Residential proximity to agricultural fields, urinary glyphosate levels and breast cancer risk: a case-control study in Argentina

Autores
Doná, Florencia; Lorenz, Virginia; Stegmayer, Georgina; Ricardo, Tamara; D'iorio, Stefanía; Ponzo, Fernando Rodolfo; Repetti, María Rosa; Demonte, Luisina Delma; Milesi, Maria Mercedes; Varayoud, Jorgelina Guadalupe
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Despite accumulated evidence indicating glyphosate herbicide (GLY) presents endocrine disrupting properties, there are still discrepancies. Moreover, few epidemiological studies have focused on hormone-related pathologies. This work aimed to investigate the associations between urinary GLY levels and breast cancer (BC) in women from a region of intense agricultural activity in Argentina, exploring residential proximity to agricultural fields as a potential risk factor for BC. This was a case-control study that involved 90 women from different populations in the Province of Santa Fe, Argentina. Demographic data, lifestyle factors, and residential history were obtained through a questionnaire, while medical outcomes and reproductive history were acquired from medical records. Spot urine samples were collected and the concentrations of GLY and its primary metabolite, aminomethylphosphonic acid (AMPA) were quantified by ultra-high-performance liquid chromatography–mass spectrometry. Odds ratios were estimated to assess the strength of the association between the case/control type and each predictor. GLY concentrations were above the limit of detection (LOD) in 86.1% of samples, with a range of 0.37–10.07 µg GLY/g creatinine. AMPA was not detected in any of the samples analyzed. Although urinary GLY concentrations showed no differences between the case and control groups, women residing near agricultural fields showed an increased risk of BC (OR: 7.38, 95% CI: 2.74–21.90). These original findings show the ubiquitous presence of GLY in adult women from Argentina. Interestingly, women living near agricultural fields have a higher risk of BC, suggesting that exposure not only to GLY but also to agrochemicals in general, could predispose to the development of BC in Argentina. While this study provides valuable insights, further and broader assessments of BC distribution in relation to agrochemical exposure acroos different regions of Argentina are needed.
Fil: Doná, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina
Fil: Lorenz, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina
Fil: Stegmayer, Georgina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigación en Señales, Sistemas e Inteligencia Computacional. Universidad Nacional del Litoral. Facultad de Ingeniería y Ciencias Hídricas. Instituto de Investigación en Señales, Sistemas e Inteligencia Computacional; Argentina
Fil: Ricardo, Tamara. Dirección Nacional del Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr.C.G.Malbran". Instituto Nacional de Epidemiologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: D'iorio, Stefanía. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Departamento de Matematicas; Argentina
Fil: Ponzo, Fernando Rodolfo. Provincia de Santa Fe. Ministerio de Salud. Hospital "Dr. José María Cullen"; Argentina
Fil: Repetti, María Rosa. Universidad Nacional del Litoral. Facultad de Ingeniería Química; Argentina
Fil: Demonte, Luisina Delma. Universidad Nacional del Litoral. Facultad de Ingeniería Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Milesi, Maria Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina
Fil: Varayoud, Jorgelina Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina
Materia
unsupervised model
machine learning
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/275147
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/275147
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network_name_str CONICET Digital (CONICET)
spelling Residential proximity to agricultural fields, urinary glyphosate levels and breast cancer risk: a case-control study in ArgentinaDoná, FlorenciaLorenz, VirginiaStegmayer, GeorginaRicardo, TamaraD'iorio, StefaníaPonzo, Fernando RodolfoRepetti, María RosaDemonte, Luisina DelmaMilesi, Maria MercedesVarayoud, Jorgelina Guadalupeunsupervised modelmachine learninghttps://purl.org/becyt/ford/1.2https://purl.org/becyt/ford/1Despite accumulated evidence indicating glyphosate herbicide (GLY) presents endocrine disrupting properties, there are still discrepancies. Moreover, few epidemiological studies have focused on hormone-related pathologies. This work aimed to investigate the associations between urinary GLY levels and breast cancer (BC) in women from a region of intense agricultural activity in Argentina, exploring residential proximity to agricultural fields as a potential risk factor for BC. This was a case-control study that involved 90 women from different populations in the Province of Santa Fe, Argentina. Demographic data, lifestyle factors, and residential history were obtained through a questionnaire, while medical outcomes and reproductive history were acquired from medical records. Spot urine samples were collected and the concentrations of GLY and its primary metabolite, aminomethylphosphonic acid (AMPA) were quantified by ultra-high-performance liquid chromatography–mass spectrometry. Odds ratios were estimated to assess the strength of the association between the case/control type and each predictor. GLY concentrations were above the limit of detection (LOD) in 86.1% of samples, with a range of 0.37–10.07 µg GLY/g creatinine. AMPA was not detected in any of the samples analyzed. Although urinary GLY concentrations showed no differences between the case and control groups, women residing near agricultural fields showed an increased risk of BC (OR: 7.38, 95% CI: 2.74–21.90). These original findings show the ubiquitous presence of GLY in adult women from Argentina. Interestingly, women living near agricultural fields have a higher risk of BC, suggesting that exposure not only to GLY but also to agrochemicals in general, could predispose to the development of BC in Argentina. While this study provides valuable insights, further and broader assessments of BC distribution in relation to agrochemical exposure acroos different regions of Argentina are needed.Fil: Doná, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; ArgentinaFil: Lorenz, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; ArgentinaFil: Stegmayer, Georgina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigación en Señales, Sistemas e Inteligencia Computacional. Universidad Nacional del Litoral. Facultad de Ingeniería y Ciencias Hídricas. Instituto de Investigación en Señales, Sistemas e Inteligencia Computacional; ArgentinaFil: Ricardo, Tamara. Dirección Nacional del Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr.C.G.Malbran". Instituto Nacional de Epidemiologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: D'iorio, Stefanía. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Departamento de Matematicas; ArgentinaFil: Ponzo, Fernando Rodolfo. Provincia de Santa Fe. Ministerio de Salud. Hospital "Dr. José María Cullen"; ArgentinaFil: Repetti, María Rosa. Universidad Nacional del Litoral. Facultad de Ingeniería Química; ArgentinaFil: Demonte, Luisina Delma. Universidad Nacional del Litoral. Facultad de Ingeniería Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Milesi, Maria Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; ArgentinaFil: Varayoud, Jorgelina Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; ArgentinaFrontiers Media2025-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/zipapplication/zipapplication/zipapplication/zipapplication/pdfhttp://hdl.handle.net/11336/275147Doná, Florencia; Lorenz, Virginia; Stegmayer, Georgina; Ricardo, Tamara; D'iorio, Stefanía; et al.; Residential proximity to agricultural fields, urinary glyphosate levels and breast cancer risk: a case-control study in Argentina; Frontiers Media; Frontiers in Toxicology; 7; 5-2025; 1-152673-3080CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/journals/toxicology/articles/10.3389/ftox.2025.1579952/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/ftox.2025.1579952info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-12-03T09:06:17Zoai:ri.conicet.gov.ar:11336/275147instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-12-03 09:06:17.75CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Residential proximity to agricultural fields, urinary glyphosate levels and breast cancer risk: a case-control study in Argentina
title Residential proximity to agricultural fields, urinary glyphosate levels and breast cancer risk: a case-control study in Argentina
spellingShingle Residential proximity to agricultural fields, urinary glyphosate levels and breast cancer risk: a case-control study in Argentina
Doná, Florencia
unsupervised model
machine learning
title_short Residential proximity to agricultural fields, urinary glyphosate levels and breast cancer risk: a case-control study in Argentina
title_full Residential proximity to agricultural fields, urinary glyphosate levels and breast cancer risk: a case-control study in Argentina
title_fullStr Residential proximity to agricultural fields, urinary glyphosate levels and breast cancer risk: a case-control study in Argentina
title_full_unstemmed Residential proximity to agricultural fields, urinary glyphosate levels and breast cancer risk: a case-control study in Argentina
title_sort Residential proximity to agricultural fields, urinary glyphosate levels and breast cancer risk: a case-control study in Argentina
dc.creator.none.fl_str_mv Doná, Florencia
Lorenz, Virginia
Stegmayer, Georgina
Ricardo, Tamara
D'iorio, Stefanía
Ponzo, Fernando Rodolfo
Repetti, María Rosa
Demonte, Luisina Delma
Milesi, Maria Mercedes
Varayoud, Jorgelina Guadalupe
author Doná, Florencia
author_facet Doná, Florencia
Lorenz, Virginia
Stegmayer, Georgina
Ricardo, Tamara
D'iorio, Stefanía
Ponzo, Fernando Rodolfo
Repetti, María Rosa
Demonte, Luisina Delma
Milesi, Maria Mercedes
Varayoud, Jorgelina Guadalupe
author_role author
author2 Lorenz, Virginia
Stegmayer, Georgina
Ricardo, Tamara
D'iorio, Stefanía
Ponzo, Fernando Rodolfo
Repetti, María Rosa
Demonte, Luisina Delma
Milesi, Maria Mercedes
Varayoud, Jorgelina Guadalupe
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv unsupervised model
machine learning
topic unsupervised model
machine learning
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.2
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Despite accumulated evidence indicating glyphosate herbicide (GLY) presents endocrine disrupting properties, there are still discrepancies. Moreover, few epidemiological studies have focused on hormone-related pathologies. This work aimed to investigate the associations between urinary GLY levels and breast cancer (BC) in women from a region of intense agricultural activity in Argentina, exploring residential proximity to agricultural fields as a potential risk factor for BC. This was a case-control study that involved 90 women from different populations in the Province of Santa Fe, Argentina. Demographic data, lifestyle factors, and residential history were obtained through a questionnaire, while medical outcomes and reproductive history were acquired from medical records. Spot urine samples were collected and the concentrations of GLY and its primary metabolite, aminomethylphosphonic acid (AMPA) were quantified by ultra-high-performance liquid chromatography–mass spectrometry. Odds ratios were estimated to assess the strength of the association between the case/control type and each predictor. GLY concentrations were above the limit of detection (LOD) in 86.1% of samples, with a range of 0.37–10.07 µg GLY/g creatinine. AMPA was not detected in any of the samples analyzed. Although urinary GLY concentrations showed no differences between the case and control groups, women residing near agricultural fields showed an increased risk of BC (OR: 7.38, 95% CI: 2.74–21.90). These original findings show the ubiquitous presence of GLY in adult women from Argentina. Interestingly, women living near agricultural fields have a higher risk of BC, suggesting that exposure not only to GLY but also to agrochemicals in general, could predispose to the development of BC in Argentina. While this study provides valuable insights, further and broader assessments of BC distribution in relation to agrochemical exposure acroos different regions of Argentina are needed.
Fil: Doná, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina
Fil: Lorenz, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina
Fil: Stegmayer, Georgina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigación en Señales, Sistemas e Inteligencia Computacional. Universidad Nacional del Litoral. Facultad de Ingeniería y Ciencias Hídricas. Instituto de Investigación en Señales, Sistemas e Inteligencia Computacional; Argentina
Fil: Ricardo, Tamara. Dirección Nacional del Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr.C.G.Malbran". Instituto Nacional de Epidemiologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: D'iorio, Stefanía. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Departamento de Matematicas; Argentina
Fil: Ponzo, Fernando Rodolfo. Provincia de Santa Fe. Ministerio de Salud. Hospital "Dr. José María Cullen"; Argentina
Fil: Repetti, María Rosa. Universidad Nacional del Litoral. Facultad de Ingeniería Química; Argentina
Fil: Demonte, Luisina Delma. Universidad Nacional del Litoral. Facultad de Ingeniería Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Milesi, Maria Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina
Fil: Varayoud, Jorgelina Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina
description Despite accumulated evidence indicating glyphosate herbicide (GLY) presents endocrine disrupting properties, there are still discrepancies. Moreover, few epidemiological studies have focused on hormone-related pathologies. This work aimed to investigate the associations between urinary GLY levels and breast cancer (BC) in women from a region of intense agricultural activity in Argentina, exploring residential proximity to agricultural fields as a potential risk factor for BC. This was a case-control study that involved 90 women from different populations in the Province of Santa Fe, Argentina. Demographic data, lifestyle factors, and residential history were obtained through a questionnaire, while medical outcomes and reproductive history were acquired from medical records. Spot urine samples were collected and the concentrations of GLY and its primary metabolite, aminomethylphosphonic acid (AMPA) were quantified by ultra-high-performance liquid chromatography–mass spectrometry. Odds ratios were estimated to assess the strength of the association between the case/control type and each predictor. GLY concentrations were above the limit of detection (LOD) in 86.1% of samples, with a range of 0.37–10.07 µg GLY/g creatinine. AMPA was not detected in any of the samples analyzed. Although urinary GLY concentrations showed no differences between the case and control groups, women residing near agricultural fields showed an increased risk of BC (OR: 7.38, 95% CI: 2.74–21.90). These original findings show the ubiquitous presence of GLY in adult women from Argentina. Interestingly, women living near agricultural fields have a higher risk of BC, suggesting that exposure not only to GLY but also to agrochemicals in general, could predispose to the development of BC in Argentina. While this study provides valuable insights, further and broader assessments of BC distribution in relation to agrochemical exposure acroos different regions of Argentina are needed.
publishDate 2025
dc.date.none.fl_str_mv 2025-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/275147
Doná, Florencia; Lorenz, Virginia; Stegmayer, Georgina; Ricardo, Tamara; D'iorio, Stefanía; et al.; Residential proximity to agricultural fields, urinary glyphosate levels and breast cancer risk: a case-control study in Argentina; Frontiers Media; Frontiers in Toxicology; 7; 5-2025; 1-15
2673-3080
CONICET Digital
CONICET
url http://hdl.handle.net/11336/275147
identifier_str_mv Doná, Florencia; Lorenz, Virginia; Stegmayer, Georgina; Ricardo, Tamara; D'iorio, Stefanía; et al.; Residential proximity to agricultural fields, urinary glyphosate levels and breast cancer risk: a case-control study in Argentina; Frontiers Media; Frontiers in Toxicology; 7; 5-2025; 1-15
2673-3080
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/doi/10.3389/ftox.2025.1579952
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/zip
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dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
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reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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