Distribution of Pyrethroid Resistant Populations of Triatoma infestans in the Southern Cone of South America
- Autores
- Bustamante Gomez, Marinely; Gonçalves Diotaiuti, Liléia; Gorla, David Eladio
- Año de publicación
- 2016
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- A number of studies published during the last 15 years showed the occurrence of insecticide resistance in Triatoma infestans populations. The different toxicological profiles and mechanisms of resistance to insecticides is due to a genetic base and environmental factors, being the insecticide selective pressure the best studied among the last factors. The studies on insecticide resistance on T. infestans did not consider the effect of environmental factors that may influence the distribution of resistance to pyrethroid insecticides. To fill this knowledge gap, the present study aims at studying the association between the spatial distribution of pyrethroid resistant populations of T. infestans and environmental variables. A total of 24 articles reporting on studies that evaluated the susceptibility to pyrethroids of 222 field-collected T. infestans populations were compiled. The relationship between resistance occurrence (according to different criteria) with environmental variables was studied using a generalized linear model. The lethal dose that kills 50% of the evaluated population (LD 50 ) showed a strong linear relationship with the corresponding resistance ratio (RR 50 ). The statistical descriptive analysis of showed that the frequency distribution of the Log(LD 50 ) is bimodal, suggesting the existence of two statistical groups. A significant model including 5 environmental variables shows the geographic distribution of high and low LD 50 groups with a particular concentration of the highest LD 50 populations over the region identified as the putative center of dispersion of T. infestans.The occurrence of these two groups concentrated over a particular region that coincides with the area where populations of the intermediate cytogenetic group were found might reflect the spatial heterogeneity of the genetic variability of T. infestans, that seems to be the cause of the insecticide resistance in the area, even on sylvatic populations of T. infestans, never before exposed to pyrethroid insecticides, representing natural and wild toxicological phenotypes. The strong linear relationship found between LD 50 and RR 50 suggest RR 50 might not be the best indicator of insecticide resistance in triatomines.
Fil: Bustamante Gomez, Marinely. Centro de Pesquisas René Rachou. Laboratório de Referência em Triatomínueos e Epidemiologia da Doença de Chagas; Brasil
Fil: Gonçalves Diotaiuti, Liléia. Centro de Pesquisas René Rachou. Laboratório de Referência em Triatomínueos e Epidemiologia da Doença de Chagas; Brasil
Fil: Gorla, David Eladio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina - Materia
-
TRIATOMA INFESTANS
PYRETHROID RESISTANCE
GEOGRAPHIC DISTRIBUTION
ECOLOGICAL NICHE MODELLING - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/17654
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spelling |
Distribution of Pyrethroid Resistant Populations of Triatoma infestans in the Southern Cone of South AmericaBustamante Gomez, MarinelyGonçalves Diotaiuti, LiléiaGorla, David EladioTRIATOMA INFESTANSPYRETHROID RESISTANCEGEOGRAPHIC DISTRIBUTIONECOLOGICAL NICHE MODELLINGhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1A number of studies published during the last 15 years showed the occurrence of insecticide resistance in Triatoma infestans populations. The different toxicological profiles and mechanisms of resistance to insecticides is due to a genetic base and environmental factors, being the insecticide selective pressure the best studied among the last factors. The studies on insecticide resistance on T. infestans did not consider the effect of environmental factors that may influence the distribution of resistance to pyrethroid insecticides. To fill this knowledge gap, the present study aims at studying the association between the spatial distribution of pyrethroid resistant populations of T. infestans and environmental variables. A total of 24 articles reporting on studies that evaluated the susceptibility to pyrethroids of 222 field-collected T. infestans populations were compiled. The relationship between resistance occurrence (according to different criteria) with environmental variables was studied using a generalized linear model. The lethal dose that kills 50% of the evaluated population (LD 50 ) showed a strong linear relationship with the corresponding resistance ratio (RR 50 ). The statistical descriptive analysis of showed that the frequency distribution of the Log(LD 50 ) is bimodal, suggesting the existence of two statistical groups. A significant model including 5 environmental variables shows the geographic distribution of high and low LD 50 groups with a particular concentration of the highest LD 50 populations over the region identified as the putative center of dispersion of T. infestans.The occurrence of these two groups concentrated over a particular region that coincides with the area where populations of the intermediate cytogenetic group were found might reflect the spatial heterogeneity of the genetic variability of T. infestans, that seems to be the cause of the insecticide resistance in the area, even on sylvatic populations of T. infestans, never before exposed to pyrethroid insecticides, representing natural and wild toxicological phenotypes. The strong linear relationship found between LD 50 and RR 50 suggest RR 50 might not be the best indicator of insecticide resistance in triatomines.Fil: Bustamante Gomez, Marinely. Centro de Pesquisas René Rachou. Laboratório de Referência em Triatomínueos e Epidemiologia da Doença de Chagas; BrasilFil: Gonçalves Diotaiuti, Liléia. Centro de Pesquisas René Rachou. Laboratório de Referência em Triatomínueos e Epidemiologia da Doença de Chagas; BrasilFil: Gorla, David Eladio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaPublic Library Of Science2016-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/17654Bustamante Gomez, Marinely; Gonçalves Diotaiuti, Liléia; Gorla, David Eladio; Distribution of Pyrethroid Resistant Populations of Triatoma infestans in the Southern Cone of South America; Public Library Of Science; Neglected Tropical Diseases; 10; 3; 3-2016; 1-151935-27351935-2727enginfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805280/info:eu-repo/semantics/altIdentifier/doi/10.1371%2Fjournal.pntd.0004561info:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0004561info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:58:26Zoai:ri.conicet.gov.ar:11336/17654instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:58:27.055CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Distribution of Pyrethroid Resistant Populations of Triatoma infestans in the Southern Cone of South America |
title |
Distribution of Pyrethroid Resistant Populations of Triatoma infestans in the Southern Cone of South America |
spellingShingle |
Distribution of Pyrethroid Resistant Populations of Triatoma infestans in the Southern Cone of South America Bustamante Gomez, Marinely TRIATOMA INFESTANS PYRETHROID RESISTANCE GEOGRAPHIC DISTRIBUTION ECOLOGICAL NICHE MODELLING |
title_short |
Distribution of Pyrethroid Resistant Populations of Triatoma infestans in the Southern Cone of South America |
title_full |
Distribution of Pyrethroid Resistant Populations of Triatoma infestans in the Southern Cone of South America |
title_fullStr |
Distribution of Pyrethroid Resistant Populations of Triatoma infestans in the Southern Cone of South America |
title_full_unstemmed |
Distribution of Pyrethroid Resistant Populations of Triatoma infestans in the Southern Cone of South America |
title_sort |
Distribution of Pyrethroid Resistant Populations of Triatoma infestans in the Southern Cone of South America |
dc.creator.none.fl_str_mv |
Bustamante Gomez, Marinely Gonçalves Diotaiuti, Liléia Gorla, David Eladio |
author |
Bustamante Gomez, Marinely |
author_facet |
Bustamante Gomez, Marinely Gonçalves Diotaiuti, Liléia Gorla, David Eladio |
author_role |
author |
author2 |
Gonçalves Diotaiuti, Liléia Gorla, David Eladio |
author2_role |
author author |
dc.subject.none.fl_str_mv |
TRIATOMA INFESTANS PYRETHROID RESISTANCE GEOGRAPHIC DISTRIBUTION ECOLOGICAL NICHE MODELLING |
topic |
TRIATOMA INFESTANS PYRETHROID RESISTANCE GEOGRAPHIC DISTRIBUTION ECOLOGICAL NICHE MODELLING |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
A number of studies published during the last 15 years showed the occurrence of insecticide resistance in Triatoma infestans populations. The different toxicological profiles and mechanisms of resistance to insecticides is due to a genetic base and environmental factors, being the insecticide selective pressure the best studied among the last factors. The studies on insecticide resistance on T. infestans did not consider the effect of environmental factors that may influence the distribution of resistance to pyrethroid insecticides. To fill this knowledge gap, the present study aims at studying the association between the spatial distribution of pyrethroid resistant populations of T. infestans and environmental variables. A total of 24 articles reporting on studies that evaluated the susceptibility to pyrethroids of 222 field-collected T. infestans populations were compiled. The relationship between resistance occurrence (according to different criteria) with environmental variables was studied using a generalized linear model. The lethal dose that kills 50% of the evaluated population (LD 50 ) showed a strong linear relationship with the corresponding resistance ratio (RR 50 ). The statistical descriptive analysis of showed that the frequency distribution of the Log(LD 50 ) is bimodal, suggesting the existence of two statistical groups. A significant model including 5 environmental variables shows the geographic distribution of high and low LD 50 groups with a particular concentration of the highest LD 50 populations over the region identified as the putative center of dispersion of T. infestans.The occurrence of these two groups concentrated over a particular region that coincides with the area where populations of the intermediate cytogenetic group were found might reflect the spatial heterogeneity of the genetic variability of T. infestans, that seems to be the cause of the insecticide resistance in the area, even on sylvatic populations of T. infestans, never before exposed to pyrethroid insecticides, representing natural and wild toxicological phenotypes. The strong linear relationship found between LD 50 and RR 50 suggest RR 50 might not be the best indicator of insecticide resistance in triatomines. Fil: Bustamante Gomez, Marinely. Centro de Pesquisas René Rachou. Laboratório de Referência em Triatomínueos e Epidemiologia da Doença de Chagas; Brasil Fil: Gonçalves Diotaiuti, Liléia. Centro de Pesquisas René Rachou. Laboratório de Referência em Triatomínueos e Epidemiologia da Doença de Chagas; Brasil Fil: Gorla, David Eladio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina |
description |
A number of studies published during the last 15 years showed the occurrence of insecticide resistance in Triatoma infestans populations. The different toxicological profiles and mechanisms of resistance to insecticides is due to a genetic base and environmental factors, being the insecticide selective pressure the best studied among the last factors. The studies on insecticide resistance on T. infestans did not consider the effect of environmental factors that may influence the distribution of resistance to pyrethroid insecticides. To fill this knowledge gap, the present study aims at studying the association between the spatial distribution of pyrethroid resistant populations of T. infestans and environmental variables. A total of 24 articles reporting on studies that evaluated the susceptibility to pyrethroids of 222 field-collected T. infestans populations were compiled. The relationship between resistance occurrence (according to different criteria) with environmental variables was studied using a generalized linear model. The lethal dose that kills 50% of the evaluated population (LD 50 ) showed a strong linear relationship with the corresponding resistance ratio (RR 50 ). The statistical descriptive analysis of showed that the frequency distribution of the Log(LD 50 ) is bimodal, suggesting the existence of two statistical groups. A significant model including 5 environmental variables shows the geographic distribution of high and low LD 50 groups with a particular concentration of the highest LD 50 populations over the region identified as the putative center of dispersion of T. infestans.The occurrence of these two groups concentrated over a particular region that coincides with the area where populations of the intermediate cytogenetic group were found might reflect the spatial heterogeneity of the genetic variability of T. infestans, that seems to be the cause of the insecticide resistance in the area, even on sylvatic populations of T. infestans, never before exposed to pyrethroid insecticides, representing natural and wild toxicological phenotypes. The strong linear relationship found between LD 50 and RR 50 suggest RR 50 might not be the best indicator of insecticide resistance in triatomines. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-03 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/17654 Bustamante Gomez, Marinely; Gonçalves Diotaiuti, Liléia; Gorla, David Eladio; Distribution of Pyrethroid Resistant Populations of Triatoma infestans in the Southern Cone of South America; Public Library Of Science; Neglected Tropical Diseases; 10; 3; 3-2016; 1-15 1935-2735 1935-2727 |
url |
http://hdl.handle.net/11336/17654 |
identifier_str_mv |
Bustamante Gomez, Marinely; Gonçalves Diotaiuti, Liléia; Gorla, David Eladio; Distribution of Pyrethroid Resistant Populations of Triatoma infestans in the Southern Cone of South America; Public Library Of Science; Neglected Tropical Diseases; 10; 3; 3-2016; 1-15 1935-2735 1935-2727 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805280/ info:eu-repo/semantics/altIdentifier/doi/10.1371%2Fjournal.pntd.0004561 info:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0004561 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Public Library Of Science |
publisher.none.fl_str_mv |
Public Library Of Science |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.13397 |