Synthesis of D-Galactofuranose-containing molecules. Design of Galactofuranosyl acceptors

Autores
Marino, María Carla; Baldoni, Luciana
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
D-Galactofuranose (D-Galf) is present in glycoconjugates of several pathogenic microorganisms but is absent in mammals, so it is a good target for the development of chemotherapeutic agents for the treatment of microbial infections. This fact has improved the interest in the synthesis of D-Galf-containing molecules for the corresponding glycobiological studies. The synthesis of oligosaccharides, glycoconjugates and mimetics of D-Galf requires specific methods for the preparation of galactose derivatives in the furanosic configuration, the synthesis of appropriate acceptors and efficient glycosylation methods for the construction of the alpha- and beta-D-Galf linkages. This review summarizes the different strategies developed for the preparation of partially protected derivatives of D-Galf, suitable as acceptors for the construction of (1,2), (1,3), (1,5) and (1,6) linkages, and describes recent applications.
Fil: Marino, María Carla. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono; Argentina
Fil: Baldoni, Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono; Argentina
Materia
Carbohydrates
Galactofuranose
Glycosylation
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/8160
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Synthesis of D-Galactofuranose-containing molecules. Design of Galactofuranosyl acceptorsMarino, María CarlaBaldoni, LucianaCarbohydratesGalactofuranoseGlycosylationhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1https://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1D-Galactofuranose (D-Galf) is present in glycoconjugates of several pathogenic microorganisms but is absent in mammals, so it is a good target for the development of chemotherapeutic agents for the treatment of microbial infections. This fact has improved the interest in the synthesis of D-Galf-containing molecules for the corresponding glycobiological studies. The synthesis of oligosaccharides, glycoconjugates and mimetics of D-Galf requires specific methods for the preparation of galactose derivatives in the furanosic configuration, the synthesis of appropriate acceptors and efficient glycosylation methods for the construction of the alpha- and beta-D-Galf linkages. This review summarizes the different strategies developed for the preparation of partially protected derivatives of D-Galf, suitable as acceptors for the construction of (1,2), (1,3), (1,5) and (1,6) linkages, and describes recent applications.Fil: Marino, María Carla. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono; ArgentinaFil: Baldoni, Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono; ArgentinaWiley2014-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/8160Marino, María Carla; Baldoni, Luciana; Synthesis of D-Galactofuranose-containing molecules. Design of Galactofuranosyl acceptors; Wiley; Chembiochem; 15; 2-2014; 188-2041439-4227enginfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/cbic.201300638/abstractinfo:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:44:50Zoai:ri.conicet.gov.ar:11336/8160instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:44:51.294CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Synthesis of D-Galactofuranose-containing molecules. Design of Galactofuranosyl acceptors
title Synthesis of D-Galactofuranose-containing molecules. Design of Galactofuranosyl acceptors
spellingShingle Synthesis of D-Galactofuranose-containing molecules. Design of Galactofuranosyl acceptors
Marino, María Carla
Carbohydrates
Galactofuranose
Glycosylation
title_short Synthesis of D-Galactofuranose-containing molecules. Design of Galactofuranosyl acceptors
title_full Synthesis of D-Galactofuranose-containing molecules. Design of Galactofuranosyl acceptors
title_fullStr Synthesis of D-Galactofuranose-containing molecules. Design of Galactofuranosyl acceptors
title_full_unstemmed Synthesis of D-Galactofuranose-containing molecules. Design of Galactofuranosyl acceptors
title_sort Synthesis of D-Galactofuranose-containing molecules. Design of Galactofuranosyl acceptors
dc.creator.none.fl_str_mv Marino, María Carla
Baldoni, Luciana
author Marino, María Carla
author_facet Marino, María Carla
Baldoni, Luciana
author_role author
author2 Baldoni, Luciana
author2_role author
dc.subject.none.fl_str_mv Carbohydrates
Galactofuranose
Glycosylation
topic Carbohydrates
Galactofuranose
Glycosylation
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv D-Galactofuranose (D-Galf) is present in glycoconjugates of several pathogenic microorganisms but is absent in mammals, so it is a good target for the development of chemotherapeutic agents for the treatment of microbial infections. This fact has improved the interest in the synthesis of D-Galf-containing molecules for the corresponding glycobiological studies. The synthesis of oligosaccharides, glycoconjugates and mimetics of D-Galf requires specific methods for the preparation of galactose derivatives in the furanosic configuration, the synthesis of appropriate acceptors and efficient glycosylation methods for the construction of the alpha- and beta-D-Galf linkages. This review summarizes the different strategies developed for the preparation of partially protected derivatives of D-Galf, suitable as acceptors for the construction of (1,2), (1,3), (1,5) and (1,6) linkages, and describes recent applications.
Fil: Marino, María Carla. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono; Argentina
Fil: Baldoni, Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono; Argentina
description D-Galactofuranose (D-Galf) is present in glycoconjugates of several pathogenic microorganisms but is absent in mammals, so it is a good target for the development of chemotherapeutic agents for the treatment of microbial infections. This fact has improved the interest in the synthesis of D-Galf-containing molecules for the corresponding glycobiological studies. The synthesis of oligosaccharides, glycoconjugates and mimetics of D-Galf requires specific methods for the preparation of galactose derivatives in the furanosic configuration, the synthesis of appropriate acceptors and efficient glycosylation methods for the construction of the alpha- and beta-D-Galf linkages. This review summarizes the different strategies developed for the preparation of partially protected derivatives of D-Galf, suitable as acceptors for the construction of (1,2), (1,3), (1,5) and (1,6) linkages, and describes recent applications.
publishDate 2014
dc.date.none.fl_str_mv 2014-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/8160
Marino, María Carla; Baldoni, Luciana; Synthesis of D-Galactofuranose-containing molecules. Design of Galactofuranosyl acceptors; Wiley; Chembiochem; 15; 2-2014; 188-204
1439-4227
url http://hdl.handle.net/11336/8160
identifier_str_mv Marino, María Carla; Baldoni, Luciana; Synthesis of D-Galactofuranose-containing molecules. Design of Galactofuranosyl acceptors; Wiley; Chembiochem; 15; 2-2014; 188-204
1439-4227
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/cbic.201300638/abstract
info:eu-repo/semantics/altIdentifier/doi/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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