Damage-associated molecular patterns modulation by microrna: Relevance on immunogenic cell death and cancer treatment outcome

Autores
Lamberti, María Julia; Nigro, Annunziata; Casolaro, Vicenzo; Rumie Vittar, Natalia Belen; Dal Col, Jessica
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Immunogenic cell death (ICD) in cancer is a functionally unique regulated form of stress-mediated cell death that activates both the innate and adaptive immune response against tumor cells. ICD makes dying cancer cells immunogenic by improving both antigenicity and adjuvanticity. The latter relies on the spatiotemporally coordinated release or exposure of danger signals (DAMPs) that drive robust antigen-presenting cell activation. The expression of DAMPs is often constitutive in tumor cells, but it is the initiating stressor, called ICD-inducer, which finally triggers the intracellular response that determines the kinetics and intensity of their release. However, the contribution of cell-autonomous features, such as the epigenetic background, to the development of ICD has not been addressed in sufficient depth. In this context, it has been revealed that several microRNAs (miRNAs), besides acting as tumor promoters or suppressors, can control the ICD-associated exposure of some DAMPs and their basal expression in cancer. Here, we provide a general overview of the dysregulation of cancer-associated miRNAs whose targets are DAMPs, through which new molecular mediators that underlie the immunogenicity of ICD were identified. The current status of miRNA-targeted therapeutics combined with ICD inducers is discussed. A solid comprehension of these processes will provide a framework to evaluate miRNA targets for cancer immunotherapy.
Fil: Lamberti, María Julia. Universidad Nacional de Rio Cuarto. Facultad de Cs.exactas Fisicoquimicas y Naturales. Instituto de Biotecnologia Ambiental y Salud. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Cordoba. Instituto de Biotecnologia Ambiental y Salud.; Argentina. Universita di Salerno; Italia
Fil: Nigro, Annunziata. Universita di Salerno; Italia
Fil: Casolaro, Vicenzo. Universita di Salerno; Italia
Fil: Rumie Vittar, Natalia Belen. Universidad Nacional de Rio Cuarto. Facultad de Cs.exactas Fisicoquimicas y Naturales. Instituto de Biotecnologia Ambiental y Salud. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Cordoba. Instituto de Biotecnologia Ambiental y Salud.; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Biología Molecular. Sección Química Biológica; Argentina
Fil: Dal Col, Jessica. Universita di Salerno; Italia
Materia
CANCER
IMMUNOGENIC CELL DEATH
MIRNA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/181486
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/181486
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Damage-associated molecular patterns modulation by microrna: Relevance on immunogenic cell death and cancer treatment outcomeLamberti, María JuliaNigro, AnnunziataCasolaro, VicenzoRumie Vittar, Natalia BelenDal Col, JessicaCANCERIMMUNOGENIC CELL DEATHMIRNAhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Immunogenic cell death (ICD) in cancer is a functionally unique regulated form of stress-mediated cell death that activates both the innate and adaptive immune response against tumor cells. ICD makes dying cancer cells immunogenic by improving both antigenicity and adjuvanticity. The latter relies on the spatiotemporally coordinated release or exposure of danger signals (DAMPs) that drive robust antigen-presenting cell activation. The expression of DAMPs is often constitutive in tumor cells, but it is the initiating stressor, called ICD-inducer, which finally triggers the intracellular response that determines the kinetics and intensity of their release. However, the contribution of cell-autonomous features, such as the epigenetic background, to the development of ICD has not been addressed in sufficient depth. In this context, it has been revealed that several microRNAs (miRNAs), besides acting as tumor promoters or suppressors, can control the ICD-associated exposure of some DAMPs and their basal expression in cancer. Here, we provide a general overview of the dysregulation of cancer-associated miRNAs whose targets are DAMPs, through which new molecular mediators that underlie the immunogenicity of ICD were identified. The current status of miRNA-targeted therapeutics combined with ICD inducers is discussed. A solid comprehension of these processes will provide a framework to evaluate miRNA targets for cancer immunotherapy.Fil: Lamberti, María Julia. Universidad Nacional de Rio Cuarto. Facultad de Cs.exactas Fisicoquimicas y Naturales. Instituto de Biotecnologia Ambiental y Salud. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Cordoba. Instituto de Biotecnologia Ambiental y Salud.; Argentina. Universita di Salerno; ItaliaFil: Nigro, Annunziata. Universita di Salerno; ItaliaFil: Casolaro, Vicenzo. Universita di Salerno; ItaliaFil: Rumie Vittar, Natalia Belen. Universidad Nacional de Rio Cuarto. Facultad de Cs.exactas Fisicoquimicas y Naturales. Instituto de Biotecnologia Ambiental y Salud. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Cordoba. Instituto de Biotecnologia Ambiental y Salud.; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Biología Molecular. Sección Química Biológica; ArgentinaFil: Dal Col, Jessica. Universita di Salerno; ItaliaMDPI AG2021-05-24info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/181486Lamberti, María Julia; Nigro, Annunziata; Casolaro, Vicenzo; Rumie Vittar, Natalia Belen; Dal Col, Jessica; Damage-associated molecular patterns modulation by microrna: Relevance on immunogenic cell death and cancer treatment outcome; MDPI AG; Cancers; 13; 11; 24-5-2021; 1-202072-6694CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3390/cancers13112566info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2072-6694/13/11/2566info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:34:49Zoai:ri.conicet.gov.ar:11336/181486instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:34:49.296CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Damage-associated molecular patterns modulation by microrna: Relevance on immunogenic cell death and cancer treatment outcome
title Damage-associated molecular patterns modulation by microrna: Relevance on immunogenic cell death and cancer treatment outcome
spellingShingle Damage-associated molecular patterns modulation by microrna: Relevance on immunogenic cell death and cancer treatment outcome
Lamberti, María Julia
CANCER
IMMUNOGENIC CELL DEATH
MIRNA
title_short Damage-associated molecular patterns modulation by microrna: Relevance on immunogenic cell death and cancer treatment outcome
title_full Damage-associated molecular patterns modulation by microrna: Relevance on immunogenic cell death and cancer treatment outcome
title_fullStr Damage-associated molecular patterns modulation by microrna: Relevance on immunogenic cell death and cancer treatment outcome
title_full_unstemmed Damage-associated molecular patterns modulation by microrna: Relevance on immunogenic cell death and cancer treatment outcome
title_sort Damage-associated molecular patterns modulation by microrna: Relevance on immunogenic cell death and cancer treatment outcome
dc.creator.none.fl_str_mv Lamberti, María Julia
Nigro, Annunziata
Casolaro, Vicenzo
Rumie Vittar, Natalia Belen
Dal Col, Jessica
author Lamberti, María Julia
author_facet Lamberti, María Julia
Nigro, Annunziata
Casolaro, Vicenzo
Rumie Vittar, Natalia Belen
Dal Col, Jessica
author_role author
author2 Nigro, Annunziata
Casolaro, Vicenzo
Rumie Vittar, Natalia Belen
Dal Col, Jessica
author2_role author
author
author
author
dc.subject.none.fl_str_mv CANCER
IMMUNOGENIC CELL DEATH
MIRNA
topic CANCER
IMMUNOGENIC CELL DEATH
MIRNA
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Immunogenic cell death (ICD) in cancer is a functionally unique regulated form of stress-mediated cell death that activates both the innate and adaptive immune response against tumor cells. ICD makes dying cancer cells immunogenic by improving both antigenicity and adjuvanticity. The latter relies on the spatiotemporally coordinated release or exposure of danger signals (DAMPs) that drive robust antigen-presenting cell activation. The expression of DAMPs is often constitutive in tumor cells, but it is the initiating stressor, called ICD-inducer, which finally triggers the intracellular response that determines the kinetics and intensity of their release. However, the contribution of cell-autonomous features, such as the epigenetic background, to the development of ICD has not been addressed in sufficient depth. In this context, it has been revealed that several microRNAs (miRNAs), besides acting as tumor promoters or suppressors, can control the ICD-associated exposure of some DAMPs and their basal expression in cancer. Here, we provide a general overview of the dysregulation of cancer-associated miRNAs whose targets are DAMPs, through which new molecular mediators that underlie the immunogenicity of ICD were identified. The current status of miRNA-targeted therapeutics combined with ICD inducers is discussed. A solid comprehension of these processes will provide a framework to evaluate miRNA targets for cancer immunotherapy.
Fil: Lamberti, María Julia. Universidad Nacional de Rio Cuarto. Facultad de Cs.exactas Fisicoquimicas y Naturales. Instituto de Biotecnologia Ambiental y Salud. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Cordoba. Instituto de Biotecnologia Ambiental y Salud.; Argentina. Universita di Salerno; Italia
Fil: Nigro, Annunziata. Universita di Salerno; Italia
Fil: Casolaro, Vicenzo. Universita di Salerno; Italia
Fil: Rumie Vittar, Natalia Belen. Universidad Nacional de Rio Cuarto. Facultad de Cs.exactas Fisicoquimicas y Naturales. Instituto de Biotecnologia Ambiental y Salud. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Cordoba. Instituto de Biotecnologia Ambiental y Salud.; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Biología Molecular. Sección Química Biológica; Argentina
Fil: Dal Col, Jessica. Universita di Salerno; Italia
description Immunogenic cell death (ICD) in cancer is a functionally unique regulated form of stress-mediated cell death that activates both the innate and adaptive immune response against tumor cells. ICD makes dying cancer cells immunogenic by improving both antigenicity and adjuvanticity. The latter relies on the spatiotemporally coordinated release or exposure of danger signals (DAMPs) that drive robust antigen-presenting cell activation. The expression of DAMPs is often constitutive in tumor cells, but it is the initiating stressor, called ICD-inducer, which finally triggers the intracellular response that determines the kinetics and intensity of their release. However, the contribution of cell-autonomous features, such as the epigenetic background, to the development of ICD has not been addressed in sufficient depth. In this context, it has been revealed that several microRNAs (miRNAs), besides acting as tumor promoters or suppressors, can control the ICD-associated exposure of some DAMPs and their basal expression in cancer. Here, we provide a general overview of the dysregulation of cancer-associated miRNAs whose targets are DAMPs, through which new molecular mediators that underlie the immunogenicity of ICD were identified. The current status of miRNA-targeted therapeutics combined with ICD inducers is discussed. A solid comprehension of these processes will provide a framework to evaluate miRNA targets for cancer immunotherapy.
publishDate 2021
dc.date.none.fl_str_mv 2021-05-24
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/181486
Lamberti, María Julia; Nigro, Annunziata; Casolaro, Vicenzo; Rumie Vittar, Natalia Belen; Dal Col, Jessica; Damage-associated molecular patterns modulation by microrna: Relevance on immunogenic cell death and cancer treatment outcome; MDPI AG; Cancers; 13; 11; 24-5-2021; 1-20
2072-6694
CONICET Digital
CONICET
url http://hdl.handle.net/11336/181486
identifier_str_mv Lamberti, María Julia; Nigro, Annunziata; Casolaro, Vicenzo; Rumie Vittar, Natalia Belen; Dal Col, Jessica; Damage-associated molecular patterns modulation by microrna: Relevance on immunogenic cell death and cancer treatment outcome; MDPI AG; Cancers; 13; 11; 24-5-2021; 1-20
2072-6694
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3390/cancers13112566
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2072-6694/13/11/2566
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI AG
publisher.none.fl_str_mv MDPI AG
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613079717904384
score 13.070432

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