos Aires; ArgentinaFil: Poderoso, Juan José. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Podestá, Ernesto J.. Universidad de Buenos Aires; ArgentinaAcademic Press Inc Elsevier Science2002-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/171931Neuman, Maria Isabel; Maloberti, Paula Mariana; Lisdero, Constanza; Colonna, Cecilia; Peralta, Jorge; et al.; β-adrenergic stimulation controls the expression of a thioesterase specific for very-long-chain fatty acids in perfused hearts; Academic Press Inc Elsevier Science; Biochemical and Biophysical Research Communications; 299; 1; 11-2002; 135-1410006-291XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0006291X02025962info:eu-repo/semantics/altIdentifier/doi/10.1016/S0006-291X(02)02596-2info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:31:19Zoai:ri.conicet.gov.ar:11336/171931instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:31:19.912CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv β-adrenergic stimulation controls the expression of a thioesterase specific for very-long-chain fatty acids in perfused hearts
title β-adrenergic stimulation controls the expression of a thioesterase specific for very-long-chain fatty acids in perfused hearts
spellingShingle β-adrenergic stimulation controls the expression of a thioesterase specific for very-long-chain fatty acids in perfused hearts
Neuman, Maria Isabel
ACYL-COA THIOESTERASE
ARACHIDONIC ACID
CARDIAC TISSUE
HEART PERFUSION
ISOPROTERENOL
MRNA LEVELS
title_short β-adrenergic stimulation controls the expression of a thioesterase specific for very-long-chain fatty acids in perfused hearts
title_full β-adrenergic stimulation controls the expression of a thioesterase specific for very-long-chain fatty acids in perfused hearts
title_fullStr β-adrenergic stimulation controls the expression of a thioesterase specific for very-long-chain fatty acids in perfused hearts
title_full_unstemmed β-adrenergic stimulation controls the expression of a thioesterase specific for very-long-chain fatty acids in perfused hearts
title_sort β-adrenergic stimulation controls the expression of a thioesterase specific for very-long-chain fatty acids in perfused hearts
dc.creator.none.fl_str_mv Neuman, Maria Isabel
Maloberti, Paula Mariana
Lisdero, Constanza
Colonna, Cecilia
Peralta, Jorge
Poderoso, Juan José
Podestá, Ernesto J.
author Neuman, Maria Isabel
author_facet Neuman, Maria Isabel
Maloberti, Paula Mariana
Lisdero, Constanza
Colonna, Cecilia
Peralta, Jorge
Poderoso, Juan José
Podestá, Ernesto J.
author_role author
author2 Maloberti, Paula Mariana
Lisdero, Constanza
Colonna, Cecilia
Peralta, Jorge
Poderoso, Juan José
Podestá, Ernesto J.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv ACYL-COA THIOESTERASE
ARACHIDONIC ACID
CARDIAC TISSUE
HEART PERFUSION
ISOPROTERENOL
MRNA LEVELS
topic ACYL-COA THIOESTERASE
ARACHIDONIC ACID
CARDIAC TISSUE
HEART PERFUSION
ISOPROTERENOL
MRNA LEVELS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Arachidonic acid is not freely stored in the cells. A number of different pathways for the mobilization of this compound have been proposed, including a novel mechanism that involves the release of arachidonic acid from arachidonoyl-CoA by a thioesterase with substrate specificity for very-long-chain fatty acids. In rat heart, the acyl-CoA thioesterase activity can be regulated by a mechanism that involves β-adrenoceptors. In this paper we demonstrate that β-adrenergic agonists also regulate the acyl-CoA thioesterase mRNA levels. Isoproterenol (10-7) a concentration known to exert physiological responses - increases in a time-dependent manner the acyl-CoA thioesterase mRNA levels, an effect blocked by a specific β-adrenoceptor antagonist. In addition, our results show that cAMP is involved in this process. The acyl-CoA thioesterase mRNA levels are also increased by fasting, but not by di(2-ethylhexyl)phthalate, a peroxisome proliferator. These results may suggest the existence of a β-adrenoceptor-activated regulatory pathway for arachidonic acid release in cardiac tissue. © 2002 Elsevier Science (USA). All rights reserved.
Fil: Neuman, Maria Isabel. Universidad de Buenos Aires; Argentina
Fil: Maloberti, Paula Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
Fil: Lisdero, Constanza. Universidad de Buenos Aires; Argentina
Fil: Colonna, Cecilia. Universidad de Buenos Aires; Argentina
Fil: Peralta, Jorge. Universidad de Buenos Aires; Argentina
Fil: Poderoso, Juan José. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Podestá, Ernesto J.. Universidad de Buenos Aires; Argentina
description Arachidonic acid is not freely stored in the cells. A number of different pathways for the mobilization of this compound have been proposed, including a novel mechanism that involves the release of arachidonic acid from arachidonoyl-CoA by a thioesterase with substrate specificity for very-long-chain fatty acids. In rat heart, the acyl-CoA thioesterase activity can be regulated by a mechanism that involves β-adrenoceptors. In this paper we demonstrate that β-adrenergic agonists also regulate the acyl-CoA thioesterase mRNA levels. Isoproterenol (10-7) a concentration known to exert physiological responses - increases in a time-dependent manner the acyl-CoA thioesterase mRNA levels, an effect blocked by a specific β-adrenoceptor antagonist. In addition, our results show that cAMP is involved in this process. The acyl-CoA thioesterase mRNA levels are also increased by fasting, but not by di(2-ethylhexyl)phthalate, a peroxisome proliferator. These results may suggest the existence of a β-adrenoceptor-activated regulatory pathway for arachidonic acid release in cardiac tissue. © 2002 Elsevier Science (USA). All rights reserved.
publishDate 2002
dc.date.none.fl_str_mv 2002-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/171931
Neuman, Maria Isabel; Maloberti, Paula Mariana; Lisdero, Constanza; Colonna, Cecilia; Peralta, Jorge; et al.; β-adrenergic stimulation controls the expression of a thioesterase specific for very-long-chain fatty acids in perfused hearts; Academic Press Inc Elsevier Science; Biochemical and Biophysical Research Communications; 299; 1; 11-2002; 135-141
0006-291X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/171931
identifier_str_mv Neuman, Maria Isabel; Maloberti, Paula Mariana; Lisdero, Constanza; Colonna, Cecilia; Peralta, Jorge; et al.; β-adrenergic stimulation controls the expression of a thioesterase specific for very-long-chain fatty acids in perfused hearts; Academic Press Inc Elsevier Science; Biochemical and Biophysical Research Communications; 299; 1; 11-2002; 135-141
0006-291X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0006291X02025962
info:eu-repo/semantics/altIdentifier/doi/10.1016/S0006-291X(02)02596-2
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Academic Press Inc Elsevier Science
publisher.none.fl_str_mv Academic Press Inc Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846082796172345344
score 13.22299

Publicaciones similares