Noise Minimisation in Gene Expression Switches
- Autores
- Monteoliva, Diana; Mccarthy, Cristina Beryl; Diambra, Luis Anibal
- Año de publicación
- 2013
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Gene expression is subject to stochastic variation which leads to fluctuations in the rate of protein production. Recently, a study in yeast at a genomic scale showed that, in some cases, gene expression variability alters phenotypes while, in other cases, these remain unchanged despite fluctuations in the expression of other genes. These studies suggested that noise in gene expression is a physiologically relevant trait and, to prevent harmful stochastic variation in the expression levels of some genes, it can be subject to minimisation. However, the mechanisms for noise minimisation are still unclear. In the present work, we analysed how noise expression depends on the architecture of the cis-regulatory system, in particular on the number of regulatory binding sites. Using analytical calculations and stochastic simulations, we found that the fluctuation level in noise expression decreased with the number of regulatory sites when regulatory transcription factors interacted with only one other bound transcription factor. In contrast, we observed that there was an optimal number of binding sites when transcription factors interacted with many bound transcription factors. This finding suggested a new mechanism for preventing large fluctuations in the expression of genes which are sensitive to the concentration of regulators.
Fil: Monteoliva, Diana. Consejo Nacional de Invest.cientif.y Tecnicas. Centro Cientifico Tecnol.conicet - la Plata. Instituto de Fisica la Plata;
Fil: Mccarthy, Cristina Beryl. Universidad Nacional de la Plata. Centro Regional de Estudios Genomicos;
Fil: Diambra, Luis Anibal. Universidad Nacional de la Plata. Centro Regional de Estudios Genomicos; - Materia
-
GENE EXPRESSION
FLUCTUATIONS
COOPERATIVITY
MASTER EQUATION - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/526
Ver los metadatos del registro completo
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Noise Minimisation in Gene Expression SwitchesMonteoliva, DianaMccarthy, Cristina BerylDiambra, Luis AnibalGENE EXPRESSIONFLUCTUATIONSCOOPERATIVITYMASTER EQUATIONhttps://purl.org/becyt/ford/1https://purl.org/becyt/ford/1.6Gene expression is subject to stochastic variation which leads to fluctuations in the rate of protein production. Recently, a study in yeast at a genomic scale showed that, in some cases, gene expression variability alters phenotypes while, in other cases, these remain unchanged despite fluctuations in the expression of other genes. These studies suggested that noise in gene expression is a physiologically relevant trait and, to prevent harmful stochastic variation in the expression levels of some genes, it can be subject to minimisation. However, the mechanisms for noise minimisation are still unclear. In the present work, we analysed how noise expression depends on the architecture of the cis-regulatory system, in particular on the number of regulatory binding sites. Using analytical calculations and stochastic simulations, we found that the fluctuation level in noise expression decreased with the number of regulatory sites when regulatory transcription factors interacted with only one other bound transcription factor. In contrast, we observed that there was an optimal number of binding sites when transcription factors interacted with many bound transcription factors. This finding suggested a new mechanism for preventing large fluctuations in the expression of genes which are sensitive to the concentration of regulators.Fil: Monteoliva, Diana. Consejo Nacional de Invest.cientif.y Tecnicas. Centro Cientifico Tecnol.conicet - la Plata. Instituto de Fisica la Plata;Fil: Mccarthy, Cristina Beryl. Universidad Nacional de la Plata. Centro Regional de Estudios Genomicos;Fil: Diambra, Luis Anibal. Universidad Nacional de la Plata. Centro Regional de Estudios Genomicos;Public Library Science2013-12-23info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/526Monteoliva, Diana; Mccarthy, Cristina Beryl; Diambra, Luis Anibal; Noise Minimisation in Gene Expression Switches; Public Library Science; Plos One; 8; 12; 23-12-2013; 84020-84029;1932-6203enginfo:eu-repo/semantics/altIdentifier/url/doi:10.1371/ journal.pone.0084020info:eu-repo/semantics/altIdentifier/url/http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0084020info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:43:59Zoai:ri.conicet.gov.ar:11336/526instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:43:59.568CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Noise Minimisation in Gene Expression Switches |
title |
Noise Minimisation in Gene Expression Switches |
spellingShingle |
Noise Minimisation in Gene Expression Switches Monteoliva, Diana GENE EXPRESSION FLUCTUATIONS COOPERATIVITY MASTER EQUATION |
title_short |
Noise Minimisation in Gene Expression Switches |
title_full |
Noise Minimisation in Gene Expression Switches |
title_fullStr |
Noise Minimisation in Gene Expression Switches |
title_full_unstemmed |
Noise Minimisation in Gene Expression Switches |
title_sort |
Noise Minimisation in Gene Expression Switches |
dc.creator.none.fl_str_mv |
Monteoliva, Diana Mccarthy, Cristina Beryl Diambra, Luis Anibal |
author |
Monteoliva, Diana |
author_facet |
Monteoliva, Diana Mccarthy, Cristina Beryl Diambra, Luis Anibal |
author_role |
author |
author2 |
Mccarthy, Cristina Beryl Diambra, Luis Anibal |
author2_role |
author author |
dc.subject.none.fl_str_mv |
GENE EXPRESSION FLUCTUATIONS COOPERATIVITY MASTER EQUATION |
topic |
GENE EXPRESSION FLUCTUATIONS COOPERATIVITY MASTER EQUATION |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1 https://purl.org/becyt/ford/1.6 |
dc.description.none.fl_txt_mv |
Gene expression is subject to stochastic variation which leads to fluctuations in the rate of protein production. Recently, a study in yeast at a genomic scale showed that, in some cases, gene expression variability alters phenotypes while, in other cases, these remain unchanged despite fluctuations in the expression of other genes. These studies suggested that noise in gene expression is a physiologically relevant trait and, to prevent harmful stochastic variation in the expression levels of some genes, it can be subject to minimisation. However, the mechanisms for noise minimisation are still unclear. In the present work, we analysed how noise expression depends on the architecture of the cis-regulatory system, in particular on the number of regulatory binding sites. Using analytical calculations and stochastic simulations, we found that the fluctuation level in noise expression decreased with the number of regulatory sites when regulatory transcription factors interacted with only one other bound transcription factor. In contrast, we observed that there was an optimal number of binding sites when transcription factors interacted with many bound transcription factors. This finding suggested a new mechanism for preventing large fluctuations in the expression of genes which are sensitive to the concentration of regulators. Fil: Monteoliva, Diana. Consejo Nacional de Invest.cientif.y Tecnicas. Centro Cientifico Tecnol.conicet - la Plata. Instituto de Fisica la Plata; Fil: Mccarthy, Cristina Beryl. Universidad Nacional de la Plata. Centro Regional de Estudios Genomicos; Fil: Diambra, Luis Anibal. Universidad Nacional de la Plata. Centro Regional de Estudios Genomicos; |
description |
Gene expression is subject to stochastic variation which leads to fluctuations in the rate of protein production. Recently, a study in yeast at a genomic scale showed that, in some cases, gene expression variability alters phenotypes while, in other cases, these remain unchanged despite fluctuations in the expression of other genes. These studies suggested that noise in gene expression is a physiologically relevant trait and, to prevent harmful stochastic variation in the expression levels of some genes, it can be subject to minimisation. However, the mechanisms for noise minimisation are still unclear. In the present work, we analysed how noise expression depends on the architecture of the cis-regulatory system, in particular on the number of regulatory binding sites. Using analytical calculations and stochastic simulations, we found that the fluctuation level in noise expression decreased with the number of regulatory sites when regulatory transcription factors interacted with only one other bound transcription factor. In contrast, we observed that there was an optimal number of binding sites when transcription factors interacted with many bound transcription factors. This finding suggested a new mechanism for preventing large fluctuations in the expression of genes which are sensitive to the concentration of regulators. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-12-23 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/526 Monteoliva, Diana; Mccarthy, Cristina Beryl; Diambra, Luis Anibal; Noise Minimisation in Gene Expression Switches; Public Library Science; Plos One; 8; 12; 23-12-2013; 84020-84029; 1932-6203 |
url |
http://hdl.handle.net/11336/526 |
identifier_str_mv |
Monteoliva, Diana; Mccarthy, Cristina Beryl; Diambra, Luis Anibal; Noise Minimisation in Gene Expression Switches; Public Library Science; Plos One; 8; 12; 23-12-2013; 84020-84029; 1932-6203 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/doi:10.1371/ journal.pone.0084020 info:eu-repo/semantics/altIdentifier/url/http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0084020 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Public Library Science |
publisher.none.fl_str_mv |
Public Library Science |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |