Proteomics, oxidative stress and male infertility
- Autores
- Agarwal, Ashok; Durairajanayagam, Damayanthi; Halabi, Jacques; Peng, Jason; Vazquez, Monica Hebe
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Oxidative stress has been established as one of the main causes of male infertility and has been implicated in many diseases associated with infertile men. It results from high concentrations of free radicals and suppressed antioxidant potential, which may alter protein expression in seminal plasma and/or spermatozoa. In recent years, proteomic analyses have been performed to characterize the protein profiles of seminal ejaculate from men with different clinical conditions, such as high oxidative stress. The aim of the present review is to summarize current findings on proteomic studies performed in men with high oxidative stress compared with those with physiological concentrations of free radicals, to better understand the aetiology of oxidative stress-induced male infertility. Each of these studies has suggested candidate biomarkers of oxidative stress, among them are DJ-1, PIP, lactotransferrin and peroxiredoxin. Changes in protein concentrations in seminal plasma samples with oxidative stress conditions were related to stress responses and to regulatory pathways, while alterations in sperm proteins were mostly associated to metabolic responses (carbohydrate metabolism) and stress responses. Future studies should include assessment of post-translational modifications in the spermatozoa as well as in seminal plasma proteomes of men diagnosed with idiopathic infertility.
Fil: Agarwal, Ashok. Center for Reproductive Medicine. Cleveland Clinic. Glickman Urological and Kidney Institute; Estados Unidos
Fil: Durairajanayagam, Damayanthi . Center for Reproductive Medicine. Cleveland Clinic. Glickman Urological and Kidney Institute; Estados Unidos. MARA University of Technology. Faculty of Medicine; Malasia
Fil: Halabi, Jacques. Center for Reproductive Medicine. Cleveland Clinic. Glickman Urological and Kidney Institute; Estados Unidos
Fil: Peng, Jason. Center for Reproductive Medicine. Cleveland Clinic. Glickman Urological and Kidney Institute; Estados Unidos
Fil: Vazquez, Monica Hebe. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina - Materia
-
Biomarkers
Male Infertility
Proteomics
Oxidative Stress - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/6444
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Proteomics, oxidative stress and male infertilityAgarwal, AshokDurairajanayagam, Damayanthi Halabi, JacquesPeng, JasonVazquez, Monica HebeBiomarkersMale InfertilityProteomicsOxidative Stresshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Oxidative stress has been established as one of the main causes of male infertility and has been implicated in many diseases associated with infertile men. It results from high concentrations of free radicals and suppressed antioxidant potential, which may alter protein expression in seminal plasma and/or spermatozoa. In recent years, proteomic analyses have been performed to characterize the protein profiles of seminal ejaculate from men with different clinical conditions, such as high oxidative stress. The aim of the present review is to summarize current findings on proteomic studies performed in men with high oxidative stress compared with those with physiological concentrations of free radicals, to better understand the aetiology of oxidative stress-induced male infertility. Each of these studies has suggested candidate biomarkers of oxidative stress, among them are DJ-1, PIP, lactotransferrin and peroxiredoxin. Changes in protein concentrations in seminal plasma samples with oxidative stress conditions were related to stress responses and to regulatory pathways, while alterations in sperm proteins were mostly associated to metabolic responses (carbohydrate metabolism) and stress responses. Future studies should include assessment of post-translational modifications in the spermatozoa as well as in seminal plasma proteomes of men diagnosed with idiopathic infertility.Fil: Agarwal, Ashok. Center for Reproductive Medicine. Cleveland Clinic. Glickman Urological and Kidney Institute; Estados UnidosFil: Durairajanayagam, Damayanthi . Center for Reproductive Medicine. Cleveland Clinic. Glickman Urological and Kidney Institute; Estados Unidos. MARA University of Technology. Faculty of Medicine; MalasiaFil: Halabi, Jacques. Center for Reproductive Medicine. Cleveland Clinic. Glickman Urological and Kidney Institute; Estados UnidosFil: Peng, Jason. Center for Reproductive Medicine. Cleveland Clinic. Glickman Urological and Kidney Institute; Estados UnidosFil: Vazquez, Monica Hebe. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaElsevier2014-03-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/6444Agarwal, Ashok; Durairajanayagam, Damayanthi ; Halabi, Jacques; Peng, Jason; Vazquez, Monica Hebe; Proteomics, oxidative stress and male infertility; Elsevier; Reproductive Biomedicine Online; 29; 1; 12-3-2014; 32-581472-64831472-6491enginfo:eu-repo/semantics/altIdentifier/url/http://www.rbmojournal.com/article/S1472-6483(14)00130-8/abstractinfo:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/doi/10.1016/j.rbmo.2014.02.013info:eu-repo/semantics/altIdentifier/pmid/24813754info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1472648314001308info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:29:44Zoai:ri.conicet.gov.ar:11336/6444instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:29:44.835CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Proteomics, oxidative stress and male infertility |
title |
Proteomics, oxidative stress and male infertility |
spellingShingle |
Proteomics, oxidative stress and male infertility Agarwal, Ashok Biomarkers Male Infertility Proteomics Oxidative Stress |
title_short |
Proteomics, oxidative stress and male infertility |
title_full |
Proteomics, oxidative stress and male infertility |
title_fullStr |
Proteomics, oxidative stress and male infertility |
title_full_unstemmed |
Proteomics, oxidative stress and male infertility |
title_sort |
Proteomics, oxidative stress and male infertility |
dc.creator.none.fl_str_mv |
Agarwal, Ashok Durairajanayagam, Damayanthi Halabi, Jacques Peng, Jason Vazquez, Monica Hebe |
author |
Agarwal, Ashok |
author_facet |
Agarwal, Ashok Durairajanayagam, Damayanthi Halabi, Jacques Peng, Jason Vazquez, Monica Hebe |
author_role |
author |
author2 |
Durairajanayagam, Damayanthi Halabi, Jacques Peng, Jason Vazquez, Monica Hebe |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
Biomarkers Male Infertility Proteomics Oxidative Stress |
topic |
Biomarkers Male Infertility Proteomics Oxidative Stress |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Oxidative stress has been established as one of the main causes of male infertility and has been implicated in many diseases associated with infertile men. It results from high concentrations of free radicals and suppressed antioxidant potential, which may alter protein expression in seminal plasma and/or spermatozoa. In recent years, proteomic analyses have been performed to characterize the protein profiles of seminal ejaculate from men with different clinical conditions, such as high oxidative stress. The aim of the present review is to summarize current findings on proteomic studies performed in men with high oxidative stress compared with those with physiological concentrations of free radicals, to better understand the aetiology of oxidative stress-induced male infertility. Each of these studies has suggested candidate biomarkers of oxidative stress, among them are DJ-1, PIP, lactotransferrin and peroxiredoxin. Changes in protein concentrations in seminal plasma samples with oxidative stress conditions were related to stress responses and to regulatory pathways, while alterations in sperm proteins were mostly associated to metabolic responses (carbohydrate metabolism) and stress responses. Future studies should include assessment of post-translational modifications in the spermatozoa as well as in seminal plasma proteomes of men diagnosed with idiopathic infertility. Fil: Agarwal, Ashok. Center for Reproductive Medicine. Cleveland Clinic. Glickman Urological and Kidney Institute; Estados Unidos Fil: Durairajanayagam, Damayanthi . Center for Reproductive Medicine. Cleveland Clinic. Glickman Urological and Kidney Institute; Estados Unidos. MARA University of Technology. Faculty of Medicine; Malasia Fil: Halabi, Jacques. Center for Reproductive Medicine. Cleveland Clinic. Glickman Urological and Kidney Institute; Estados Unidos Fil: Peng, Jason. Center for Reproductive Medicine. Cleveland Clinic. Glickman Urological and Kidney Institute; Estados Unidos Fil: Vazquez, Monica Hebe. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina |
description |
Oxidative stress has been established as one of the main causes of male infertility and has been implicated in many diseases associated with infertile men. It results from high concentrations of free radicals and suppressed antioxidant potential, which may alter protein expression in seminal plasma and/or spermatozoa. In recent years, proteomic analyses have been performed to characterize the protein profiles of seminal ejaculate from men with different clinical conditions, such as high oxidative stress. The aim of the present review is to summarize current findings on proteomic studies performed in men with high oxidative stress compared with those with physiological concentrations of free radicals, to better understand the aetiology of oxidative stress-induced male infertility. Each of these studies has suggested candidate biomarkers of oxidative stress, among them are DJ-1, PIP, lactotransferrin and peroxiredoxin. Changes in protein concentrations in seminal plasma samples with oxidative stress conditions were related to stress responses and to regulatory pathways, while alterations in sperm proteins were mostly associated to metabolic responses (carbohydrate metabolism) and stress responses. Future studies should include assessment of post-translational modifications in the spermatozoa as well as in seminal plasma proteomes of men diagnosed with idiopathic infertility. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-03-12 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/6444 Agarwal, Ashok; Durairajanayagam, Damayanthi ; Halabi, Jacques; Peng, Jason; Vazquez, Monica Hebe; Proteomics, oxidative stress and male infertility; Elsevier; Reproductive Biomedicine Online; 29; 1; 12-3-2014; 32-58 1472-6483 1472-6491 |
url |
http://hdl.handle.net/11336/6444 |
identifier_str_mv |
Agarwal, Ashok; Durairajanayagam, Damayanthi ; Halabi, Jacques; Peng, Jason; Vazquez, Monica Hebe; Proteomics, oxidative stress and male infertility; Elsevier; Reproductive Biomedicine Online; 29; 1; 12-3-2014; 32-58 1472-6483 1472-6491 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://www.rbmojournal.com/article/S1472-6483(14)00130-8/abstract info:eu-repo/semantics/altIdentifier/doi/ info:eu-repo/semantics/altIdentifier/doi/10.1016/j.rbmo.2014.02.013 info:eu-repo/semantics/altIdentifier/pmid/24813754 info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1472648314001308 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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