Systematic Review: microRNAs as Potential Biomarkers in Mild Cognitive Impairment Diagnosis
- Autores
- Ogonowski, Natalia Soledad; Salcidua, Stefanny; Leon, Tomas; Chamorro Veloso, Nayaret; Valls, Cristian; Avalos, Constanza; Bisquertt, Alejandro; Rentería, Miguel E.; Orellana, Paulina; Duran Aniotz, Claudia
- Año de publicación
- 2022
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The rate of progression from Mild Cognitive Impairment (MCI) to Alzheimer's disease (AD) is estimated at >10% per year, reaching up to 80–90% after 6 years. MCI is considered an indicator of early-stage AD. In this context, the diagnostic screening of MCI is crucial for detecting individuals at high risk of AD before they progress and manifest further severe symptoms. Typically, MCI has been determined using neuropsychological assessment tools such as the Montreal Cognitive Assessment (MoCA) or Mini-Mental Status Examination (MMSE). Unfortunately, other diagnostic methods are not available or are unable to identify MCI in its early stages. Therefore, identifying new biomarkers for MCI diagnosis and prognosis is a significant challenge. In this framework, miRNAs in serum, plasma, and other body fluids have emerged as a promising source of biomarkers for MCI and AD-related cognitive impairments. Interestingly, miRNAs can regulate several signaling pathways via multiple and diverse targets in response to pathophysiological stimuli. This systematic review aims to describe the current state of the art regarding AD-related target genes modulated by differentially expressed miRNAs in peripheral fluids samples in MCI subjects to identify potential miRNA biomarkers in the early stages of AD. We found 30 articles that described five miRNA expression profiles from peripheral fluid in MCI subjects, showing possible candidates for miRNA biomarkers that may be followed up as fluid biomarkers or therapeutic targets of early-stage AD. However, additional research is needed to validate these miRNAs and characterize the precise neuropathological mechanisms.
Fil: Ogonowski, Natalia Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Adolfo Ibañez; Chile
Fil: Salcidua, Stefanny. Universidad Adolfo Ibañez; Chile
Fil: Leon, Tomas. Universidad de Chile; Chile. Trinity College; Irlanda
Fil: Chamorro Veloso, Nayaret. Neurognos Spa; Chile
Fil: Valls, Cristian. Neurognos Spa; Chile
Fil: Avalos, Constanza. Universidad Adolfo Ibañez; Chile
Fil: Bisquertt, Alejandro. Neurognos Spa; Chile
Fil: Rentería, Miguel E.. Berghofer Medical Research Institute; Australia
Fil: Orellana, Paulina. Universidad Adolfo Ibañez; Chile
Fil: Duran Aniotz, Claudia. Universidad Adolfo Ibañez; Chile - Materia
-
BIOMARKERS
DIAGNOSIS
FLUID BIOMARKERS
MICRORNA
MILD COGNITIVE IMPAIRMENT
SYSTEMATIC REVIEW - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/213496
Ver los metadatos del registro completo
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Systematic Review: microRNAs as Potential Biomarkers in Mild Cognitive Impairment DiagnosisOgonowski, Natalia SoledadSalcidua, StefannyLeon, TomasChamorro Veloso, NayaretValls, CristianAvalos, ConstanzaBisquertt, AlejandroRentería, Miguel E.Orellana, PaulinaDuran Aniotz, ClaudiaBIOMARKERSDIAGNOSISFLUID BIOMARKERSMICRORNAMILD COGNITIVE IMPAIRMENTSYSTEMATIC REVIEWhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3The rate of progression from Mild Cognitive Impairment (MCI) to Alzheimer's disease (AD) is estimated at >10% per year, reaching up to 80–90% after 6 years. MCI is considered an indicator of early-stage AD. In this context, the diagnostic screening of MCI is crucial for detecting individuals at high risk of AD before they progress and manifest further severe symptoms. Typically, MCI has been determined using neuropsychological assessment tools such as the Montreal Cognitive Assessment (MoCA) or Mini-Mental Status Examination (MMSE). Unfortunately, other diagnostic methods are not available or are unable to identify MCI in its early stages. Therefore, identifying new biomarkers for MCI diagnosis and prognosis is a significant challenge. In this framework, miRNAs in serum, plasma, and other body fluids have emerged as a promising source of biomarkers for MCI and AD-related cognitive impairments. Interestingly, miRNAs can regulate several signaling pathways via multiple and diverse targets in response to pathophysiological stimuli. This systematic review aims to describe the current state of the art regarding AD-related target genes modulated by differentially expressed miRNAs in peripheral fluids samples in MCI subjects to identify potential miRNA biomarkers in the early stages of AD. We found 30 articles that described five miRNA expression profiles from peripheral fluid in MCI subjects, showing possible candidates for miRNA biomarkers that may be followed up as fluid biomarkers or therapeutic targets of early-stage AD. However, additional research is needed to validate these miRNAs and characterize the precise neuropathological mechanisms.Fil: Ogonowski, Natalia Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Adolfo Ibañez; ChileFil: Salcidua, Stefanny. Universidad Adolfo Ibañez; ChileFil: Leon, Tomas. Universidad de Chile; Chile. Trinity College; IrlandaFil: Chamorro Veloso, Nayaret. Neurognos Spa; ChileFil: Valls, Cristian. Neurognos Spa; ChileFil: Avalos, Constanza. Universidad Adolfo Ibañez; ChileFil: Bisquertt, Alejandro. Neurognos Spa; ChileFil: Rentería, Miguel E.. Berghofer Medical Research Institute; AustraliaFil: Orellana, Paulina. Universidad Adolfo Ibañez; ChileFil: Duran Aniotz, Claudia. Universidad Adolfo Ibañez; ChileFrontiers Media S.A.2022-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/213496Ogonowski, Natalia Soledad; Salcidua, Stefanny; Leon, Tomas; Chamorro Veloso, Nayaret; Valls, Cristian; et al.; Systematic Review: microRNAs as Potential Biomarkers in Mild Cognitive Impairment Diagnosis; Frontiers Media S.A.; Frontiers in Aging Neuroscience; 13; 1-2022; 1-221663-4365CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fnagi.2021.807764/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fnagi.2021.807764info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:23:31Zoai:ri.conicet.gov.ar:11336/213496instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:23:31.625CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Systematic Review: microRNAs as Potential Biomarkers in Mild Cognitive Impairment Diagnosis |
title |
Systematic Review: microRNAs as Potential Biomarkers in Mild Cognitive Impairment Diagnosis |
spellingShingle |
Systematic Review: microRNAs as Potential Biomarkers in Mild Cognitive Impairment Diagnosis Ogonowski, Natalia Soledad BIOMARKERS DIAGNOSIS FLUID BIOMARKERS MICRORNA MILD COGNITIVE IMPAIRMENT SYSTEMATIC REVIEW |
title_short |
Systematic Review: microRNAs as Potential Biomarkers in Mild Cognitive Impairment Diagnosis |
title_full |
Systematic Review: microRNAs as Potential Biomarkers in Mild Cognitive Impairment Diagnosis |
title_fullStr |
Systematic Review: microRNAs as Potential Biomarkers in Mild Cognitive Impairment Diagnosis |
title_full_unstemmed |
Systematic Review: microRNAs as Potential Biomarkers in Mild Cognitive Impairment Diagnosis |
title_sort |
Systematic Review: microRNAs as Potential Biomarkers in Mild Cognitive Impairment Diagnosis |
dc.creator.none.fl_str_mv |
Ogonowski, Natalia Soledad Salcidua, Stefanny Leon, Tomas Chamorro Veloso, Nayaret Valls, Cristian Avalos, Constanza Bisquertt, Alejandro Rentería, Miguel E. Orellana, Paulina Duran Aniotz, Claudia |
author |
Ogonowski, Natalia Soledad |
author_facet |
Ogonowski, Natalia Soledad Salcidua, Stefanny Leon, Tomas Chamorro Veloso, Nayaret Valls, Cristian Avalos, Constanza Bisquertt, Alejandro Rentería, Miguel E. Orellana, Paulina Duran Aniotz, Claudia |
author_role |
author |
author2 |
Salcidua, Stefanny Leon, Tomas Chamorro Veloso, Nayaret Valls, Cristian Avalos, Constanza Bisquertt, Alejandro Rentería, Miguel E. Orellana, Paulina Duran Aniotz, Claudia |
author2_role |
author author author author author author author author author |
dc.subject.none.fl_str_mv |
BIOMARKERS DIAGNOSIS FLUID BIOMARKERS MICRORNA MILD COGNITIVE IMPAIRMENT SYSTEMATIC REVIEW |
topic |
BIOMARKERS DIAGNOSIS FLUID BIOMARKERS MICRORNA MILD COGNITIVE IMPAIRMENT SYSTEMATIC REVIEW |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
The rate of progression from Mild Cognitive Impairment (MCI) to Alzheimer's disease (AD) is estimated at >10% per year, reaching up to 80–90% after 6 years. MCI is considered an indicator of early-stage AD. In this context, the diagnostic screening of MCI is crucial for detecting individuals at high risk of AD before they progress and manifest further severe symptoms. Typically, MCI has been determined using neuropsychological assessment tools such as the Montreal Cognitive Assessment (MoCA) or Mini-Mental Status Examination (MMSE). Unfortunately, other diagnostic methods are not available or are unable to identify MCI in its early stages. Therefore, identifying new biomarkers for MCI diagnosis and prognosis is a significant challenge. In this framework, miRNAs in serum, plasma, and other body fluids have emerged as a promising source of biomarkers for MCI and AD-related cognitive impairments. Interestingly, miRNAs can regulate several signaling pathways via multiple and diverse targets in response to pathophysiological stimuli. This systematic review aims to describe the current state of the art regarding AD-related target genes modulated by differentially expressed miRNAs in peripheral fluids samples in MCI subjects to identify potential miRNA biomarkers in the early stages of AD. We found 30 articles that described five miRNA expression profiles from peripheral fluid in MCI subjects, showing possible candidates for miRNA biomarkers that may be followed up as fluid biomarkers or therapeutic targets of early-stage AD. However, additional research is needed to validate these miRNAs and characterize the precise neuropathological mechanisms. Fil: Ogonowski, Natalia Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Adolfo Ibañez; Chile Fil: Salcidua, Stefanny. Universidad Adolfo Ibañez; Chile Fil: Leon, Tomas. Universidad de Chile; Chile. Trinity College; Irlanda Fil: Chamorro Veloso, Nayaret. Neurognos Spa; Chile Fil: Valls, Cristian. Neurognos Spa; Chile Fil: Avalos, Constanza. Universidad Adolfo Ibañez; Chile Fil: Bisquertt, Alejandro. Neurognos Spa; Chile Fil: Rentería, Miguel E.. Berghofer Medical Research Institute; Australia Fil: Orellana, Paulina. Universidad Adolfo Ibañez; Chile Fil: Duran Aniotz, Claudia. Universidad Adolfo Ibañez; Chile |
description |
The rate of progression from Mild Cognitive Impairment (MCI) to Alzheimer's disease (AD) is estimated at >10% per year, reaching up to 80–90% after 6 years. MCI is considered an indicator of early-stage AD. In this context, the diagnostic screening of MCI is crucial for detecting individuals at high risk of AD before they progress and manifest further severe symptoms. Typically, MCI has been determined using neuropsychological assessment tools such as the Montreal Cognitive Assessment (MoCA) or Mini-Mental Status Examination (MMSE). Unfortunately, other diagnostic methods are not available or are unable to identify MCI in its early stages. Therefore, identifying new biomarkers for MCI diagnosis and prognosis is a significant challenge. In this framework, miRNAs in serum, plasma, and other body fluids have emerged as a promising source of biomarkers for MCI and AD-related cognitive impairments. Interestingly, miRNAs can regulate several signaling pathways via multiple and diverse targets in response to pathophysiological stimuli. This systematic review aims to describe the current state of the art regarding AD-related target genes modulated by differentially expressed miRNAs in peripheral fluids samples in MCI subjects to identify potential miRNA biomarkers in the early stages of AD. We found 30 articles that described five miRNA expression profiles from peripheral fluid in MCI subjects, showing possible candidates for miRNA biomarkers that may be followed up as fluid biomarkers or therapeutic targets of early-stage AD. However, additional research is needed to validate these miRNAs and characterize the precise neuropathological mechanisms. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/213496 Ogonowski, Natalia Soledad; Salcidua, Stefanny; Leon, Tomas; Chamorro Veloso, Nayaret; Valls, Cristian; et al.; Systematic Review: microRNAs as Potential Biomarkers in Mild Cognitive Impairment Diagnosis; Frontiers Media S.A.; Frontiers in Aging Neuroscience; 13; 1-2022; 1-22 1663-4365 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/213496 |
identifier_str_mv |
Ogonowski, Natalia Soledad; Salcidua, Stefanny; Leon, Tomas; Chamorro Veloso, Nayaret; Valls, Cristian; et al.; Systematic Review: microRNAs as Potential Biomarkers in Mild Cognitive Impairment Diagnosis; Frontiers Media S.A.; Frontiers in Aging Neuroscience; 13; 1-2022; 1-22 1663-4365 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fnagi.2021.807764/full info:eu-repo/semantics/altIdentifier/doi/10.3389/fnagi.2021.807764 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
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openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers Media S.A. |
publisher.none.fl_str_mv |
Frontiers Media S.A. |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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