Mediators and mechanisms of heat shock protein 70 based cytoprotection in obstructive nephropathy

Autores
Mazzei, Luciana Jorgelina; Docherty, Neil G.; Manucha, Walter Ariel Fernando
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Urinary heat shock protein 70 (Hsp70) is rapidly increased in patients with clinical acute kidney injury, indicating that it constitutes a component of the endogenous stress response to renal injury. Moreover, experimental models have demonstrated that Hsp70 activation is associated with the cytoprotective actions of several drugs following obstruction, including nitric oxide (NO) donors, geranylgeranylacetone, vitamin D and rosuvastatin. Discrete and synergistic effects of the biological activities of Hsp70 may explain its cytoprotective role in obstructive nephropathy. Basic studies point to a combination of effects including: inhibition of apoptosis and inflammation, repair of damaged proteins, prevention of unfolded protein aggregation, targeting of damaged protein for degradation and cytoskeletal stabilization as primary effectors of Hsp70 action. This review summarizes our understanding of how the biological actions of Hsp70 may effect renal cytoprotection in the context of obstructive injury. The potential of Hsp70 to be of central importance to the mechanism of action of various drugs that modify the genesis of experimental obstructive nephropathy is considered.
Fil: Mazzei, Luciana Jorgelina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Departamento de Patología; Argentina
Fil: Docherty, Neil G.. Universidad de Dublin; Irlanda
Fil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Departamento de Patología; Argentina
Materia
APOPTOSIS
HEAT SHOCK PROTEIN 70
INFLAMMATION
NITRIC OXIDE
OBSTRUCTIVE NEPHROPATHY
WT-1
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/124645
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Mediators and mechanisms of heat shock protein 70 based cytoprotection in obstructive nephropathyMazzei, Luciana JorgelinaDocherty, Neil G.Manucha, Walter Ariel FernandoAPOPTOSISHEAT SHOCK PROTEIN 70INFLAMMATIONNITRIC OXIDEOBSTRUCTIVE NEPHROPATHYWT-1https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Urinary heat shock protein 70 (Hsp70) is rapidly increased in patients with clinical acute kidney injury, indicating that it constitutes a component of the endogenous stress response to renal injury. Moreover, experimental models have demonstrated that Hsp70 activation is associated with the cytoprotective actions of several drugs following obstruction, including nitric oxide (NO) donors, geranylgeranylacetone, vitamin D and rosuvastatin. Discrete and synergistic effects of the biological activities of Hsp70 may explain its cytoprotective role in obstructive nephropathy. Basic studies point to a combination of effects including: inhibition of apoptosis and inflammation, repair of damaged proteins, prevention of unfolded protein aggregation, targeting of damaged protein for degradation and cytoskeletal stabilization as primary effectors of Hsp70 action. This review summarizes our understanding of how the biological actions of Hsp70 may effect renal cytoprotection in the context of obstructive injury. The potential of Hsp70 to be of central importance to the mechanism of action of various drugs that modify the genesis of experimental obstructive nephropathy is considered.Fil: Mazzei, Luciana Jorgelina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Departamento de Patología; ArgentinaFil: Docherty, Neil G.. Universidad de Dublin; IrlandaFil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Departamento de Patología; ArgentinaSpringer2015-07-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/124645Mazzei, Luciana Jorgelina; Docherty, Neil G.; Manucha, Walter Ariel Fernando; Mediators and mechanisms of heat shock protein 70 based cytoprotection in obstructive nephropathy; Springer; Cell Stress & Chaperones; 20; 6; 31-7-2015; 893-9061355-8145CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007%2Fs12192-015-0622-zinfo:eu-repo/semantics/altIdentifier/doi/10.1007/s12192-015-0622-zinfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595437/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:58:21Zoai:ri.conicet.gov.ar:11336/124645instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:58:21.435CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Mediators and mechanisms of heat shock protein 70 based cytoprotection in obstructive nephropathy
title Mediators and mechanisms of heat shock protein 70 based cytoprotection in obstructive nephropathy
spellingShingle Mediators and mechanisms of heat shock protein 70 based cytoprotection in obstructive nephropathy
Mazzei, Luciana Jorgelina
APOPTOSIS
HEAT SHOCK PROTEIN 70
INFLAMMATION
NITRIC OXIDE
OBSTRUCTIVE NEPHROPATHY
WT-1
title_short Mediators and mechanisms of heat shock protein 70 based cytoprotection in obstructive nephropathy
title_full Mediators and mechanisms of heat shock protein 70 based cytoprotection in obstructive nephropathy
title_fullStr Mediators and mechanisms of heat shock protein 70 based cytoprotection in obstructive nephropathy
title_full_unstemmed Mediators and mechanisms of heat shock protein 70 based cytoprotection in obstructive nephropathy
title_sort Mediators and mechanisms of heat shock protein 70 based cytoprotection in obstructive nephropathy
dc.creator.none.fl_str_mv Mazzei, Luciana Jorgelina
Docherty, Neil G.
Manucha, Walter Ariel Fernando
author Mazzei, Luciana Jorgelina
author_facet Mazzei, Luciana Jorgelina
Docherty, Neil G.
Manucha, Walter Ariel Fernando
author_role author
author2 Docherty, Neil G.
Manucha, Walter Ariel Fernando
author2_role author
author
dc.subject.none.fl_str_mv APOPTOSIS
HEAT SHOCK PROTEIN 70
INFLAMMATION
NITRIC OXIDE
OBSTRUCTIVE NEPHROPATHY
WT-1
topic APOPTOSIS
HEAT SHOCK PROTEIN 70
INFLAMMATION
NITRIC OXIDE
OBSTRUCTIVE NEPHROPATHY
WT-1
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Urinary heat shock protein 70 (Hsp70) is rapidly increased in patients with clinical acute kidney injury, indicating that it constitutes a component of the endogenous stress response to renal injury. Moreover, experimental models have demonstrated that Hsp70 activation is associated with the cytoprotective actions of several drugs following obstruction, including nitric oxide (NO) donors, geranylgeranylacetone, vitamin D and rosuvastatin. Discrete and synergistic effects of the biological activities of Hsp70 may explain its cytoprotective role in obstructive nephropathy. Basic studies point to a combination of effects including: inhibition of apoptosis and inflammation, repair of damaged proteins, prevention of unfolded protein aggregation, targeting of damaged protein for degradation and cytoskeletal stabilization as primary effectors of Hsp70 action. This review summarizes our understanding of how the biological actions of Hsp70 may effect renal cytoprotection in the context of obstructive injury. The potential of Hsp70 to be of central importance to the mechanism of action of various drugs that modify the genesis of experimental obstructive nephropathy is considered.
Fil: Mazzei, Luciana Jorgelina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Departamento de Patología; Argentina
Fil: Docherty, Neil G.. Universidad de Dublin; Irlanda
Fil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Departamento de Patología; Argentina
description Urinary heat shock protein 70 (Hsp70) is rapidly increased in patients with clinical acute kidney injury, indicating that it constitutes a component of the endogenous stress response to renal injury. Moreover, experimental models have demonstrated that Hsp70 activation is associated with the cytoprotective actions of several drugs following obstruction, including nitric oxide (NO) donors, geranylgeranylacetone, vitamin D and rosuvastatin. Discrete and synergistic effects of the biological activities of Hsp70 may explain its cytoprotective role in obstructive nephropathy. Basic studies point to a combination of effects including: inhibition of apoptosis and inflammation, repair of damaged proteins, prevention of unfolded protein aggregation, targeting of damaged protein for degradation and cytoskeletal stabilization as primary effectors of Hsp70 action. This review summarizes our understanding of how the biological actions of Hsp70 may effect renal cytoprotection in the context of obstructive injury. The potential of Hsp70 to be of central importance to the mechanism of action of various drugs that modify the genesis of experimental obstructive nephropathy is considered.
publishDate 2015
dc.date.none.fl_str_mv 2015-07-31
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/124645
Mazzei, Luciana Jorgelina; Docherty, Neil G.; Manucha, Walter Ariel Fernando; Mediators and mechanisms of heat shock protein 70 based cytoprotection in obstructive nephropathy; Springer; Cell Stress & Chaperones; 20; 6; 31-7-2015; 893-906
1355-8145
CONICET Digital
CONICET
url http://hdl.handle.net/11336/124645
identifier_str_mv Mazzei, Luciana Jorgelina; Docherty, Neil G.; Manucha, Walter Ariel Fernando; Mediators and mechanisms of heat shock protein 70 based cytoprotection in obstructive nephropathy; Springer; Cell Stress & Chaperones; 20; 6; 31-7-2015; 893-906
1355-8145
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007%2Fs12192-015-0622-z
info:eu-repo/semantics/altIdentifier/doi/10.1007/s12192-015-0622-z
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595437/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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