Environmental stress-induced testis differentiation: Androgen as a by-product of cortisol inactivation

Autores
Fernandino, Juan Ignacio; Hattori, Ricardo S.; Moreno Acosta, Omar David; Strüssmann, Carlos A.; Somoza, Gustavo Manuel
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This review deals with the gonadal masculinization induced by thermal stress in fish with focus on the action of 11b-hydroxysteroid dehydrogenase (11b-HSD) as this mechanism key transducer. High temper- atures have been reported to produce male-skewed sex ratios in several species with TSD (temperature- dependent sex determination), and in some of them, this process was reported to be associated with high levels of cortisol, the hormone-related stress in vertebrates, during early gonad development. In addition, in pejerrey larvae reared at high-masculinizing temperatures, 11-ketotestosterone (11-KT), the main and most potent androgen in fish, was also detected at high levels. In testicular explants, cortisol induced the synthesis of 11-KT, suggesting that its synthesis could be under the control of the stress axis at the time of gonadal fate determination. 11b-HSD is one of the enzymes shared by the glucocorticoid and androgen pathways; this enzyme converts cortisol to cortisone and also participates in the finals steps of the syn- thesis of the 11-oxigenated androgens. Based on these data and literature information, here we propose that the masculinization induced by thermal stress can be considered as a consequence of cortisol inac- tivation and the concomitant synthesis of 11-KT and discussing this as a possible mechanism of mascu- linization induced by different types of environmental stressors.
Fil: Fernandino, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); Argentina
Fil: Hattori, Ricardo S.. Tokyo University; Japón
Fil: Moreno Acosta, Omar David. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); Argentina
Fil: Strüssmann, Carlos A.. Tokyo University; Japón
Fil: Somoza, Gustavo Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); Argentina
Materia
Environmental Sex Determination
Stress
Masculinization
11b-Hsd
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/24374
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/24374
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Environmental stress-induced testis differentiation: Androgen as a by-product of cortisol inactivationFernandino, Juan IgnacioHattori, Ricardo S.Moreno Acosta, Omar DavidStrüssmann, Carlos A.Somoza, Gustavo ManuelEnvironmental Sex DeterminationStressMasculinization11b-Hsdhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1This review deals with the gonadal masculinization induced by thermal stress in fish with focus on the action of 11b-hydroxysteroid dehydrogenase (11b-HSD) as this mechanism key transducer. High temper- atures have been reported to produce male-skewed sex ratios in several species with TSD (temperature- dependent sex determination), and in some of them, this process was reported to be associated with high levels of cortisol, the hormone-related stress in vertebrates, during early gonad development. In addition, in pejerrey larvae reared at high-masculinizing temperatures, 11-ketotestosterone (11-KT), the main and most potent androgen in fish, was also detected at high levels. In testicular explants, cortisol induced the synthesis of 11-KT, suggesting that its synthesis could be under the control of the stress axis at the time of gonadal fate determination. 11b-HSD is one of the enzymes shared by the glucocorticoid and androgen pathways; this enzyme converts cortisol to cortisone and also participates in the finals steps of the syn- thesis of the 11-oxigenated androgens. Based on these data and literature information, here we propose that the masculinization induced by thermal stress can be considered as a consequence of cortisol inac- tivation and the concomitant synthesis of 11-KT and discussing this as a possible mechanism of mascu- linization induced by different types of environmental stressors.Fil: Fernandino, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); ArgentinaFil: Hattori, Ricardo S.. Tokyo University; JapónFil: Moreno Acosta, Omar David. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); ArgentinaFil: Strüssmann, Carlos A.. Tokyo University; JapónFil: Somoza, Gustavo Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); ArgentinaAcademic Press Inc Elsevier Science2013-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/24374Fernandino, Juan Ignacio; Hattori, Ricardo S.; Moreno Acosta, Omar David; Strüssmann, Carlos A.; Somoza, Gustavo Manuel; Environmental stress-induced testis differentiation: Androgen as a by-product of cortisol inactivation; Academic Press Inc Elsevier Science; General and Comparative Endocrinology; 192; 1-10-2013; 36-440016-6480CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.ygcen.2013.05.024info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0016648013002633info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:58:49Zoai:ri.conicet.gov.ar:11336/24374instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:58:49.535CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Environmental stress-induced testis differentiation: Androgen as a by-product of cortisol inactivation
title Environmental stress-induced testis differentiation: Androgen as a by-product of cortisol inactivation
spellingShingle Environmental stress-induced testis differentiation: Androgen as a by-product of cortisol inactivation
Fernandino, Juan Ignacio
Environmental Sex Determination
Stress
Masculinization
11b-Hsd
title_short Environmental stress-induced testis differentiation: Androgen as a by-product of cortisol inactivation
title_full Environmental stress-induced testis differentiation: Androgen as a by-product of cortisol inactivation
title_fullStr Environmental stress-induced testis differentiation: Androgen as a by-product of cortisol inactivation
title_full_unstemmed Environmental stress-induced testis differentiation: Androgen as a by-product of cortisol inactivation
title_sort Environmental stress-induced testis differentiation: Androgen as a by-product of cortisol inactivation
dc.creator.none.fl_str_mv Fernandino, Juan Ignacio
Hattori, Ricardo S.
Moreno Acosta, Omar David
Strüssmann, Carlos A.
Somoza, Gustavo Manuel
author Fernandino, Juan Ignacio
author_facet Fernandino, Juan Ignacio
Hattori, Ricardo S.
Moreno Acosta, Omar David
Strüssmann, Carlos A.
Somoza, Gustavo Manuel
author_role author
author2 Hattori, Ricardo S.
Moreno Acosta, Omar David
Strüssmann, Carlos A.
Somoza, Gustavo Manuel
author2_role author
author
author
author
dc.subject.none.fl_str_mv Environmental Sex Determination
Stress
Masculinization
11b-Hsd
topic Environmental Sex Determination
Stress
Masculinization
11b-Hsd
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv This review deals with the gonadal masculinization induced by thermal stress in fish with focus on the action of 11b-hydroxysteroid dehydrogenase (11b-HSD) as this mechanism key transducer. High temper- atures have been reported to produce male-skewed sex ratios in several species with TSD (temperature- dependent sex determination), and in some of them, this process was reported to be associated with high levels of cortisol, the hormone-related stress in vertebrates, during early gonad development. In addition, in pejerrey larvae reared at high-masculinizing temperatures, 11-ketotestosterone (11-KT), the main and most potent androgen in fish, was also detected at high levels. In testicular explants, cortisol induced the synthesis of 11-KT, suggesting that its synthesis could be under the control of the stress axis at the time of gonadal fate determination. 11b-HSD is one of the enzymes shared by the glucocorticoid and androgen pathways; this enzyme converts cortisol to cortisone and also participates in the finals steps of the syn- thesis of the 11-oxigenated androgens. Based on these data and literature information, here we propose that the masculinization induced by thermal stress can be considered as a consequence of cortisol inac- tivation and the concomitant synthesis of 11-KT and discussing this as a possible mechanism of mascu- linization induced by different types of environmental stressors.
Fil: Fernandino, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); Argentina
Fil: Hattori, Ricardo S.. Tokyo University; Japón
Fil: Moreno Acosta, Omar David. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); Argentina
Fil: Strüssmann, Carlos A.. Tokyo University; Japón
Fil: Somoza, Gustavo Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); Argentina
description This review deals with the gonadal masculinization induced by thermal stress in fish with focus on the action of 11b-hydroxysteroid dehydrogenase (11b-HSD) as this mechanism key transducer. High temper- atures have been reported to produce male-skewed sex ratios in several species with TSD (temperature- dependent sex determination), and in some of them, this process was reported to be associated with high levels of cortisol, the hormone-related stress in vertebrates, during early gonad development. In addition, in pejerrey larvae reared at high-masculinizing temperatures, 11-ketotestosterone (11-KT), the main and most potent androgen in fish, was also detected at high levels. In testicular explants, cortisol induced the synthesis of 11-KT, suggesting that its synthesis could be under the control of the stress axis at the time of gonadal fate determination. 11b-HSD is one of the enzymes shared by the glucocorticoid and androgen pathways; this enzyme converts cortisol to cortisone and also participates in the finals steps of the syn- thesis of the 11-oxigenated androgens. Based on these data and literature information, here we propose that the masculinization induced by thermal stress can be considered as a consequence of cortisol inac- tivation and the concomitant synthesis of 11-KT and discussing this as a possible mechanism of mascu- linization induced by different types of environmental stressors.
publishDate 2013
dc.date.none.fl_str_mv 2013-10-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/24374
Fernandino, Juan Ignacio; Hattori, Ricardo S.; Moreno Acosta, Omar David; Strüssmann, Carlos A.; Somoza, Gustavo Manuel; Environmental stress-induced testis differentiation: Androgen as a by-product of cortisol inactivation; Academic Press Inc Elsevier Science; General and Comparative Endocrinology; 192; 1-10-2013; 36-44
0016-6480
CONICET Digital
CONICET
url http://hdl.handle.net/11336/24374
identifier_str_mv Fernandino, Juan Ignacio; Hattori, Ricardo S.; Moreno Acosta, Omar David; Strüssmann, Carlos A.; Somoza, Gustavo Manuel; Environmental stress-induced testis differentiation: Androgen as a by-product of cortisol inactivation; Academic Press Inc Elsevier Science; General and Comparative Endocrinology; 192; 1-10-2013; 36-44
0016-6480
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ygcen.2013.05.024
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0016648013002633
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Academic Press Inc Elsevier Science
publisher.none.fl_str_mv Academic Press Inc Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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