Deleterious effects of inflammation on parturition and fetal development

Autores
Schander, Julieta Aylen; Correa, Fernando Gabriel; Franchi, Ana Maria; Domínguez Rubio, Ana Paula
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Preterm birth is a major determinant of neonatal mortality and morbidity worldwide. One of the main causes of preterm parturition is maternal infection Dissemination of microorganisms from the vagina and cervix via the ascending route is the preponderant way of infection, although microorganisms may also access the amniotic cavity and the fetus via other pathways. The pathophysiological processes that are set in motion during maternal infection lead to preterm labor and fetal damage with severe consequences both for the mother as well as the offspring. During inflammation associated to infection, a plethora of pro-inflammatory agents are produced in high levels. Thus, prostaglandins are released simultaneously with nitric oxide and their overproduction promotes uterine contractions contributing to embryonic and fetal expulsion. Oxygen and nitrogen reactive species and pro-inflammatory cytokines have been associated with preterm birth as well as fetal damage and they might contribute to the high mortality and morbidity associated with preterm labor. The study of these pathophysiological processes is necessary to develop better tocolytic agents. Therefore, it is essential to establish good animal models of infectioninduced preterm labor that would mimic the human parturition biology.
Fil: Schander, Julieta Aylen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Correa, Fernando Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Franchi, Ana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Domínguez Rubio, Ana Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Materia
pregnancy
preterm birth
infection
inflammation
fetal damage
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/13693
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/13693
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Deleterious effects of inflammation on parturition and fetal developmentSchander, Julieta AylenCorrea, Fernando GabrielFranchi, Ana MariaDomínguez Rubio, Ana Paulapregnancypreterm birthinfectioninflammationfetal damagehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Preterm birth is a major determinant of neonatal mortality and morbidity worldwide. One of the main causes of preterm parturition is maternal infection Dissemination of microorganisms from the vagina and cervix via the ascending route is the preponderant way of infection, although microorganisms may also access the amniotic cavity and the fetus via other pathways. The pathophysiological processes that are set in motion during maternal infection lead to preterm labor and fetal damage with severe consequences both for the mother as well as the offspring. During inflammation associated to infection, a plethora of pro-inflammatory agents are produced in high levels. Thus, prostaglandins are released simultaneously with nitric oxide and their overproduction promotes uterine contractions contributing to embryonic and fetal expulsion. Oxygen and nitrogen reactive species and pro-inflammatory cytokines have been associated with preterm birth as well as fetal damage and they might contribute to the high mortality and morbidity associated with preterm labor. The study of these pathophysiological processes is necessary to develop better tocolytic agents. Therefore, it is essential to establish good animal models of infectioninduced preterm labor that would mimic the human parturition biology.Fil: Schander, Julieta Aylen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Correa, Fernando Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Franchi, Ana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Domínguez Rubio, Ana Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaSociedad Argentina de Fisiología2014-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/13693Schander, Julieta Aylen; Correa, Fernando Gabriel; Franchi, Ana Maria; Domínguez Rubio, Ana Paula; Deleterious effects of inflammation on parturition and fetal development; Sociedad Argentina de Fisiología; Physiological Mini Reviews; 7; 3; 5-2014; 28-431669-54021669-5410enginfo:eu-repo/semantics/altIdentifier/url/https://pmr.safisiol.org.ar/archive/id/64info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:07:22Zoai:ri.conicet.gov.ar:11336/13693instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:07:22.283CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Deleterious effects of inflammation on parturition and fetal development
title Deleterious effects of inflammation on parturition and fetal development
spellingShingle Deleterious effects of inflammation on parturition and fetal development
Schander, Julieta Aylen
pregnancy
preterm birth
infection
inflammation
fetal damage
title_short Deleterious effects of inflammation on parturition and fetal development
title_full Deleterious effects of inflammation on parturition and fetal development
title_fullStr Deleterious effects of inflammation on parturition and fetal development
title_full_unstemmed Deleterious effects of inflammation on parturition and fetal development
title_sort Deleterious effects of inflammation on parturition and fetal development
dc.creator.none.fl_str_mv Schander, Julieta Aylen
Correa, Fernando Gabriel
Franchi, Ana Maria
Domínguez Rubio, Ana Paula
author Schander, Julieta Aylen
author_facet Schander, Julieta Aylen
Correa, Fernando Gabriel
Franchi, Ana Maria
Domínguez Rubio, Ana Paula
author_role author
author2 Correa, Fernando Gabriel
Franchi, Ana Maria
Domínguez Rubio, Ana Paula
author2_role author
author
author
dc.subject.none.fl_str_mv pregnancy
preterm birth
infection
inflammation
fetal damage
topic pregnancy
preterm birth
infection
inflammation
fetal damage
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Preterm birth is a major determinant of neonatal mortality and morbidity worldwide. One of the main causes of preterm parturition is maternal infection Dissemination of microorganisms from the vagina and cervix via the ascending route is the preponderant way of infection, although microorganisms may also access the amniotic cavity and the fetus via other pathways. The pathophysiological processes that are set in motion during maternal infection lead to preterm labor and fetal damage with severe consequences both for the mother as well as the offspring. During inflammation associated to infection, a plethora of pro-inflammatory agents are produced in high levels. Thus, prostaglandins are released simultaneously with nitric oxide and their overproduction promotes uterine contractions contributing to embryonic and fetal expulsion. Oxygen and nitrogen reactive species and pro-inflammatory cytokines have been associated with preterm birth as well as fetal damage and they might contribute to the high mortality and morbidity associated with preterm labor. The study of these pathophysiological processes is necessary to develop better tocolytic agents. Therefore, it is essential to establish good animal models of infectioninduced preterm labor that would mimic the human parturition biology.
Fil: Schander, Julieta Aylen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Correa, Fernando Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Franchi, Ana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Domínguez Rubio, Ana Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
description Preterm birth is a major determinant of neonatal mortality and morbidity worldwide. One of the main causes of preterm parturition is maternal infection Dissemination of microorganisms from the vagina and cervix via the ascending route is the preponderant way of infection, although microorganisms may also access the amniotic cavity and the fetus via other pathways. The pathophysiological processes that are set in motion during maternal infection lead to preterm labor and fetal damage with severe consequences both for the mother as well as the offspring. During inflammation associated to infection, a plethora of pro-inflammatory agents are produced in high levels. Thus, prostaglandins are released simultaneously with nitric oxide and their overproduction promotes uterine contractions contributing to embryonic and fetal expulsion. Oxygen and nitrogen reactive species and pro-inflammatory cytokines have been associated with preterm birth as well as fetal damage and they might contribute to the high mortality and morbidity associated with preterm labor. The study of these pathophysiological processes is necessary to develop better tocolytic agents. Therefore, it is essential to establish good animal models of infectioninduced preterm labor that would mimic the human parturition biology.
publishDate 2014
dc.date.none.fl_str_mv 2014-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/13693
Schander, Julieta Aylen; Correa, Fernando Gabriel; Franchi, Ana Maria; Domínguez Rubio, Ana Paula; Deleterious effects of inflammation on parturition and fetal development; Sociedad Argentina de Fisiología; Physiological Mini Reviews; 7; 3; 5-2014; 28-43
1669-5402
1669-5410
url http://hdl.handle.net/11336/13693
identifier_str_mv Schander, Julieta Aylen; Correa, Fernando Gabriel; Franchi, Ana Maria; Domínguez Rubio, Ana Paula; Deleterious effects of inflammation on parturition and fetal development; Sociedad Argentina de Fisiología; Physiological Mini Reviews; 7; 3; 5-2014; 28-43
1669-5402
1669-5410
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://pmr.safisiol.org.ar/archive/id/64
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Sociedad Argentina de Fisiología
publisher.none.fl_str_mv Sociedad Argentina de Fisiología
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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