Motor-language coupling: Direct evidence from early Parkinson's disease and intracranial cortical recordings
- Autores
- Ibañez, Agustin Mariano; Cardona, Juan F.; Dos Santos, Yamil Vidal; Blenkmann, Alejandro Omar; Aravena, Pía; Roca, María; Hurtado, Esteban; Nerguizian, Mirna; Amoruso, Lucía; Gómez Arévalo, Gonzalo; Chade, Anable; Dubrovsky, Alberto; Gershanik, Oscar; Kochen, Sara Silvia; Glenberg, Arthur; Manes, Facundo Francisco; Bekinschtein, Tristán Andrés
- Año de publicación
- 2013
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Language and action systems are functionally coupled in the brain as demonstrated by converging evidence using Functional magnetic resonance imaging (fMRI), electroencephalography (EEG), transcranial magnetic stimulation (TMS), and lesion studies. In particular, this coupling has been demonstrated using the action-sentence compatibility effect (ACE) in which motor activity and language interact. The ACE task requires participants to listen to sentences that described actions typically performed with an open hand (e.g., clapping), a closed hand (e.g., hammering), or without any hand action (neutral); and to press a large button with either an open hand position or closed hand position immediately upon comprehending each sentence. The ACE is defined as a longer reaction time (RT) in the action-sentence incompatible conditions than in the compatible conditions. Here we investigated direct motor-language coupling in two novel and uniquely informative ways. First, we measured the behavioural ACE in patients with motor impairment (early Parkinson’s disease – EPD), and second, in epileptic patients with direct electrocorticography (ECoG) recordings. In experiment 1, EPD participants with preserved general cognitive repertoire, showed a much diminished ACE relative to non-EPD volunteers. Moreover, a correlation between ACE performance and action-verb processing (kissing and dancing test – KDT) was observed. Direct cortical recordings (ECoG) in motor and language areas (experiment 2) demonstrated simultaneous bidirectional effects: motor preparation affected language processing (N400 at left inferior frontal gyrus and middle/superior temporal gyrus), and language processing affected activity in movement-related areas (motor potential at premotor and M1). Our findings show that the ACE paradigm requires ongoing integration of preserved motor and language coupling (abolished in EPD) and engages motor-temporal cortices in a bidirectional way. In addition, both experiments suggest the presence of a motor-language network which is not restricted to somatotopically defined brain areas. These results open new pathways in the fields of motor diseases, theoretical approaches to language understanding, and models of action-perception coupling.
Fil: Ibanez Barassi, Agustin Mariano. Instituto de Neurologia Cognitiva. Laboratorio de Psicologia Experimental y Neurociencia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Diego Portales; Chile. Instituto de Neurología Cognitiva; Argentina
Fil: Cardona, Juan F.. Instituto de Neurologia Cognitiva. Laboratorio de Psicologia Experimental y Neurociencia; Argentina. Universidad de Buenos Aires. Facultad de Psicologia; Argentina. Instituto de Neurología Cognitiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Dos Santos, Yamil Vidal. Instituto de Neurologia Cognitiva. Laboratorio de Psicologia Experimental y Neurociencia; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física. Laboratorio de Neurociencia Integrativa; Argentina
Fil: Blenkmann, Alejandro Omar. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina. Universidad Nacional de la Plata. Facultad de Ingenieria. Departamento de Electrotecnia. Laboratorio de Electronica Ind., Control E Instrumentac.; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital Gral.de Agudos "ramos Mejia"; Argentina
Fil: Aravena, Pía. Institut des Sciences Cognitives; Francia
Fil: Roca, María. Instituto de Neurología Cognitiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Neurologia Cognitiva. Laboratorio de Psicologia Experimental y Neurociencia; Argentina
Fil: Hurtado, Esteban. Pontificia Universidad Católica de Chile; Chile
Fil: Nerguizian, Mirna. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro; Argentina. Instituto de Neurologia Cognitiva. Laboratorio de Psicologia Experimental y Neurociencia; Argentina
Fil: Amoruso, Lucía. Instituto de Neurología Cognitiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Neurologia Cognitiva. Laboratorio de Psicologia Experimental y Neurociencia; Argentina
Fil: Gómez Arévalo, Gonzalo. Instituto de Neurología Cognitiva; Argentina. Instituto de Neurologia Cognitiva. Laboratorio de Psicologia Experimental y Neurociencia; Argentina
Fil: Chade, Anable. Instituto de Neurología Cognitiva; Argentina. Instituto de Neurologia Cognitiva. Laboratorio de Psicologia Experimental y Neurociencia; Argentina
Fil: Dubrovsky, Alberto. Instituto de Neurología Cognitiva; Argentina. Instituto de Neurologia Cognitiva. Laboratorio de Psicologia Experimental y Neurociencia; Argentina
Fil: Gershanik, Oscar. Instituto de Neurología Cognitiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Neurologia Cognitiva. Laboratorio de Psicologia Experimental y Neurociencia; Argentina
Fil: Kochen, Sara Silvia. Gobierno de la Ciudad de Buenos Aires. Hospital Gral.de Agudos "ramos Mejia"; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Glenberg, Arthur. Arizona State University; Estados Unidos. University Of Wisconsin; Estados Unidos
Fil: Manes, Facundo Francisco. Instituto de Neurologia Cognitiva. Laboratorio de Psicologia Experimental y Neurociencia; Argentina. Instituto de Neurología Cognitiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bekinschtein, Tristán Andrés. Instituto de Neurologia Cognitiva. Laboratorio de Psicologia Experimental y Neurociencia; Argentina. Instituto de Neurología Cognitiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Medical Research Council. Cognition and Brain Sciences Unit; Reino Unido - Materia
-
Ace
Parkinson'S Disease
Ecog
Intracranial N400
Intracranial Mp - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/10909
Ver los metadatos del registro completo
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Motor-language coupling: Direct evidence from early Parkinson's disease and intracranial cortical recordingsIbañez, Agustin MarianoCardona, Juan F.Dos Santos, Yamil VidalBlenkmann, Alejandro OmarAravena, PíaRoca, MaríaHurtado, EstebanNerguizian, MirnaAmoruso, LucíaGómez Arévalo, GonzaloChade, AnableDubrovsky, AlbertoGershanik, OscarKochen, Sara SilviaGlenberg, ArthurManes, Facundo FranciscoBekinschtein, Tristán AndrésAceParkinson'S DiseaseEcogIntracranial N400Intracranial Mphttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Language and action systems are functionally coupled in the brain as demonstrated by converging evidence using Functional magnetic resonance imaging (fMRI), electroencephalography (EEG), transcranial magnetic stimulation (TMS), and lesion studies. In particular, this coupling has been demonstrated using the action-sentence compatibility effect (ACE) in which motor activity and language interact. The ACE task requires participants to listen to sentences that described actions typically performed with an open hand (e.g., clapping), a closed hand (e.g., hammering), or without any hand action (neutral); and to press a large button with either an open hand position or closed hand position immediately upon comprehending each sentence. The ACE is defined as a longer reaction time (RT) in the action-sentence incompatible conditions than in the compatible conditions. Here we investigated direct motor-language coupling in two novel and uniquely informative ways. First, we measured the behavioural ACE in patients with motor impairment (early Parkinson’s disease – EPD), and second, in epileptic patients with direct electrocorticography (ECoG) recordings. In experiment 1, EPD participants with preserved general cognitive repertoire, showed a much diminished ACE relative to non-EPD volunteers. Moreover, a correlation between ACE performance and action-verb processing (kissing and dancing test – KDT) was observed. Direct cortical recordings (ECoG) in motor and language areas (experiment 2) demonstrated simultaneous bidirectional effects: motor preparation affected language processing (N400 at left inferior frontal gyrus and middle/superior temporal gyrus), and language processing affected activity in movement-related areas (motor potential at premotor and M1). Our findings show that the ACE paradigm requires ongoing integration of preserved motor and language coupling (abolished in EPD) and engages motor-temporal cortices in a bidirectional way. In addition, both experiments suggest the presence of a motor-language network which is not restricted to somatotopically defined brain areas. These results open new pathways in the fields of motor diseases, theoretical approaches to language understanding, and models of action-perception coupling.Fil: Ibanez Barassi, Agustin Mariano. Instituto de Neurologia Cognitiva. Laboratorio de Psicologia Experimental y Neurociencia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Diego Portales; Chile. Instituto de Neurología Cognitiva; ArgentinaFil: Cardona, Juan F.. Instituto de Neurologia Cognitiva. Laboratorio de Psicologia Experimental y Neurociencia; Argentina. Universidad de Buenos Aires. Facultad de Psicologia; Argentina. Instituto de Neurología Cognitiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Dos Santos, Yamil Vidal. Instituto de Neurologia Cognitiva. Laboratorio de Psicologia Experimental y Neurociencia; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física. Laboratorio de Neurociencia Integrativa; ArgentinaFil: Blenkmann, Alejandro Omar. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina. Universidad Nacional de la Plata. Facultad de Ingenieria. Departamento de Electrotecnia. Laboratorio de Electronica Ind., Control E Instrumentac.; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital Gral.de Agudos "ramos Mejia"; ArgentinaFil: Aravena, Pía. Institut des Sciences Cognitives; FranciaFil: Roca, María. Instituto de Neurología Cognitiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Neurologia Cognitiva. Laboratorio de Psicologia Experimental y Neurociencia; ArgentinaFil: Hurtado, Esteban. Pontificia Universidad Católica de Chile; ChileFil: Nerguizian, Mirna. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro; Argentina. Instituto de Neurologia Cognitiva. Laboratorio de Psicologia Experimental y Neurociencia; ArgentinaFil: Amoruso, Lucía. Instituto de Neurología Cognitiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Neurologia Cognitiva. Laboratorio de Psicologia Experimental y Neurociencia; ArgentinaFil: Gómez Arévalo, Gonzalo. Instituto de Neurología Cognitiva; Argentina. Instituto de Neurologia Cognitiva. Laboratorio de Psicologia Experimental y Neurociencia; ArgentinaFil: Chade, Anable. Instituto de Neurología Cognitiva; Argentina. Instituto de Neurologia Cognitiva. Laboratorio de Psicologia Experimental y Neurociencia; ArgentinaFil: Dubrovsky, Alberto. Instituto de Neurología Cognitiva; Argentina. Instituto de Neurologia Cognitiva. Laboratorio de Psicologia Experimental y Neurociencia; ArgentinaFil: Gershanik, Oscar. Instituto de Neurología Cognitiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Neurologia Cognitiva. Laboratorio de Psicologia Experimental y Neurociencia; ArgentinaFil: Kochen, Sara Silvia. Gobierno de la Ciudad de Buenos Aires. Hospital Gral.de Agudos "ramos Mejia"; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Glenberg, Arthur. Arizona State University; Estados Unidos. University Of Wisconsin; Estados UnidosFil: Manes, Facundo Francisco. Instituto de Neurologia Cognitiva. Laboratorio de Psicologia Experimental y Neurociencia; Argentina. Instituto de Neurología Cognitiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bekinschtein, Tristán Andrés. Instituto de Neurologia Cognitiva. Laboratorio de Psicologia Experimental y Neurociencia; Argentina. Instituto de Neurología Cognitiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Medical Research Council. Cognition and Brain Sciences Unit; Reino UnidoElsevier Masson2013-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/10909Ibanez Barassi, Agustin Mariano; Cardona, Juan F.; Dos Santos, Yamil Vidal; Blenkmann, Alejandro Omar; Aravena, Pía; et al.; Motor-language coupling: Direct evidence from early Parkinson's disease and intracranial cortical recordings; Elsevier Masson; Cortex; 49; 4; 4-2013; 968-9840010-9452enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0010945212000834info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cortex.2012.02.014info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:20:52Zoai:ri.conicet.gov.ar:11336/10909instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:20:52.823CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Motor-language coupling: Direct evidence from early Parkinson's disease and intracranial cortical recordings |
| title |
Motor-language coupling: Direct evidence from early Parkinson's disease and intracranial cortical recordings |
| spellingShingle |
Motor-language coupling: Direct evidence from early Parkinson's disease and intracranial cortical recordings Ibañez, Agustin Mariano Ace Parkinson'S Disease Ecog Intracranial N400 Intracranial Mp |
| title_short |
Motor-language coupling: Direct evidence from early Parkinson's disease and intracranial cortical recordings |
| title_full |
Motor-language coupling: Direct evidence from early Parkinson's disease and intracranial cortical recordings |
| title_fullStr |
Motor-language coupling: Direct evidence from early Parkinson's disease and intracranial cortical recordings |
| title_full_unstemmed |
Motor-language coupling: Direct evidence from early Parkinson's disease and intracranial cortical recordings |
| title_sort |
Motor-language coupling: Direct evidence from early Parkinson's disease and intracranial cortical recordings |
| dc.creator.none.fl_str_mv |
Ibañez, Agustin Mariano Cardona, Juan F. Dos Santos, Yamil Vidal Blenkmann, Alejandro Omar Aravena, Pía Roca, María Hurtado, Esteban Nerguizian, Mirna Amoruso, Lucía Gómez Arévalo, Gonzalo Chade, Anable Dubrovsky, Alberto Gershanik, Oscar Kochen, Sara Silvia Glenberg, Arthur Manes, Facundo Francisco Bekinschtein, Tristán Andrés |
| author |
Ibañez, Agustin Mariano |
| author_facet |
Ibañez, Agustin Mariano Cardona, Juan F. Dos Santos, Yamil Vidal Blenkmann, Alejandro Omar Aravena, Pía Roca, María Hurtado, Esteban Nerguizian, Mirna Amoruso, Lucía Gómez Arévalo, Gonzalo Chade, Anable Dubrovsky, Alberto Gershanik, Oscar Kochen, Sara Silvia Glenberg, Arthur Manes, Facundo Francisco Bekinschtein, Tristán Andrés |
| author_role |
author |
| author2 |
Cardona, Juan F. Dos Santos, Yamil Vidal Blenkmann, Alejandro Omar Aravena, Pía Roca, María Hurtado, Esteban Nerguizian, Mirna Amoruso, Lucía Gómez Arévalo, Gonzalo Chade, Anable Dubrovsky, Alberto Gershanik, Oscar Kochen, Sara Silvia Glenberg, Arthur Manes, Facundo Francisco Bekinschtein, Tristán Andrés |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Ace Parkinson'S Disease Ecog Intracranial N400 Intracranial Mp |
| topic |
Ace Parkinson'S Disease Ecog Intracranial N400 Intracranial Mp |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
| dc.description.none.fl_txt_mv |
Language and action systems are functionally coupled in the brain as demonstrated by converging evidence using Functional magnetic resonance imaging (fMRI), electroencephalography (EEG), transcranial magnetic stimulation (TMS), and lesion studies. In particular, this coupling has been demonstrated using the action-sentence compatibility effect (ACE) in which motor activity and language interact. The ACE task requires participants to listen to sentences that described actions typically performed with an open hand (e.g., clapping), a closed hand (e.g., hammering), or without any hand action (neutral); and to press a large button with either an open hand position or closed hand position immediately upon comprehending each sentence. The ACE is defined as a longer reaction time (RT) in the action-sentence incompatible conditions than in the compatible conditions. Here we investigated direct motor-language coupling in two novel and uniquely informative ways. First, we measured the behavioural ACE in patients with motor impairment (early Parkinson’s disease – EPD), and second, in epileptic patients with direct electrocorticography (ECoG) recordings. In experiment 1, EPD participants with preserved general cognitive repertoire, showed a much diminished ACE relative to non-EPD volunteers. Moreover, a correlation between ACE performance and action-verb processing (kissing and dancing test – KDT) was observed. Direct cortical recordings (ECoG) in motor and language areas (experiment 2) demonstrated simultaneous bidirectional effects: motor preparation affected language processing (N400 at left inferior frontal gyrus and middle/superior temporal gyrus), and language processing affected activity in movement-related areas (motor potential at premotor and M1). Our findings show that the ACE paradigm requires ongoing integration of preserved motor and language coupling (abolished in EPD) and engages motor-temporal cortices in a bidirectional way. In addition, both experiments suggest the presence of a motor-language network which is not restricted to somatotopically defined brain areas. These results open new pathways in the fields of motor diseases, theoretical approaches to language understanding, and models of action-perception coupling. Fil: Ibanez Barassi, Agustin Mariano. Instituto de Neurologia Cognitiva. Laboratorio de Psicologia Experimental y Neurociencia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Diego Portales; Chile. Instituto de Neurología Cognitiva; Argentina Fil: Cardona, Juan F.. Instituto de Neurologia Cognitiva. Laboratorio de Psicologia Experimental y Neurociencia; Argentina. Universidad de Buenos Aires. Facultad de Psicologia; Argentina. Instituto de Neurología Cognitiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Dos Santos, Yamil Vidal. Instituto de Neurologia Cognitiva. Laboratorio de Psicologia Experimental y Neurociencia; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física. Laboratorio de Neurociencia Integrativa; Argentina Fil: Blenkmann, Alejandro Omar. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina. Universidad Nacional de la Plata. Facultad de Ingenieria. Departamento de Electrotecnia. Laboratorio de Electronica Ind., Control E Instrumentac.; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital Gral.de Agudos "ramos Mejia"; Argentina Fil: Aravena, Pía. Institut des Sciences Cognitives; Francia Fil: Roca, María. Instituto de Neurología Cognitiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Neurologia Cognitiva. Laboratorio de Psicologia Experimental y Neurociencia; Argentina Fil: Hurtado, Esteban. Pontificia Universidad Católica de Chile; Chile Fil: Nerguizian, Mirna. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro; Argentina. Instituto de Neurologia Cognitiva. Laboratorio de Psicologia Experimental y Neurociencia; Argentina Fil: Amoruso, Lucía. Instituto de Neurología Cognitiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Neurologia Cognitiva. Laboratorio de Psicologia Experimental y Neurociencia; Argentina Fil: Gómez Arévalo, Gonzalo. Instituto de Neurología Cognitiva; Argentina. Instituto de Neurologia Cognitiva. Laboratorio de Psicologia Experimental y Neurociencia; Argentina Fil: Chade, Anable. Instituto de Neurología Cognitiva; Argentina. Instituto de Neurologia Cognitiva. Laboratorio de Psicologia Experimental y Neurociencia; Argentina Fil: Dubrovsky, Alberto. Instituto de Neurología Cognitiva; Argentina. Instituto de Neurologia Cognitiva. Laboratorio de Psicologia Experimental y Neurociencia; Argentina Fil: Gershanik, Oscar. Instituto de Neurología Cognitiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Neurologia Cognitiva. Laboratorio de Psicologia Experimental y Neurociencia; Argentina Fil: Kochen, Sara Silvia. Gobierno de la Ciudad de Buenos Aires. Hospital Gral.de Agudos "ramos Mejia"; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Glenberg, Arthur. Arizona State University; Estados Unidos. University Of Wisconsin; Estados Unidos Fil: Manes, Facundo Francisco. Instituto de Neurologia Cognitiva. Laboratorio de Psicologia Experimental y Neurociencia; Argentina. Instituto de Neurología Cognitiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Bekinschtein, Tristán Andrés. Instituto de Neurologia Cognitiva. Laboratorio de Psicologia Experimental y Neurociencia; Argentina. Instituto de Neurología Cognitiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Medical Research Council. Cognition and Brain Sciences Unit; Reino Unido |
| description |
Language and action systems are functionally coupled in the brain as demonstrated by converging evidence using Functional magnetic resonance imaging (fMRI), electroencephalography (EEG), transcranial magnetic stimulation (TMS), and lesion studies. In particular, this coupling has been demonstrated using the action-sentence compatibility effect (ACE) in which motor activity and language interact. The ACE task requires participants to listen to sentences that described actions typically performed with an open hand (e.g., clapping), a closed hand (e.g., hammering), or without any hand action (neutral); and to press a large button with either an open hand position or closed hand position immediately upon comprehending each sentence. The ACE is defined as a longer reaction time (RT) in the action-sentence incompatible conditions than in the compatible conditions. Here we investigated direct motor-language coupling in two novel and uniquely informative ways. First, we measured the behavioural ACE in patients with motor impairment (early Parkinson’s disease – EPD), and second, in epileptic patients with direct electrocorticography (ECoG) recordings. In experiment 1, EPD participants with preserved general cognitive repertoire, showed a much diminished ACE relative to non-EPD volunteers. Moreover, a correlation between ACE performance and action-verb processing (kissing and dancing test – KDT) was observed. Direct cortical recordings (ECoG) in motor and language areas (experiment 2) demonstrated simultaneous bidirectional effects: motor preparation affected language processing (N400 at left inferior frontal gyrus and middle/superior temporal gyrus), and language processing affected activity in movement-related areas (motor potential at premotor and M1). Our findings show that the ACE paradigm requires ongoing integration of preserved motor and language coupling (abolished in EPD) and engages motor-temporal cortices in a bidirectional way. In addition, both experiments suggest the presence of a motor-language network which is not restricted to somatotopically defined brain areas. These results open new pathways in the fields of motor diseases, theoretical approaches to language understanding, and models of action-perception coupling. |
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2013 |
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2013-04 |
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http://hdl.handle.net/11336/10909 Ibanez Barassi, Agustin Mariano; Cardona, Juan F.; Dos Santos, Yamil Vidal; Blenkmann, Alejandro Omar; Aravena, Pía; et al.; Motor-language coupling: Direct evidence from early Parkinson's disease and intracranial cortical recordings; Elsevier Masson; Cortex; 49; 4; 4-2013; 968-984 0010-9452 |
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http://hdl.handle.net/11336/10909 |
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Ibanez Barassi, Agustin Mariano; Cardona, Juan F.; Dos Santos, Yamil Vidal; Blenkmann, Alejandro Omar; Aravena, Pía; et al.; Motor-language coupling: Direct evidence from early Parkinson's disease and intracranial cortical recordings; Elsevier Masson; Cortex; 49; 4; 4-2013; 968-984 0010-9452 |
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