Morphologic and nanomechanical characterization of bone tissue growth around bioactive sol–gel coatings containing wollastonite particles applied on stainless steel implants

Autores
Ballarre, Josefina; Selzer, Rocio; Mendoza, Emigdio; Orellano, Juan Carlos; Mai, Yiu Wing; García, Claudia; Ceré, Silvia
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Metals are the most widely used materials in orthopaedic and dental implants due to their excellent mechanical properties. However, they do not bond naturally with mineralized bone. Further, they can release metallic particles that may finally result in the removal of the implant. There are two strategies to avoid these drawbacks: one is to protect the metallic implant with a biocompatible coating and the other is to add bioactive particles to enhance implant fixation to the existing bone. In this work, surgical grade stainless steel implants coated with tetraethoxysilane (TEOS)-methyltriethoxysilane (MTES) and 10 wt.% of commercial wollastonite particles were implanted in the Hokkaido femur rats. Transversal sections of the tibia samples were examined with SEM, AFM, histological analysis and nanoindentation experiments in air and under physiological conditions to characterize the hydroxyapatite deposits and the composition of the newly formed tissue around the implant. The results showed no presence of harmful ions or metallic particles in the surrounding tissues and that the coating promoted formation and growth of new bone in the periphery of the implant, both in contact with the old bone (remodellation zone) and the marrow (new bone). The relative mechanical behavior of old, remodeled and new bone tissues obtained in air cannot be directly extrapolated to live or in vivo-physiological response. This may be caused by the different degree of hydration and SBF/structure interaction among the three types of bones but these values are near the normal hydrated bone response.
Fil: Ballarre, Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Selzer, Rocio. University of Sydney; Australia
Fil: Mendoza, Emigdio. Universidad Nacional de Colombia; Colombia
Fil: Orellano, Juan Carlos. Hospital Interzonal General de Agudos “Oscar Alende”; Argentina
Fil: Mai, Yiu Wing. University of Sydney; Australia
Fil: García, Claudia. Universidad Nacional de Colombia; Colombia
Fil: Ceré, Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Materia
Bioactive Coatings
Bone Formation
Nanoindentation
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/78722
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/78722
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Morphologic and nanomechanical characterization of bone tissue growth around bioactive sol–gel coatings containing wollastonite particles applied on stainless steel implantsBallarre, JosefinaSelzer, RocioMendoza, EmigdioOrellano, Juan CarlosMai, Yiu WingGarcía, ClaudiaCeré, SilviaBioactive CoatingsBone FormationNanoindentationhttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2https://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/2Metals are the most widely used materials in orthopaedic and dental implants due to their excellent mechanical properties. However, they do not bond naturally with mineralized bone. Further, they can release metallic particles that may finally result in the removal of the implant. There are two strategies to avoid these drawbacks: one is to protect the metallic implant with a biocompatible coating and the other is to add bioactive particles to enhance implant fixation to the existing bone. In this work, surgical grade stainless steel implants coated with tetraethoxysilane (TEOS)-methyltriethoxysilane (MTES) and 10 wt.% of commercial wollastonite particles were implanted in the Hokkaido femur rats. Transversal sections of the tibia samples were examined with SEM, AFM, histological analysis and nanoindentation experiments in air and under physiological conditions to characterize the hydroxyapatite deposits and the composition of the newly formed tissue around the implant. The results showed no presence of harmful ions or metallic particles in the surrounding tissues and that the coating promoted formation and growth of new bone in the periphery of the implant, both in contact with the old bone (remodellation zone) and the marrow (new bone). The relative mechanical behavior of old, remodeled and new bone tissues obtained in air cannot be directly extrapolated to live or in vivo-physiological response. This may be caused by the different degree of hydration and SBF/structure interaction among the three types of bones but these values are near the normal hydrated bone response.Fil: Ballarre, Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Selzer, Rocio. University of Sydney; AustraliaFil: Mendoza, Emigdio. Universidad Nacional de Colombia; ColombiaFil: Orellano, Juan Carlos. Hospital Interzonal General de Agudos “Oscar Alende”; ArgentinaFil: Mai, Yiu Wing. University of Sydney; AustraliaFil: García, Claudia. Universidad Nacional de Colombia; ColombiaFil: Ceré, Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaElsevier Science2011-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/78722Ballarre, Josefina; Selzer, Rocio; Mendoza, Emigdio; Orellano, Juan Carlos; Mai, Yiu Wing; et al.; Morphologic and nanomechanical characterization of bone tissue growth around bioactive sol–gel coatings containing wollastonite particles applied on stainless steel implants; Elsevier Science; Materials Science and Engineering: C; 31; 3; 4-2011; 545-5520928-4931CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0928493110003449info:eu-repo/semantics/altIdentifier/doi/10.1016/j.msec.2010.11.030info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:03:51Zoai:ri.conicet.gov.ar:11336/78722instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:03:51.467CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Morphologic and nanomechanical characterization of bone tissue growth around bioactive sol–gel coatings containing wollastonite particles applied on stainless steel implants
title Morphologic and nanomechanical characterization of bone tissue growth around bioactive sol–gel coatings containing wollastonite particles applied on stainless steel implants
spellingShingle Morphologic and nanomechanical characterization of bone tissue growth around bioactive sol–gel coatings containing wollastonite particles applied on stainless steel implants
Ballarre, Josefina
Bioactive Coatings
Bone Formation
Nanoindentation
title_short Morphologic and nanomechanical characterization of bone tissue growth around bioactive sol–gel coatings containing wollastonite particles applied on stainless steel implants
title_full Morphologic and nanomechanical characterization of bone tissue growth around bioactive sol–gel coatings containing wollastonite particles applied on stainless steel implants
title_fullStr Morphologic and nanomechanical characterization of bone tissue growth around bioactive sol–gel coatings containing wollastonite particles applied on stainless steel implants
title_full_unstemmed Morphologic and nanomechanical characterization of bone tissue growth around bioactive sol–gel coatings containing wollastonite particles applied on stainless steel implants
title_sort Morphologic and nanomechanical characterization of bone tissue growth around bioactive sol–gel coatings containing wollastonite particles applied on stainless steel implants
dc.creator.none.fl_str_mv Ballarre, Josefina
Selzer, Rocio
Mendoza, Emigdio
Orellano, Juan Carlos
Mai, Yiu Wing
García, Claudia
Ceré, Silvia
author Ballarre, Josefina
author_facet Ballarre, Josefina
Selzer, Rocio
Mendoza, Emigdio
Orellano, Juan Carlos
Mai, Yiu Wing
García, Claudia
Ceré, Silvia
author_role author
author2 Selzer, Rocio
Mendoza, Emigdio
Orellano, Juan Carlos
Mai, Yiu Wing
García, Claudia
Ceré, Silvia
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Bioactive Coatings
Bone Formation
Nanoindentation
topic Bioactive Coatings
Bone Formation
Nanoindentation
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
https://purl.org/becyt/ford/2.5
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Metals are the most widely used materials in orthopaedic and dental implants due to their excellent mechanical properties. However, they do not bond naturally with mineralized bone. Further, they can release metallic particles that may finally result in the removal of the implant. There are two strategies to avoid these drawbacks: one is to protect the metallic implant with a biocompatible coating and the other is to add bioactive particles to enhance implant fixation to the existing bone. In this work, surgical grade stainless steel implants coated with tetraethoxysilane (TEOS)-methyltriethoxysilane (MTES) and 10 wt.% of commercial wollastonite particles were implanted in the Hokkaido femur rats. Transversal sections of the tibia samples were examined with SEM, AFM, histological analysis and nanoindentation experiments in air and under physiological conditions to characterize the hydroxyapatite deposits and the composition of the newly formed tissue around the implant. The results showed no presence of harmful ions or metallic particles in the surrounding tissues and that the coating promoted formation and growth of new bone in the periphery of the implant, both in contact with the old bone (remodellation zone) and the marrow (new bone). The relative mechanical behavior of old, remodeled and new bone tissues obtained in air cannot be directly extrapolated to live or in vivo-physiological response. This may be caused by the different degree of hydration and SBF/structure interaction among the three types of bones but these values are near the normal hydrated bone response.
Fil: Ballarre, Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Selzer, Rocio. University of Sydney; Australia
Fil: Mendoza, Emigdio. Universidad Nacional de Colombia; Colombia
Fil: Orellano, Juan Carlos. Hospital Interzonal General de Agudos “Oscar Alende”; Argentina
Fil: Mai, Yiu Wing. University of Sydney; Australia
Fil: García, Claudia. Universidad Nacional de Colombia; Colombia
Fil: Ceré, Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
description Metals are the most widely used materials in orthopaedic and dental implants due to their excellent mechanical properties. However, they do not bond naturally with mineralized bone. Further, they can release metallic particles that may finally result in the removal of the implant. There are two strategies to avoid these drawbacks: one is to protect the metallic implant with a biocompatible coating and the other is to add bioactive particles to enhance implant fixation to the existing bone. In this work, surgical grade stainless steel implants coated with tetraethoxysilane (TEOS)-methyltriethoxysilane (MTES) and 10 wt.% of commercial wollastonite particles were implanted in the Hokkaido femur rats. Transversal sections of the tibia samples were examined with SEM, AFM, histological analysis and nanoindentation experiments in air and under physiological conditions to characterize the hydroxyapatite deposits and the composition of the newly formed tissue around the implant. The results showed no presence of harmful ions or metallic particles in the surrounding tissues and that the coating promoted formation and growth of new bone in the periphery of the implant, both in contact with the old bone (remodellation zone) and the marrow (new bone). The relative mechanical behavior of old, remodeled and new bone tissues obtained in air cannot be directly extrapolated to live or in vivo-physiological response. This may be caused by the different degree of hydration and SBF/structure interaction among the three types of bones but these values are near the normal hydrated bone response.
publishDate 2011
dc.date.none.fl_str_mv 2011-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/78722
Ballarre, Josefina; Selzer, Rocio; Mendoza, Emigdio; Orellano, Juan Carlos; Mai, Yiu Wing; et al.; Morphologic and nanomechanical characterization of bone tissue growth around bioactive sol–gel coatings containing wollastonite particles applied on stainless steel implants; Elsevier Science; Materials Science and Engineering: C; 31; 3; 4-2011; 545-552
0928-4931
CONICET Digital
CONICET
url http://hdl.handle.net/11336/78722
identifier_str_mv Ballarre, Josefina; Selzer, Rocio; Mendoza, Emigdio; Orellano, Juan Carlos; Mai, Yiu Wing; et al.; Morphologic and nanomechanical characterization of bone tissue growth around bioactive sol–gel coatings containing wollastonite particles applied on stainless steel implants; Elsevier Science; Materials Science and Engineering: C; 31; 3; 4-2011; 545-552
0928-4931
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0928493110003449
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.msec.2010.11.030
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.004268

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