Actin Paracrystals Display Double Schottky Diode-Like Electrical Behavior

Autores
Cantiello, Horacio Fabio; Gutierrez, Brenda Celeste; Cantero, Maria del Rocio
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Actin filaments are abundant intracellular polymers implicated in cell motility and contraction. Actin also forms paracrystalline structures under various conditions, including lanthanides and other high ionic strength conditions. Here we tested the electrical properties of purified actin paracrystals induced by either MgCl2 or GdCl3. Tight electrically seal-voltage-clamped crystals displayed strong rectification with a nonlinear conductance under symmetrical and biionic conditions, including 20 mM GdCl3/140 mM KCl and 10 mM MgCl2/140 mM KCl. Rectification was observed in symmetrical ionic conditions with positive-to-negative conductance ratios ranging from 4.18 to 9.00 nS. The current-to-voltage relationships could be fitted with theoretical double Schottky equations and resembled the behavior of semiconducting nanotubes. The highly nonlinear electrical properties of paracrystalline actin arrays may help explain the physiology of actin-rich cellular compartments, such as stereocilia of the cochlea and neuronal dendritic spines also suggest potentially relevant nano-technological properties of this protein.
Fil: Cantiello, Horacio Fabio. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet Noa Sur. Instituto Multidisciplinario de Salud, Tecnologia y Desarrollo. - Universidad Nacional de Santiago del Estero. Instituto Multidisciplinario de Salud, Tecnologia y Desarrollo.; Argentina
Fil: Gutierrez, Brenda Celeste. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet Noa Sur. Instituto Multidisciplinario de Salud, Tecnologia y Desarrollo. - Universidad Nacional de Santiago del Estero. Instituto Multidisciplinario de Salud, Tecnologia y Desarrollo.; Argentina
Fil: Cantero, Maria del Rocio. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet Noa Sur. Instituto Multidisciplinario de Salud, Tecnologia y Desarrollo. - Universidad Nacional de Santiago del Estero. Instituto Multidisciplinario de Salud, Tecnologia y Desarrollo.; Argentina
Materia
ACTIN
ACTIN FILAMENTS
CYTOSKELETON
ELECTRICAL RECTIFICATION
DIODE EQUATION
SCHOTTKY DIODE
NANOWIRE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/233143
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/233143
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Actin Paracrystals Display Double Schottky Diode-Like Electrical BehaviorCantiello, Horacio FabioGutierrez, Brenda CelesteCantero, Maria del RocioACTINACTIN FILAMENTSCYTOSKELETONELECTRICAL RECTIFICATIONDIODE EQUATIONSCHOTTKY DIODENANOWIREhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Actin filaments are abundant intracellular polymers implicated in cell motility and contraction. Actin also forms paracrystalline structures under various conditions, including lanthanides and other high ionic strength conditions. Here we tested the electrical properties of purified actin paracrystals induced by either MgCl2 or GdCl3. Tight electrically seal-voltage-clamped crystals displayed strong rectification with a nonlinear conductance under symmetrical and biionic conditions, including 20 mM GdCl3/140 mM KCl and 10 mM MgCl2/140 mM KCl. Rectification was observed in symmetrical ionic conditions with positive-to-negative conductance ratios ranging from 4.18 to 9.00 nS. The current-to-voltage relationships could be fitted with theoretical double Schottky equations and resembled the behavior of semiconducting nanotubes. The highly nonlinear electrical properties of paracrystalline actin arrays may help explain the physiology of actin-rich cellular compartments, such as stereocilia of the cochlea and neuronal dendritic spines also suggest potentially relevant nano-technological properties of this protein.Fil: Cantiello, Horacio Fabio. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet Noa Sur. Instituto Multidisciplinario de Salud, Tecnologia y Desarrollo. - Universidad Nacional de Santiago del Estero. Instituto Multidisciplinario de Salud, Tecnologia y Desarrollo.; ArgentinaFil: Gutierrez, Brenda Celeste. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet Noa Sur. Instituto Multidisciplinario de Salud, Tecnologia y Desarrollo. - Universidad Nacional de Santiago del Estero. Instituto Multidisciplinario de Salud, Tecnologia y Desarrollo.; ArgentinaFil: Cantero, Maria del Rocio. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet Noa Sur. Instituto Multidisciplinario de Salud, Tecnologia y Desarrollo. - Universidad Nacional de Santiago del Estero. Instituto Multidisciplinario de Salud, Tecnologia y Desarrollo.; ArgentinaJohn Wiley & Sons2023-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/233143Cantiello, Horacio Fabio; Gutierrez, Brenda Celeste; Cantero, Maria del Rocio; Actin Paracrystals Display Double Schottky Diode-Like Electrical Behavior; John Wiley & Sons; Advanced Electronic Materials; 10; 2; 5-2023; 1-92199-160XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1002/aelm.202300144info:eu-repo/semantics/altIdentifier/doi/10.1002/aelm.202300144info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:27:23Zoai:ri.conicet.gov.ar:11336/233143instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:27:24.104CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Actin Paracrystals Display Double Schottky Diode-Like Electrical Behavior
title Actin Paracrystals Display Double Schottky Diode-Like Electrical Behavior
spellingShingle Actin Paracrystals Display Double Schottky Diode-Like Electrical Behavior
Cantiello, Horacio Fabio
ACTIN
ACTIN FILAMENTS
CYTOSKELETON
ELECTRICAL RECTIFICATION
DIODE EQUATION
SCHOTTKY DIODE
NANOWIRE
title_short Actin Paracrystals Display Double Schottky Diode-Like Electrical Behavior
title_full Actin Paracrystals Display Double Schottky Diode-Like Electrical Behavior
title_fullStr Actin Paracrystals Display Double Schottky Diode-Like Electrical Behavior
title_full_unstemmed Actin Paracrystals Display Double Schottky Diode-Like Electrical Behavior
title_sort Actin Paracrystals Display Double Schottky Diode-Like Electrical Behavior
dc.creator.none.fl_str_mv Cantiello, Horacio Fabio
Gutierrez, Brenda Celeste
Cantero, Maria del Rocio
author Cantiello, Horacio Fabio
author_facet Cantiello, Horacio Fabio
Gutierrez, Brenda Celeste
Cantero, Maria del Rocio
author_role author
author2 Gutierrez, Brenda Celeste
Cantero, Maria del Rocio
author2_role author
author
dc.subject.none.fl_str_mv ACTIN
ACTIN FILAMENTS
CYTOSKELETON
ELECTRICAL RECTIFICATION
DIODE EQUATION
SCHOTTKY DIODE
NANOWIRE
topic ACTIN
ACTIN FILAMENTS
CYTOSKELETON
ELECTRICAL RECTIFICATION
DIODE EQUATION
SCHOTTKY DIODE
NANOWIRE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Actin filaments are abundant intracellular polymers implicated in cell motility and contraction. Actin also forms paracrystalline structures under various conditions, including lanthanides and other high ionic strength conditions. Here we tested the electrical properties of purified actin paracrystals induced by either MgCl2 or GdCl3. Tight electrically seal-voltage-clamped crystals displayed strong rectification with a nonlinear conductance under symmetrical and biionic conditions, including 20 mM GdCl3/140 mM KCl and 10 mM MgCl2/140 mM KCl. Rectification was observed in symmetrical ionic conditions with positive-to-negative conductance ratios ranging from 4.18 to 9.00 nS. The current-to-voltage relationships could be fitted with theoretical double Schottky equations and resembled the behavior of semiconducting nanotubes. The highly nonlinear electrical properties of paracrystalline actin arrays may help explain the physiology of actin-rich cellular compartments, such as stereocilia of the cochlea and neuronal dendritic spines also suggest potentially relevant nano-technological properties of this protein.
Fil: Cantiello, Horacio Fabio. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet Noa Sur. Instituto Multidisciplinario de Salud, Tecnologia y Desarrollo. - Universidad Nacional de Santiago del Estero. Instituto Multidisciplinario de Salud, Tecnologia y Desarrollo.; Argentina
Fil: Gutierrez, Brenda Celeste. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet Noa Sur. Instituto Multidisciplinario de Salud, Tecnologia y Desarrollo. - Universidad Nacional de Santiago del Estero. Instituto Multidisciplinario de Salud, Tecnologia y Desarrollo.; Argentina
Fil: Cantero, Maria del Rocio. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet Noa Sur. Instituto Multidisciplinario de Salud, Tecnologia y Desarrollo. - Universidad Nacional de Santiago del Estero. Instituto Multidisciplinario de Salud, Tecnologia y Desarrollo.; Argentina
description Actin filaments are abundant intracellular polymers implicated in cell motility and contraction. Actin also forms paracrystalline structures under various conditions, including lanthanides and other high ionic strength conditions. Here we tested the electrical properties of purified actin paracrystals induced by either MgCl2 or GdCl3. Tight electrically seal-voltage-clamped crystals displayed strong rectification with a nonlinear conductance under symmetrical and biionic conditions, including 20 mM GdCl3/140 mM KCl and 10 mM MgCl2/140 mM KCl. Rectification was observed in symmetrical ionic conditions with positive-to-negative conductance ratios ranging from 4.18 to 9.00 nS. The current-to-voltage relationships could be fitted with theoretical double Schottky equations and resembled the behavior of semiconducting nanotubes. The highly nonlinear electrical properties of paracrystalline actin arrays may help explain the physiology of actin-rich cellular compartments, such as stereocilia of the cochlea and neuronal dendritic spines also suggest potentially relevant nano-technological properties of this protein.
publishDate 2023
dc.date.none.fl_str_mv 2023-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/233143
Cantiello, Horacio Fabio; Gutierrez, Brenda Celeste; Cantero, Maria del Rocio; Actin Paracrystals Display Double Schottky Diode-Like Electrical Behavior; John Wiley & Sons; Advanced Electronic Materials; 10; 2; 5-2023; 1-9
2199-160X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/233143
identifier_str_mv Cantiello, Horacio Fabio; Gutierrez, Brenda Celeste; Cantero, Maria del Rocio; Actin Paracrystals Display Double Schottky Diode-Like Electrical Behavior; John Wiley & Sons; Advanced Electronic Materials; 10; 2; 5-2023; 1-9
2199-160X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1002/aelm.202300144
info:eu-repo/semantics/altIdentifier/doi/10.1002/aelm.202300144
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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