Host macrocyclic acylcarnitines mediate symbiotic interactions between frogs and their skin microbiome

Autores
Brunetti, Andrés Eduardo; Lucio Lyra, Mariana; Bauermeister, Anelize; Bunk, Boyke; Boedeker, Christian; Müsken, Mathias; Carnevale Neto, Fausto; Mendonca, Jacqueline Nakau; Caraballo Rodríguez, Andrés Mauricio; Melo, Weilan G. P.; Pupo, Mónica T.; Haddad, Célio F. B.; Cabrera, Gabriela Myriam; Overmann, Jörg; Peporine Lopes, Norberto
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The host-microbiome associations occurring on the skin of vertebrates significantly influence hosts’health. However, the factors mediating their interactions remain largely unknown. Herein, we used integrated technical and ecological frameworks to investigate the skin metabolites sustaining a beneficialsymbiosis between tree frogs and bacteria. We characterize macrocyclic acylcarnitines as the major metabolites secreted by the frogs’ skin and trace their origin to an enzymatic unbalance of carnitine palmitoyltransferases. We found that these compounds colocalize with bacteria on the skin surface and aremostly represented by members of the Pseudomonas community. We showed that Pseudomonas sp.MPFS isolated from frogs’ skin can exploit acylcarnitines as its sole carbon and nitrogen source, andthis metabolic capability is widespread in Pseudomonas. We summarize frogs’ multiple mechanisms to filter environmental bacteria and highlight that acylcarnitines likely evolved for another function but wereco-opted to provide nutritional benefits to the symbionts
Fil: Brunetti, Andrés Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Universidad Nacional de Misiones. Instituto de Biología Subtropical; Argentina. Universidade de Sao Paulo; Brasil. Max Planck Institute for Chemical Ecology; Alemania
Fil: Lucio Lyra, Mariana. New York University Abu Dhabi; Arabia Saudita
Fil: Bauermeister, Anelize. Universidade de Sao Paulo; Brasil
Fil: Bunk, Boyke. Leibniz - Institute of Freshwater Ecology and Inland Fisheries; Alemania
Fil: Boedeker, Christian. Leibniz - Institute of Freshwater Ecology and Inland Fisheries; Alemania
Fil: Müsken, Mathias. Helmholtz Centre For Infection Research; Alemania
Fil: Carnevale Neto, Fausto. University of Washington; Estados Unidos
Fil: Mendonca, Jacqueline Nakau. Universidade de Sao Paulo; Brasil
Fil: Caraballo Rodríguez, Andrés Mauricio. University of California at San Diego; Estados Unidos
Fil: Melo, Weilan G. P.. Universidade de Sao Paulo; Brasil
Fil: Pupo, Mónica T.. Universidade de Sao Paulo; Brasil
Fil: Haddad, Célio F. B.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Cabrera, Gabriela Myriam. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad de Microanálisis y Métodos Físicos en Química Orgánica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Unidad de Microanálisis y Métodos Físicos en Química Orgánica; Argentina
Fil: Overmann, Jörg. Leibniz Institute For Zoo And Wildlife Research.; Alemania
Fil: Peporine Lopes, Norberto. Universidade de Sao Paulo; Brasil
Materia
ACYLCARNITINES
FROGS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/228613
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/228613
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Host macrocyclic acylcarnitines mediate symbiotic interactions between frogs and their skin microbiomeBrunetti, Andrés EduardoLucio Lyra, MarianaBauermeister, AnelizeBunk, BoykeBoedeker, ChristianMüsken, MathiasCarnevale Neto, FaustoMendonca, Jacqueline NakauCaraballo Rodríguez, Andrés MauricioMelo, Weilan G. P.Pupo, Mónica T.Haddad, Célio F. B.Cabrera, Gabriela MyriamOvermann, JörgPeporine Lopes, NorbertoACYLCARNITINESFROGShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The host-microbiome associations occurring on the skin of vertebrates significantly influence hosts’health. However, the factors mediating their interactions remain largely unknown. Herein, we used integrated technical and ecological frameworks to investigate the skin metabolites sustaining a beneficialsymbiosis between tree frogs and bacteria. We characterize macrocyclic acylcarnitines as the major metabolites secreted by the frogs’ skin and trace their origin to an enzymatic unbalance of carnitine palmitoyltransferases. We found that these compounds colocalize with bacteria on the skin surface and aremostly represented by members of the Pseudomonas community. We showed that Pseudomonas sp.MPFS isolated from frogs’ skin can exploit acylcarnitines as its sole carbon and nitrogen source, andthis metabolic capability is widespread in Pseudomonas. We summarize frogs’ multiple mechanisms to filter environmental bacteria and highlight that acylcarnitines likely evolved for another function but wereco-opted to provide nutritional benefits to the symbiontsFil: Brunetti, Andrés Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Universidad Nacional de Misiones. Instituto de Biología Subtropical; Argentina. Universidade de Sao Paulo; Brasil. Max Planck Institute for Chemical Ecology; AlemaniaFil: Lucio Lyra, Mariana. New York University Abu Dhabi; Arabia SauditaFil: Bauermeister, Anelize. Universidade de Sao Paulo; BrasilFil: Bunk, Boyke. Leibniz - Institute of Freshwater Ecology and Inland Fisheries; AlemaniaFil: Boedeker, Christian. Leibniz - Institute of Freshwater Ecology and Inland Fisheries; AlemaniaFil: Müsken, Mathias. Helmholtz Centre For Infection Research; AlemaniaFil: Carnevale Neto, Fausto. University of Washington; Estados UnidosFil: Mendonca, Jacqueline Nakau. Universidade de Sao Paulo; BrasilFil: Caraballo Rodríguez, Andrés Mauricio. University of California at San Diego; Estados UnidosFil: Melo, Weilan G. P.. Universidade de Sao Paulo; BrasilFil: Pupo, Mónica T.. Universidade de Sao Paulo; BrasilFil: Haddad, Célio F. B.. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Cabrera, Gabriela Myriam. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad de Microanálisis y Métodos Físicos en Química Orgánica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Unidad de Microanálisis y Métodos Físicos en Química Orgánica; ArgentinaFil: Overmann, Jörg. Leibniz Institute For Zoo And Wildlife Research.; AlemaniaFil: Peporine Lopes, Norberto. Universidade de Sao Paulo; BrasilCell Press2023-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/228613Brunetti, Andrés Eduardo; Lucio Lyra, Mariana; Bauermeister, Anelize; Bunk, Boyke; Boedeker, Christian; et al.; Host macrocyclic acylcarnitines mediate symbiotic interactions between frogs and their skin microbiome; Cell Press; IScience; 26; 11; 10-2023; 1-202589-0042CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/ j.isci.2023.108109info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10587524/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:58:43Zoai:ri.conicet.gov.ar:11336/228613instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:58:43.382CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Host macrocyclic acylcarnitines mediate symbiotic interactions between frogs and their skin microbiome
title Host macrocyclic acylcarnitines mediate symbiotic interactions between frogs and their skin microbiome
spellingShingle Host macrocyclic acylcarnitines mediate symbiotic interactions between frogs and their skin microbiome
Brunetti, Andrés Eduardo
ACYLCARNITINES
FROGS
title_short Host macrocyclic acylcarnitines mediate symbiotic interactions between frogs and their skin microbiome
title_full Host macrocyclic acylcarnitines mediate symbiotic interactions between frogs and their skin microbiome
title_fullStr Host macrocyclic acylcarnitines mediate symbiotic interactions between frogs and their skin microbiome
title_full_unstemmed Host macrocyclic acylcarnitines mediate symbiotic interactions between frogs and their skin microbiome
title_sort Host macrocyclic acylcarnitines mediate symbiotic interactions between frogs and their skin microbiome
dc.creator.none.fl_str_mv Brunetti, Andrés Eduardo
Lucio Lyra, Mariana
Bauermeister, Anelize
Bunk, Boyke
Boedeker, Christian
Müsken, Mathias
Carnevale Neto, Fausto
Mendonca, Jacqueline Nakau
Caraballo Rodríguez, Andrés Mauricio
Melo, Weilan G. P.
Pupo, Mónica T.
Haddad, Célio F. B.
Cabrera, Gabriela Myriam
Overmann, Jörg
Peporine Lopes, Norberto
author Brunetti, Andrés Eduardo
author_facet Brunetti, Andrés Eduardo
Lucio Lyra, Mariana
Bauermeister, Anelize
Bunk, Boyke
Boedeker, Christian
Müsken, Mathias
Carnevale Neto, Fausto
Mendonca, Jacqueline Nakau
Caraballo Rodríguez, Andrés Mauricio
Melo, Weilan G. P.
Pupo, Mónica T.
Haddad, Célio F. B.
Cabrera, Gabriela Myriam
Overmann, Jörg
Peporine Lopes, Norberto
author_role author
author2 Lucio Lyra, Mariana
Bauermeister, Anelize
Bunk, Boyke
Boedeker, Christian
Müsken, Mathias
Carnevale Neto, Fausto
Mendonca, Jacqueline Nakau
Caraballo Rodríguez, Andrés Mauricio
Melo, Weilan G. P.
Pupo, Mónica T.
Haddad, Célio F. B.
Cabrera, Gabriela Myriam
Overmann, Jörg
Peporine Lopes, Norberto
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ACYLCARNITINES
FROGS
topic ACYLCARNITINES
FROGS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The host-microbiome associations occurring on the skin of vertebrates significantly influence hosts’health. However, the factors mediating their interactions remain largely unknown. Herein, we used integrated technical and ecological frameworks to investigate the skin metabolites sustaining a beneficialsymbiosis between tree frogs and bacteria. We characterize macrocyclic acylcarnitines as the major metabolites secreted by the frogs’ skin and trace their origin to an enzymatic unbalance of carnitine palmitoyltransferases. We found that these compounds colocalize with bacteria on the skin surface and aremostly represented by members of the Pseudomonas community. We showed that Pseudomonas sp.MPFS isolated from frogs’ skin can exploit acylcarnitines as its sole carbon and nitrogen source, andthis metabolic capability is widespread in Pseudomonas. We summarize frogs’ multiple mechanisms to filter environmental bacteria and highlight that acylcarnitines likely evolved for another function but wereco-opted to provide nutritional benefits to the symbionts
Fil: Brunetti, Andrés Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Universidad Nacional de Misiones. Instituto de Biología Subtropical; Argentina. Universidade de Sao Paulo; Brasil. Max Planck Institute for Chemical Ecology; Alemania
Fil: Lucio Lyra, Mariana. New York University Abu Dhabi; Arabia Saudita
Fil: Bauermeister, Anelize. Universidade de Sao Paulo; Brasil
Fil: Bunk, Boyke. Leibniz - Institute of Freshwater Ecology and Inland Fisheries; Alemania
Fil: Boedeker, Christian. Leibniz - Institute of Freshwater Ecology and Inland Fisheries; Alemania
Fil: Müsken, Mathias. Helmholtz Centre For Infection Research; Alemania
Fil: Carnevale Neto, Fausto. University of Washington; Estados Unidos
Fil: Mendonca, Jacqueline Nakau. Universidade de Sao Paulo; Brasil
Fil: Caraballo Rodríguez, Andrés Mauricio. University of California at San Diego; Estados Unidos
Fil: Melo, Weilan G. P.. Universidade de Sao Paulo; Brasil
Fil: Pupo, Mónica T.. Universidade de Sao Paulo; Brasil
Fil: Haddad, Célio F. B.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Cabrera, Gabriela Myriam. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad de Microanálisis y Métodos Físicos en Química Orgánica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Unidad de Microanálisis y Métodos Físicos en Química Orgánica; Argentina
Fil: Overmann, Jörg. Leibniz Institute For Zoo And Wildlife Research.; Alemania
Fil: Peporine Lopes, Norberto. Universidade de Sao Paulo; Brasil
description The host-microbiome associations occurring on the skin of vertebrates significantly influence hosts’health. However, the factors mediating their interactions remain largely unknown. Herein, we used integrated technical and ecological frameworks to investigate the skin metabolites sustaining a beneficialsymbiosis between tree frogs and bacteria. We characterize macrocyclic acylcarnitines as the major metabolites secreted by the frogs’ skin and trace their origin to an enzymatic unbalance of carnitine palmitoyltransferases. We found that these compounds colocalize with bacteria on the skin surface and aremostly represented by members of the Pseudomonas community. We showed that Pseudomonas sp.MPFS isolated from frogs’ skin can exploit acylcarnitines as its sole carbon and nitrogen source, andthis metabolic capability is widespread in Pseudomonas. We summarize frogs’ multiple mechanisms to filter environmental bacteria and highlight that acylcarnitines likely evolved for another function but wereco-opted to provide nutritional benefits to the symbionts
publishDate 2023
dc.date.none.fl_str_mv 2023-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/228613
Brunetti, Andrés Eduardo; Lucio Lyra, Mariana; Bauermeister, Anelize; Bunk, Boyke; Boedeker, Christian; et al.; Host macrocyclic acylcarnitines mediate symbiotic interactions between frogs and their skin microbiome; Cell Press; IScience; 26; 11; 10-2023; 1-20
2589-0042
CONICET Digital
CONICET
url http://hdl.handle.net/11336/228613
identifier_str_mv Brunetti, Andrés Eduardo; Lucio Lyra, Mariana; Bauermeister, Anelize; Bunk, Boyke; Boedeker, Christian; et al.; Host macrocyclic acylcarnitines mediate symbiotic interactions between frogs and their skin microbiome; Cell Press; IScience; 26; 11; 10-2023; 1-20
2589-0042
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/ j.isci.2023.108109
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10587524/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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