Nanotechnology, Drug Delivery Systems and their Potential Applications in Hepatitis B Vaccines

Autores
Perazzo, Priscila; Rodriguez del Valle, Nicolás; Sordelli, Andrea; Gonzalez, Rodrigo Horacio; Nusblat, Alejandro David; Cuestas, María Luján
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Since the Nobel Prize in Physiology or Medicine 1976 Baruch Blumberg and Irving Millman developed the first prophylactic plasma-derived hepatitis B vaccine - also considered the world´s first cancer vaccine- so much progress has been made in the development of new immunogenic and safe vaccines. However, improvements are still clearly required since vaccines currently available in the market produce mainly a humoral immune response, require cold storage, a three dose schedule, the costs of the vaccines are high, many developing or low-incoming countries display a poor compliance in vaccination programs, and 5-10% of the vaccinated individuals are poor or non-responders.To overcome such drawbacks, nanotechnology has emerged as a new platform for vaccine development. Nanocarrier-based delivery systems offer an opportunity to stimulate both humoral as well as cell-mediated responses and to induce mucosal and systemic immunity simultaneously. Furthermore, nanocarrier-based delivery systems avoid the need for sterile needles. This manuscript reviews the current knowledges on the vailable hepatitis B vaccines and introduces the recent advances in nanocarrier-based hepatitis B vaccine delivery systems. The challenges in the development of needle-free nanotechnologies are also discussed.
Fil: Perazzo, Priscila. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
Fil: Rodriguez del Valle, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
Fil: Sordelli, Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
Fil: Gonzalez, Rodrigo Horacio. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología Industrial y Biotecnología; Argentina
Fil: Nusblat, Alejandro David. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología Industrial y Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cuestas, María Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
Materia
HBV
PROPHYLACTIC
VACCINES
HBSAG
NANOCARRIER
DELIVERY
SYSTEM
NEEDLE
FREE
NANOTECHNOLOGIES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/136182
Acceder
id CONICETDig_18258d4187e8fa07b56637d0f7637231
oai_identifier_str oai:ri.conicet.gov.ar:11336/136182
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Nanotechnology, Drug Delivery Systems and their Potential Applications in Hepatitis B VaccinesPerazzo, PriscilaRodriguez del Valle, NicolásSordelli, AndreaGonzalez, Rodrigo HoracioNusblat, Alejandro DavidCuestas, María LujánHBVPROPHYLACTICVACCINESHBSAGNANOCARRIERDELIVERYSYSTEMNEEDLEFREENANOTECHNOLOGIEShttps://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3Since the Nobel Prize in Physiology or Medicine 1976 Baruch Blumberg and Irving Millman developed the first prophylactic plasma-derived hepatitis B vaccine - also considered the world´s first cancer vaccine- so much progress has been made in the development of new immunogenic and safe vaccines. However, improvements are still clearly required since vaccines currently available in the market produce mainly a humoral immune response, require cold storage, a three dose schedule, the costs of the vaccines are high, many developing or low-incoming countries display a poor compliance in vaccination programs, and 5-10% of the vaccinated individuals are poor or non-responders.To overcome such drawbacks, nanotechnology has emerged as a new platform for vaccine development. Nanocarrier-based delivery systems offer an opportunity to stimulate both humoral as well as cell-mediated responses and to induce mucosal and systemic immunity simultaneously. Furthermore, nanocarrier-based delivery systems avoid the need for sterile needles. This manuscript reviews the current knowledges on the vailable hepatitis B vaccines and introduces the recent advances in nanocarrier-based hepatitis B vaccine delivery systems. The challenges in the development of needle-free nanotechnologies are also discussed.Fil: Perazzo, Priscila. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; ArgentinaFil: Rodriguez del Valle, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; ArgentinaFil: Sordelli, Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; ArgentinaFil: Gonzalez, Rodrigo Horacio. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología Industrial y Biotecnología; ArgentinaFil: Nusblat, Alejandro David. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología Industrial y Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cuestas, María Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; ArgentinaMedCrave2015-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/136182Perazzo, Priscila; Rodriguez del Valle, Nicolás; Sordelli, Andrea; Gonzalez, Rodrigo Horacio; Nusblat, Alejandro David; et al.; Nanotechnology, Drug Delivery Systems and their Potential Applications in Hepatitis B Vaccines; MedCrave; International Journal of Vaccines & Vaccination; 1; 2; 9-2015; 7-132470-9980CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://medcraveonline.com/IJVV/nanotechnology-drug-delivery-systems-and-their-potential-applications-in-hepatitis-b-vaccine.htmlinfo:eu-repo/semantics/altIdentifier/doi/10.15406/ijvv.2015.01.00007info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:42:43Zoai:ri.conicet.gov.ar:11336/136182instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:42:43.767CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Nanotechnology, Drug Delivery Systems and their Potential Applications in Hepatitis B Vaccines
title Nanotechnology, Drug Delivery Systems and their Potential Applications in Hepatitis B Vaccines
spellingShingle Nanotechnology, Drug Delivery Systems and their Potential Applications in Hepatitis B Vaccines
Perazzo, Priscila
HBV
PROPHYLACTIC
VACCINES
HBSAG
NANOCARRIER
DELIVERY
SYSTEM
NEEDLE
FREE
NANOTECHNOLOGIES
title_short Nanotechnology, Drug Delivery Systems and their Potential Applications in Hepatitis B Vaccines
title_full Nanotechnology, Drug Delivery Systems and their Potential Applications in Hepatitis B Vaccines
title_fullStr Nanotechnology, Drug Delivery Systems and their Potential Applications in Hepatitis B Vaccines
title_full_unstemmed Nanotechnology, Drug Delivery Systems and their Potential Applications in Hepatitis B Vaccines
title_sort Nanotechnology, Drug Delivery Systems and their Potential Applications in Hepatitis B Vaccines
dc.creator.none.fl_str_mv Perazzo, Priscila
Rodriguez del Valle, Nicolás
Sordelli, Andrea
Gonzalez, Rodrigo Horacio
Nusblat, Alejandro David
Cuestas, María Luján
author Perazzo, Priscila
author_facet Perazzo, Priscila
Rodriguez del Valle, Nicolás
Sordelli, Andrea
Gonzalez, Rodrigo Horacio
Nusblat, Alejandro David
Cuestas, María Luján
author_role author
author2 Rodriguez del Valle, Nicolás
Sordelli, Andrea
Gonzalez, Rodrigo Horacio
Nusblat, Alejandro David
Cuestas, María Luján
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv HBV
PROPHYLACTIC
VACCINES
HBSAG
NANOCARRIER
DELIVERY
SYSTEM
NEEDLE
FREE
NANOTECHNOLOGIES
topic HBV
PROPHYLACTIC
VACCINES
HBSAG
NANOCARRIER
DELIVERY
SYSTEM
NEEDLE
FREE
NANOTECHNOLOGIES
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Since the Nobel Prize in Physiology or Medicine 1976 Baruch Blumberg and Irving Millman developed the first prophylactic plasma-derived hepatitis B vaccine - also considered the world´s first cancer vaccine- so much progress has been made in the development of new immunogenic and safe vaccines. However, improvements are still clearly required since vaccines currently available in the market produce mainly a humoral immune response, require cold storage, a three dose schedule, the costs of the vaccines are high, many developing or low-incoming countries display a poor compliance in vaccination programs, and 5-10% of the vaccinated individuals are poor or non-responders.To overcome such drawbacks, nanotechnology has emerged as a new platform for vaccine development. Nanocarrier-based delivery systems offer an opportunity to stimulate both humoral as well as cell-mediated responses and to induce mucosal and systemic immunity simultaneously. Furthermore, nanocarrier-based delivery systems avoid the need for sterile needles. This manuscript reviews the current knowledges on the vailable hepatitis B vaccines and introduces the recent advances in nanocarrier-based hepatitis B vaccine delivery systems. The challenges in the development of needle-free nanotechnologies are also discussed.
Fil: Perazzo, Priscila. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
Fil: Rodriguez del Valle, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
Fil: Sordelli, Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
Fil: Gonzalez, Rodrigo Horacio. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología Industrial y Biotecnología; Argentina
Fil: Nusblat, Alejandro David. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología Industrial y Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cuestas, María Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
description Since the Nobel Prize in Physiology or Medicine 1976 Baruch Blumberg and Irving Millman developed the first prophylactic plasma-derived hepatitis B vaccine - also considered the world´s first cancer vaccine- so much progress has been made in the development of new immunogenic and safe vaccines. However, improvements are still clearly required since vaccines currently available in the market produce mainly a humoral immune response, require cold storage, a three dose schedule, the costs of the vaccines are high, many developing or low-incoming countries display a poor compliance in vaccination programs, and 5-10% of the vaccinated individuals are poor or non-responders.To overcome such drawbacks, nanotechnology has emerged as a new platform for vaccine development. Nanocarrier-based delivery systems offer an opportunity to stimulate both humoral as well as cell-mediated responses and to induce mucosal and systemic immunity simultaneously. Furthermore, nanocarrier-based delivery systems avoid the need for sterile needles. This manuscript reviews the current knowledges on the vailable hepatitis B vaccines and introduces the recent advances in nanocarrier-based hepatitis B vaccine delivery systems. The challenges in the development of needle-free nanotechnologies are also discussed.
publishDate 2015
dc.date.none.fl_str_mv 2015-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/136182
Perazzo, Priscila; Rodriguez del Valle, Nicolás; Sordelli, Andrea; Gonzalez, Rodrigo Horacio; Nusblat, Alejandro David; et al.; Nanotechnology, Drug Delivery Systems and their Potential Applications in Hepatitis B Vaccines; MedCrave; International Journal of Vaccines & Vaccination; 1; 2; 9-2015; 7-13
2470-9980
CONICET Digital
CONICET
url http://hdl.handle.net/11336/136182
identifier_str_mv Perazzo, Priscila; Rodriguez del Valle, Nicolás; Sordelli, Andrea; Gonzalez, Rodrigo Horacio; Nusblat, Alejandro David; et al.; Nanotechnology, Drug Delivery Systems and their Potential Applications in Hepatitis B Vaccines; MedCrave; International Journal of Vaccines & Vaccination; 1; 2; 9-2015; 7-13
2470-9980
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://medcraveonline.com/IJVV/nanotechnology-drug-delivery-systems-and-their-potential-applications-in-hepatitis-b-vaccine.html
info:eu-repo/semantics/altIdentifier/doi/10.15406/ijvv.2015.01.00007
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv MedCrave
publisher.none.fl_str_mv MedCrave
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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