The pedunclopontine nucleus and Parkinson's disease

Autores
Tubert, Cecilia; Galtieri, Daniel; Surmeier, D. James
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In the last decade, scientific and clinical interest in the pedunculopontine nucleus (PPN) has grown dramatically. This growth is largely a consequence of experimental work demonstrating its connection to the control of gait and of clinical work implicating PPN pathology in levodopa-insensitive gait symptoms of Parkinson's disease (PD). In addition, the development of optogenetic and chemogenetic approaches has made experimental analysis of PPN circuitry and function more tractable. In this brief review, recent findings in the field linking PPN to the basal ganglia and PD are summarized; in addition, an attempt is made to identify key gaps in our understanding and challenges this field faces in moving forward.
Fil: Tubert, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina. Northwestern University; Estados Unidos
Fil: Galtieri, Daniel. Northwestern University; Estados Unidos
Fil: Surmeier, D. James. Northwestern University; Estados Unidos
Materia
PARKINSON'S DISEASE
PEDUNCULOPONTINE
CHOLINERGIC NEURONS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/120829
Acceder
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network_name_str CONICET Digital (CONICET)
spelling The pedunclopontine nucleus and Parkinson's diseaseTubert, CeciliaGaltieri, DanielSurmeier, D. JamesPARKINSON'S DISEASEPEDUNCULOPONTINECHOLINERGIC NEURONShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3In the last decade, scientific and clinical interest in the pedunculopontine nucleus (PPN) has grown dramatically. This growth is largely a consequence of experimental work demonstrating its connection to the control of gait and of clinical work implicating PPN pathology in levodopa-insensitive gait symptoms of Parkinson's disease (PD). In addition, the development of optogenetic and chemogenetic approaches has made experimental analysis of PPN circuitry and function more tractable. In this brief review, recent findings in the field linking PPN to the basal ganglia and PD are summarized; in addition, an attempt is made to identify key gaps in our understanding and challenges this field faces in moving forward.Fil: Tubert, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina. Northwestern University; Estados UnidosFil: Galtieri, Daniel. Northwestern University; Estados UnidosFil: Surmeier, D. James. Northwestern University; Estados UnidosAcademic Press Inc Elsevier Science2019-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/120829Tubert, Cecilia; Galtieri, Daniel; Surmeier, D. James; The pedunclopontine nucleus and Parkinson's disease; Academic Press Inc Elsevier Science; Neurobiology of Disease; 128; 8-2019; 3-80969-9961CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0969996118304935info:eu-repo/semantics/altIdentifier/doi/10.1016/j.nbd.2018.08.017info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-17T10:54:07Zoai:ri.conicet.gov.ar:11336/120829instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-17 10:54:07.321CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The pedunclopontine nucleus and Parkinson's disease
title The pedunclopontine nucleus and Parkinson's disease
spellingShingle The pedunclopontine nucleus and Parkinson's disease
Tubert, Cecilia
PARKINSON'S DISEASE
PEDUNCULOPONTINE
CHOLINERGIC NEURONS
title_short The pedunclopontine nucleus and Parkinson's disease
title_full The pedunclopontine nucleus and Parkinson's disease
title_fullStr The pedunclopontine nucleus and Parkinson's disease
title_full_unstemmed The pedunclopontine nucleus and Parkinson's disease
title_sort The pedunclopontine nucleus and Parkinson's disease
dc.creator.none.fl_str_mv Tubert, Cecilia
Galtieri, Daniel
Surmeier, D. James
author Tubert, Cecilia
author_facet Tubert, Cecilia
Galtieri, Daniel
Surmeier, D. James
author_role author
author2 Galtieri, Daniel
Surmeier, D. James
author2_role author
author
dc.subject.none.fl_str_mv PARKINSON'S DISEASE
PEDUNCULOPONTINE
CHOLINERGIC NEURONS
topic PARKINSON'S DISEASE
PEDUNCULOPONTINE
CHOLINERGIC NEURONS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv In the last decade, scientific and clinical interest in the pedunculopontine nucleus (PPN) has grown dramatically. This growth is largely a consequence of experimental work demonstrating its connection to the control of gait and of clinical work implicating PPN pathology in levodopa-insensitive gait symptoms of Parkinson's disease (PD). In addition, the development of optogenetic and chemogenetic approaches has made experimental analysis of PPN circuitry and function more tractable. In this brief review, recent findings in the field linking PPN to the basal ganglia and PD are summarized; in addition, an attempt is made to identify key gaps in our understanding and challenges this field faces in moving forward.
Fil: Tubert, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina. Northwestern University; Estados Unidos
Fil: Galtieri, Daniel. Northwestern University; Estados Unidos
Fil: Surmeier, D. James. Northwestern University; Estados Unidos
description In the last decade, scientific and clinical interest in the pedunculopontine nucleus (PPN) has grown dramatically. This growth is largely a consequence of experimental work demonstrating its connection to the control of gait and of clinical work implicating PPN pathology in levodopa-insensitive gait symptoms of Parkinson's disease (PD). In addition, the development of optogenetic and chemogenetic approaches has made experimental analysis of PPN circuitry and function more tractable. In this brief review, recent findings in the field linking PPN to the basal ganglia and PD are summarized; in addition, an attempt is made to identify key gaps in our understanding and challenges this field faces in moving forward.
publishDate 2019
dc.date.none.fl_str_mv 2019-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/120829
Tubert, Cecilia; Galtieri, Daniel; Surmeier, D. James; The pedunclopontine nucleus and Parkinson's disease; Academic Press Inc Elsevier Science; Neurobiology of Disease; 128; 8-2019; 3-8
0969-9961
CONICET Digital
CONICET
url http://hdl.handle.net/11336/120829
identifier_str_mv Tubert, Cecilia; Galtieri, Daniel; Surmeier, D. James; The pedunclopontine nucleus and Parkinson's disease; Academic Press Inc Elsevier Science; Neurobiology of Disease; 128; 8-2019; 3-8
0969-9961
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0969996118304935
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.nbd.2018.08.017
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Academic Press Inc Elsevier Science
publisher.none.fl_str_mv Academic Press Inc Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.000565

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