β-adrenergic stimulation controls the expression of a thioesterase specific for very-long-chain fatty acids in perfused hearts
- Autores
- Neuman, Maria Isabel; Maloberti, Paula Mariana; Lisdero, Constanza; Colonna, Cecilia; Peralta, Jorge; Poderoso, Juan José; Podestá, Ernesto J.
- Año de publicación
- 2002
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Arachidonic acid is not freely stored in the cells. A number of different pathways for the mobilization of this compound have been proposed, including a novel mechanism that involves the release of arachidonic acid from arachidonoyl-CoA by a thioesterase with substrate specificity for very-long-chain fatty acids. In rat heart, the acyl-CoA thioesterase activity can be regulated by a mechanism that involves β-adrenoceptors. In this paper we demonstrate that β-adrenergic agonists also regulate the acyl-CoA thioesterase mRNA levels. Isoproterenol (10-7) a concentration known to exert physiological responses - increases in a time-dependent manner the acyl-CoA thioesterase mRNA levels, an effect blocked by a specific β-adrenoceptor antagonist. In addition, our results show that cAMP is involved in this process. The acyl-CoA thioesterase mRNA levels are also increased by fasting, but not by di(2-ethylhexyl)phthalate, a peroxisome proliferator. These results may suggest the existence of a β-adrenoceptor-activated regulatory pathway for arachidonic acid release in cardiac tissue. © 2002 Elsevier Science (USA). All rights reserved.
Fil: Neuman, Maria Isabel. Universidad de Buenos Aires; Argentina
Fil: Maloberti, Paula Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
Fil: Lisdero, Constanza. Universidad de Buenos Aires; Argentina
Fil: Colonna, Cecilia. Universidad de Buenos Aires; Argentina
Fil: Peralta, Jorge. Universidad de Buenos Aires; Argentina
Fil: Poderoso, Juan José. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Podestá, Ernesto J.. Universidad de Buenos Aires; Argentina - Materia
-
ACYL-COA THIOESTERASE
ARACHIDONIC ACID
CARDIAC TISSUE
HEART PERFUSION
ISOPROTERENOL
MRNA LEVELS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/171931
Ver los metadatos del registro completo
id |
CONICETDig_1969e38b79636713a8a4783a8e4654f2 |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/171931 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
β-adrenergic stimulation controls the expression of a thioesterase specific for very-long-chain fatty acids in perfused heartsNeuman, Maria IsabelMaloberti, Paula MarianaLisdero, ConstanzaColonna, CeciliaPeralta, JorgePoderoso, Juan JoséPodestá, Ernesto J.ACYL-COA THIOESTERASEARACHIDONIC ACIDCARDIAC TISSUEHEART PERFUSIONISOPROTERENOLMRNA LEVELShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Arachidonic acid is not freely stored in the cells. A number of different pathways for the mobilization of this compound have been proposed, including a novel mechanism that involves the release of arachidonic acid from arachidonoyl-CoA by a thioesterase with substrate specificity for very-long-chain fatty acids. In rat heart, the acyl-CoA thioesterase activity can be regulated by a mechanism that involves β-adrenoceptors. In this paper we demonstrate that β-adrenergic agonists also regulate the acyl-CoA thioesterase mRNA levels. Isoproterenol (10-7) a concentration known to exert physiological responses - increases in a time-dependent manner the acyl-CoA thioesterase mRNA levels, an effect blocked by a specific β-adrenoceptor antagonist. In addition, our results show that cAMP is involved in this process. The acyl-CoA thioesterase mRNA levels are also increased by fasting, but not by di(2-ethylhexyl)phthalate, a peroxisome proliferator. These results may suggest the existence of a β-adrenoceptor-activated regulatory pathway for arachidonic acid release in cardiac tissue. © 2002 Elsevier Science (USA). All rights reserved.Fil: Neuman, Maria Isabel. Universidad de Buenos Aires; ArgentinaFil: Maloberti, Paula Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; ArgentinaFil: Lisdero, Constanza. Universidad de Buenos Aires; ArgentinaFil: Colonna, Cecilia. Universidad de Buenos Aires; ArgentinaFil: Peralta, Jorge. Universidad de Buenos Aires; ArgentinaFil: Poderoso, Juan José. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Podestá, Ernesto J.. Universidad de Buenos Aires; ArgentinaAcademic Press Inc Elsevier Science2002-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/171931Neuman, Maria Isabel; Maloberti, Paula Mariana; Lisdero, Constanza; Colonna, Cecilia; Peralta, Jorge; et al.; β-adrenergic stimulation controls the expression of a thioesterase specific for very-long-chain fatty acids in perfused hearts; Academic Press Inc Elsevier Science; Biochemical and Biophysical Research Communications; 299; 1; 11-2002; 135-1410006-291XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0006291X02025962info:eu-repo/semantics/altIdentifier/doi/10.1016/S0006-291X(02)02596-2info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:10:01Zoai:ri.conicet.gov.ar:11336/171931instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:10:01.632CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
β-adrenergic stimulation controls the expression of a thioesterase specific for very-long-chain fatty acids in perfused hearts |
title |
β-adrenergic stimulation controls the expression of a thioesterase specific for very-long-chain fatty acids in perfused hearts |
spellingShingle |
β-adrenergic stimulation controls the expression of a thioesterase specific for very-long-chain fatty acids in perfused hearts Neuman, Maria Isabel ACYL-COA THIOESTERASE ARACHIDONIC ACID CARDIAC TISSUE HEART PERFUSION ISOPROTERENOL MRNA LEVELS |
title_short |
β-adrenergic stimulation controls the expression of a thioesterase specific for very-long-chain fatty acids in perfused hearts |
title_full |
β-adrenergic stimulation controls the expression of a thioesterase specific for very-long-chain fatty acids in perfused hearts |
title_fullStr |
β-adrenergic stimulation controls the expression of a thioesterase specific for very-long-chain fatty acids in perfused hearts |
title_full_unstemmed |
β-adrenergic stimulation controls the expression of a thioesterase specific for very-long-chain fatty acids in perfused hearts |
title_sort |
β-adrenergic stimulation controls the expression of a thioesterase specific for very-long-chain fatty acids in perfused hearts |
dc.creator.none.fl_str_mv |
Neuman, Maria Isabel Maloberti, Paula Mariana Lisdero, Constanza Colonna, Cecilia Peralta, Jorge Poderoso, Juan José Podestá, Ernesto J. |
author |
Neuman, Maria Isabel |
author_facet |
Neuman, Maria Isabel Maloberti, Paula Mariana Lisdero, Constanza Colonna, Cecilia Peralta, Jorge Poderoso, Juan José Podestá, Ernesto J. |
author_role |
author |
author2 |
Maloberti, Paula Mariana Lisdero, Constanza Colonna, Cecilia Peralta, Jorge Poderoso, Juan José Podestá, Ernesto J. |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
ACYL-COA THIOESTERASE ARACHIDONIC ACID CARDIAC TISSUE HEART PERFUSION ISOPROTERENOL MRNA LEVELS |
topic |
ACYL-COA THIOESTERASE ARACHIDONIC ACID CARDIAC TISSUE HEART PERFUSION ISOPROTERENOL MRNA LEVELS |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Arachidonic acid is not freely stored in the cells. A number of different pathways for the mobilization of this compound have been proposed, including a novel mechanism that involves the release of arachidonic acid from arachidonoyl-CoA by a thioesterase with substrate specificity for very-long-chain fatty acids. In rat heart, the acyl-CoA thioesterase activity can be regulated by a mechanism that involves β-adrenoceptors. In this paper we demonstrate that β-adrenergic agonists also regulate the acyl-CoA thioesterase mRNA levels. Isoproterenol (10-7) a concentration known to exert physiological responses - increases in a time-dependent manner the acyl-CoA thioesterase mRNA levels, an effect blocked by a specific β-adrenoceptor antagonist. In addition, our results show that cAMP is involved in this process. The acyl-CoA thioesterase mRNA levels are also increased by fasting, but not by di(2-ethylhexyl)phthalate, a peroxisome proliferator. These results may suggest the existence of a β-adrenoceptor-activated regulatory pathway for arachidonic acid release in cardiac tissue. © 2002 Elsevier Science (USA). All rights reserved. Fil: Neuman, Maria Isabel. Universidad de Buenos Aires; Argentina Fil: Maloberti, Paula Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina Fil: Lisdero, Constanza. Universidad de Buenos Aires; Argentina Fil: Colonna, Cecilia. Universidad de Buenos Aires; Argentina Fil: Peralta, Jorge. Universidad de Buenos Aires; Argentina Fil: Poderoso, Juan José. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Podestá, Ernesto J.. Universidad de Buenos Aires; Argentina |
description |
Arachidonic acid is not freely stored in the cells. A number of different pathways for the mobilization of this compound have been proposed, including a novel mechanism that involves the release of arachidonic acid from arachidonoyl-CoA by a thioesterase with substrate specificity for very-long-chain fatty acids. In rat heart, the acyl-CoA thioesterase activity can be regulated by a mechanism that involves β-adrenoceptors. In this paper we demonstrate that β-adrenergic agonists also regulate the acyl-CoA thioesterase mRNA levels. Isoproterenol (10-7) a concentration known to exert physiological responses - increases in a time-dependent manner the acyl-CoA thioesterase mRNA levels, an effect blocked by a specific β-adrenoceptor antagonist. In addition, our results show that cAMP is involved in this process. The acyl-CoA thioesterase mRNA levels are also increased by fasting, but not by di(2-ethylhexyl)phthalate, a peroxisome proliferator. These results may suggest the existence of a β-adrenoceptor-activated regulatory pathway for arachidonic acid release in cardiac tissue. © 2002 Elsevier Science (USA). All rights reserved. |
publishDate |
2002 |
dc.date.none.fl_str_mv |
2002-11 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/171931 Neuman, Maria Isabel; Maloberti, Paula Mariana; Lisdero, Constanza; Colonna, Cecilia; Peralta, Jorge; et al.; β-adrenergic stimulation controls the expression of a thioesterase specific for very-long-chain fatty acids in perfused hearts; Academic Press Inc Elsevier Science; Biochemical and Biophysical Research Communications; 299; 1; 11-2002; 135-141 0006-291X CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/171931 |
identifier_str_mv |
Neuman, Maria Isabel; Maloberti, Paula Mariana; Lisdero, Constanza; Colonna, Cecilia; Peralta, Jorge; et al.; β-adrenergic stimulation controls the expression of a thioesterase specific for very-long-chain fatty acids in perfused hearts; Academic Press Inc Elsevier Science; Biochemical and Biophysical Research Communications; 299; 1; 11-2002; 135-141 0006-291X CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0006291X02025962 info:eu-repo/semantics/altIdentifier/doi/10.1016/S0006-291X(02)02596-2 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Academic Press Inc Elsevier Science |
publisher.none.fl_str_mv |
Academic Press Inc Elsevier Science |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1846781455870459904 |
score |
12.982451 |