Sexual dimorphism of neuroendocrine-immune interactions

Autores
Spinedi, Nahuel; Gaillard, Rolf C.; Chisari, Andrea Nancy
Año de publicación
2002
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In the bidirectional interplay between the immune and endocrine systems, the communications most deeply investigated up to now have been those between the immuhC:and the hypothalamo-pituita~y-adrenal (HPA) and the HP-gonadal (HPG) [for review see, axes. For instance, mitogen/antigen-activated immune cells secrete cytokines; in turn, these substances are able to stimulate the hypothalamus thus inducing the activation of the corticotropin-releasing hormone (CRR)-ergic function . Once the eRR neuronal system has been activated, this peptide is able to locally (centrally) inhibit the HPG axis function [for references see, and, via the corticotrope cells, to stimulate HPA axis function . Evidence indicates that gonadal steroids modulate immunological function . Our findings and those of other researchers suggest that while estrogens enhance the immune response , androgens inhibit it and that gonadectomyalters this response.
Fil: Spinedi, Nahuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Endocrinología Experimental y Aplicada. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Endocrinología Experimental y Aplicada; Argentina
Fil: Gaillard, Rolf C.. Lausanne University Hospital; Suiza
Fil: Chisari, Andrea Nancy. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
Materia
adrenal
dimorphism
CRH axis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/150629
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Sexual dimorphism of neuroendocrine-immune interactionsSpinedi, NahuelGaillard, Rolf C.Chisari, Andrea NancyadrenaldimorphismCRH axishttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3In the bidirectional interplay between the immune and endocrine systems, the communications most deeply investigated up to now have been those between the immuhC:and the hypothalamo-pituita~y-adrenal (HPA) and the HP-gonadal (HPG) [for review see, axes. For instance, mitogen/antigen-activated immune cells secrete cytokines; in turn, these substances are able to stimulate the hypothalamus thus inducing the activation of the corticotropin-releasing hormone (CRR)-ergic function . Once the eRR neuronal system has been activated, this peptide is able to locally (centrally) inhibit the HPG axis function [for references see, and, via the corticotrope cells, to stimulate HPA axis function . Evidence indicates that gonadal steroids modulate immunological function . Our findings and those of other researchers suggest that while estrogens enhance the immune response , androgens inhibit it and that gonadectomyalters this response.Fil: Spinedi, Nahuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Endocrinología Experimental y Aplicada. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Endocrinología Experimental y Aplicada; ArgentinaFil: Gaillard, Rolf C.. Lausanne University Hospital; SuizaFil: Chisari, Andrea Nancy. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; ArgentinaKarger2002-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/150629Spinedi, Nahuel; Gaillard, Rolf C.; Chisari, Andrea Nancy; Sexual dimorphism of neuroendocrine-immune interactions; Karger; Frontiers in Hormone Research; 29; 12-2002; 91-1070301-3073CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1159/000061059info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:48:30Zoai:ri.conicet.gov.ar:11336/150629instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:48:31.064CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Sexual dimorphism of neuroendocrine-immune interactions
title Sexual dimorphism of neuroendocrine-immune interactions
spellingShingle Sexual dimorphism of neuroendocrine-immune interactions
Spinedi, Nahuel
adrenal
dimorphism
CRH axis
title_short Sexual dimorphism of neuroendocrine-immune interactions
title_full Sexual dimorphism of neuroendocrine-immune interactions
title_fullStr Sexual dimorphism of neuroendocrine-immune interactions
title_full_unstemmed Sexual dimorphism of neuroendocrine-immune interactions
title_sort Sexual dimorphism of neuroendocrine-immune interactions
dc.creator.none.fl_str_mv Spinedi, Nahuel
Gaillard, Rolf C.
Chisari, Andrea Nancy
author Spinedi, Nahuel
author_facet Spinedi, Nahuel
Gaillard, Rolf C.
Chisari, Andrea Nancy
author_role author
author2 Gaillard, Rolf C.
Chisari, Andrea Nancy
author2_role author
author
dc.subject.none.fl_str_mv adrenal
dimorphism
CRH axis
topic adrenal
dimorphism
CRH axis
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv In the bidirectional interplay between the immune and endocrine systems, the communications most deeply investigated up to now have been those between the immuhC:and the hypothalamo-pituita~y-adrenal (HPA) and the HP-gonadal (HPG) [for review see, axes. For instance, mitogen/antigen-activated immune cells secrete cytokines; in turn, these substances are able to stimulate the hypothalamus thus inducing the activation of the corticotropin-releasing hormone (CRR)-ergic function . Once the eRR neuronal system has been activated, this peptide is able to locally (centrally) inhibit the HPG axis function [for references see, and, via the corticotrope cells, to stimulate HPA axis function . Evidence indicates that gonadal steroids modulate immunological function . Our findings and those of other researchers suggest that while estrogens enhance the immune response , androgens inhibit it and that gonadectomyalters this response.
Fil: Spinedi, Nahuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Endocrinología Experimental y Aplicada. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Endocrinología Experimental y Aplicada; Argentina
Fil: Gaillard, Rolf C.. Lausanne University Hospital; Suiza
Fil: Chisari, Andrea Nancy. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
description In the bidirectional interplay between the immune and endocrine systems, the communications most deeply investigated up to now have been those between the immuhC:and the hypothalamo-pituita~y-adrenal (HPA) and the HP-gonadal (HPG) [for review see, axes. For instance, mitogen/antigen-activated immune cells secrete cytokines; in turn, these substances are able to stimulate the hypothalamus thus inducing the activation of the corticotropin-releasing hormone (CRR)-ergic function . Once the eRR neuronal system has been activated, this peptide is able to locally (centrally) inhibit the HPG axis function [for references see, and, via the corticotrope cells, to stimulate HPA axis function . Evidence indicates that gonadal steroids modulate immunological function . Our findings and those of other researchers suggest that while estrogens enhance the immune response , androgens inhibit it and that gonadectomyalters this response.
publishDate 2002
dc.date.none.fl_str_mv 2002-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/150629
Spinedi, Nahuel; Gaillard, Rolf C.; Chisari, Andrea Nancy; Sexual dimorphism of neuroendocrine-immune interactions; Karger; Frontiers in Hormone Research; 29; 12-2002; 91-107
0301-3073
CONICET Digital
CONICET
url http://hdl.handle.net/11336/150629
identifier_str_mv Spinedi, Nahuel; Gaillard, Rolf C.; Chisari, Andrea Nancy; Sexual dimorphism of neuroendocrine-immune interactions; Karger; Frontiers in Hormone Research; 29; 12-2002; 91-107
0301-3073
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1159/000061059
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Karger
publisher.none.fl_str_mv Karger
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268927376228352
score 13.13397

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