Mitochondrial DNA control region data reveal high prevalence of Native American lineages in Jujuy province, NW Argentina

Autores
Cardoso, Sergio; Palencia Madrid, Leire; Valverde, Laura; Alfonso Sanchez, Miguel A.; Gomez Perez, Luis; Alfaro, Emma; Bravi, Claudio Marcelo; Dipierri, Jose Edgardo; Peña, José M.; de Pancorbo, Marian M.
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Mitochondrial control region (16024-576) sequences were generated from 180 individuals of four population nuclei from the province of Jujuy (NW Argentina), located at different altitudes above sea level. The frequency at which a randomly selected mtDNA profile would be expected to occur in the general population (random match probability) was estimated at 0.011, indicating a relatively high diversity. Analysis of the haplogroup distribution revealed that Native American lineages A2 (13.9%), B (56.7%), C1 (17.8%), D1 (8.9%) and D4h3a (1.1%) accounted for more than 98% of the total mtDNA haplogroup diversity in the sample examined. We detected a certain degree of genetic heterogeneity between two subpopulations located at different points along the altitudinal gradient (Valles and Puna), suggesting that altitude above sea level cannot be ruled out as a factor promoting divergences in mtDNA haplogroup frequencies, since altitude is closely associated with human living conditions, and consequently, with low demographic sizes and the occurrence of genetic drift processes in human communities. In all, mitochondrial DNA database obtained for Jujuy province strongly points to the need for creating local mtDNA databases, to avoid bias in forensic estimations caused by genetic substructuring of the populations.
Fil: Cardoso, Sergio. Universidad del País Vasco; España
Fil: Palencia Madrid, Leire. Universidad del País Vasco; España
Fil: Valverde, Laura. Universidad del País Vasco; España
Fil: Alfonso Sanchez, Miguel A.. Universidad del País Vasco; España
Fil: Gomez Perez, Luis. Universidad del País Vasco; España
Fil: Alfaro, Emma. Universidad Nacional de Jujuy. Instituto de Biología de la Altura; Argentina
Fil: Bravi, Claudio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: Dipierri, Jose Edgardo. Universidad Nacional de Jujuy. Instituto de Biología de la Altura; Argentina
Fil: Peña, José M.. Universidad del País Vasco; España
Fil: de Pancorbo, Marian M.. Universidad del País Vasco; España
Materia
Mitochondrial Dna
Control Region
Argentina
Jujuy
Empop
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/23972
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/23972
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Mitochondrial DNA control region data reveal high prevalence of Native American lineages in Jujuy province, NW ArgentinaCardoso, SergioPalencia Madrid, LeireValverde, LauraAlfonso Sanchez, Miguel A.Gomez Perez, LuisAlfaro, EmmaBravi, Claudio MarceloDipierri, Jose EdgardoPeña, José M.de Pancorbo, Marian M.Mitochondrial DnaControl RegionArgentinaJujuyEmpophttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Mitochondrial control region (16024-576) sequences were generated from 180 individuals of four population nuclei from the province of Jujuy (NW Argentina), located at different altitudes above sea level. The frequency at which a randomly selected mtDNA profile would be expected to occur in the general population (random match probability) was estimated at 0.011, indicating a relatively high diversity. Analysis of the haplogroup distribution revealed that Native American lineages A2 (13.9%), B (56.7%), C1 (17.8%), D1 (8.9%) and D4h3a (1.1%) accounted for more than 98% of the total mtDNA haplogroup diversity in the sample examined. We detected a certain degree of genetic heterogeneity between two subpopulations located at different points along the altitudinal gradient (Valles and Puna), suggesting that altitude above sea level cannot be ruled out as a factor promoting divergences in mtDNA haplogroup frequencies, since altitude is closely associated with human living conditions, and consequently, with low demographic sizes and the occurrence of genetic drift processes in human communities. In all, mitochondrial DNA database obtained for Jujuy province strongly points to the need for creating local mtDNA databases, to avoid bias in forensic estimations caused by genetic substructuring of the populations.Fil: Cardoso, Sergio. Universidad del País Vasco; EspañaFil: Palencia Madrid, Leire. Universidad del País Vasco; EspañaFil: Valverde, Laura. Universidad del País Vasco; EspañaFil: Alfonso Sanchez, Miguel A.. Universidad del País Vasco; EspañaFil: Gomez Perez, Luis. Universidad del País Vasco; EspañaFil: Alfaro, Emma. Universidad Nacional de Jujuy. Instituto de Biología de la Altura; ArgentinaFil: Bravi, Claudio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: Dipierri, Jose Edgardo. Universidad Nacional de Jujuy. Instituto de Biología de la Altura; ArgentinaFil: Peña, José M.. Universidad del País Vasco; EspañaFil: de Pancorbo, Marian M.. Universidad del País Vasco; EspañaElsevier Ireland2013-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/23972Cardoso, Sergio; Palencia Madrid, Leire; Valverde, Laura; Alfonso Sanchez, Miguel A.; Gomez Perez, Luis; et al.; Mitochondrial DNA control region data reveal high prevalence of Native American lineages in Jujuy province, NW Argentina; Elsevier Ireland; Forensic Science International: Genetics; 7; 3; 5-2013; 52-551872-4973CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1872497313000380info:eu-repo/semantics/altIdentifier/doi/10.1016/j.fsigen.2013.01.007info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:07:51Zoai:ri.conicet.gov.ar:11336/23972instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:07:51.927CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Mitochondrial DNA control region data reveal high prevalence of Native American lineages in Jujuy province, NW Argentina
title Mitochondrial DNA control region data reveal high prevalence of Native American lineages in Jujuy province, NW Argentina
spellingShingle Mitochondrial DNA control region data reveal high prevalence of Native American lineages in Jujuy province, NW Argentina
Cardoso, Sergio
Mitochondrial Dna
Control Region
Argentina
Jujuy
Empop
title_short Mitochondrial DNA control region data reveal high prevalence of Native American lineages in Jujuy province, NW Argentina
title_full Mitochondrial DNA control region data reveal high prevalence of Native American lineages in Jujuy province, NW Argentina
title_fullStr Mitochondrial DNA control region data reveal high prevalence of Native American lineages in Jujuy province, NW Argentina
title_full_unstemmed Mitochondrial DNA control region data reveal high prevalence of Native American lineages in Jujuy province, NW Argentina
title_sort Mitochondrial DNA control region data reveal high prevalence of Native American lineages in Jujuy province, NW Argentina
dc.creator.none.fl_str_mv Cardoso, Sergio
Palencia Madrid, Leire
Valverde, Laura
Alfonso Sanchez, Miguel A.
Gomez Perez, Luis
Alfaro, Emma
Bravi, Claudio Marcelo
Dipierri, Jose Edgardo
Peña, José M.
de Pancorbo, Marian M.
author Cardoso, Sergio
author_facet Cardoso, Sergio
Palencia Madrid, Leire
Valverde, Laura
Alfonso Sanchez, Miguel A.
Gomez Perez, Luis
Alfaro, Emma
Bravi, Claudio Marcelo
Dipierri, Jose Edgardo
Peña, José M.
de Pancorbo, Marian M.
author_role author
author2 Palencia Madrid, Leire
Valverde, Laura
Alfonso Sanchez, Miguel A.
Gomez Perez, Luis
Alfaro, Emma
Bravi, Claudio Marcelo
Dipierri, Jose Edgardo
Peña, José M.
de Pancorbo, Marian M.
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Mitochondrial Dna
Control Region
Argentina
Jujuy
Empop
topic Mitochondrial Dna
Control Region
Argentina
Jujuy
Empop
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Mitochondrial control region (16024-576) sequences were generated from 180 individuals of four population nuclei from the province of Jujuy (NW Argentina), located at different altitudes above sea level. The frequency at which a randomly selected mtDNA profile would be expected to occur in the general population (random match probability) was estimated at 0.011, indicating a relatively high diversity. Analysis of the haplogroup distribution revealed that Native American lineages A2 (13.9%), B (56.7%), C1 (17.8%), D1 (8.9%) and D4h3a (1.1%) accounted for more than 98% of the total mtDNA haplogroup diversity in the sample examined. We detected a certain degree of genetic heterogeneity between two subpopulations located at different points along the altitudinal gradient (Valles and Puna), suggesting that altitude above sea level cannot be ruled out as a factor promoting divergences in mtDNA haplogroup frequencies, since altitude is closely associated with human living conditions, and consequently, with low demographic sizes and the occurrence of genetic drift processes in human communities. In all, mitochondrial DNA database obtained for Jujuy province strongly points to the need for creating local mtDNA databases, to avoid bias in forensic estimations caused by genetic substructuring of the populations.
Fil: Cardoso, Sergio. Universidad del País Vasco; España
Fil: Palencia Madrid, Leire. Universidad del País Vasco; España
Fil: Valverde, Laura. Universidad del País Vasco; España
Fil: Alfonso Sanchez, Miguel A.. Universidad del País Vasco; España
Fil: Gomez Perez, Luis. Universidad del País Vasco; España
Fil: Alfaro, Emma. Universidad Nacional de Jujuy. Instituto de Biología de la Altura; Argentina
Fil: Bravi, Claudio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: Dipierri, Jose Edgardo. Universidad Nacional de Jujuy. Instituto de Biología de la Altura; Argentina
Fil: Peña, José M.. Universidad del País Vasco; España
Fil: de Pancorbo, Marian M.. Universidad del País Vasco; España
description Mitochondrial control region (16024-576) sequences were generated from 180 individuals of four population nuclei from the province of Jujuy (NW Argentina), located at different altitudes above sea level. The frequency at which a randomly selected mtDNA profile would be expected to occur in the general population (random match probability) was estimated at 0.011, indicating a relatively high diversity. Analysis of the haplogroup distribution revealed that Native American lineages A2 (13.9%), B (56.7%), C1 (17.8%), D1 (8.9%) and D4h3a (1.1%) accounted for more than 98% of the total mtDNA haplogroup diversity in the sample examined. We detected a certain degree of genetic heterogeneity between two subpopulations located at different points along the altitudinal gradient (Valles and Puna), suggesting that altitude above sea level cannot be ruled out as a factor promoting divergences in mtDNA haplogroup frequencies, since altitude is closely associated with human living conditions, and consequently, with low demographic sizes and the occurrence of genetic drift processes in human communities. In all, mitochondrial DNA database obtained for Jujuy province strongly points to the need for creating local mtDNA databases, to avoid bias in forensic estimations caused by genetic substructuring of the populations.
publishDate 2013
dc.date.none.fl_str_mv 2013-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/23972
Cardoso, Sergio; Palencia Madrid, Leire; Valverde, Laura; Alfonso Sanchez, Miguel A.; Gomez Perez, Luis; et al.; Mitochondrial DNA control region data reveal high prevalence of Native American lineages in Jujuy province, NW Argentina; Elsevier Ireland; Forensic Science International: Genetics; 7; 3; 5-2013; 52-55
1872-4973
CONICET Digital
CONICET
url http://hdl.handle.net/11336/23972
identifier_str_mv Cardoso, Sergio; Palencia Madrid, Leire; Valverde, Laura; Alfonso Sanchez, Miguel A.; Gomez Perez, Luis; et al.; Mitochondrial DNA control region data reveal high prevalence of Native American lineages in Jujuy province, NW Argentina; Elsevier Ireland; Forensic Science International: Genetics; 7; 3; 5-2013; 52-55
1872-4973
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1872497313000380
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.fsigen.2013.01.007
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Ireland
publisher.none.fl_str_mv Elsevier Ireland
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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