Addenbrooke's Cognitive Examination validation in Parkinson's disease

Autores
Reyes, M. A.; Perez Lloret, Santiago; Gerscovich, E. R.; Martin, M. E.; Leiguarda, R.; Merello, Marcelo Jorge
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: There is a clear need for brief, sensitive and specific cognitive screening instruments in Parkinson's disease (PD). Objectives: To study Addenbrooke's Cognitive Examination (ACE) validity for cognitive assessment of PD patient's using the Mattis Dementia Rating Scale (MDRS) as reference method. A specific scale for cognitive evaluation in PD, in this instance the Scales for Outcomes of Parkinson's disease - Cognition (SCOPA-COG), as well as a general use scale the Mini-mental state examination (MMSE) were also studied for further correlation. Methods: Forty-four PD patients were studied, of these 27 were males (61%), with a mean (SD) age of 69.5 (11.8) years, mean (SD) disease duration of 7.6 (6.4) years (range 1-25), mean (SD) total Unified Parkinson's Disease Rating Scale (UPDRS) score 37 (24) points, UPDRS III 16.5 (11.3) points. MDRS, ACE and SCOPA-COG scales were administered in random order. All patients remained in on-state during the study. Results: Addenbrooke's Cognitive Examination correlated with SCOPA-COG (r = 0.93, P < 0.0001), and MDRS (r = 0.91 P < 0.0001) and also with MMSE (r = 0.84, P < 0.001). Area under the receiver-operating curve, taking MDRS as the reference test, was 0.97 [95% confidence interval (CI): 0.92-1.00] for ACE, 0.92 (95% CI: 0.83-1.00) for SCOPA-COG and 0.91 (95% CI: 0.83-1.00) for MMSE. Best cut-off value for ACE was 83 points [Sensitivity (Se) = 92%; Specificity (Sp) = 91%; Kappa concordance (K) = 0.79], 20 points for the SCOPA-COG (Se = 92%; Sp = 87%; K = 0.74) and 26 points for MMSE (Se = 61%; Sp = 100%; K = 0.69). Conclusion: Addenbrooke's Cognitive Examination appears to be a valid tool for dementia evaluation in PD, with a cut-off point which should probably be set at 83 points, displaying good correlation with both the scale specifically designed for cognitive deficits in PD namely SCOPA-COG, as well as with less specific tests such as MMSE.
Fil: Reyes, M. A.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad Militar Nueva Granada; Colombia
Fil: Perez Lloret, Santiago. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gerscovich, E. R.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Martin, M. E.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Leiguarda, R.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Merello, Marcelo Jorge. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
COGNITIVE EVALUATION
DEMENTIA
NEUROLOGY
PARKINSON 'S DISEASE
VALIDATION STUDY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/118107
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/118107
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Addenbrooke's Cognitive Examination validation in Parkinson's diseaseReyes, M. A.Perez Lloret, SantiagoGerscovich, E. R.Martin, M. E.Leiguarda, R.Merello, Marcelo JorgeCOGNITIVE EVALUATIONDEMENTIANEUROLOGYPARKINSON 'S DISEASEVALIDATION STUDYhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Background: There is a clear need for brief, sensitive and specific cognitive screening instruments in Parkinson's disease (PD). Objectives: To study Addenbrooke's Cognitive Examination (ACE) validity for cognitive assessment of PD patient's using the Mattis Dementia Rating Scale (MDRS) as reference method. A specific scale for cognitive evaluation in PD, in this instance the Scales for Outcomes of Parkinson's disease - Cognition (SCOPA-COG), as well as a general use scale the Mini-mental state examination (MMSE) were also studied for further correlation. Methods: Forty-four PD patients were studied, of these 27 were males (61%), with a mean (SD) age of 69.5 (11.8) years, mean (SD) disease duration of 7.6 (6.4) years (range 1-25), mean (SD) total Unified Parkinson's Disease Rating Scale (UPDRS) score 37 (24) points, UPDRS III 16.5 (11.3) points. MDRS, ACE and SCOPA-COG scales were administered in random order. All patients remained in on-state during the study. Results: Addenbrooke's Cognitive Examination correlated with SCOPA-COG (r = 0.93, P < 0.0001), and MDRS (r = 0.91 P < 0.0001) and also with MMSE (r = 0.84, P < 0.001). Area under the receiver-operating curve, taking MDRS as the reference test, was 0.97 [95% confidence interval (CI): 0.92-1.00] for ACE, 0.92 (95% CI: 0.83-1.00) for SCOPA-COG and 0.91 (95% CI: 0.83-1.00) for MMSE. Best cut-off value for ACE was 83 points [Sensitivity (Se) = 92%; Specificity (Sp) = 91%; Kappa concordance (K) = 0.79], 20 points for the SCOPA-COG (Se = 92%; Sp = 87%; K = 0.74) and 26 points for MMSE (Se = 61%; Sp = 100%; K = 0.69). Conclusion: Addenbrooke's Cognitive Examination appears to be a valid tool for dementia evaluation in PD, with a cut-off point which should probably be set at 83 points, displaying good correlation with both the scale specifically designed for cognitive deficits in PD namely SCOPA-COG, as well as with less specific tests such as MMSE.Fil: Reyes, M. A.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad Militar Nueva Granada; ColombiaFil: Perez Lloret, Santiago. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gerscovich, E. R.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Martin, M. E.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Leiguarda, R.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Merello, Marcelo Jorge. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaWiley Blackwell Publishing, Inc2009-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/118107Reyes, M. A.; Perez Lloret, Santiago; Gerscovich, E. R.; Martin, M. E.; Leiguarda, R.; et al.; Addenbrooke's Cognitive Examination validation in Parkinson's disease; Wiley Blackwell Publishing, Inc; European Journal of Neurology; 16; 1; 1-2009; 142-1471351-5101CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1468-1331.2008.02384.xinfo:eu-repo/semantics/altIdentifier/doi/10.1111/j.1468-1331.2008.02384.xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:40:27Zoai:ri.conicet.gov.ar:11336/118107instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:40:28.126CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Addenbrooke's Cognitive Examination validation in Parkinson's disease
title Addenbrooke's Cognitive Examination validation in Parkinson's disease
spellingShingle Addenbrooke's Cognitive Examination validation in Parkinson's disease
Reyes, M. A.
COGNITIVE EVALUATION
DEMENTIA
NEUROLOGY
PARKINSON 'S DISEASE
VALIDATION STUDY
title_short Addenbrooke's Cognitive Examination validation in Parkinson's disease
title_full Addenbrooke's Cognitive Examination validation in Parkinson's disease
title_fullStr Addenbrooke's Cognitive Examination validation in Parkinson's disease
title_full_unstemmed Addenbrooke's Cognitive Examination validation in Parkinson's disease
title_sort Addenbrooke's Cognitive Examination validation in Parkinson's disease
dc.creator.none.fl_str_mv Reyes, M. A.
Perez Lloret, Santiago
Gerscovich, E. R.
Martin, M. E.
Leiguarda, R.
Merello, Marcelo Jorge
author Reyes, M. A.
author_facet Reyes, M. A.
Perez Lloret, Santiago
Gerscovich, E. R.
Martin, M. E.
Leiguarda, R.
Merello, Marcelo Jorge
author_role author
author2 Perez Lloret, Santiago
Gerscovich, E. R.
Martin, M. E.
Leiguarda, R.
Merello, Marcelo Jorge
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv COGNITIVE EVALUATION
DEMENTIA
NEUROLOGY
PARKINSON 'S DISEASE
VALIDATION STUDY
topic COGNITIVE EVALUATION
DEMENTIA
NEUROLOGY
PARKINSON 'S DISEASE
VALIDATION STUDY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: There is a clear need for brief, sensitive and specific cognitive screening instruments in Parkinson's disease (PD). Objectives: To study Addenbrooke's Cognitive Examination (ACE) validity for cognitive assessment of PD patient's using the Mattis Dementia Rating Scale (MDRS) as reference method. A specific scale for cognitive evaluation in PD, in this instance the Scales for Outcomes of Parkinson's disease - Cognition (SCOPA-COG), as well as a general use scale the Mini-mental state examination (MMSE) were also studied for further correlation. Methods: Forty-four PD patients were studied, of these 27 were males (61%), with a mean (SD) age of 69.5 (11.8) years, mean (SD) disease duration of 7.6 (6.4) years (range 1-25), mean (SD) total Unified Parkinson's Disease Rating Scale (UPDRS) score 37 (24) points, UPDRS III 16.5 (11.3) points. MDRS, ACE and SCOPA-COG scales were administered in random order. All patients remained in on-state during the study. Results: Addenbrooke's Cognitive Examination correlated with SCOPA-COG (r = 0.93, P < 0.0001), and MDRS (r = 0.91 P < 0.0001) and also with MMSE (r = 0.84, P < 0.001). Area under the receiver-operating curve, taking MDRS as the reference test, was 0.97 [95% confidence interval (CI): 0.92-1.00] for ACE, 0.92 (95% CI: 0.83-1.00) for SCOPA-COG and 0.91 (95% CI: 0.83-1.00) for MMSE. Best cut-off value for ACE was 83 points [Sensitivity (Se) = 92%; Specificity (Sp) = 91%; Kappa concordance (K) = 0.79], 20 points for the SCOPA-COG (Se = 92%; Sp = 87%; K = 0.74) and 26 points for MMSE (Se = 61%; Sp = 100%; K = 0.69). Conclusion: Addenbrooke's Cognitive Examination appears to be a valid tool for dementia evaluation in PD, with a cut-off point which should probably be set at 83 points, displaying good correlation with both the scale specifically designed for cognitive deficits in PD namely SCOPA-COG, as well as with less specific tests such as MMSE.
Fil: Reyes, M. A.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad Militar Nueva Granada; Colombia
Fil: Perez Lloret, Santiago. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gerscovich, E. R.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Martin, M. E.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Leiguarda, R.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Merello, Marcelo Jorge. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Background: There is a clear need for brief, sensitive and specific cognitive screening instruments in Parkinson's disease (PD). Objectives: To study Addenbrooke's Cognitive Examination (ACE) validity for cognitive assessment of PD patient's using the Mattis Dementia Rating Scale (MDRS) as reference method. A specific scale for cognitive evaluation in PD, in this instance the Scales for Outcomes of Parkinson's disease - Cognition (SCOPA-COG), as well as a general use scale the Mini-mental state examination (MMSE) were also studied for further correlation. Methods: Forty-four PD patients were studied, of these 27 were males (61%), with a mean (SD) age of 69.5 (11.8) years, mean (SD) disease duration of 7.6 (6.4) years (range 1-25), mean (SD) total Unified Parkinson's Disease Rating Scale (UPDRS) score 37 (24) points, UPDRS III 16.5 (11.3) points. MDRS, ACE and SCOPA-COG scales were administered in random order. All patients remained in on-state during the study. Results: Addenbrooke's Cognitive Examination correlated with SCOPA-COG (r = 0.93, P < 0.0001), and MDRS (r = 0.91 P < 0.0001) and also with MMSE (r = 0.84, P < 0.001). Area under the receiver-operating curve, taking MDRS as the reference test, was 0.97 [95% confidence interval (CI): 0.92-1.00] for ACE, 0.92 (95% CI: 0.83-1.00) for SCOPA-COG and 0.91 (95% CI: 0.83-1.00) for MMSE. Best cut-off value for ACE was 83 points [Sensitivity (Se) = 92%; Specificity (Sp) = 91%; Kappa concordance (K) = 0.79], 20 points for the SCOPA-COG (Se = 92%; Sp = 87%; K = 0.74) and 26 points for MMSE (Se = 61%; Sp = 100%; K = 0.69). Conclusion: Addenbrooke's Cognitive Examination appears to be a valid tool for dementia evaluation in PD, with a cut-off point which should probably be set at 83 points, displaying good correlation with both the scale specifically designed for cognitive deficits in PD namely SCOPA-COG, as well as with less specific tests such as MMSE.
publishDate 2009
dc.date.none.fl_str_mv 2009-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/118107
Reyes, M. A.; Perez Lloret, Santiago; Gerscovich, E. R.; Martin, M. E.; Leiguarda, R.; et al.; Addenbrooke's Cognitive Examination validation in Parkinson's disease; Wiley Blackwell Publishing, Inc; European Journal of Neurology; 16; 1; 1-2009; 142-147
1351-5101
CONICET Digital
CONICET
url http://hdl.handle.net/11336/118107
identifier_str_mv Reyes, M. A.; Perez Lloret, Santiago; Gerscovich, E. R.; Martin, M. E.; Leiguarda, R.; et al.; Addenbrooke's Cognitive Examination validation in Parkinson's disease; Wiley Blackwell Publishing, Inc; European Journal of Neurology; 16; 1; 1-2009; 142-147
1351-5101
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1468-1331.2008.02384.x
info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1468-1331.2008.02384.x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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