Role of hormonal circuitry upon T cell development in Chagas disease: Possible implications on T cell dysfunctions

Autores
Perez, Ana Rosa; Morrot, Alexandre; Carvalho, Vinicius Frias; de Meis, Juliana; Savino, Wilson
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
T cell response plays an essential role in the host resistance to infection by the protozoan parasite Trypanosoma cruzi, the causative agent of Chagas disease. This infection is often associated with multiple manifestations of T cell dysfunction, both during the acute and the chronic phases of disease. Additionally, the normal development of T cells is affected. As seen in animal models of Chagas disease, there is a strong thymic atrophy due to massive death of CD4+CD8+ double-positive cells by apoptosis and an abnormal escape of immature and potentially autoreactive thymocytes from the organ. Furthermore, an increase in the release of corticosterone triggered by T. cruzi-driven systemic inflammation is strongly associated with the alterations seen in the thymus of infected animals. Moreover, changes in the levels of other hormones, including growth hormone, prolactin, and testosterone are also able to contribute to the disruption of thymic homeostasis secondary to T. cruzi infection. In this review, we discuss the role of hormonal circuits involved in the normal T cell development and trafficking, as well as their role on the thymic alterations likely related to the peripheral T cell disturbances largely reported in both chagasic patients and animal models of Chagas disease.
Fil: Perez, Ana Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina
Fil: Morrot, Alexandre. Fundación Oswaldo Cruz; Brasil. Universidade Federal do Rio de Janeiro; Brasil
Fil: Carvalho, Vinicius Frias. Fundación Oswaldo Cruz; Brasil
Fil: de Meis, Juliana. Fundación Oswaldo Cruz; Brasil
Fil: Savino, Wilson. Fundación Oswaldo Cruz; Brasil
Materia
CHAGAS DISEASE
GROWTH HORMONE
HYPOTHALAMUS-PITUITARY-ADRENAL AXIS
PROLACTIN
THYMOCYTES
THYMUS ATROPHY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/91519
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Role of hormonal circuitry upon T cell development in Chagas disease: Possible implications on T cell dysfunctionsPerez, Ana RosaMorrot, AlexandreCarvalho, Vinicius Friasde Meis, JulianaSavino, WilsonCHAGAS DISEASEGROWTH HORMONEHYPOTHALAMUS-PITUITARY-ADRENAL AXISPROLACTINTHYMOCYTESTHYMUS ATROPHYhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3T cell response plays an essential role in the host resistance to infection by the protozoan parasite Trypanosoma cruzi, the causative agent of Chagas disease. This infection is often associated with multiple manifestations of T cell dysfunction, both during the acute and the chronic phases of disease. Additionally, the normal development of T cells is affected. As seen in animal models of Chagas disease, there is a strong thymic atrophy due to massive death of CD4+CD8+ double-positive cells by apoptosis and an abnormal escape of immature and potentially autoreactive thymocytes from the organ. Furthermore, an increase in the release of corticosterone triggered by T. cruzi-driven systemic inflammation is strongly associated with the alterations seen in the thymus of infected animals. Moreover, changes in the levels of other hormones, including growth hormone, prolactin, and testosterone are also able to contribute to the disruption of thymic homeostasis secondary to T. cruzi infection. In this review, we discuss the role of hormonal circuits involved in the normal T cell development and trafficking, as well as their role on the thymic alterations likely related to the peripheral T cell disturbances largely reported in both chagasic patients and animal models of Chagas disease.Fil: Perez, Ana Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; ArgentinaFil: Morrot, Alexandre. Fundación Oswaldo Cruz; Brasil. Universidade Federal do Rio de Janeiro; BrasilFil: Carvalho, Vinicius Frias. Fundación Oswaldo Cruz; BrasilFil: de Meis, Juliana. Fundación Oswaldo Cruz; BrasilFil: Savino, Wilson. Fundación Oswaldo Cruz; BrasilFrontiers Research Foundation2018-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/91519Perez, Ana Rosa; Morrot, Alexandre; Carvalho, Vinicius Frias; de Meis, Juliana; Savino, Wilson; Role of hormonal circuitry upon T cell development in Chagas disease: Possible implications on T cell dysfunctions; Frontiers Research Foundation; Frontiers in endocrinology; 9; JUN; 6-2018; 1-81664-2392CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/article/10.3389/fendo.2018.00334/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fendo.2018.00334info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:37:32Zoai:ri.conicet.gov.ar:11336/91519instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:37:32.849CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Role of hormonal circuitry upon T cell development in Chagas disease: Possible implications on T cell dysfunctions
title Role of hormonal circuitry upon T cell development in Chagas disease: Possible implications on T cell dysfunctions
spellingShingle Role of hormonal circuitry upon T cell development in Chagas disease: Possible implications on T cell dysfunctions
Perez, Ana Rosa
CHAGAS DISEASE
GROWTH HORMONE
HYPOTHALAMUS-PITUITARY-ADRENAL AXIS
PROLACTIN
THYMOCYTES
THYMUS ATROPHY
title_short Role of hormonal circuitry upon T cell development in Chagas disease: Possible implications on T cell dysfunctions
title_full Role of hormonal circuitry upon T cell development in Chagas disease: Possible implications on T cell dysfunctions
title_fullStr Role of hormonal circuitry upon T cell development in Chagas disease: Possible implications on T cell dysfunctions
title_full_unstemmed Role of hormonal circuitry upon T cell development in Chagas disease: Possible implications on T cell dysfunctions
title_sort Role of hormonal circuitry upon T cell development in Chagas disease: Possible implications on T cell dysfunctions
dc.creator.none.fl_str_mv Perez, Ana Rosa
Morrot, Alexandre
Carvalho, Vinicius Frias
de Meis, Juliana
Savino, Wilson
author Perez, Ana Rosa
author_facet Perez, Ana Rosa
Morrot, Alexandre
Carvalho, Vinicius Frias
de Meis, Juliana
Savino, Wilson
author_role author
author2 Morrot, Alexandre
Carvalho, Vinicius Frias
de Meis, Juliana
Savino, Wilson
author2_role author
author
author
author
dc.subject.none.fl_str_mv CHAGAS DISEASE
GROWTH HORMONE
HYPOTHALAMUS-PITUITARY-ADRENAL AXIS
PROLACTIN
THYMOCYTES
THYMUS ATROPHY
topic CHAGAS DISEASE
GROWTH HORMONE
HYPOTHALAMUS-PITUITARY-ADRENAL AXIS
PROLACTIN
THYMOCYTES
THYMUS ATROPHY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv T cell response plays an essential role in the host resistance to infection by the protozoan parasite Trypanosoma cruzi, the causative agent of Chagas disease. This infection is often associated with multiple manifestations of T cell dysfunction, both during the acute and the chronic phases of disease. Additionally, the normal development of T cells is affected. As seen in animal models of Chagas disease, there is a strong thymic atrophy due to massive death of CD4+CD8+ double-positive cells by apoptosis and an abnormal escape of immature and potentially autoreactive thymocytes from the organ. Furthermore, an increase in the release of corticosterone triggered by T. cruzi-driven systemic inflammation is strongly associated with the alterations seen in the thymus of infected animals. Moreover, changes in the levels of other hormones, including growth hormone, prolactin, and testosterone are also able to contribute to the disruption of thymic homeostasis secondary to T. cruzi infection. In this review, we discuss the role of hormonal circuits involved in the normal T cell development and trafficking, as well as their role on the thymic alterations likely related to the peripheral T cell disturbances largely reported in both chagasic patients and animal models of Chagas disease.
Fil: Perez, Ana Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina
Fil: Morrot, Alexandre. Fundación Oswaldo Cruz; Brasil. Universidade Federal do Rio de Janeiro; Brasil
Fil: Carvalho, Vinicius Frias. Fundación Oswaldo Cruz; Brasil
Fil: de Meis, Juliana. Fundación Oswaldo Cruz; Brasil
Fil: Savino, Wilson. Fundación Oswaldo Cruz; Brasil
description T cell response plays an essential role in the host resistance to infection by the protozoan parasite Trypanosoma cruzi, the causative agent of Chagas disease. This infection is often associated with multiple manifestations of T cell dysfunction, both during the acute and the chronic phases of disease. Additionally, the normal development of T cells is affected. As seen in animal models of Chagas disease, there is a strong thymic atrophy due to massive death of CD4+CD8+ double-positive cells by apoptosis and an abnormal escape of immature and potentially autoreactive thymocytes from the organ. Furthermore, an increase in the release of corticosterone triggered by T. cruzi-driven systemic inflammation is strongly associated with the alterations seen in the thymus of infected animals. Moreover, changes in the levels of other hormones, including growth hormone, prolactin, and testosterone are also able to contribute to the disruption of thymic homeostasis secondary to T. cruzi infection. In this review, we discuss the role of hormonal circuits involved in the normal T cell development and trafficking, as well as their role on the thymic alterations likely related to the peripheral T cell disturbances largely reported in both chagasic patients and animal models of Chagas disease.
publishDate 2018
dc.date.none.fl_str_mv 2018-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/91519
Perez, Ana Rosa; Morrot, Alexandre; Carvalho, Vinicius Frias; de Meis, Juliana; Savino, Wilson; Role of hormonal circuitry upon T cell development in Chagas disease: Possible implications on T cell dysfunctions; Frontiers Research Foundation; Frontiers in endocrinology; 9; JUN; 6-2018; 1-8
1664-2392
CONICET Digital
CONICET
url http://hdl.handle.net/11336/91519
identifier_str_mv Perez, Ana Rosa; Morrot, Alexandre; Carvalho, Vinicius Frias; de Meis, Juliana; Savino, Wilson; Role of hormonal circuitry upon T cell development in Chagas disease: Possible implications on T cell dysfunctions; Frontiers Research Foundation; Frontiers in endocrinology; 9; JUN; 6-2018; 1-8
1664-2392
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/article/10.3389/fendo.2018.00334/full
info:eu-repo/semantics/altIdentifier/doi/10.3389/fendo.2018.00334
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Research Foundation
publisher.none.fl_str_mv Frontiers Research Foundation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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