Hemolytic uremic syndrome: pathogenesis and update of interventions

Autores
Palermo, Marina Sandra; Exeni, Ramón Alfonso; Fernández, Gabriela Cristina
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The typical form of hemolytic uremic syndrome (HUS) is the major complication of Shiga toxin-producing Escherichia coli infections. HUS is a critical health problem in Argentina since it is the main cause of acute renal failure in children and the second cause of chronic renal failure, accounting for 20% of renal transplants in children and adolescents in Argentina. Despite extensive research in the field, the mainstay of treatment for patients with HUS is supportive therapy, and there are no specific therapies preventing or ameliorating the disease course. In this review, we present the current knowledge about pathogenic mechanisms and discuss traditional and innovative therapeutic approaches, with special focus in Argentinean contribution. The hope that a better understanding of transmission dynamics and pathogenesis of this disease will produce better therapies to prevent the acute mortality and the long-term morbidity of HUS is the driving force for intensified research.
Fil: Palermo, Marina Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Exeni, Ramón Alfonso. Municipio de La Matanza. Hospital del Niño; Argentina
Fil: Fernández, Gabriela Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Materia
Escherichia Coli Infections
Hus
Fluid Therapy
Hemolitic Uremic Syndrome
Shiga Toxin
Argentina
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/55090
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Hemolytic uremic syndrome: pathogenesis and update of interventionsPalermo, Marina SandraExeni, Ramón AlfonsoFernández, Gabriela CristinaEscherichia Coli InfectionsHusFluid TherapyHemolitic Uremic SyndromeShiga ToxinArgentinahttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The typical form of hemolytic uremic syndrome (HUS) is the major complication of Shiga toxin-producing Escherichia coli infections. HUS is a critical health problem in Argentina since it is the main cause of acute renal failure in children and the second cause of chronic renal failure, accounting for 20% of renal transplants in children and adolescents in Argentina. Despite extensive research in the field, the mainstay of treatment for patients with HUS is supportive therapy, and there are no specific therapies preventing or ameliorating the disease course. In this review, we present the current knowledge about pathogenic mechanisms and discuss traditional and innovative therapeutic approaches, with special focus in Argentinean contribution. The hope that a better understanding of transmission dynamics and pathogenesis of this disease will produce better therapies to prevent the acute mortality and the long-term morbidity of HUS is the driving force for intensified research.Fil: Palermo, Marina Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Exeni, Ramón Alfonso. Municipio de La Matanza. Hospital del Niño; ArgentinaFil: Fernández, Gabriela Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFuture Drugs Ltd.2009-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/55090Palermo, Marina Sandra; Exeni, Ramón Alfonso; Fernández, Gabriela Cristina; Hemolytic uremic syndrome: pathogenesis and update of interventions; Future Drugs Ltd.; Expert review of anti-infective therapy; 7; 6; 12-2009; 697-7071478-72101744-8336CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/full/10.1586/eri.09.49info:eu-repo/semantics/altIdentifier/doi/10.1586/eri.09.49info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:54:34Zoai:ri.conicet.gov.ar:11336/55090instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:54:35.29CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Hemolytic uremic syndrome: pathogenesis and update of interventions
title Hemolytic uremic syndrome: pathogenesis and update of interventions
spellingShingle Hemolytic uremic syndrome: pathogenesis and update of interventions
Palermo, Marina Sandra
Escherichia Coli Infections
Hus
Fluid Therapy
Hemolitic Uremic Syndrome
Shiga Toxin
Argentina
title_short Hemolytic uremic syndrome: pathogenesis and update of interventions
title_full Hemolytic uremic syndrome: pathogenesis and update of interventions
title_fullStr Hemolytic uremic syndrome: pathogenesis and update of interventions
title_full_unstemmed Hemolytic uremic syndrome: pathogenesis and update of interventions
title_sort Hemolytic uremic syndrome: pathogenesis and update of interventions
dc.creator.none.fl_str_mv Palermo, Marina Sandra
Exeni, Ramón Alfonso
Fernández, Gabriela Cristina
author Palermo, Marina Sandra
author_facet Palermo, Marina Sandra
Exeni, Ramón Alfonso
Fernández, Gabriela Cristina
author_role author
author2 Exeni, Ramón Alfonso
Fernández, Gabriela Cristina
author2_role author
author
dc.subject.none.fl_str_mv Escherichia Coli Infections
Hus
Fluid Therapy
Hemolitic Uremic Syndrome
Shiga Toxin
Argentina
topic Escherichia Coli Infections
Hus
Fluid Therapy
Hemolitic Uremic Syndrome
Shiga Toxin
Argentina
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The typical form of hemolytic uremic syndrome (HUS) is the major complication of Shiga toxin-producing Escherichia coli infections. HUS is a critical health problem in Argentina since it is the main cause of acute renal failure in children and the second cause of chronic renal failure, accounting for 20% of renal transplants in children and adolescents in Argentina. Despite extensive research in the field, the mainstay of treatment for patients with HUS is supportive therapy, and there are no specific therapies preventing or ameliorating the disease course. In this review, we present the current knowledge about pathogenic mechanisms and discuss traditional and innovative therapeutic approaches, with special focus in Argentinean contribution. The hope that a better understanding of transmission dynamics and pathogenesis of this disease will produce better therapies to prevent the acute mortality and the long-term morbidity of HUS is the driving force for intensified research.
Fil: Palermo, Marina Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Exeni, Ramón Alfonso. Municipio de La Matanza. Hospital del Niño; Argentina
Fil: Fernández, Gabriela Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
description The typical form of hemolytic uremic syndrome (HUS) is the major complication of Shiga toxin-producing Escherichia coli infections. HUS is a critical health problem in Argentina since it is the main cause of acute renal failure in children and the second cause of chronic renal failure, accounting for 20% of renal transplants in children and adolescents in Argentina. Despite extensive research in the field, the mainstay of treatment for patients with HUS is supportive therapy, and there are no specific therapies preventing or ameliorating the disease course. In this review, we present the current knowledge about pathogenic mechanisms and discuss traditional and innovative therapeutic approaches, with special focus in Argentinean contribution. The hope that a better understanding of transmission dynamics and pathogenesis of this disease will produce better therapies to prevent the acute mortality and the long-term morbidity of HUS is the driving force for intensified research.
publishDate 2009
dc.date.none.fl_str_mv 2009-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/55090
Palermo, Marina Sandra; Exeni, Ramón Alfonso; Fernández, Gabriela Cristina; Hemolytic uremic syndrome: pathogenesis and update of interventions; Future Drugs Ltd.; Expert review of anti-infective therapy; 7; 6; 12-2009; 697-707
1478-7210
1744-8336
CONICET Digital
CONICET
url http://hdl.handle.net/11336/55090
identifier_str_mv Palermo, Marina Sandra; Exeni, Ramón Alfonso; Fernández, Gabriela Cristina; Hemolytic uremic syndrome: pathogenesis and update of interventions; Future Drugs Ltd.; Expert review of anti-infective therapy; 7; 6; 12-2009; 697-707
1478-7210
1744-8336
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/full/10.1586/eri.09.49
info:eu-repo/semantics/altIdentifier/doi/10.1586/eri.09.49
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Future Drugs Ltd.
publisher.none.fl_str_mv Future Drugs Ltd.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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