Stress and telomere length in leukocytes: Investigating the role of GABRA6 gene polymorphism and cortisol

Autores
Martino, Pablo Luis; Perez Alarcón, Mario; Deconinck, Luna; De Raedt, Rudi; Vanderhasselt, Marie Anne; Kozusznik, Malgorzata W.; Kooy, Frank; Hidalgo, Vanesa; Venero, César; Salvador, Alicia; Baeken, Chris; Pulopulos, Matias M.
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Telomere length (TL) is considered a biomarker of aging, and short TL in leukocytes is related to age and stress-related health problems. Cumulative lifetime stress exposure has also been associated with shorter TL and age-related health problems, but the mechanisms are not well understood. We tested in 108 individuals whether shorter TL in leukocytes is observed in individuals with the GABRA6 TT genotype, which has been associated with dysregulation of hypothalamic-pituitary-adrenal axis activity (the main biological stress system) compared to the CC genotype. We also investigated if individuals carrying the TT genotype show higher stress-induced and diurnal cortisol secretion and if cortisol explains the interindividual variability in TL. The analysis pipeline of this study was pre-registered, and the results showed that GABRA6 TT carriers had shorter TL in CD8+CD28+ cells (Bonferroni corrected). In contrast to previous studies, no differences between groups in cortisol secretion were observed, and TL and cortisol did not show significant associations. This study shows, for the first time, shorter TL in CD8+CD28+ cells in TT carriers for GABRA6 compared to CC carriers, suggesting accelerated cellular aging. Although this difference could be linked to an increased susceptibility to stress in the TT carriers, this could not be attributed to the direct influence of cortisol, suggesting the involvement of other mechanisms.
Fil: Martino, Pablo Luis. Universidad Nacional de San Luis; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; Argentina
Fil: Perez Alarcón, Mario. Facultad de Psicologia. ; Universidad de Valencia;
Fil: Deconinck, Luna. Universiteit Antwerp; Bélgica
Fil: De Raedt, Rudi. University of Ghent; Bélgica
Fil: Vanderhasselt, Marie Anne. University of Ghent; Bélgica
Fil: Kozusznik, Malgorzata W.. University of Ghent; Bélgica
Fil: Kooy, Frank. Universiteit Antwerp; Bélgica
Fil: Hidalgo, Vanesa. Facultad de Psicologia. ; Universidad de Valencia;
Fil: Venero, César. Universidad Nacional de Educación a Distancia; España
Fil: Salvador, Alicia. Facultad de Psicologia. ; Universidad de Valencia;
Fil: Baeken, Chris. University of Ghent; Bélgica
Fil: Pulopulos, Matias M.. University of Ghent; Bélgica
Materia
Stress
Aging
Genes
Cortisol
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/282602
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/282602
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Stress and telomere length in leukocytes: Investigating the role of GABRA6 gene polymorphism and cortisolMartino, Pablo LuisPerez Alarcón, MarioDeconinck, LunaDe Raedt, RudiVanderhasselt, Marie AnneKozusznik, Malgorzata W.Kooy, FrankHidalgo, VanesaVenero, CésarSalvador, AliciaBaeken, ChrisPulopulos, Matias M.StressAgingGenesCortisolhttps://purl.org/becyt/ford/5.1https://purl.org/becyt/ford/5Telomere length (TL) is considered a biomarker of aging, and short TL in leukocytes is related to age and stress-related health problems. Cumulative lifetime stress exposure has also been associated with shorter TL and age-related health problems, but the mechanisms are not well understood. We tested in 108 individuals whether shorter TL in leukocytes is observed in individuals with the GABRA6 TT genotype, which has been associated with dysregulation of hypothalamic-pituitary-adrenal axis activity (the main biological stress system) compared to the CC genotype. We also investigated if individuals carrying the TT genotype show higher stress-induced and diurnal cortisol secretion and if cortisol explains the interindividual variability in TL. The analysis pipeline of this study was pre-registered, and the results showed that GABRA6 TT carriers had shorter TL in CD8+CD28+ cells (Bonferroni corrected). In contrast to previous studies, no differences between groups in cortisol secretion were observed, and TL and cortisol did not show significant associations. This study shows, for the first time, shorter TL in CD8+CD28+ cells in TT carriers for GABRA6 compared to CC carriers, suggesting accelerated cellular aging. Although this difference could be linked to an increased susceptibility to stress in the TT carriers, this could not be attributed to the direct influence of cortisol, suggesting the involvement of other mechanisms.Fil: Martino, Pablo Luis. Universidad Nacional de San Luis; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; ArgentinaFil: Perez Alarcón, Mario. Facultad de Psicologia. ; Universidad de Valencia;Fil: Deconinck, Luna. Universiteit Antwerp; BélgicaFil: De Raedt, Rudi. University of Ghent; BélgicaFil: Vanderhasselt, Marie Anne. University of Ghent; BélgicaFil: Kozusznik, Malgorzata W.. University of Ghent; BélgicaFil: Kooy, Frank. Universiteit Antwerp; BélgicaFil: Hidalgo, Vanesa. Facultad de Psicologia. ; Universidad de Valencia;Fil: Venero, César. Universidad Nacional de Educación a Distancia; EspañaFil: Salvador, Alicia. Facultad de Psicologia. ; Universidad de Valencia;Fil: Baeken, Chris. University of Ghent; BélgicaFil: Pulopulos, Matias M.. University of Ghent; BélgicaPergamon-Elsevier Science Ltd2025-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/282602Martino, Pablo Luis; Perez Alarcón, Mario; Deconinck, Luna; De Raedt, Rudi; Vanderhasselt, Marie Anne; et al.; Stress and telomere length in leukocytes: Investigating the role of GABRA6 gene polymorphism and cortisol; Pergamon-Elsevier Science Ltd; Psychoneuroendocrinology; 173; 107358; 3-2025; 1-980306-4530CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0306453025000812info:eu-repo/semantics/altIdentifier/doi/10.1016/j.psyneuen.2025.107358info:eu-repo/semantics/altIdentifier/url/https://research.tue.nl/en/publications/stress-and-telomere-length-in-leukocytes-investigating-the-role-o/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-03-31T15:24:44Zoai:ri.conicet.gov.ar:11336/282602instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-03-31 15:24:44.36CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Stress and telomere length in leukocytes: Investigating the role of GABRA6 gene polymorphism and cortisol
title Stress and telomere length in leukocytes: Investigating the role of GABRA6 gene polymorphism and cortisol
spellingShingle Stress and telomere length in leukocytes: Investigating the role of GABRA6 gene polymorphism and cortisol
Martino, Pablo Luis
Stress
Aging
Genes
Cortisol
title_short Stress and telomere length in leukocytes: Investigating the role of GABRA6 gene polymorphism and cortisol
title_full Stress and telomere length in leukocytes: Investigating the role of GABRA6 gene polymorphism and cortisol
title_fullStr Stress and telomere length in leukocytes: Investigating the role of GABRA6 gene polymorphism and cortisol
title_full_unstemmed Stress and telomere length in leukocytes: Investigating the role of GABRA6 gene polymorphism and cortisol
title_sort Stress and telomere length in leukocytes: Investigating the role of GABRA6 gene polymorphism and cortisol
dc.creator.none.fl_str_mv Martino, Pablo Luis
Perez Alarcón, Mario
Deconinck, Luna
De Raedt, Rudi
Vanderhasselt, Marie Anne
Kozusznik, Malgorzata W.
Kooy, Frank
Hidalgo, Vanesa
Venero, César
Salvador, Alicia
Baeken, Chris
Pulopulos, Matias M.
author Martino, Pablo Luis
author_facet Martino, Pablo Luis
Perez Alarcón, Mario
Deconinck, Luna
De Raedt, Rudi
Vanderhasselt, Marie Anne
Kozusznik, Malgorzata W.
Kooy, Frank
Hidalgo, Vanesa
Venero, César
Salvador, Alicia
Baeken, Chris
Pulopulos, Matias M.
author_role author
author2 Perez Alarcón, Mario
Deconinck, Luna
De Raedt, Rudi
Vanderhasselt, Marie Anne
Kozusznik, Malgorzata W.
Kooy, Frank
Hidalgo, Vanesa
Venero, César
Salvador, Alicia
Baeken, Chris
Pulopulos, Matias M.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Stress
Aging
Genes
Cortisol
topic Stress
Aging
Genes
Cortisol
purl_subject.fl_str_mv https://purl.org/becyt/ford/5.1
https://purl.org/becyt/ford/5
dc.description.none.fl_txt_mv Telomere length (TL) is considered a biomarker of aging, and short TL in leukocytes is related to age and stress-related health problems. Cumulative lifetime stress exposure has also been associated with shorter TL and age-related health problems, but the mechanisms are not well understood. We tested in 108 individuals whether shorter TL in leukocytes is observed in individuals with the GABRA6 TT genotype, which has been associated with dysregulation of hypothalamic-pituitary-adrenal axis activity (the main biological stress system) compared to the CC genotype. We also investigated if individuals carrying the TT genotype show higher stress-induced and diurnal cortisol secretion and if cortisol explains the interindividual variability in TL. The analysis pipeline of this study was pre-registered, and the results showed that GABRA6 TT carriers had shorter TL in CD8+CD28+ cells (Bonferroni corrected). In contrast to previous studies, no differences between groups in cortisol secretion were observed, and TL and cortisol did not show significant associations. This study shows, for the first time, shorter TL in CD8+CD28+ cells in TT carriers for GABRA6 compared to CC carriers, suggesting accelerated cellular aging. Although this difference could be linked to an increased susceptibility to stress in the TT carriers, this could not be attributed to the direct influence of cortisol, suggesting the involvement of other mechanisms.
Fil: Martino, Pablo Luis. Universidad Nacional de San Luis; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; Argentina
Fil: Perez Alarcón, Mario. Facultad de Psicologia. ; Universidad de Valencia;
Fil: Deconinck, Luna. Universiteit Antwerp; Bélgica
Fil: De Raedt, Rudi. University of Ghent; Bélgica
Fil: Vanderhasselt, Marie Anne. University of Ghent; Bélgica
Fil: Kozusznik, Malgorzata W.. University of Ghent; Bélgica
Fil: Kooy, Frank. Universiteit Antwerp; Bélgica
Fil: Hidalgo, Vanesa. Facultad de Psicologia. ; Universidad de Valencia;
Fil: Venero, César. Universidad Nacional de Educación a Distancia; España
Fil: Salvador, Alicia. Facultad de Psicologia. ; Universidad de Valencia;
Fil: Baeken, Chris. University of Ghent; Bélgica
Fil: Pulopulos, Matias M.. University of Ghent; Bélgica
description Telomere length (TL) is considered a biomarker of aging, and short TL in leukocytes is related to age and stress-related health problems. Cumulative lifetime stress exposure has also been associated with shorter TL and age-related health problems, but the mechanisms are not well understood. We tested in 108 individuals whether shorter TL in leukocytes is observed in individuals with the GABRA6 TT genotype, which has been associated with dysregulation of hypothalamic-pituitary-adrenal axis activity (the main biological stress system) compared to the CC genotype. We also investigated if individuals carrying the TT genotype show higher stress-induced and diurnal cortisol secretion and if cortisol explains the interindividual variability in TL. The analysis pipeline of this study was pre-registered, and the results showed that GABRA6 TT carriers had shorter TL in CD8+CD28+ cells (Bonferroni corrected). In contrast to previous studies, no differences between groups in cortisol secretion were observed, and TL and cortisol did not show significant associations. This study shows, for the first time, shorter TL in CD8+CD28+ cells in TT carriers for GABRA6 compared to CC carriers, suggesting accelerated cellular aging. Although this difference could be linked to an increased susceptibility to stress in the TT carriers, this could not be attributed to the direct influence of cortisol, suggesting the involvement of other mechanisms.
publishDate 2025
dc.date.none.fl_str_mv 2025-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/282602
Martino, Pablo Luis; Perez Alarcón, Mario; Deconinck, Luna; De Raedt, Rudi; Vanderhasselt, Marie Anne; et al.; Stress and telomere length in leukocytes: Investigating the role of GABRA6 gene polymorphism and cortisol; Pergamon-Elsevier Science Ltd; Psychoneuroendocrinology; 173; 107358; 3-2025; 1-98
0306-4530
CONICET Digital
CONICET
url http://hdl.handle.net/11336/282602
identifier_str_mv Martino, Pablo Luis; Perez Alarcón, Mario; Deconinck, Luna; De Raedt, Rudi; Vanderhasselt, Marie Anne; et al.; Stress and telomere length in leukocytes: Investigating the role of GABRA6 gene polymorphism and cortisol; Pergamon-Elsevier Science Ltd; Psychoneuroendocrinology; 173; 107358; 3-2025; 1-98
0306-4530
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0306453025000812
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.psyneuen.2025.107358
info:eu-repo/semantics/altIdentifier/url/https://research.tue.nl/en/publications/stress-and-telomere-length-in-leukocytes-investigating-the-role-o/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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