Noise Minimisation in Gene Expression Switches

Autores
Monteoliva, Diana; Mccarthy, Cristina Beryl; Diambra, Luis Anibal
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Gene expression is subject to stochastic variation which leads to fluctuations in the rate of protein production. Recently, a study in yeast at a genomic scale showed that, in some cases, gene expression variability alters phenotypes while, in other cases, these remain unchanged despite fluctuations in the expression of other genes. These studies suggested that noise in gene expression is a physiologically relevant trait and, to prevent harmful stochastic variation in the expression levels of some genes, it can be subject to minimisation. However, the mechanisms for noise minimisation are still unclear. In the present work, we analysed how noise expression depends on the architecture of the cis-regulatory system, in particular on the number of regulatory binding sites. Using analytical calculations and stochastic simulations, we found that the fluctuation level in noise expression decreased with the number of regulatory sites when regulatory transcription factors interacted with only one other bound transcription factor. In contrast, we observed that there was an optimal number of binding sites when transcription factors interacted with many bound transcription factors. This finding suggested a new mechanism for preventing large fluctuations in the expression of genes which are sensitive to the concentration of regulators.
Fil: Monteoliva, Diana. Consejo Nacional de Invest.cientif.y Tecnicas. Centro Cientifico Tecnol.conicet - la Plata. Instituto de Fisica la Plata;
Fil: Mccarthy, Cristina Beryl. Universidad Nacional de la Plata. Centro Regional de Estudios Genomicos;
Fil: Diambra, Luis Anibal. Universidad Nacional de la Plata. Centro Regional de Estudios Genomicos;
Materia
GENE EXPRESSION
FLUCTUATIONS
COOPERATIVITY
MASTER EQUATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/526

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spelling Noise Minimisation in Gene Expression SwitchesMonteoliva, DianaMccarthy, Cristina BerylDiambra, Luis AnibalGENE EXPRESSIONFLUCTUATIONSCOOPERATIVITYMASTER EQUATIONhttps://purl.org/becyt/ford/1https://purl.org/becyt/ford/1.6Gene expression is subject to stochastic variation which leads to fluctuations in the rate of protein production. Recently, a study in yeast at a genomic scale showed that, in some cases, gene expression variability alters phenotypes while, in other cases, these remain unchanged despite fluctuations in the expression of other genes. These studies suggested that noise in gene expression is a physiologically relevant trait and, to prevent harmful stochastic variation in the expression levels of some genes, it can be subject to minimisation. However, the mechanisms for noise minimisation are still unclear. In the present work, we analysed how noise expression depends on the architecture of the cis-regulatory system, in particular on the number of regulatory binding sites. Using analytical calculations and stochastic simulations, we found that the fluctuation level in noise expression decreased with the number of regulatory sites when regulatory transcription factors interacted with only one other bound transcription factor. In contrast, we observed that there was an optimal number of binding sites when transcription factors interacted with many bound transcription factors. This finding suggested a new mechanism for preventing large fluctuations in the expression of genes which are sensitive to the concentration of regulators.Fil: Monteoliva, Diana. Consejo Nacional de Invest.cientif.y Tecnicas. Centro Cientifico Tecnol.conicet - la Plata. Instituto de Fisica la Plata;Fil: Mccarthy, Cristina Beryl. Universidad Nacional de la Plata. Centro Regional de Estudios Genomicos;Fil: Diambra, Luis Anibal. Universidad Nacional de la Plata. Centro Regional de Estudios Genomicos;Public Library Science2013-12-23info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/526Monteoliva, Diana; Mccarthy, Cristina Beryl; Diambra, Luis Anibal; Noise Minimisation in Gene Expression Switches; Public Library Science; Plos One; 8; 12; 23-12-2013; 84020-84029;1932-6203enginfo:eu-repo/semantics/altIdentifier/url/doi:10.1371/ journal.pone.0084020info:eu-repo/semantics/altIdentifier/url/http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0084020info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:43:59Zoai:ri.conicet.gov.ar:11336/526instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:43:59.568CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Noise Minimisation in Gene Expression Switches
title Noise Minimisation in Gene Expression Switches
spellingShingle Noise Minimisation in Gene Expression Switches
Monteoliva, Diana
GENE EXPRESSION
FLUCTUATIONS
COOPERATIVITY
MASTER EQUATION
title_short Noise Minimisation in Gene Expression Switches
title_full Noise Minimisation in Gene Expression Switches
title_fullStr Noise Minimisation in Gene Expression Switches
title_full_unstemmed Noise Minimisation in Gene Expression Switches
title_sort Noise Minimisation in Gene Expression Switches
dc.creator.none.fl_str_mv Monteoliva, Diana
Mccarthy, Cristina Beryl
Diambra, Luis Anibal
author Monteoliva, Diana
author_facet Monteoliva, Diana
Mccarthy, Cristina Beryl
Diambra, Luis Anibal
author_role author
author2 Mccarthy, Cristina Beryl
Diambra, Luis Anibal
author2_role author
author
dc.subject.none.fl_str_mv GENE EXPRESSION
FLUCTUATIONS
COOPERATIVITY
MASTER EQUATION
topic GENE EXPRESSION
FLUCTUATIONS
COOPERATIVITY
MASTER EQUATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/1.6
dc.description.none.fl_txt_mv Gene expression is subject to stochastic variation which leads to fluctuations in the rate of protein production. Recently, a study in yeast at a genomic scale showed that, in some cases, gene expression variability alters phenotypes while, in other cases, these remain unchanged despite fluctuations in the expression of other genes. These studies suggested that noise in gene expression is a physiologically relevant trait and, to prevent harmful stochastic variation in the expression levels of some genes, it can be subject to minimisation. However, the mechanisms for noise minimisation are still unclear. In the present work, we analysed how noise expression depends on the architecture of the cis-regulatory system, in particular on the number of regulatory binding sites. Using analytical calculations and stochastic simulations, we found that the fluctuation level in noise expression decreased with the number of regulatory sites when regulatory transcription factors interacted with only one other bound transcription factor. In contrast, we observed that there was an optimal number of binding sites when transcription factors interacted with many bound transcription factors. This finding suggested a new mechanism for preventing large fluctuations in the expression of genes which are sensitive to the concentration of regulators.
Fil: Monteoliva, Diana. Consejo Nacional de Invest.cientif.y Tecnicas. Centro Cientifico Tecnol.conicet - la Plata. Instituto de Fisica la Plata;
Fil: Mccarthy, Cristina Beryl. Universidad Nacional de la Plata. Centro Regional de Estudios Genomicos;
Fil: Diambra, Luis Anibal. Universidad Nacional de la Plata. Centro Regional de Estudios Genomicos;
description Gene expression is subject to stochastic variation which leads to fluctuations in the rate of protein production. Recently, a study in yeast at a genomic scale showed that, in some cases, gene expression variability alters phenotypes while, in other cases, these remain unchanged despite fluctuations in the expression of other genes. These studies suggested that noise in gene expression is a physiologically relevant trait and, to prevent harmful stochastic variation in the expression levels of some genes, it can be subject to minimisation. However, the mechanisms for noise minimisation are still unclear. In the present work, we analysed how noise expression depends on the architecture of the cis-regulatory system, in particular on the number of regulatory binding sites. Using analytical calculations and stochastic simulations, we found that the fluctuation level in noise expression decreased with the number of regulatory sites when regulatory transcription factors interacted with only one other bound transcription factor. In contrast, we observed that there was an optimal number of binding sites when transcription factors interacted with many bound transcription factors. This finding suggested a new mechanism for preventing large fluctuations in the expression of genes which are sensitive to the concentration of regulators.
publishDate 2013
dc.date.none.fl_str_mv 2013-12-23
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/526
Monteoliva, Diana; Mccarthy, Cristina Beryl; Diambra, Luis Anibal; Noise Minimisation in Gene Expression Switches; Public Library Science; Plos One; 8; 12; 23-12-2013; 84020-84029;
1932-6203
url http://hdl.handle.net/11336/526
identifier_str_mv Monteoliva, Diana; Mccarthy, Cristina Beryl; Diambra, Luis Anibal; Noise Minimisation in Gene Expression Switches; Public Library Science; Plos One; 8; 12; 23-12-2013; 84020-84029;
1932-6203
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/doi:10.1371/ journal.pone.0084020
info:eu-repo/semantics/altIdentifier/url/http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0084020
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library Science
publisher.none.fl_str_mv Public Library Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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