Gastroprotective Effect of Acacia aroma Gill. ex Hook. and Arn: Leaves Extracts in Gastric Ulcer Models in Rats

Autores
Taboada, Félix Facundo; Habib, Natalia Cecilia; Genta, Susana Beatriz de Fátima
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Peptic ulcer is a disease caused by imbalance between protective and aggressive factors in the gastric mucosa. Acacia aroma Gill.ex Hook. and Arn. (tusca) is widely used in Argentinian?s folk medicine forgastrointestinal disorders. The present study was designed to evaluatethe protective effect of two A. aroma leaf extracts, 5% infusion and 10%hydroalcoholic extract in experimental models of acute gastric ulcerationin rats. Methods: The gastroprotective action of the extracts was evaluated in absolute ethanol-induced gastric lesion models in adult Westarrats through macroscopic, histological and biochemical analyses of thestomach and gastric wall. We also determined the effects on the gastricjuice parameters with a pylorus ligature model in rats. Evaluation of theacute toxicity of each extract was performed in adult normal Wistar rats.All results were statistically analyzed. Results: The lowest effective dosewas 150 mg/Kg for each extract. Both of them showed a high protectionof the mucosa against absolute ethanol. Pre-treatments with the extractsproduced a significant increase in adherent mucus. These extracts showeda free radical scavenging capacity and they caused a significant reductionof the malondialdehyde, reduced glutathione levels, catalase and myeloperoxidase activities. The animals presented no signs of acute toxicityindicating a high safety margin for both extracts. Conclusion: This studyshows for the first time the gastroprotective efficacy of 5% infusion and10% hydroalcoholic extract of A. aroma leaves, highlighting their benefitsas a prophylactic approach to maintain the integrity of the gastric mucosa.
Fil: Taboada, Félix Facundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Fil: Habib, Natalia Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina
Fil: Genta, Susana Beatriz de Fátima. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Materia
ACUTE TOXICITY
ANTIOXIDANT ACTIVITY
GASTROPROTECTION
TUSCA
PRECLINICAL STUDIES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/121423
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/121423
network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Gastroprotective Effect of Acacia aroma Gill. ex Hook. and Arn: Leaves Extracts in Gastric Ulcer Models in RatsTaboada, Félix FacundoHabib, Natalia CeciliaGenta, Susana Beatriz de FátimaACUTE TOXICITYANTIOXIDANT ACTIVITYGASTROPROTECTIONTUSCAPRECLINICAL STUDIEShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Background: Peptic ulcer is a disease caused by imbalance between protective and aggressive factors in the gastric mucosa. Acacia aroma Gill.ex Hook. and Arn. (tusca) is widely used in Argentinian?s folk medicine forgastrointestinal disorders. The present study was designed to evaluatethe protective effect of two A. aroma leaf extracts, 5% infusion and 10%hydroalcoholic extract in experimental models of acute gastric ulcerationin rats. Methods: The gastroprotective action of the extracts was evaluated in absolute ethanol-induced gastric lesion models in adult Westarrats through macroscopic, histological and biochemical analyses of thestomach and gastric wall. We also determined the effects on the gastricjuice parameters with a pylorus ligature model in rats. Evaluation of theacute toxicity of each extract was performed in adult normal Wistar rats.All results were statistically analyzed. Results: The lowest effective dosewas 150 mg/Kg for each extract. Both of them showed a high protectionof the mucosa against absolute ethanol. Pre-treatments with the extractsproduced a significant increase in adherent mucus. These extracts showeda free radical scavenging capacity and they caused a significant reductionof the malondialdehyde, reduced glutathione levels, catalase and myeloperoxidase activities. The animals presented no signs of acute toxicityindicating a high safety margin for both extracts. Conclusion: This studyshows for the first time the gastroprotective efficacy of 5% infusion and10% hydroalcoholic extract of A. aroma leaves, highlighting their benefitsas a prophylactic approach to maintain the integrity of the gastric mucosa.Fil: Taboada, Félix Facundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; ArgentinaFil: Habib, Natalia Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; ArgentinaFil: Genta, Susana Beatriz de Fátima. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; ArgentinaMedknow Publications2019-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/121423Taboada, Félix Facundo; Habib, Natalia Cecilia; Genta, Susana Beatriz de Fátima; Gastroprotective Effect of Acacia aroma Gill. ex Hook. and Arn: Leaves Extracts in Gastric Ulcer Models in Rats; Medknow Publications; International Journal of Pharmaceutical Investigation; 9; 4; 12-2019; 187-1942230-973X2230-9713CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.5530/ijpi.2019.4.35info:eu-repo/semantics/altIdentifier/url/http://www.jpionline.org/index.php/ijpi/article/view/352info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:13:55Zoai:ri.conicet.gov.ar:11336/121423instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:13:55.852CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Gastroprotective Effect of Acacia aroma Gill. ex Hook. and Arn: Leaves Extracts in Gastric Ulcer Models in Rats
title Gastroprotective Effect of Acacia aroma Gill. ex Hook. and Arn: Leaves Extracts in Gastric Ulcer Models in Rats
spellingShingle Gastroprotective Effect of Acacia aroma Gill. ex Hook. and Arn: Leaves Extracts in Gastric Ulcer Models in Rats
Taboada, Félix Facundo
ACUTE TOXICITY
ANTIOXIDANT ACTIVITY
GASTROPROTECTION
TUSCA
PRECLINICAL STUDIES
title_short Gastroprotective Effect of Acacia aroma Gill. ex Hook. and Arn: Leaves Extracts in Gastric Ulcer Models in Rats
title_full Gastroprotective Effect of Acacia aroma Gill. ex Hook. and Arn: Leaves Extracts in Gastric Ulcer Models in Rats
title_fullStr Gastroprotective Effect of Acacia aroma Gill. ex Hook. and Arn: Leaves Extracts in Gastric Ulcer Models in Rats
title_full_unstemmed Gastroprotective Effect of Acacia aroma Gill. ex Hook. and Arn: Leaves Extracts in Gastric Ulcer Models in Rats
title_sort Gastroprotective Effect of Acacia aroma Gill. ex Hook. and Arn: Leaves Extracts in Gastric Ulcer Models in Rats
dc.creator.none.fl_str_mv Taboada, Félix Facundo
Habib, Natalia Cecilia
Genta, Susana Beatriz de Fátima
author Taboada, Félix Facundo
author_facet Taboada, Félix Facundo
Habib, Natalia Cecilia
Genta, Susana Beatriz de Fátima
author_role author
author2 Habib, Natalia Cecilia
Genta, Susana Beatriz de Fátima
author2_role author
author
dc.subject.none.fl_str_mv ACUTE TOXICITY
ANTIOXIDANT ACTIVITY
GASTROPROTECTION
TUSCA
PRECLINICAL STUDIES
topic ACUTE TOXICITY
ANTIOXIDANT ACTIVITY
GASTROPROTECTION
TUSCA
PRECLINICAL STUDIES
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Background: Peptic ulcer is a disease caused by imbalance between protective and aggressive factors in the gastric mucosa. Acacia aroma Gill.ex Hook. and Arn. (tusca) is widely used in Argentinian?s folk medicine forgastrointestinal disorders. The present study was designed to evaluatethe protective effect of two A. aroma leaf extracts, 5% infusion and 10%hydroalcoholic extract in experimental models of acute gastric ulcerationin rats. Methods: The gastroprotective action of the extracts was evaluated in absolute ethanol-induced gastric lesion models in adult Westarrats through macroscopic, histological and biochemical analyses of thestomach and gastric wall. We also determined the effects on the gastricjuice parameters with a pylorus ligature model in rats. Evaluation of theacute toxicity of each extract was performed in adult normal Wistar rats.All results were statistically analyzed. Results: The lowest effective dosewas 150 mg/Kg for each extract. Both of them showed a high protectionof the mucosa against absolute ethanol. Pre-treatments with the extractsproduced a significant increase in adherent mucus. These extracts showeda free radical scavenging capacity and they caused a significant reductionof the malondialdehyde, reduced glutathione levels, catalase and myeloperoxidase activities. The animals presented no signs of acute toxicityindicating a high safety margin for both extracts. Conclusion: This studyshows for the first time the gastroprotective efficacy of 5% infusion and10% hydroalcoholic extract of A. aroma leaves, highlighting their benefitsas a prophylactic approach to maintain the integrity of the gastric mucosa.
Fil: Taboada, Félix Facundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Fil: Habib, Natalia Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina
Fil: Genta, Susana Beatriz de Fátima. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
description Background: Peptic ulcer is a disease caused by imbalance between protective and aggressive factors in the gastric mucosa. Acacia aroma Gill.ex Hook. and Arn. (tusca) is widely used in Argentinian?s folk medicine forgastrointestinal disorders. The present study was designed to evaluatethe protective effect of two A. aroma leaf extracts, 5% infusion and 10%hydroalcoholic extract in experimental models of acute gastric ulcerationin rats. Methods: The gastroprotective action of the extracts was evaluated in absolute ethanol-induced gastric lesion models in adult Westarrats through macroscopic, histological and biochemical analyses of thestomach and gastric wall. We also determined the effects on the gastricjuice parameters with a pylorus ligature model in rats. Evaluation of theacute toxicity of each extract was performed in adult normal Wistar rats.All results were statistically analyzed. Results: The lowest effective dosewas 150 mg/Kg for each extract. Both of them showed a high protectionof the mucosa against absolute ethanol. Pre-treatments with the extractsproduced a significant increase in adherent mucus. These extracts showeda free radical scavenging capacity and they caused a significant reductionof the malondialdehyde, reduced glutathione levels, catalase and myeloperoxidase activities. The animals presented no signs of acute toxicityindicating a high safety margin for both extracts. Conclusion: This studyshows for the first time the gastroprotective efficacy of 5% infusion and10% hydroalcoholic extract of A. aroma leaves, highlighting their benefitsas a prophylactic approach to maintain the integrity of the gastric mucosa.
publishDate 2019
dc.date.none.fl_str_mv 2019-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/121423
Taboada, Félix Facundo; Habib, Natalia Cecilia; Genta, Susana Beatriz de Fátima; Gastroprotective Effect of Acacia aroma Gill. ex Hook. and Arn: Leaves Extracts in Gastric Ulcer Models in Rats; Medknow Publications; International Journal of Pharmaceutical Investigation; 9; 4; 12-2019; 187-194
2230-973X
2230-9713
CONICET Digital
CONICET
url http://hdl.handle.net/11336/121423
identifier_str_mv Taboada, Félix Facundo; Habib, Natalia Cecilia; Genta, Susana Beatriz de Fátima; Gastroprotective Effect of Acacia aroma Gill. ex Hook. and Arn: Leaves Extracts in Gastric Ulcer Models in Rats; Medknow Publications; International Journal of Pharmaceutical Investigation; 9; 4; 12-2019; 187-194
2230-973X
2230-9713
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.5530/ijpi.2019.4.35
info:eu-repo/semantics/altIdentifier/url/http://www.jpionline.org/index.php/ijpi/article/view/352
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Medknow Publications
publisher.none.fl_str_mv Medknow Publications
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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