Apoptosis and expression of Bcl-2 and Bax in eutopic endometrium from women with endometriosis

Autores
Meresman, Gabriela Fabiana; Vighi, Susana; Buquet, Ricardo A.; Contreras Ortiz, Oscar; Tesone, Marta; Rumi, Lia S.
Año de publicación
2000
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
To evaluate and compare spontaneous apoptosis and Bcl-2 and Bax expression in eutopic endometrium from women with and without endometriosis. Spontaneous apoptosis was significantly lower in eutopic endometrium from patients with endometriosis, compared with healthy controls (2.26 +/- 0.53 and 9.37 +/- 1.69 apoptotic cells/field, respectively) and was independent of cycle phase. An increased expression of Bcl-2 protein was found in proliferative eutopic endometrium from patients with endometriosis. Bax expression was absent in proliferative endometrium, whereas there was an increase in its expression in secretory endometrium from both patients and controls.Women with endometriosis show decreased number of apoptotic cells in eutopic endometrium. The abnormal survival of endometrial cells may result in their continuing growth into ectopic locations
Fil: Meresman, Gabriela Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Vighi, Susana. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Buquet, Ricardo A.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Contreras Ortiz, Oscar. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Tesone, Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Rumi, Lia S.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Materia
Endometriosis
Eutopic Endometrium
Apoptosis
Bcl-2 Bax
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/31331
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Apoptosis and expression of Bcl-2 and Bax in eutopic endometrium from women with endometriosisMeresman, Gabriela FabianaVighi, SusanaBuquet, Ricardo A.Contreras Ortiz, OscarTesone, MartaRumi, Lia S.EndometriosisEutopic EndometriumApoptosisBcl-2 Baxhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3To evaluate and compare spontaneous apoptosis and Bcl-2 and Bax expression in eutopic endometrium from women with and without endometriosis. Spontaneous apoptosis was significantly lower in eutopic endometrium from patients with endometriosis, compared with healthy controls (2.26 +/- 0.53 and 9.37 +/- 1.69 apoptotic cells/field, respectively) and was independent of cycle phase. An increased expression of Bcl-2 protein was found in proliferative eutopic endometrium from patients with endometriosis. Bax expression was absent in proliferative endometrium, whereas there was an increase in its expression in secretory endometrium from both patients and controls.Women with endometriosis show decreased number of apoptotic cells in eutopic endometrium. The abnormal survival of endometrial cells may result in their continuing growth into ectopic locationsFil: Meresman, Gabriela Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Vighi, Susana. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Buquet, Ricardo A.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Contreras Ortiz, Oscar. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Tesone, Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Rumi, Lia S.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaElsevier Science Inc2000-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/31331Meresman, Gabriela Fabiana; Vighi, Susana; Buquet, Ricardo A.; Contreras Ortiz, Oscar; Tesone, Marta; et al.; Apoptosis and expression of Bcl-2 and Bax in eutopic endometrium from women with endometriosis; Elsevier Science Inc; Fertility and Sterility; 74; 4; 4-2000; 760-7660015-02821556-5653CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.fertstert.org/article/S0015-0282(00)01522-3/fulltextinfo:eu-repo/semantics/altIdentifier/doi/10.1016/S0015-0282(00)01522-3info:eu-repo/semantics/altIdentifier/pmid/https://www.ncbi.nlm.nih.gov/pubmed/11020520info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:57:20Zoai:ri.conicet.gov.ar:11336/31331instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:57:20.636CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Apoptosis and expression of Bcl-2 and Bax in eutopic endometrium from women with endometriosis
title Apoptosis and expression of Bcl-2 and Bax in eutopic endometrium from women with endometriosis
spellingShingle Apoptosis and expression of Bcl-2 and Bax in eutopic endometrium from women with endometriosis
Meresman, Gabriela Fabiana
Endometriosis
Eutopic Endometrium
Apoptosis
Bcl-2 Bax
title_short Apoptosis and expression of Bcl-2 and Bax in eutopic endometrium from women with endometriosis
title_full Apoptosis and expression of Bcl-2 and Bax in eutopic endometrium from women with endometriosis
title_fullStr Apoptosis and expression of Bcl-2 and Bax in eutopic endometrium from women with endometriosis
title_full_unstemmed Apoptosis and expression of Bcl-2 and Bax in eutopic endometrium from women with endometriosis
title_sort Apoptosis and expression of Bcl-2 and Bax in eutopic endometrium from women with endometriosis
dc.creator.none.fl_str_mv Meresman, Gabriela Fabiana
Vighi, Susana
Buquet, Ricardo A.
Contreras Ortiz, Oscar
Tesone, Marta
Rumi, Lia S.
author Meresman, Gabriela Fabiana
author_facet Meresman, Gabriela Fabiana
Vighi, Susana
Buquet, Ricardo A.
Contreras Ortiz, Oscar
Tesone, Marta
Rumi, Lia S.
author_role author
author2 Vighi, Susana
Buquet, Ricardo A.
Contreras Ortiz, Oscar
Tesone, Marta
Rumi, Lia S.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Endometriosis
Eutopic Endometrium
Apoptosis
Bcl-2 Bax
topic Endometriosis
Eutopic Endometrium
Apoptosis
Bcl-2 Bax
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv To evaluate and compare spontaneous apoptosis and Bcl-2 and Bax expression in eutopic endometrium from women with and without endometriosis. Spontaneous apoptosis was significantly lower in eutopic endometrium from patients with endometriosis, compared with healthy controls (2.26 +/- 0.53 and 9.37 +/- 1.69 apoptotic cells/field, respectively) and was independent of cycle phase. An increased expression of Bcl-2 protein was found in proliferative eutopic endometrium from patients with endometriosis. Bax expression was absent in proliferative endometrium, whereas there was an increase in its expression in secretory endometrium from both patients and controls.Women with endometriosis show decreased number of apoptotic cells in eutopic endometrium. The abnormal survival of endometrial cells may result in their continuing growth into ectopic locations
Fil: Meresman, Gabriela Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Vighi, Susana. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Buquet, Ricardo A.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Contreras Ortiz, Oscar. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Tesone, Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Rumi, Lia S.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
description To evaluate and compare spontaneous apoptosis and Bcl-2 and Bax expression in eutopic endometrium from women with and without endometriosis. Spontaneous apoptosis was significantly lower in eutopic endometrium from patients with endometriosis, compared with healthy controls (2.26 +/- 0.53 and 9.37 +/- 1.69 apoptotic cells/field, respectively) and was independent of cycle phase. An increased expression of Bcl-2 protein was found in proliferative eutopic endometrium from patients with endometriosis. Bax expression was absent in proliferative endometrium, whereas there was an increase in its expression in secretory endometrium from both patients and controls.Women with endometriosis show decreased number of apoptotic cells in eutopic endometrium. The abnormal survival of endometrial cells may result in their continuing growth into ectopic locations
publishDate 2000
dc.date.none.fl_str_mv 2000-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/31331
Meresman, Gabriela Fabiana; Vighi, Susana; Buquet, Ricardo A.; Contreras Ortiz, Oscar; Tesone, Marta; et al.; Apoptosis and expression of Bcl-2 and Bax in eutopic endometrium from women with endometriosis; Elsevier Science Inc; Fertility and Sterility; 74; 4; 4-2000; 760-766
0015-0282
1556-5653
CONICET Digital
CONICET
url http://hdl.handle.net/11336/31331
identifier_str_mv Meresman, Gabriela Fabiana; Vighi, Susana; Buquet, Ricardo A.; Contreras Ortiz, Oscar; Tesone, Marta; et al.; Apoptosis and expression of Bcl-2 and Bax in eutopic endometrium from women with endometriosis; Elsevier Science Inc; Fertility and Sterility; 74; 4; 4-2000; 760-766
0015-0282
1556-5653
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.fertstert.org/article/S0015-0282(00)01522-3/fulltext
info:eu-repo/semantics/altIdentifier/doi/10.1016/S0015-0282(00)01522-3
info:eu-repo/semantics/altIdentifier/pmid/https://www.ncbi.nlm.nih.gov/pubmed/11020520
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Inc
publisher.none.fl_str_mv Elsevier Science Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269456762404864
score 13.13397

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