Design and Development of Soap Herbal Tablet of Larrea divaricata (Cav.) with Antifungal Activity Against Candida albicans

Autores
Jofre, Maria de Los Angeles; Favier, Laura Silvina; Cianchino, Valeria Andrea; Divizia, Maria Julia; Ortiz, Javier Esteban; Feresin, Gabriela Egly; Ortega, Claudia Alicia
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In this present work soap herbal tablet of Larrea divaricata Cav. ethanolic extract (LdE) with antifungal activity against Candida albicans, was designed and developed. The chemical profile of main compounds and quantification of nordihydroguaiaretic acid (NDGA) in the LdE was performed by means of UPLC-MS/MS. Two formulations (F1 and F2) were prepared by direct compression with different concentrations of active herbal ingredient (AHI). The performance of three carriers for impregnating LdE was evaluated. TRI-CAFOS® 500 was selected as carrier after a comparative study by Scanning Electron Microscope with AEROSIL® 200 and AEROPERL® 300. StarLac® 90, a coprocessed lactose, was employed as binder. The soap herbal tablets quality parameters were evaluated in accordance with United States Pharmacopeia (USP-43) guidelines, weight variation, hardness, friability, disintegration test, foam stability test and microbiological assay against candida albicans were performed. The F1 (LdE + TRI-CAFOS®500 (LdET1) 62.8%, StarLac®90 0.1%, Microcrystalline cellulose 10%, vitamin E 0.1%, Betan F® 5%, Lactic acid 5%, Rose essence 0.1%, Low density Hyaluronic acid 1.5% and magnesium stearate 0.5%) showed optimal rheological properties, good biopharmaceutical parameters (Disintegration test (27.33s), Hardness (3.00Kp), Friability (0.92%), Foam stability (1.12)) and Minimum inhibitory concentration (MIC) 25 mg/ml for Candida albicans. Considering that there are no soap herbal tablets on the market, the present design can be used as a novel herbal cosmetic form of vaginal hygiene.
Fil: Jofre, Maria de Los Angeles. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Favier, Laura Silvina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Cianchino, Valeria Andrea. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Divizia, Maria Julia. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ortiz, Javier Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina
Fil: Feresin, Gabriela Egly. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina
Fil: Ortega, Claudia Alicia. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Materia
LARREA DIVARICATA CAV. EXTRACT
SOAP HERBAL TABLETS
STARLAC® 90
CANDIDA ALBICANS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/246884
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/246884
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Design and Development of Soap Herbal Tablet of Larrea divaricata (Cav.) with Antifungal Activity Against Candida albicansJofre, Maria de Los AngelesFavier, Laura SilvinaCianchino, Valeria AndreaDivizia, Maria JuliaOrtiz, Javier EstebanFeresin, Gabriela EglyOrtega, Claudia AliciaLARREA DIVARICATA CAV. EXTRACTSOAP HERBAL TABLETSSTARLAC® 90CANDIDA ALBICANShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1In this present work soap herbal tablet of Larrea divaricata Cav. ethanolic extract (LdE) with antifungal activity against Candida albicans, was designed and developed. The chemical profile of main compounds and quantification of nordihydroguaiaretic acid (NDGA) in the LdE was performed by means of UPLC-MS/MS. Two formulations (F1 and F2) were prepared by direct compression with different concentrations of active herbal ingredient (AHI). The performance of three carriers for impregnating LdE was evaluated. TRI-CAFOS® 500 was selected as carrier after a comparative study by Scanning Electron Microscope with AEROSIL® 200 and AEROPERL® 300. StarLac® 90, a coprocessed lactose, was employed as binder. The soap herbal tablets quality parameters were evaluated in accordance with United States Pharmacopeia (USP-43) guidelines, weight variation, hardness, friability, disintegration test, foam stability test and microbiological assay against candida albicans were performed. The F1 (LdE + TRI-CAFOS®500 (LdET1) 62.8%, StarLac®90 0.1%, Microcrystalline cellulose 10%, vitamin E 0.1%, Betan F® 5%, Lactic acid 5%, Rose essence 0.1%, Low density Hyaluronic acid 1.5% and magnesium stearate 0.5%) showed optimal rheological properties, good biopharmaceutical parameters (Disintegration test (27.33s), Hardness (3.00Kp), Friability (0.92%), Foam stability (1.12)) and Minimum inhibitory concentration (MIC) 25 mg/ml for Candida albicans. Considering that there are no soap herbal tablets on the market, the present design can be used as a novel herbal cosmetic form of vaginal hygiene.Fil: Jofre, Maria de Los Angeles. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; ArgentinaFil: Favier, Laura Silvina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; ArgentinaFil: Cianchino, Valeria Andrea. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; ArgentinaFil: Divizia, Maria Julia. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ortiz, Javier Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; ArgentinaFil: Feresin, Gabriela Egly. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; ArgentinaFil: Ortega, Claudia Alicia. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; ArgentinaActa Scientific2024-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/246884Jofre, Maria de Los Angeles; Favier, Laura Silvina; Cianchino, Valeria Andrea; Divizia, Maria Julia; Ortiz, Javier Esteban; et al.; Design and Development of Soap Herbal Tablet of Larrea divaricata (Cav.) with Antifungal Activity Against Candida albicans; Acta Scientific; Acta Scientific Nutritional Health; 8; 10; 10-2024; 42-482582-1423CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.actascientific.com/ASNH/ASNH-08-1443.phpinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:31:06Zoai:ri.conicet.gov.ar:11336/246884instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:31:06.743CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Design and Development of Soap Herbal Tablet of Larrea divaricata (Cav.) with Antifungal Activity Against Candida albicans
title Design and Development of Soap Herbal Tablet of Larrea divaricata (Cav.) with Antifungal Activity Against Candida albicans
spellingShingle Design and Development of Soap Herbal Tablet of Larrea divaricata (Cav.) with Antifungal Activity Against Candida albicans
Jofre, Maria de Los Angeles
LARREA DIVARICATA CAV. EXTRACT
SOAP HERBAL TABLETS
STARLAC® 90
CANDIDA ALBICANS
title_short Design and Development of Soap Herbal Tablet of Larrea divaricata (Cav.) with Antifungal Activity Against Candida albicans
title_full Design and Development of Soap Herbal Tablet of Larrea divaricata (Cav.) with Antifungal Activity Against Candida albicans
title_fullStr Design and Development of Soap Herbal Tablet of Larrea divaricata (Cav.) with Antifungal Activity Against Candida albicans
title_full_unstemmed Design and Development of Soap Herbal Tablet of Larrea divaricata (Cav.) with Antifungal Activity Against Candida albicans
title_sort Design and Development of Soap Herbal Tablet of Larrea divaricata (Cav.) with Antifungal Activity Against Candida albicans
dc.creator.none.fl_str_mv Jofre, Maria de Los Angeles
Favier, Laura Silvina
Cianchino, Valeria Andrea
Divizia, Maria Julia
Ortiz, Javier Esteban
Feresin, Gabriela Egly
Ortega, Claudia Alicia
author Jofre, Maria de Los Angeles
author_facet Jofre, Maria de Los Angeles
Favier, Laura Silvina
Cianchino, Valeria Andrea
Divizia, Maria Julia
Ortiz, Javier Esteban
Feresin, Gabriela Egly
Ortega, Claudia Alicia
author_role author
author2 Favier, Laura Silvina
Cianchino, Valeria Andrea
Divizia, Maria Julia
Ortiz, Javier Esteban
Feresin, Gabriela Egly
Ortega, Claudia Alicia
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv LARREA DIVARICATA CAV. EXTRACT
SOAP HERBAL TABLETS
STARLAC® 90
CANDIDA ALBICANS
topic LARREA DIVARICATA CAV. EXTRACT
SOAP HERBAL TABLETS
STARLAC® 90
CANDIDA ALBICANS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv In this present work soap herbal tablet of Larrea divaricata Cav. ethanolic extract (LdE) with antifungal activity against Candida albicans, was designed and developed. The chemical profile of main compounds and quantification of nordihydroguaiaretic acid (NDGA) in the LdE was performed by means of UPLC-MS/MS. Two formulations (F1 and F2) were prepared by direct compression with different concentrations of active herbal ingredient (AHI). The performance of three carriers for impregnating LdE was evaluated. TRI-CAFOS® 500 was selected as carrier after a comparative study by Scanning Electron Microscope with AEROSIL® 200 and AEROPERL® 300. StarLac® 90, a coprocessed lactose, was employed as binder. The soap herbal tablets quality parameters were evaluated in accordance with United States Pharmacopeia (USP-43) guidelines, weight variation, hardness, friability, disintegration test, foam stability test and microbiological assay against candida albicans were performed. The F1 (LdE + TRI-CAFOS®500 (LdET1) 62.8%, StarLac®90 0.1%, Microcrystalline cellulose 10%, vitamin E 0.1%, Betan F® 5%, Lactic acid 5%, Rose essence 0.1%, Low density Hyaluronic acid 1.5% and magnesium stearate 0.5%) showed optimal rheological properties, good biopharmaceutical parameters (Disintegration test (27.33s), Hardness (3.00Kp), Friability (0.92%), Foam stability (1.12)) and Minimum inhibitory concentration (MIC) 25 mg/ml for Candida albicans. Considering that there are no soap herbal tablets on the market, the present design can be used as a novel herbal cosmetic form of vaginal hygiene.
Fil: Jofre, Maria de Los Angeles. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Favier, Laura Silvina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Cianchino, Valeria Andrea. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Divizia, Maria Julia. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ortiz, Javier Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina
Fil: Feresin, Gabriela Egly. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina
Fil: Ortega, Claudia Alicia. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
description In this present work soap herbal tablet of Larrea divaricata Cav. ethanolic extract (LdE) with antifungal activity against Candida albicans, was designed and developed. The chemical profile of main compounds and quantification of nordihydroguaiaretic acid (NDGA) in the LdE was performed by means of UPLC-MS/MS. Two formulations (F1 and F2) were prepared by direct compression with different concentrations of active herbal ingredient (AHI). The performance of three carriers for impregnating LdE was evaluated. TRI-CAFOS® 500 was selected as carrier after a comparative study by Scanning Electron Microscope with AEROSIL® 200 and AEROPERL® 300. StarLac® 90, a coprocessed lactose, was employed as binder. The soap herbal tablets quality parameters were evaluated in accordance with United States Pharmacopeia (USP-43) guidelines, weight variation, hardness, friability, disintegration test, foam stability test and microbiological assay against candida albicans were performed. The F1 (LdE + TRI-CAFOS®500 (LdET1) 62.8%, StarLac®90 0.1%, Microcrystalline cellulose 10%, vitamin E 0.1%, Betan F® 5%, Lactic acid 5%, Rose essence 0.1%, Low density Hyaluronic acid 1.5% and magnesium stearate 0.5%) showed optimal rheological properties, good biopharmaceutical parameters (Disintegration test (27.33s), Hardness (3.00Kp), Friability (0.92%), Foam stability (1.12)) and Minimum inhibitory concentration (MIC) 25 mg/ml for Candida albicans. Considering that there are no soap herbal tablets on the market, the present design can be used as a novel herbal cosmetic form of vaginal hygiene.
publishDate 2024
dc.date.none.fl_str_mv 2024-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/246884
Jofre, Maria de Los Angeles; Favier, Laura Silvina; Cianchino, Valeria Andrea; Divizia, Maria Julia; Ortiz, Javier Esteban; et al.; Design and Development of Soap Herbal Tablet of Larrea divaricata (Cav.) with Antifungal Activity Against Candida albicans; Acta Scientific; Acta Scientific Nutritional Health; 8; 10; 10-2024; 42-48
2582-1423
CONICET Digital
CONICET
url http://hdl.handle.net/11336/246884
identifier_str_mv Jofre, Maria de Los Angeles; Favier, Laura Silvina; Cianchino, Valeria Andrea; Divizia, Maria Julia; Ortiz, Javier Esteban; et al.; Design and Development of Soap Herbal Tablet of Larrea divaricata (Cav.) with Antifungal Activity Against Candida albicans; Acta Scientific; Acta Scientific Nutritional Health; 8; 10; 10-2024; 42-48
2582-1423
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.actascientific.com/ASNH/ASNH-08-1443.php
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Acta Scientific
publisher.none.fl_str_mv Acta Scientific
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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