Human milk cortisol is inversely associated with infant BMI and mediates the association between maternal plasma and infant salivary cortisol concentrations

Autores
Kruger, Ana Luz; Malpeli, Agustina; Sala, Marisa Esther; Casado, Carla; Mendez, Ignacio; Fotia, Lucrecia; Tournier, Andrea; Fasano, María Victoria; Andreoli, Maria Florencia
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Purpose The pathways through which milk cortisol affects infant body weight and adiposity remain poorly understood. Aims To assess the influence of maternal weight status on maternal cortisol concentrations and infant outcomes; to evaluate the relationship between maternal plasma and milk cortisol concentrations and infant salivary cortisol, body weight and adiposity during the first 3 months of life in a cohort of exclusively breastfed infants; to determine whether milk cortisol mediates these effects; and to explore the association between infant salivary cortisol and measures of body weight and adiposity. Methods In this prospective observational study, we measured cortisol concentrations in plasma and milk samples from lactating women at 10 days (n = 68) and 3 months postpartum (n = 34), and in saliva samples from their 3-month-old infants (n = 34). Multiple linear regression and mediation analysis were conducted to determine the relationship between maternal characteristics and infant anthropometric measurements or salivary cortisol concentration and whether they were mediated by milk cortisol. Results Plasma and milk cortisol concentrations were inversely associated with gestational weight gain and postpartum weight retention at 10 days postpartum. Maternal plasma and milk cortisol concentrations were directly with infant salivary cortisol concentration [Beta (95% CI): 0.05 (0.00, 0.09), p = 0.038; 0.95 (0.51, 1.39), p < 0.001], and inversely associated with infant BMI z-score [Beta (95% CI): −0.11 (−0.17, −0.04), p = 0.004; −1.04 (−1.69, −0.39), p = 0.003] at 3 months of lactation, the former mediated by milk cortisol (p = 0.039). Infant salivary cortisol was not associated with body weight and adiposity at 3 months of lactation. Conclusion Our study shows that in exclusively breastfed infants, milk cortisol is inversely associated with BMI z-score and influences salivary cortisol at 3 months postpartum. Further research is warranted to explore the mechanisms involved and how these interactions evolve across different stages of lactation.
Fil: Kruger, Ana Luz. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata. Instituto de Desarrollo e Investigaciones Pediátricas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Malpeli, Agustina. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata. Instituto de Desarrollo e Investigaciones Pediátricas; Argentina
Fil: Sala, Marisa Esther. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata. Instituto de Desarrollo e Investigaciones Pediátricas; Argentina
Fil: Casado, Carla. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata. Instituto de Desarrollo e Investigaciones Pediátricas; Argentina
Fil: Mendez, Ignacio. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata. Instituto de Desarrollo e Investigaciones Pediátricas; Argentina
Fil: Fotia, Lucrecia. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata. Instituto de Desarrollo e Investigaciones Pediátricas; Argentina
Fil: Tournier, Andrea. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; Argentina
Fil: Fasano, María Victoria. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata. Instituto de Desarrollo e Investigaciones Pediátricas; Argentina
Fil: Andreoli, Maria Florencia. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata. Instituto de Desarrollo e Investigaciones Pediátricas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Materia
Cortisol
Infant Plasma Cortisol
Milk cortisol
Obesity
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/282341
Acceder
id CONICETDig_53ba90ca43fe4ba7aee3da39588e1867
oai_identifier_str oai:ri.conicet.gov.ar:11336/282341
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Human milk cortisol is inversely associated with infant BMI and mediates the association between maternal plasma and infant salivary cortisol concentrationsKruger, Ana LuzMalpeli, AgustinaSala, Marisa EstherCasado, CarlaMendez, IgnacioFotia, LucreciaTournier, AndreaFasano, María VictoriaAndreoli, Maria FlorenciaCortisolInfant Plasma CortisolMilk cortisolObesityhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Purpose The pathways through which milk cortisol affects infant body weight and adiposity remain poorly understood. Aims To assess the influence of maternal weight status on maternal cortisol concentrations and infant outcomes; to evaluate the relationship between maternal plasma and milk cortisol concentrations and infant salivary cortisol, body weight and adiposity during the first 3 months of life in a cohort of exclusively breastfed infants; to determine whether milk cortisol mediates these effects; and to explore the association between infant salivary cortisol and measures of body weight and adiposity. Methods In this prospective observational study, we measured cortisol concentrations in plasma and milk samples from lactating women at 10 days (n = 68) and 3 months postpartum (n = 34), and in saliva samples from their 3-month-old infants (n = 34). Multiple linear regression and mediation analysis were conducted to determine the relationship between maternal characteristics and infant anthropometric measurements or salivary cortisol concentration and whether they were mediated by milk cortisol. Results Plasma and milk cortisol concentrations were inversely associated with gestational weight gain and postpartum weight retention at 10 days postpartum. Maternal plasma and milk cortisol concentrations were directly with infant salivary cortisol concentration [Beta (95% CI): 0.05 (0.00, 0.09), p = 0.038; 0.95 (0.51, 1.39), p < 0.001], and inversely associated with infant BMI z-score [Beta (95% CI): −0.11 (−0.17, −0.04), p = 0.004; −1.04 (−1.69, −0.39), p = 0.003] at 3 months of lactation, the former mediated by milk cortisol (p = 0.039). Infant salivary cortisol was not associated with body weight and adiposity at 3 months of lactation. Conclusion Our study shows that in exclusively breastfed infants, milk cortisol is inversely associated with BMI z-score and influences salivary cortisol at 3 months postpartum. Further research is warranted to explore the mechanisms involved and how these interactions evolve across different stages of lactation.Fil: Kruger, Ana Luz. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata. Instituto de Desarrollo e Investigaciones Pediátricas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Malpeli, Agustina. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata. Instituto de Desarrollo e Investigaciones Pediátricas; ArgentinaFil: Sala, Marisa Esther. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata. Instituto de Desarrollo e Investigaciones Pediátricas; ArgentinaFil: Casado, Carla. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata. Instituto de Desarrollo e Investigaciones Pediátricas; ArgentinaFil: Mendez, Ignacio. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata. Instituto de Desarrollo e Investigaciones Pediátricas; ArgentinaFil: Fotia, Lucrecia. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata. Instituto de Desarrollo e Investigaciones Pediátricas; ArgentinaFil: Tournier, Andrea. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; ArgentinaFil: Fasano, María Victoria. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata. Instituto de Desarrollo e Investigaciones Pediátricas; ArgentinaFil: Andreoli, Maria Florencia. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata. Instituto de Desarrollo e Investigaciones Pediátricas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaNature Publishing Group2025-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/282341Kruger, Ana Luz; Malpeli, Agustina; Sala, Marisa Esther; Casado, Carla; Mendez, Ignacio; et al.; Human milk cortisol is inversely associated with infant BMI and mediates the association between maternal plasma and infant salivary cortisol concentrations; Nature Publishing Group; International Journal Of Obesity; 49; 8; 5-2025; 1632-16410307-0565CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41366-025-01815-4info:eu-repo/semantics/altIdentifier/doi/10.1038/s41366-025-01815-4info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-03-11T12:32:43Zoai:ri.conicet.gov.ar:11336/282341instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-03-11 12:32:43.416CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Human milk cortisol is inversely associated with infant BMI and mediates the association between maternal plasma and infant salivary cortisol concentrations
title Human milk cortisol is inversely associated with infant BMI and mediates the association between maternal plasma and infant salivary cortisol concentrations
spellingShingle Human milk cortisol is inversely associated with infant BMI and mediates the association between maternal plasma and infant salivary cortisol concentrations
Kruger, Ana Luz
Cortisol
Infant Plasma Cortisol
Milk cortisol
Obesity
title_short Human milk cortisol is inversely associated with infant BMI and mediates the association between maternal plasma and infant salivary cortisol concentrations
title_full Human milk cortisol is inversely associated with infant BMI and mediates the association between maternal plasma and infant salivary cortisol concentrations
title_fullStr Human milk cortisol is inversely associated with infant BMI and mediates the association between maternal plasma and infant salivary cortisol concentrations
title_full_unstemmed Human milk cortisol is inversely associated with infant BMI and mediates the association between maternal plasma and infant salivary cortisol concentrations
title_sort Human milk cortisol is inversely associated with infant BMI and mediates the association between maternal plasma and infant salivary cortisol concentrations
dc.creator.none.fl_str_mv Kruger, Ana Luz
Malpeli, Agustina
Sala, Marisa Esther
Casado, Carla
Mendez, Ignacio
Fotia, Lucrecia
Tournier, Andrea
Fasano, María Victoria
Andreoli, Maria Florencia
author Kruger, Ana Luz
author_facet Kruger, Ana Luz
Malpeli, Agustina
Sala, Marisa Esther
Casado, Carla
Mendez, Ignacio
Fotia, Lucrecia
Tournier, Andrea
Fasano, María Victoria
Andreoli, Maria Florencia
author_role author
author2 Malpeli, Agustina
Sala, Marisa Esther
Casado, Carla
Mendez, Ignacio
Fotia, Lucrecia
Tournier, Andrea
Fasano, María Victoria
Andreoli, Maria Florencia
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cortisol
Infant Plasma Cortisol
Milk cortisol
Obesity
topic Cortisol
Infant Plasma Cortisol
Milk cortisol
Obesity
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Purpose The pathways through which milk cortisol affects infant body weight and adiposity remain poorly understood. Aims To assess the influence of maternal weight status on maternal cortisol concentrations and infant outcomes; to evaluate the relationship between maternal plasma and milk cortisol concentrations and infant salivary cortisol, body weight and adiposity during the first 3 months of life in a cohort of exclusively breastfed infants; to determine whether milk cortisol mediates these effects; and to explore the association between infant salivary cortisol and measures of body weight and adiposity. Methods In this prospective observational study, we measured cortisol concentrations in plasma and milk samples from lactating women at 10 days (n = 68) and 3 months postpartum (n = 34), and in saliva samples from their 3-month-old infants (n = 34). Multiple linear regression and mediation analysis were conducted to determine the relationship between maternal characteristics and infant anthropometric measurements or salivary cortisol concentration and whether they were mediated by milk cortisol. Results Plasma and milk cortisol concentrations were inversely associated with gestational weight gain and postpartum weight retention at 10 days postpartum. Maternal plasma and milk cortisol concentrations were directly with infant salivary cortisol concentration [Beta (95% CI): 0.05 (0.00, 0.09), p = 0.038; 0.95 (0.51, 1.39), p < 0.001], and inversely associated with infant BMI z-score [Beta (95% CI): −0.11 (−0.17, −0.04), p = 0.004; −1.04 (−1.69, −0.39), p = 0.003] at 3 months of lactation, the former mediated by milk cortisol (p = 0.039). Infant salivary cortisol was not associated with body weight and adiposity at 3 months of lactation. Conclusion Our study shows that in exclusively breastfed infants, milk cortisol is inversely associated with BMI z-score and influences salivary cortisol at 3 months postpartum. Further research is warranted to explore the mechanisms involved and how these interactions evolve across different stages of lactation.
Fil: Kruger, Ana Luz. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata. Instituto de Desarrollo e Investigaciones Pediátricas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Malpeli, Agustina. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata. Instituto de Desarrollo e Investigaciones Pediátricas; Argentina
Fil: Sala, Marisa Esther. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata. Instituto de Desarrollo e Investigaciones Pediátricas; Argentina
Fil: Casado, Carla. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata. Instituto de Desarrollo e Investigaciones Pediátricas; Argentina
Fil: Mendez, Ignacio. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata. Instituto de Desarrollo e Investigaciones Pediátricas; Argentina
Fil: Fotia, Lucrecia. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata. Instituto de Desarrollo e Investigaciones Pediátricas; Argentina
Fil: Tournier, Andrea. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; Argentina
Fil: Fasano, María Victoria. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata. Instituto de Desarrollo e Investigaciones Pediátricas; Argentina
Fil: Andreoli, Maria Florencia. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata. Instituto de Desarrollo e Investigaciones Pediátricas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
description Purpose The pathways through which milk cortisol affects infant body weight and adiposity remain poorly understood. Aims To assess the influence of maternal weight status on maternal cortisol concentrations and infant outcomes; to evaluate the relationship between maternal plasma and milk cortisol concentrations and infant salivary cortisol, body weight and adiposity during the first 3 months of life in a cohort of exclusively breastfed infants; to determine whether milk cortisol mediates these effects; and to explore the association between infant salivary cortisol and measures of body weight and adiposity. Methods In this prospective observational study, we measured cortisol concentrations in plasma and milk samples from lactating women at 10 days (n = 68) and 3 months postpartum (n = 34), and in saliva samples from their 3-month-old infants (n = 34). Multiple linear regression and mediation analysis were conducted to determine the relationship between maternal characteristics and infant anthropometric measurements or salivary cortisol concentration and whether they were mediated by milk cortisol. Results Plasma and milk cortisol concentrations were inversely associated with gestational weight gain and postpartum weight retention at 10 days postpartum. Maternal plasma and milk cortisol concentrations were directly with infant salivary cortisol concentration [Beta (95% CI): 0.05 (0.00, 0.09), p = 0.038; 0.95 (0.51, 1.39), p < 0.001], and inversely associated with infant BMI z-score [Beta (95% CI): −0.11 (−0.17, −0.04), p = 0.004; −1.04 (−1.69, −0.39), p = 0.003] at 3 months of lactation, the former mediated by milk cortisol (p = 0.039). Infant salivary cortisol was not associated with body weight and adiposity at 3 months of lactation. Conclusion Our study shows that in exclusively breastfed infants, milk cortisol is inversely associated with BMI z-score and influences salivary cortisol at 3 months postpartum. Further research is warranted to explore the mechanisms involved and how these interactions evolve across different stages of lactation.
publishDate 2025
dc.date.none.fl_str_mv 2025-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/282341
Kruger, Ana Luz; Malpeli, Agustina; Sala, Marisa Esther; Casado, Carla; Mendez, Ignacio; et al.; Human milk cortisol is inversely associated with infant BMI and mediates the association between maternal plasma and infant salivary cortisol concentrations; Nature Publishing Group; International Journal Of Obesity; 49; 8; 5-2025; 1632-1641
0307-0565
CONICET Digital
CONICET
url http://hdl.handle.net/11336/282341
identifier_str_mv Kruger, Ana Luz; Malpeli, Agustina; Sala, Marisa Esther; Casado, Carla; Mendez, Ignacio; et al.; Human milk cortisol is inversely associated with infant BMI and mediates the association between maternal plasma and infant salivary cortisol concentrations; Nature Publishing Group; International Journal Of Obesity; 49; 8; 5-2025; 1632-1641
0307-0565
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41366-025-01815-4
info:eu-repo/semantics/altIdentifier/doi/10.1038/s41366-025-01815-4
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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