WT-1 Expresion linked to nitric oxide availability during neonatal obstructive nephropathy

Autores
Mazzei, Luciana Jorgelina; Manucha, Walter Ariel Fernando
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The wt-1 gene encodes a zinc finger DNA-binding protein that acts as a transcriptional activator or repressor depending on the cellular or chromosomal context. The wt-1 regulates the expression of a large number of genes that have a critical role in kidney development. Congenital obstructive nephropathy disrupts normal renal development and causes chronic progressive interstitial fibrosis, which contributes to renal growth arrest, ultimately leading to chronic renal failure. Wt-1 is downregulated during congenital obstructive nephropathy, leading to apoptosis. Of great interest, nitric oxide bioavailability associated with heat shock protein 70 (Hsp70) interaction may modulate wt-1 mRNA expression, preventing obstruction-induced cell death during neonatal unilateral ureteral obstruction. Moreover, recent genetic researches have allowed characterization of many of the complex interactions among the individual components cited, but the realization of new biochemical, molecular and functional experiments as proposed in our and other research labs, allow us to establish a deeper level of commitment among proteins involved and the potential pathogenic consequences of their imbalance.
Fil: Mazzei, Luciana Jorgelina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médica; Argentina
Materia
KIDNEY DEVELOPMENT
WT-1
NITRIC OXIDE
APOPTOSIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/10073
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling WT-1 Expresion linked to nitric oxide availability during neonatal obstructive nephropathyMazzei, Luciana JorgelinaManucha, Walter Ariel FernandoKIDNEY DEVELOPMENTWT-1NITRIC OXIDEAPOPTOSIShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The wt-1 gene encodes a zinc finger DNA-binding protein that acts as a transcriptional activator or repressor depending on the cellular or chromosomal context. The wt-1 regulates the expression of a large number of genes that have a critical role in kidney development. Congenital obstructive nephropathy disrupts normal renal development and causes chronic progressive interstitial fibrosis, which contributes to renal growth arrest, ultimately leading to chronic renal failure. Wt-1 is downregulated during congenital obstructive nephropathy, leading to apoptosis. Of great interest, nitric oxide bioavailability associated with heat shock protein 70 (Hsp70) interaction may modulate wt-1 mRNA expression, preventing obstruction-induced cell death during neonatal unilateral ureteral obstruction. Moreover, recent genetic researches have allowed characterization of many of the complex interactions among the individual components cited, but the realization of new biochemical, molecular and functional experiments as proposed in our and other research labs, allow us to establish a deeper level of commitment among proteins involved and the potential pathogenic consequences of their imbalance.Fil: Mazzei, Luciana Jorgelina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médica; ArgentinaHindawi Publishing Corporation2013-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/10073Mazzei, Luciana Jorgelina; Manucha, Walter Ariel Fernando; WT-1 Expresion linked to nitric oxide availability during neonatal obstructive nephropathy; Hindawi Publishing Corporation; Advances in Urology; 2013; 11-2013; 1-61918-3003enginfo:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/au/2013/401750/info:eu-repo/semantics/altIdentifier/doi/10.1155/2013/401750info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:52:51Zoai:ri.conicet.gov.ar:11336/10073instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:52:52.047CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv WT-1 Expresion linked to nitric oxide availability during neonatal obstructive nephropathy
title WT-1 Expresion linked to nitric oxide availability during neonatal obstructive nephropathy
spellingShingle WT-1 Expresion linked to nitric oxide availability during neonatal obstructive nephropathy
Mazzei, Luciana Jorgelina
KIDNEY DEVELOPMENT
WT-1
NITRIC OXIDE
APOPTOSIS
title_short WT-1 Expresion linked to nitric oxide availability during neonatal obstructive nephropathy
title_full WT-1 Expresion linked to nitric oxide availability during neonatal obstructive nephropathy
title_fullStr WT-1 Expresion linked to nitric oxide availability during neonatal obstructive nephropathy
title_full_unstemmed WT-1 Expresion linked to nitric oxide availability during neonatal obstructive nephropathy
title_sort WT-1 Expresion linked to nitric oxide availability during neonatal obstructive nephropathy
dc.creator.none.fl_str_mv Mazzei, Luciana Jorgelina
Manucha, Walter Ariel Fernando
author Mazzei, Luciana Jorgelina
author_facet Mazzei, Luciana Jorgelina
Manucha, Walter Ariel Fernando
author_role author
author2 Manucha, Walter Ariel Fernando
author2_role author
dc.subject.none.fl_str_mv KIDNEY DEVELOPMENT
WT-1
NITRIC OXIDE
APOPTOSIS
topic KIDNEY DEVELOPMENT
WT-1
NITRIC OXIDE
APOPTOSIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The wt-1 gene encodes a zinc finger DNA-binding protein that acts as a transcriptional activator or repressor depending on the cellular or chromosomal context. The wt-1 regulates the expression of a large number of genes that have a critical role in kidney development. Congenital obstructive nephropathy disrupts normal renal development and causes chronic progressive interstitial fibrosis, which contributes to renal growth arrest, ultimately leading to chronic renal failure. Wt-1 is downregulated during congenital obstructive nephropathy, leading to apoptosis. Of great interest, nitric oxide bioavailability associated with heat shock protein 70 (Hsp70) interaction may modulate wt-1 mRNA expression, preventing obstruction-induced cell death during neonatal unilateral ureteral obstruction. Moreover, recent genetic researches have allowed characterization of many of the complex interactions among the individual components cited, but the realization of new biochemical, molecular and functional experiments as proposed in our and other research labs, allow us to establish a deeper level of commitment among proteins involved and the potential pathogenic consequences of their imbalance.
Fil: Mazzei, Luciana Jorgelina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médica; Argentina
description The wt-1 gene encodes a zinc finger DNA-binding protein that acts as a transcriptional activator or repressor depending on the cellular or chromosomal context. The wt-1 regulates the expression of a large number of genes that have a critical role in kidney development. Congenital obstructive nephropathy disrupts normal renal development and causes chronic progressive interstitial fibrosis, which contributes to renal growth arrest, ultimately leading to chronic renal failure. Wt-1 is downregulated during congenital obstructive nephropathy, leading to apoptosis. Of great interest, nitric oxide bioavailability associated with heat shock protein 70 (Hsp70) interaction may modulate wt-1 mRNA expression, preventing obstruction-induced cell death during neonatal unilateral ureteral obstruction. Moreover, recent genetic researches have allowed characterization of many of the complex interactions among the individual components cited, but the realization of new biochemical, molecular and functional experiments as proposed in our and other research labs, allow us to establish a deeper level of commitment among proteins involved and the potential pathogenic consequences of their imbalance.
publishDate 2013
dc.date.none.fl_str_mv 2013-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/10073
Mazzei, Luciana Jorgelina; Manucha, Walter Ariel Fernando; WT-1 Expresion linked to nitric oxide availability during neonatal obstructive nephropathy; Hindawi Publishing Corporation; Advances in Urology; 2013; 11-2013; 1-6
1918-3003
url http://hdl.handle.net/11336/10073
identifier_str_mv Mazzei, Luciana Jorgelina; Manucha, Walter Ariel Fernando; WT-1 Expresion linked to nitric oxide availability during neonatal obstructive nephropathy; Hindawi Publishing Corporation; Advances in Urology; 2013; 11-2013; 1-6
1918-3003
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/au/2013/401750/
info:eu-repo/semantics/altIdentifier/doi/10.1155/2013/401750
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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