Proteomics, oxidative stress and male infertility

Autores
Agarwal, Ashok; Durairajanayagam, Damayanthi; Halabi, Jacques; Peng, Jason; Vazquez, Monica Hebe
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Oxidative stress has been established as one of the main causes of male infertility and has been implicated in many diseases associated with infertile men. It results from high concentrations of free radicals and suppressed antioxidant potential, which may alter protein expression in seminal plasma and/or spermatozoa. In recent years, proteomic analyses have been performed to characterize the protein profiles of seminal ejaculate from men with different clinical conditions, such as high oxidative stress. The aim of the present review is to summarize current findings on proteomic studies performed in men with high oxidative stress compared with those with physiological concentrations of free radicals, to better understand the aetiology of oxidative stress-induced male infertility. Each of these studies has suggested candidate biomarkers of oxidative stress, among them are DJ-1, PIP, lactotransferrin and peroxiredoxin. Changes in protein concentrations in seminal plasma samples with oxidative stress conditions were related to stress responses and to regulatory pathways, while alterations in sperm proteins were mostly associated to metabolic responses (carbohydrate metabolism) and stress responses. Future studies should include assessment of post-translational modifications in the spermatozoa as well as in seminal plasma proteomes of men diagnosed with idiopathic infertility.
Fil: Agarwal, Ashok. Center for Reproductive Medicine. Cleveland Clinic. Glickman Urological and Kidney Institute; Estados Unidos
Fil: Durairajanayagam, Damayanthi . Center for Reproductive Medicine. Cleveland Clinic. Glickman Urological and Kidney Institute; Estados Unidos. MARA University of Technology. Faculty of Medicine; Malasia
Fil: Halabi, Jacques. Center for Reproductive Medicine. Cleveland Clinic. Glickman Urological and Kidney Institute; Estados Unidos
Fil: Peng, Jason. Center for Reproductive Medicine. Cleveland Clinic. Glickman Urological and Kidney Institute; Estados Unidos
Fil: Vazquez, Monica Hebe. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Materia
Biomarkers
Male Infertility
Proteomics
Oxidative Stress
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/6444

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spelling Proteomics, oxidative stress and male infertilityAgarwal, AshokDurairajanayagam, Damayanthi Halabi, JacquesPeng, JasonVazquez, Monica HebeBiomarkersMale InfertilityProteomicsOxidative Stresshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Oxidative stress has been established as one of the main causes of male infertility and has been implicated in many diseases associated with infertile men. It results from high concentrations of free radicals and suppressed antioxidant potential, which may alter protein expression in seminal plasma and/or spermatozoa. In recent years, proteomic analyses have been performed to characterize the protein profiles of seminal ejaculate from men with different clinical conditions, such as high oxidative stress. The aim of the present review is to summarize current findings on proteomic studies performed in men with high oxidative stress compared with those with physiological concentrations of free radicals, to better understand the aetiology of oxidative stress-induced male infertility. Each of these studies has suggested candidate biomarkers of oxidative stress, among them are DJ-1, PIP, lactotransferrin and peroxiredoxin. Changes in protein concentrations in seminal plasma samples with oxidative stress conditions were related to stress responses and to regulatory pathways, while alterations in sperm proteins were mostly associated to metabolic responses (carbohydrate metabolism) and stress responses. Future studies should include assessment of post-translational modifications in the spermatozoa as well as in seminal plasma proteomes of men diagnosed with idiopathic infertility.Fil: Agarwal, Ashok. Center for Reproductive Medicine. Cleveland Clinic. Glickman Urological and Kidney Institute; Estados UnidosFil: Durairajanayagam, Damayanthi . Center for Reproductive Medicine. Cleveland Clinic. Glickman Urological and Kidney Institute; Estados Unidos. MARA University of Technology. Faculty of Medicine; MalasiaFil: Halabi, Jacques. Center for Reproductive Medicine. Cleveland Clinic. Glickman Urological and Kidney Institute; Estados UnidosFil: Peng, Jason. Center for Reproductive Medicine. Cleveland Clinic. Glickman Urological and Kidney Institute; Estados UnidosFil: Vazquez, Monica Hebe. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaElsevier2014-03-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/6444Agarwal, Ashok; Durairajanayagam, Damayanthi ; Halabi, Jacques; Peng, Jason; Vazquez, Monica Hebe; Proteomics, oxidative stress and male infertility; Elsevier; Reproductive Biomedicine Online; 29; 1; 12-3-2014; 32-581472-64831472-6491enginfo:eu-repo/semantics/altIdentifier/url/http://www.rbmojournal.com/article/S1472-6483(14)00130-8/abstractinfo:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/doi/10.1016/j.rbmo.2014.02.013info:eu-repo/semantics/altIdentifier/pmid/24813754info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1472648314001308info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:29:44Zoai:ri.conicet.gov.ar:11336/6444instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:29:44.835CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Proteomics, oxidative stress and male infertility
title Proteomics, oxidative stress and male infertility
spellingShingle Proteomics, oxidative stress and male infertility
Agarwal, Ashok
Biomarkers
Male Infertility
Proteomics
Oxidative Stress
title_short Proteomics, oxidative stress and male infertility
title_full Proteomics, oxidative stress and male infertility
title_fullStr Proteomics, oxidative stress and male infertility
title_full_unstemmed Proteomics, oxidative stress and male infertility
title_sort Proteomics, oxidative stress and male infertility
dc.creator.none.fl_str_mv Agarwal, Ashok
Durairajanayagam, Damayanthi
Halabi, Jacques
Peng, Jason
Vazquez, Monica Hebe
author Agarwal, Ashok
author_facet Agarwal, Ashok
Durairajanayagam, Damayanthi
Halabi, Jacques
Peng, Jason
Vazquez, Monica Hebe
author_role author
author2 Durairajanayagam, Damayanthi
Halabi, Jacques
Peng, Jason
Vazquez, Monica Hebe
author2_role author
author
author
author
dc.subject.none.fl_str_mv Biomarkers
Male Infertility
Proteomics
Oxidative Stress
topic Biomarkers
Male Infertility
Proteomics
Oxidative Stress
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Oxidative stress has been established as one of the main causes of male infertility and has been implicated in many diseases associated with infertile men. It results from high concentrations of free radicals and suppressed antioxidant potential, which may alter protein expression in seminal plasma and/or spermatozoa. In recent years, proteomic analyses have been performed to characterize the protein profiles of seminal ejaculate from men with different clinical conditions, such as high oxidative stress. The aim of the present review is to summarize current findings on proteomic studies performed in men with high oxidative stress compared with those with physiological concentrations of free radicals, to better understand the aetiology of oxidative stress-induced male infertility. Each of these studies has suggested candidate biomarkers of oxidative stress, among them are DJ-1, PIP, lactotransferrin and peroxiredoxin. Changes in protein concentrations in seminal plasma samples with oxidative stress conditions were related to stress responses and to regulatory pathways, while alterations in sperm proteins were mostly associated to metabolic responses (carbohydrate metabolism) and stress responses. Future studies should include assessment of post-translational modifications in the spermatozoa as well as in seminal plasma proteomes of men diagnosed with idiopathic infertility.
Fil: Agarwal, Ashok. Center for Reproductive Medicine. Cleveland Clinic. Glickman Urological and Kidney Institute; Estados Unidos
Fil: Durairajanayagam, Damayanthi . Center for Reproductive Medicine. Cleveland Clinic. Glickman Urological and Kidney Institute; Estados Unidos. MARA University of Technology. Faculty of Medicine; Malasia
Fil: Halabi, Jacques. Center for Reproductive Medicine. Cleveland Clinic. Glickman Urological and Kidney Institute; Estados Unidos
Fil: Peng, Jason. Center for Reproductive Medicine. Cleveland Clinic. Glickman Urological and Kidney Institute; Estados Unidos
Fil: Vazquez, Monica Hebe. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
description Oxidative stress has been established as one of the main causes of male infertility and has been implicated in many diseases associated with infertile men. It results from high concentrations of free radicals and suppressed antioxidant potential, which may alter protein expression in seminal plasma and/or spermatozoa. In recent years, proteomic analyses have been performed to characterize the protein profiles of seminal ejaculate from men with different clinical conditions, such as high oxidative stress. The aim of the present review is to summarize current findings on proteomic studies performed in men with high oxidative stress compared with those with physiological concentrations of free radicals, to better understand the aetiology of oxidative stress-induced male infertility. Each of these studies has suggested candidate biomarkers of oxidative stress, among them are DJ-1, PIP, lactotransferrin and peroxiredoxin. Changes in protein concentrations in seminal plasma samples with oxidative stress conditions were related to stress responses and to regulatory pathways, while alterations in sperm proteins were mostly associated to metabolic responses (carbohydrate metabolism) and stress responses. Future studies should include assessment of post-translational modifications in the spermatozoa as well as in seminal plasma proteomes of men diagnosed with idiopathic infertility.
publishDate 2014
dc.date.none.fl_str_mv 2014-03-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/6444
Agarwal, Ashok; Durairajanayagam, Damayanthi ; Halabi, Jacques; Peng, Jason; Vazquez, Monica Hebe; Proteomics, oxidative stress and male infertility; Elsevier; Reproductive Biomedicine Online; 29; 1; 12-3-2014; 32-58
1472-6483
1472-6491
url http://hdl.handle.net/11336/6444
identifier_str_mv Agarwal, Ashok; Durairajanayagam, Damayanthi ; Halabi, Jacques; Peng, Jason; Vazquez, Monica Hebe; Proteomics, oxidative stress and male infertility; Elsevier; Reproductive Biomedicine Online; 29; 1; 12-3-2014; 32-58
1472-6483
1472-6491
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.rbmojournal.com/article/S1472-6483(14)00130-8/abstract
info:eu-repo/semantics/altIdentifier/doi/
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.rbmo.2014.02.013
info:eu-repo/semantics/altIdentifier/pmid/24813754
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1472648314001308
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
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