Distribution of Pyrethroid Resistant Populations of Triatoma infestans in the Southern Cone of South America

Autores
Bustamante Gomez, Marinely; Gonçalves Diotaiuti, Liléia; Gorla, David Eladio
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A number of studies published during the last 15 years showed the occurrence of insecticide resistance in Triatoma infestans populations. The different toxicological profiles and mechanisms of resistance to insecticides is due to a genetic base and environmental factors, being the insecticide selective pressure the best studied among the last factors. The studies on insecticide resistance on T. infestans did not consider the effect of environmental factors that may influence the distribution of resistance to pyrethroid insecticides. To fill this knowledge gap, the present study aims at studying the association between the spatial distribution of pyrethroid resistant populations of T. infestans and environmental variables. A total of 24 articles reporting on studies that evaluated the susceptibility to pyrethroids of 222 field-collected T. infestans populations were compiled. The relationship between resistance occurrence (according to different criteria) with environmental variables was studied using a generalized linear model. The lethal dose that kills 50% of the evaluated population (LD 50 ) showed a strong linear relationship with the corresponding resistance ratio (RR 50 ). The statistical descriptive analysis of showed that the frequency distribution of the Log(LD 50 ) is bimodal, suggesting the existence of two statistical groups. A significant model including 5 environmental variables shows the geographic distribution of high and low LD 50 groups with a particular concentration of the highest LD 50 populations over the region identified as the putative center of dispersion of T. infestans.The occurrence of these two groups concentrated over a particular region that coincides with the area where populations of the intermediate cytogenetic group were found might reflect the spatial heterogeneity of the genetic variability of T. infestans, that seems to be the cause of the insecticide resistance in the area, even on sylvatic populations of T. infestans, never before exposed to pyrethroid insecticides, representing natural and wild toxicological phenotypes. The strong linear relationship found between LD 50 and RR 50 suggest RR 50 might not be the best indicator of insecticide resistance in triatomines.
Fil: Bustamante Gomez, Marinely. Centro de Pesquisas René Rachou. Laboratório de Referência em Triatomínueos e Epidemiologia da Doença de Chagas; Brasil
Fil: Gonçalves Diotaiuti, Liléia. Centro de Pesquisas René Rachou. Laboratório de Referência em Triatomínueos e Epidemiologia da Doença de Chagas; Brasil
Fil: Gorla, David Eladio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Materia
TRIATOMA INFESTANS
PYRETHROID RESISTANCE
GEOGRAPHIC DISTRIBUTION
ECOLOGICAL NICHE MODELLING
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/17654

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network_name_str CONICET Digital (CONICET)
spelling Distribution of Pyrethroid Resistant Populations of Triatoma infestans in the Southern Cone of South AmericaBustamante Gomez, MarinelyGonçalves Diotaiuti, LiléiaGorla, David EladioTRIATOMA INFESTANSPYRETHROID RESISTANCEGEOGRAPHIC DISTRIBUTIONECOLOGICAL NICHE MODELLINGhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1A number of studies published during the last 15 years showed the occurrence of insecticide resistance in Triatoma infestans populations. The different toxicological profiles and mechanisms of resistance to insecticides is due to a genetic base and environmental factors, being the insecticide selective pressure the best studied among the last factors. The studies on insecticide resistance on T. infestans did not consider the effect of environmental factors that may influence the distribution of resistance to pyrethroid insecticides. To fill this knowledge gap, the present study aims at studying the association between the spatial distribution of pyrethroid resistant populations of T. infestans and environmental variables. A total of 24 articles reporting on studies that evaluated the susceptibility to pyrethroids of 222 field-collected T. infestans populations were compiled. The relationship between resistance occurrence (according to different criteria) with environmental variables was studied using a generalized linear model. The lethal dose that kills 50% of the evaluated population (LD 50 ) showed a strong linear relationship with the corresponding resistance ratio (RR 50 ). The statistical descriptive analysis of showed that the frequency distribution of the Log(LD 50 ) is bimodal, suggesting the existence of two statistical groups. A significant model including 5 environmental variables shows the geographic distribution of high and low LD 50 groups with a particular concentration of the highest LD 50 populations over the region identified as the putative center of dispersion of T. infestans.The occurrence of these two groups concentrated over a particular region that coincides with the area where populations of the intermediate cytogenetic group were found might reflect the spatial heterogeneity of the genetic variability of T. infestans, that seems to be the cause of the insecticide resistance in the area, even on sylvatic populations of T. infestans, never before exposed to pyrethroid insecticides, representing natural and wild toxicological phenotypes. The strong linear relationship found between LD 50 and RR 50 suggest RR 50 might not be the best indicator of insecticide resistance in triatomines.Fil: Bustamante Gomez, Marinely. Centro de Pesquisas René Rachou. Laboratório de Referência em Triatomínueos e Epidemiologia da Doença de Chagas; BrasilFil: Gonçalves Diotaiuti, Liléia. Centro de Pesquisas René Rachou. Laboratório de Referência em Triatomínueos e Epidemiologia da Doença de Chagas; BrasilFil: Gorla, David Eladio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaPublic Library Of Science2016-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/17654Bustamante Gomez, Marinely; Gonçalves Diotaiuti, Liléia; Gorla, David Eladio; Distribution of Pyrethroid Resistant Populations of Triatoma infestans in the Southern Cone of South America; Public Library Of Science; Neglected Tropical Diseases; 10; 3; 3-2016; 1-151935-27351935-2727enginfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805280/info:eu-repo/semantics/altIdentifier/doi/10.1371%2Fjournal.pntd.0004561info:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0004561info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:58:26Zoai:ri.conicet.gov.ar:11336/17654instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:58:27.055CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Distribution of Pyrethroid Resistant Populations of Triatoma infestans in the Southern Cone of South America
title Distribution of Pyrethroid Resistant Populations of Triatoma infestans in the Southern Cone of South America
spellingShingle Distribution of Pyrethroid Resistant Populations of Triatoma infestans in the Southern Cone of South America
Bustamante Gomez, Marinely
TRIATOMA INFESTANS
PYRETHROID RESISTANCE
GEOGRAPHIC DISTRIBUTION
ECOLOGICAL NICHE MODELLING
title_short Distribution of Pyrethroid Resistant Populations of Triatoma infestans in the Southern Cone of South America
title_full Distribution of Pyrethroid Resistant Populations of Triatoma infestans in the Southern Cone of South America
title_fullStr Distribution of Pyrethroid Resistant Populations of Triatoma infestans in the Southern Cone of South America
title_full_unstemmed Distribution of Pyrethroid Resistant Populations of Triatoma infestans in the Southern Cone of South America
title_sort Distribution of Pyrethroid Resistant Populations of Triatoma infestans in the Southern Cone of South America
dc.creator.none.fl_str_mv Bustamante Gomez, Marinely
Gonçalves Diotaiuti, Liléia
Gorla, David Eladio
author Bustamante Gomez, Marinely
author_facet Bustamante Gomez, Marinely
Gonçalves Diotaiuti, Liléia
Gorla, David Eladio
author_role author
author2 Gonçalves Diotaiuti, Liléia
Gorla, David Eladio
author2_role author
author
dc.subject.none.fl_str_mv TRIATOMA INFESTANS
PYRETHROID RESISTANCE
GEOGRAPHIC DISTRIBUTION
ECOLOGICAL NICHE MODELLING
topic TRIATOMA INFESTANS
PYRETHROID RESISTANCE
GEOGRAPHIC DISTRIBUTION
ECOLOGICAL NICHE MODELLING
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv A number of studies published during the last 15 years showed the occurrence of insecticide resistance in Triatoma infestans populations. The different toxicological profiles and mechanisms of resistance to insecticides is due to a genetic base and environmental factors, being the insecticide selective pressure the best studied among the last factors. The studies on insecticide resistance on T. infestans did not consider the effect of environmental factors that may influence the distribution of resistance to pyrethroid insecticides. To fill this knowledge gap, the present study aims at studying the association between the spatial distribution of pyrethroid resistant populations of T. infestans and environmental variables. A total of 24 articles reporting on studies that evaluated the susceptibility to pyrethroids of 222 field-collected T. infestans populations were compiled. The relationship between resistance occurrence (according to different criteria) with environmental variables was studied using a generalized linear model. The lethal dose that kills 50% of the evaluated population (LD 50 ) showed a strong linear relationship with the corresponding resistance ratio (RR 50 ). The statistical descriptive analysis of showed that the frequency distribution of the Log(LD 50 ) is bimodal, suggesting the existence of two statistical groups. A significant model including 5 environmental variables shows the geographic distribution of high and low LD 50 groups with a particular concentration of the highest LD 50 populations over the region identified as the putative center of dispersion of T. infestans.The occurrence of these two groups concentrated over a particular region that coincides with the area where populations of the intermediate cytogenetic group were found might reflect the spatial heterogeneity of the genetic variability of T. infestans, that seems to be the cause of the insecticide resistance in the area, even on sylvatic populations of T. infestans, never before exposed to pyrethroid insecticides, representing natural and wild toxicological phenotypes. The strong linear relationship found between LD 50 and RR 50 suggest RR 50 might not be the best indicator of insecticide resistance in triatomines.
Fil: Bustamante Gomez, Marinely. Centro de Pesquisas René Rachou. Laboratório de Referência em Triatomínueos e Epidemiologia da Doença de Chagas; Brasil
Fil: Gonçalves Diotaiuti, Liléia. Centro de Pesquisas René Rachou. Laboratório de Referência em Triatomínueos e Epidemiologia da Doença de Chagas; Brasil
Fil: Gorla, David Eladio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
description A number of studies published during the last 15 years showed the occurrence of insecticide resistance in Triatoma infestans populations. The different toxicological profiles and mechanisms of resistance to insecticides is due to a genetic base and environmental factors, being the insecticide selective pressure the best studied among the last factors. The studies on insecticide resistance on T. infestans did not consider the effect of environmental factors that may influence the distribution of resistance to pyrethroid insecticides. To fill this knowledge gap, the present study aims at studying the association between the spatial distribution of pyrethroid resistant populations of T. infestans and environmental variables. A total of 24 articles reporting on studies that evaluated the susceptibility to pyrethroids of 222 field-collected T. infestans populations were compiled. The relationship between resistance occurrence (according to different criteria) with environmental variables was studied using a generalized linear model. The lethal dose that kills 50% of the evaluated population (LD 50 ) showed a strong linear relationship with the corresponding resistance ratio (RR 50 ). The statistical descriptive analysis of showed that the frequency distribution of the Log(LD 50 ) is bimodal, suggesting the existence of two statistical groups. A significant model including 5 environmental variables shows the geographic distribution of high and low LD 50 groups with a particular concentration of the highest LD 50 populations over the region identified as the putative center of dispersion of T. infestans.The occurrence of these two groups concentrated over a particular region that coincides with the area where populations of the intermediate cytogenetic group were found might reflect the spatial heterogeneity of the genetic variability of T. infestans, that seems to be the cause of the insecticide resistance in the area, even on sylvatic populations of T. infestans, never before exposed to pyrethroid insecticides, representing natural and wild toxicological phenotypes. The strong linear relationship found between LD 50 and RR 50 suggest RR 50 might not be the best indicator of insecticide resistance in triatomines.
publishDate 2016
dc.date.none.fl_str_mv 2016-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/17654
Bustamante Gomez, Marinely; Gonçalves Diotaiuti, Liléia; Gorla, David Eladio; Distribution of Pyrethroid Resistant Populations of Triatoma infestans in the Southern Cone of South America; Public Library Of Science; Neglected Tropical Diseases; 10; 3; 3-2016; 1-15
1935-2735
1935-2727
url http://hdl.handle.net/11336/17654
identifier_str_mv Bustamante Gomez, Marinely; Gonçalves Diotaiuti, Liléia; Gorla, David Eladio; Distribution of Pyrethroid Resistant Populations of Triatoma infestans in the Southern Cone of South America; Public Library Of Science; Neglected Tropical Diseases; 10; 3; 3-2016; 1-15
1935-2735
1935-2727
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805280/
info:eu-repo/semantics/altIdentifier/doi/10.1371%2Fjournal.pntd.0004561
info:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0004561
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library Of Science
publisher.none.fl_str_mv Public Library Of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
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reponame_str CONICET Digital (CONICET)
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