Protective effect of CCR2-64I and not of CCR5-Δ32 and SDF1-3'A in pediatric HIV-1 infection
- Autores
- Mangano, A.; Kopka, J.; Batalla, M.; Bologna, R.; Sen, Luisa
- Año de publicación
- 2000
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The effects of chemokine and chemokine receptor genetic polymorphisms such as stromal derived factor 1 (SDF1-3'A), CCR2-64I, and CCR5-Δ32 associated with HIV-1 transmission and/or rate of disease progression in infected study subjects remain highly controversial and have been analyzed primarily only in adults. We have investigated whether these polymorphisms may provide similar beneficial effects in children exposed to HIV-1 perinatally. The prevalence of CCR2-64I allele was significantly increased (p = .03) and the CCR2-64I genotype distribution was not in Hardy-Weinberg equilibrium, among HIV-1-exposed uninfected infants. Moreover, in the HIV-1- infected group, a delay to AIDS progression was observed among carriers of CCR2-64I allele. This is the first report that suggests a protective role of CCR2-64I allele in mother-to-infant HIV-1 transmission and documents a delay in disease progression, after the child has been infected with HIV-1. However, SDF1-3'A and CCR5-Δ32 alleles did not modify the rate of HIV-1 transmission or disease progression in HIV-1-infected children.
Fil: Mangano, A.. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Kopka, J.. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Batalla, M.. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Bologna, R.. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Sen, Luisa. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina - Materia
-
CCR2
CCR5
CHEMOKINE RECEPTORS
HIV-1
PEDIATRIC AIDS
SDF1
VERTICAL TRANSMISSION - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/149060
Ver los metadatos del registro completo
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Protective effect of CCR2-64I and not of CCR5-Δ32 and SDF1-3'A in pediatric HIV-1 infectionMangano, A.Kopka, J.Batalla, M.Bologna, R.Sen, LuisaCCR2CCR5CHEMOKINE RECEPTORSHIV-1PEDIATRIC AIDSSDF1VERTICAL TRANSMISSIONhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The effects of chemokine and chemokine receptor genetic polymorphisms such as stromal derived factor 1 (SDF1-3'A), CCR2-64I, and CCR5-Δ32 associated with HIV-1 transmission and/or rate of disease progression in infected study subjects remain highly controversial and have been analyzed primarily only in adults. We have investigated whether these polymorphisms may provide similar beneficial effects in children exposed to HIV-1 perinatally. The prevalence of CCR2-64I allele was significantly increased (p = .03) and the CCR2-64I genotype distribution was not in Hardy-Weinberg equilibrium, among HIV-1-exposed uninfected infants. Moreover, in the HIV-1- infected group, a delay to AIDS progression was observed among carriers of CCR2-64I allele. This is the first report that suggests a protective role of CCR2-64I allele in mother-to-infant HIV-1 transmission and documents a delay in disease progression, after the child has been infected with HIV-1. However, SDF1-3'A and CCR5-Δ32 alleles did not modify the rate of HIV-1 transmission or disease progression in HIV-1-infected children.Fil: Mangano, A.. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Kopka, J.. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Batalla, M.. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Bologna, R.. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Sen, Luisa. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaLippincott Williams2000-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/149060Mangano, A.; Kopka, J.; Batalla, M.; Bologna, R.; Sen, Luisa; Protective effect of CCR2-64I and not of CCR5-Δ32 and SDF1-3'A in pediatric HIV-1 infection; Lippincott Williams; Journal Of Acquired Immune Deficiency Syndromes And Human Retrovirology; 23; 1; 1-2000; 52-571525-41351077-9450CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://journals.lww.com/jaids/Abstract/2000/01010/Protective_Effect_of_CCR2_64I_and_Not_of_CCR5__32.7.aspxinfo:eu-repo/semantics/altIdentifier/doi/10.1097/00126334-200001010-00007info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:33:39Zoai:ri.conicet.gov.ar:11336/149060instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:33:39.981CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Protective effect of CCR2-64I and not of CCR5-Δ32 and SDF1-3'A in pediatric HIV-1 infection |
| title |
Protective effect of CCR2-64I and not of CCR5-Δ32 and SDF1-3'A in pediatric HIV-1 infection |
| spellingShingle |
Protective effect of CCR2-64I and not of CCR5-Δ32 and SDF1-3'A in pediatric HIV-1 infection Mangano, A. CCR2 CCR5 CHEMOKINE RECEPTORS HIV-1 PEDIATRIC AIDS SDF1 VERTICAL TRANSMISSION |
| title_short |
Protective effect of CCR2-64I and not of CCR5-Δ32 and SDF1-3'A in pediatric HIV-1 infection |
| title_full |
Protective effect of CCR2-64I and not of CCR5-Δ32 and SDF1-3'A in pediatric HIV-1 infection |
| title_fullStr |
Protective effect of CCR2-64I and not of CCR5-Δ32 and SDF1-3'A in pediatric HIV-1 infection |
| title_full_unstemmed |
Protective effect of CCR2-64I and not of CCR5-Δ32 and SDF1-3'A in pediatric HIV-1 infection |
| title_sort |
Protective effect of CCR2-64I and not of CCR5-Δ32 and SDF1-3'A in pediatric HIV-1 infection |
| dc.creator.none.fl_str_mv |
Mangano, A. Kopka, J. Batalla, M. Bologna, R. Sen, Luisa |
| author |
Mangano, A. |
| author_facet |
Mangano, A. Kopka, J. Batalla, M. Bologna, R. Sen, Luisa |
| author_role |
author |
| author2 |
Kopka, J. Batalla, M. Bologna, R. Sen, Luisa |
| author2_role |
author author author author |
| dc.subject.none.fl_str_mv |
CCR2 CCR5 CHEMOKINE RECEPTORS HIV-1 PEDIATRIC AIDS SDF1 VERTICAL TRANSMISSION |
| topic |
CCR2 CCR5 CHEMOKINE RECEPTORS HIV-1 PEDIATRIC AIDS SDF1 VERTICAL TRANSMISSION |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
| dc.description.none.fl_txt_mv |
The effects of chemokine and chemokine receptor genetic polymorphisms such as stromal derived factor 1 (SDF1-3'A), CCR2-64I, and CCR5-Δ32 associated with HIV-1 transmission and/or rate of disease progression in infected study subjects remain highly controversial and have been analyzed primarily only in adults. We have investigated whether these polymorphisms may provide similar beneficial effects in children exposed to HIV-1 perinatally. The prevalence of CCR2-64I allele was significantly increased (p = .03) and the CCR2-64I genotype distribution was not in Hardy-Weinberg equilibrium, among HIV-1-exposed uninfected infants. Moreover, in the HIV-1- infected group, a delay to AIDS progression was observed among carriers of CCR2-64I allele. This is the first report that suggests a protective role of CCR2-64I allele in mother-to-infant HIV-1 transmission and documents a delay in disease progression, after the child has been infected with HIV-1. However, SDF1-3'A and CCR5-Δ32 alleles did not modify the rate of HIV-1 transmission or disease progression in HIV-1-infected children. Fil: Mangano, A.. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina Fil: Kopka, J.. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina Fil: Batalla, M.. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina Fil: Bologna, R.. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina Fil: Sen, Luisa. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
| description |
The effects of chemokine and chemokine receptor genetic polymorphisms such as stromal derived factor 1 (SDF1-3'A), CCR2-64I, and CCR5-Δ32 associated with HIV-1 transmission and/or rate of disease progression in infected study subjects remain highly controversial and have been analyzed primarily only in adults. We have investigated whether these polymorphisms may provide similar beneficial effects in children exposed to HIV-1 perinatally. The prevalence of CCR2-64I allele was significantly increased (p = .03) and the CCR2-64I genotype distribution was not in Hardy-Weinberg equilibrium, among HIV-1-exposed uninfected infants. Moreover, in the HIV-1- infected group, a delay to AIDS progression was observed among carriers of CCR2-64I allele. This is the first report that suggests a protective role of CCR2-64I allele in mother-to-infant HIV-1 transmission and documents a delay in disease progression, after the child has been infected with HIV-1. However, SDF1-3'A and CCR5-Δ32 alleles did not modify the rate of HIV-1 transmission or disease progression in HIV-1-infected children. |
| publishDate |
2000 |
| dc.date.none.fl_str_mv |
2000-01 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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article |
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publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/149060 Mangano, A.; Kopka, J.; Batalla, M.; Bologna, R.; Sen, Luisa; Protective effect of CCR2-64I and not of CCR5-Δ32 and SDF1-3'A in pediatric HIV-1 infection; Lippincott Williams; Journal Of Acquired Immune Deficiency Syndromes And Human Retrovirology; 23; 1; 1-2000; 52-57 1525-4135 1077-9450 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/149060 |
| identifier_str_mv |
Mangano, A.; Kopka, J.; Batalla, M.; Bologna, R.; Sen, Luisa; Protective effect of CCR2-64I and not of CCR5-Δ32 and SDF1-3'A in pediatric HIV-1 infection; Lippincott Williams; Journal Of Acquired Immune Deficiency Syndromes And Human Retrovirology; 23; 1; 1-2000; 52-57 1525-4135 1077-9450 CONICET Digital CONICET |
| dc.language.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://journals.lww.com/jaids/Abstract/2000/01010/Protective_Effect_of_CCR2_64I_and_Not_of_CCR5__32.7.aspx info:eu-repo/semantics/altIdentifier/doi/10.1097/00126334-200001010-00007 |
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info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
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openAccess |
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https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
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application/pdf application/pdf |
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Lippincott Williams |
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Lippincott Williams |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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