A hypothalamic-thalamostriatal circuit that controls approach-avoidance conflict in rats

Autores
Engelke, D. S.; Zhang, X. O.; O’Malley, J. J.; Fernandez Leon, Jose Alberto; Li, S.; Kirouac, G. J.; Beierlein, M.; Do Monte, F. H.
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Survival depends on a balance between seeking rewards and avoiding potential threats, but the neural circuits that regulate this motivational conflict remain largely unknown. Using an approach-food vs. avoid-predator threat conflict test in rats, we identified a subpopulation of neurons in the anterior portion of the paraventricular thalamic nucleus (aPVT) which express corticotrophin-releasing factor (CRF) and are preferentially recruited during conflict. Inactivation of aPVTCRF neurons during conflict biases animal’s response toward food, whereas activation of these cells recapitulates the food-seeking suppression observed during conflict. aPVTCRF neurons project densely to the nucleus accumbens (NAc), and activity in this pathway reduces food seeking and increases avoidance. In addition, we identified the ventromedial hypothalamus (VMH) as a critical input to aPVTCRF neurons, and demonstrated that VMH-aPVT neurons mediate defensive behaviors exclusively during conflict. Together, our findings describe a hypothalamic-thalamostriatal circuit that suppresses reward-seeking behavior under the competing demands of avoiding threats.
Fil: Engelke, D. S.. The University of Texas Health Science Center; Estados Unidos
Fil: Zhang, X. O.. The University of Texas Health Science Center; Estados Unidos
Fil: O’Malley, J. J.. The University of Texas Health Science Center; Estados Unidos
Fil: Fernandez Leon, Jose Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires. Sede Olavarría del Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aire. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires. Sede Olavarría del Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires; Argentina
Fil: Li, S.. University of Manitoba; Canadá
Fil: Kirouac, G. J.. University of Manitoba; Canadá
Fil: Beierlein, M.. The University of Texas Health Science Center; Estados Unidos
Fil: Do Monte, F. H.. The University of Texas Health Science Center; Estados Unidos
Materia
paraventricular thalamic nucleus
reward
avoidance
food seeking
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/182720
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling A hypothalamic-thalamostriatal circuit that controls approach-avoidance conflict in ratsEngelke, D. S.Zhang, X. O.O’Malley, J. J.Fernandez Leon, Jose AlbertoLi, S.Kirouac, G. J.Beierlein, M.Do Monte, F. H.paraventricular thalamic nucleusrewardavoidancefood seekinghttps://purl.org/becyt/ford/1.2https://purl.org/becyt/ford/1https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Survival depends on a balance between seeking rewards and avoiding potential threats, but the neural circuits that regulate this motivational conflict remain largely unknown. Using an approach-food vs. avoid-predator threat conflict test in rats, we identified a subpopulation of neurons in the anterior portion of the paraventricular thalamic nucleus (aPVT) which express corticotrophin-releasing factor (CRF) and are preferentially recruited during conflict. Inactivation of aPVTCRF neurons during conflict biases animal’s response toward food, whereas activation of these cells recapitulates the food-seeking suppression observed during conflict. aPVTCRF neurons project densely to the nucleus accumbens (NAc), and activity in this pathway reduces food seeking and increases avoidance. In addition, we identified the ventromedial hypothalamus (VMH) as a critical input to aPVTCRF neurons, and demonstrated that VMH-aPVT neurons mediate defensive behaviors exclusively during conflict. Together, our findings describe a hypothalamic-thalamostriatal circuit that suppresses reward-seeking behavior under the competing demands of avoiding threats.Fil: Engelke, D. S.. The University of Texas Health Science Center; Estados UnidosFil: Zhang, X. O.. The University of Texas Health Science Center; Estados UnidosFil: O’Malley, J. J.. The University of Texas Health Science Center; Estados UnidosFil: Fernandez Leon, Jose Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires. Sede Olavarría del Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aire. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires. Sede Olavarría del Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires; ArgentinaFil: Li, S.. University of Manitoba; CanadáFil: Kirouac, G. J.. University of Manitoba; CanadáFil: Beierlein, M.. The University of Texas Health Science Center; Estados UnidosFil: Do Monte, F. H.. The University of Texas Health Science Center; Estados UnidosNature2021-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/182720Engelke, D. S.; Zhang, X. O.; O’Malley, J. J.; Fernandez Leon, Jose Alberto; Li, S.; et al.; A hypothalamic-thalamostriatal circuit that controls approach-avoidance conflict in rats; Nature; Nature Communications; 12; 1; 5-2021; 1-192041-1723CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/s41467-021-22730-yinfo:eu-repo/semantics/altIdentifier/doi/10.1038/s41467-021-22730-yinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:17:59Zoai:ri.conicet.gov.ar:11336/182720instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:17:59.941CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A hypothalamic-thalamostriatal circuit that controls approach-avoidance conflict in rats
title A hypothalamic-thalamostriatal circuit that controls approach-avoidance conflict in rats
spellingShingle A hypothalamic-thalamostriatal circuit that controls approach-avoidance conflict in rats
Engelke, D. S.
paraventricular thalamic nucleus
reward
avoidance
food seeking
title_short A hypothalamic-thalamostriatal circuit that controls approach-avoidance conflict in rats
title_full A hypothalamic-thalamostriatal circuit that controls approach-avoidance conflict in rats
title_fullStr A hypothalamic-thalamostriatal circuit that controls approach-avoidance conflict in rats
title_full_unstemmed A hypothalamic-thalamostriatal circuit that controls approach-avoidance conflict in rats
title_sort A hypothalamic-thalamostriatal circuit that controls approach-avoidance conflict in rats
dc.creator.none.fl_str_mv Engelke, D. S.
Zhang, X. O.
O’Malley, J. J.
Fernandez Leon, Jose Alberto
Li, S.
Kirouac, G. J.
Beierlein, M.
Do Monte, F. H.
author Engelke, D. S.
author_facet Engelke, D. S.
Zhang, X. O.
O’Malley, J. J.
Fernandez Leon, Jose Alberto
Li, S.
Kirouac, G. J.
Beierlein, M.
Do Monte, F. H.
author_role author
author2 Zhang, X. O.
O’Malley, J. J.
Fernandez Leon, Jose Alberto
Li, S.
Kirouac, G. J.
Beierlein, M.
Do Monte, F. H.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv paraventricular thalamic nucleus
reward
avoidance
food seeking
topic paraventricular thalamic nucleus
reward
avoidance
food seeking
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.2
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Survival depends on a balance between seeking rewards and avoiding potential threats, but the neural circuits that regulate this motivational conflict remain largely unknown. Using an approach-food vs. avoid-predator threat conflict test in rats, we identified a subpopulation of neurons in the anterior portion of the paraventricular thalamic nucleus (aPVT) which express corticotrophin-releasing factor (CRF) and are preferentially recruited during conflict. Inactivation of aPVTCRF neurons during conflict biases animal’s response toward food, whereas activation of these cells recapitulates the food-seeking suppression observed during conflict. aPVTCRF neurons project densely to the nucleus accumbens (NAc), and activity in this pathway reduces food seeking and increases avoidance. In addition, we identified the ventromedial hypothalamus (VMH) as a critical input to aPVTCRF neurons, and demonstrated that VMH-aPVT neurons mediate defensive behaviors exclusively during conflict. Together, our findings describe a hypothalamic-thalamostriatal circuit that suppresses reward-seeking behavior under the competing demands of avoiding threats.
Fil: Engelke, D. S.. The University of Texas Health Science Center; Estados Unidos
Fil: Zhang, X. O.. The University of Texas Health Science Center; Estados Unidos
Fil: O’Malley, J. J.. The University of Texas Health Science Center; Estados Unidos
Fil: Fernandez Leon, Jose Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires. Sede Olavarría del Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aire. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires. Sede Olavarría del Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires; Argentina
Fil: Li, S.. University of Manitoba; Canadá
Fil: Kirouac, G. J.. University of Manitoba; Canadá
Fil: Beierlein, M.. The University of Texas Health Science Center; Estados Unidos
Fil: Do Monte, F. H.. The University of Texas Health Science Center; Estados Unidos
description Survival depends on a balance between seeking rewards and avoiding potential threats, but the neural circuits that regulate this motivational conflict remain largely unknown. Using an approach-food vs. avoid-predator threat conflict test in rats, we identified a subpopulation of neurons in the anterior portion of the paraventricular thalamic nucleus (aPVT) which express corticotrophin-releasing factor (CRF) and are preferentially recruited during conflict. Inactivation of aPVTCRF neurons during conflict biases animal’s response toward food, whereas activation of these cells recapitulates the food-seeking suppression observed during conflict. aPVTCRF neurons project densely to the nucleus accumbens (NAc), and activity in this pathway reduces food seeking and increases avoidance. In addition, we identified the ventromedial hypothalamus (VMH) as a critical input to aPVTCRF neurons, and demonstrated that VMH-aPVT neurons mediate defensive behaviors exclusively during conflict. Together, our findings describe a hypothalamic-thalamostriatal circuit that suppresses reward-seeking behavior under the competing demands of avoiding threats.
publishDate 2021
dc.date.none.fl_str_mv 2021-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/182720
Engelke, D. S.; Zhang, X. O.; O’Malley, J. J.; Fernandez Leon, Jose Alberto; Li, S.; et al.; A hypothalamic-thalamostriatal circuit that controls approach-avoidance conflict in rats; Nature; Nature Communications; 12; 1; 5-2021; 1-19
2041-1723
CONICET Digital
CONICET
url http://hdl.handle.net/11336/182720
identifier_str_mv Engelke, D. S.; Zhang, X. O.; O’Malley, J. J.; Fernandez Leon, Jose Alberto; Li, S.; et al.; A hypothalamic-thalamostriatal circuit that controls approach-avoidance conflict in rats; Nature; Nature Communications; 12; 1; 5-2021; 1-19
2041-1723
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/s41467-021-22730-y
info:eu-repo/semantics/altIdentifier/doi/10.1038/s41467-021-22730-y
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature
publisher.none.fl_str_mv Nature
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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