Bradykinin and electrical stimulation increase prostaglandin production in the rat vas deferens

Autores
Peredo, Horacio Angel; Celuch, Stella Maris
Año de publicación
2001
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The epididymal portion of the rat vas deferens produced prostaglandins (PG) E2, F2αand 6-keto F1 α. Electrical stimulation (ES, 0.1 Hz, 1 ms) increased such production by 100%, and similar results were obtained in the presence of 1.0 μM bradykinin (Bk). When both stimuli were applied simultaneously, the increases in PG production were 1100% for PGE2, 800% for PGF2αand 400% for PG6-keto F1 α. Prazosin abolished the effect of ES on PG production. A selective Bk B2-receptor antagonist abolished the increase in PG production induced by Bk, both in non-stimulated and in ES tissues. Bk (1.0 μM) elicited contractile responses in non-stimulated as well as in ES tissues, responses that were not modified in the presence of 10 μM indomethacin. In conclusion, the effects of Bk on prostaglandin production appears to depend on the activation of B2receptors, while the increase in prostaglandin release induced by ES, and the effects observed with both stimuli simultaneously, should be mediated by the release of noradrenaline and the subsequent activation of α1adrenoceptors.
Fil: Peredo, Horacio Angel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. ININFA; Argentina
Fil: Celuch, Stella Maris. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. ININFA; Argentina
Materia
VAS DEFERENS
BRADYKININ
PROSTAGLANDINS
ELECTRICAL STIMULATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/93791
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/93791
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Bradykinin and electrical stimulation increase prostaglandin production in the rat vas deferensPeredo, Horacio AngelCeluch, Stella MarisVAS DEFERENSBRADYKININPROSTAGLANDINSELECTRICAL STIMULATIONhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The epididymal portion of the rat vas deferens produced prostaglandins (PG) E2, F2αand 6-keto F1 α. Electrical stimulation (ES, 0.1 Hz, 1 ms) increased such production by 100%, and similar results were obtained in the presence of 1.0 μM bradykinin (Bk). When both stimuli were applied simultaneously, the increases in PG production were 1100% for PGE2, 800% for PGF2αand 400% for PG6-keto F1 α. Prazosin abolished the effect of ES on PG production. A selective Bk B2-receptor antagonist abolished the increase in PG production induced by Bk, both in non-stimulated and in ES tissues. Bk (1.0 μM) elicited contractile responses in non-stimulated as well as in ES tissues, responses that were not modified in the presence of 10 μM indomethacin. In conclusion, the effects of Bk on prostaglandin production appears to depend on the activation of B2receptors, while the increase in prostaglandin release induced by ES, and the effects observed with both stimuli simultaneously, should be mediated by the release of noradrenaline and the subsequent activation of α1adrenoceptors.Fil: Peredo, Horacio Angel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. ININFA; ArgentinaFil: Celuch, Stella Maris. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. ININFA; ArgentinaElsevier2001-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/93791Peredo, Horacio Angel; Celuch, Stella Maris; Bradykinin and electrical stimulation increase prostaglandin production in the rat vas deferens; Elsevier; Prostaglandins Leukotrienes and Essential Fatty Acids; 65; 1; 7-2001; 9-140952-3278CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0952327801902807info:eu-repo/semantics/altIdentifier/doi/10.1054/plef.2001.0280info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:47:50Zoai:ri.conicet.gov.ar:11336/93791instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:47:50.429CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Bradykinin and electrical stimulation increase prostaglandin production in the rat vas deferens
title Bradykinin and electrical stimulation increase prostaglandin production in the rat vas deferens
spellingShingle Bradykinin and electrical stimulation increase prostaglandin production in the rat vas deferens
Peredo, Horacio Angel
VAS DEFERENS
BRADYKININ
PROSTAGLANDINS
ELECTRICAL STIMULATION
title_short Bradykinin and electrical stimulation increase prostaglandin production in the rat vas deferens
title_full Bradykinin and electrical stimulation increase prostaglandin production in the rat vas deferens
title_fullStr Bradykinin and electrical stimulation increase prostaglandin production in the rat vas deferens
title_full_unstemmed Bradykinin and electrical stimulation increase prostaglandin production in the rat vas deferens
title_sort Bradykinin and electrical stimulation increase prostaglandin production in the rat vas deferens
dc.creator.none.fl_str_mv Peredo, Horacio Angel
Celuch, Stella Maris
author Peredo, Horacio Angel
author_facet Peredo, Horacio Angel
Celuch, Stella Maris
author_role author
author2 Celuch, Stella Maris
author2_role author
dc.subject.none.fl_str_mv VAS DEFERENS
BRADYKININ
PROSTAGLANDINS
ELECTRICAL STIMULATION
topic VAS DEFERENS
BRADYKININ
PROSTAGLANDINS
ELECTRICAL STIMULATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The epididymal portion of the rat vas deferens produced prostaglandins (PG) E2, F2αand 6-keto F1 α. Electrical stimulation (ES, 0.1 Hz, 1 ms) increased such production by 100%, and similar results were obtained in the presence of 1.0 μM bradykinin (Bk). When both stimuli were applied simultaneously, the increases in PG production were 1100% for PGE2, 800% for PGF2αand 400% for PG6-keto F1 α. Prazosin abolished the effect of ES on PG production. A selective Bk B2-receptor antagonist abolished the increase in PG production induced by Bk, both in non-stimulated and in ES tissues. Bk (1.0 μM) elicited contractile responses in non-stimulated as well as in ES tissues, responses that were not modified in the presence of 10 μM indomethacin. In conclusion, the effects of Bk on prostaglandin production appears to depend on the activation of B2receptors, while the increase in prostaglandin release induced by ES, and the effects observed with both stimuli simultaneously, should be mediated by the release of noradrenaline and the subsequent activation of α1adrenoceptors.
Fil: Peredo, Horacio Angel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. ININFA; Argentina
Fil: Celuch, Stella Maris. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. ININFA; Argentina
description The epididymal portion of the rat vas deferens produced prostaglandins (PG) E2, F2αand 6-keto F1 α. Electrical stimulation (ES, 0.1 Hz, 1 ms) increased such production by 100%, and similar results were obtained in the presence of 1.0 μM bradykinin (Bk). When both stimuli were applied simultaneously, the increases in PG production were 1100% for PGE2, 800% for PGF2αand 400% for PG6-keto F1 α. Prazosin abolished the effect of ES on PG production. A selective Bk B2-receptor antagonist abolished the increase in PG production induced by Bk, both in non-stimulated and in ES tissues. Bk (1.0 μM) elicited contractile responses in non-stimulated as well as in ES tissues, responses that were not modified in the presence of 10 μM indomethacin. In conclusion, the effects of Bk on prostaglandin production appears to depend on the activation of B2receptors, while the increase in prostaglandin release induced by ES, and the effects observed with both stimuli simultaneously, should be mediated by the release of noradrenaline and the subsequent activation of α1adrenoceptors.
publishDate 2001
dc.date.none.fl_str_mv 2001-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/93791
Peredo, Horacio Angel; Celuch, Stella Maris; Bradykinin and electrical stimulation increase prostaglandin production in the rat vas deferens; Elsevier; Prostaglandins Leukotrienes and Essential Fatty Acids; 65; 1; 7-2001; 9-14
0952-3278
CONICET Digital
CONICET
url http://hdl.handle.net/11336/93791
identifier_str_mv Peredo, Horacio Angel; Celuch, Stella Maris; Bradykinin and electrical stimulation increase prostaglandin production in the rat vas deferens; Elsevier; Prostaglandins Leukotrienes and Essential Fatty Acids; 65; 1; 7-2001; 9-14
0952-3278
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0952327801902807
info:eu-repo/semantics/altIdentifier/doi/10.1054/plef.2001.0280
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268884966572032
score 13.13397

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