Evaluation of gastroprotective activity and acute toxicity of Solidago chilensis Meyen (Asteraceae)

Autores
Bucciarelli, Alejandro; Minetti, Alejandra; Milczakowskyg, Cristina; Skliar, Mario Ignacio
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Context: Solidago chilensis Meyen (Asteraceae) is widely used in South America in traditional medicine as an anti-inflammatory and diuretic, and to treat gastrointestinal disorders. However, no scientific evidence exists in literature to corroborate the therapeutic use of the plant. Despite its traditional uses, no reports are available on the safety of this utilization or on the relationship between the pharmacological activities and its phytochemical compounds. Objective: This study investigates for the first time the acute toxicity and the gastroprotective effect of the aqueous extract from inflorescences of S. chilensis. Materials and methods: The gastroprotective activity was evaluated in mice subjected to ethanol-induced gastric ulcer model at 125, 250, 400, 800, 1200, and 2000mg/kg doses. Acute toxicity study was performed at one dose of 2000mg/kg. At the end of the exposure behavioral and functional parameters and motor activity were assessed in all animals. Results: Results demonstrated that the extract exhibited a significant antiulcer activity when given at 125-2000mg/kg (P<0.05), but did not show acute toxicity in mice treated with 2000mg/kg p.o. Discussion and conclusion: This study demonstrated that the oral administration of S. chilensis aqueous extract prevents the formation of gastric lesions caused by an aggressive factor as ethanol but does not produce toxicity by acute exposure in mice. These promising results support a better pharmacological study of S. chilensis as a potential antiulcerogenic species for studies targeted towards the development of antiulcerogenic agents. © 2010 Informa Healthcare USA, Inc.
Fil: Bucciarelli, Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Laboratorio de Farmacognosia; Argentina
Fil: Minetti, Alejandra. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Milczakowskyg, Cristina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Laboratorio de Farmacognosia; Argentina
Fil: Skliar, Mario Ignacio. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Laboratorio de Farmacognosia; Argentina
Materia
AQUEOUS EXTRACT
ASTERACEAE
FLAVONOIDS
GASTROPROTECTION
TRADITIONAL MEDICINE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/67656
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/67656
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Evaluation of gastroprotective activity and acute toxicity of Solidago chilensis Meyen (Asteraceae)Bucciarelli, AlejandroMinetti, AlejandraMilczakowskyg, CristinaSkliar, Mario IgnacioAQUEOUS EXTRACTASTERACEAEFLAVONOIDSGASTROPROTECTIONTRADITIONAL MEDICINEhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Context: Solidago chilensis Meyen (Asteraceae) is widely used in South America in traditional medicine as an anti-inflammatory and diuretic, and to treat gastrointestinal disorders. However, no scientific evidence exists in literature to corroborate the therapeutic use of the plant. Despite its traditional uses, no reports are available on the safety of this utilization or on the relationship between the pharmacological activities and its phytochemical compounds. Objective: This study investigates for the first time the acute toxicity and the gastroprotective effect of the aqueous extract from inflorescences of S. chilensis. Materials and methods: The gastroprotective activity was evaluated in mice subjected to ethanol-induced gastric ulcer model at 125, 250, 400, 800, 1200, and 2000mg/kg doses. Acute toxicity study was performed at one dose of 2000mg/kg. At the end of the exposure behavioral and functional parameters and motor activity were assessed in all animals. Results: Results demonstrated that the extract exhibited a significant antiulcer activity when given at 125-2000mg/kg (P<0.05), but did not show acute toxicity in mice treated with 2000mg/kg p.o. Discussion and conclusion: This study demonstrated that the oral administration of S. chilensis aqueous extract prevents the formation of gastric lesions caused by an aggressive factor as ethanol but does not produce toxicity by acute exposure in mice. These promising results support a better pharmacological study of S. chilensis as a potential antiulcerogenic species for studies targeted towards the development of antiulcerogenic agents. © 2010 Informa Healthcare USA, Inc.Fil: Bucciarelli, Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Laboratorio de Farmacognosia; ArgentinaFil: Minetti, Alejandra. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Milczakowskyg, Cristina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Laboratorio de Farmacognosia; ArgentinaFil: Skliar, Mario Ignacio. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Laboratorio de Farmacognosia; ArgentinaTaylor2010-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/67656Bucciarelli, Alejandro; Minetti, Alejandra; Milczakowskyg, Cristina; Skliar, Mario Ignacio; Evaluation of gastroprotective activity and acute toxicity of Solidago chilensis Meyen (Asteraceae); Taylor ; Pharmaceutical Biology; 48; 9; 9-2010; 1025-10301388-0209CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3109/13880200903453131info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.3109/13880200903453131info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:21:17Zoai:ri.conicet.gov.ar:11336/67656instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:21:18.16CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Evaluation of gastroprotective activity and acute toxicity of Solidago chilensis Meyen (Asteraceae)
title Evaluation of gastroprotective activity and acute toxicity of Solidago chilensis Meyen (Asteraceae)
spellingShingle Evaluation of gastroprotective activity and acute toxicity of Solidago chilensis Meyen (Asteraceae)
Bucciarelli, Alejandro
AQUEOUS EXTRACT
ASTERACEAE
FLAVONOIDS
GASTROPROTECTION
TRADITIONAL MEDICINE
title_short Evaluation of gastroprotective activity and acute toxicity of Solidago chilensis Meyen (Asteraceae)
title_full Evaluation of gastroprotective activity and acute toxicity of Solidago chilensis Meyen (Asteraceae)
title_fullStr Evaluation of gastroprotective activity and acute toxicity of Solidago chilensis Meyen (Asteraceae)
title_full_unstemmed Evaluation of gastroprotective activity and acute toxicity of Solidago chilensis Meyen (Asteraceae)
title_sort Evaluation of gastroprotective activity and acute toxicity of Solidago chilensis Meyen (Asteraceae)
dc.creator.none.fl_str_mv Bucciarelli, Alejandro
Minetti, Alejandra
Milczakowskyg, Cristina
Skliar, Mario Ignacio
author Bucciarelli, Alejandro
author_facet Bucciarelli, Alejandro
Minetti, Alejandra
Milczakowskyg, Cristina
Skliar, Mario Ignacio
author_role author
author2 Minetti, Alejandra
Milczakowskyg, Cristina
Skliar, Mario Ignacio
author2_role author
author
author
dc.subject.none.fl_str_mv AQUEOUS EXTRACT
ASTERACEAE
FLAVONOIDS
GASTROPROTECTION
TRADITIONAL MEDICINE
topic AQUEOUS EXTRACT
ASTERACEAE
FLAVONOIDS
GASTROPROTECTION
TRADITIONAL MEDICINE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Context: Solidago chilensis Meyen (Asteraceae) is widely used in South America in traditional medicine as an anti-inflammatory and diuretic, and to treat gastrointestinal disorders. However, no scientific evidence exists in literature to corroborate the therapeutic use of the plant. Despite its traditional uses, no reports are available on the safety of this utilization or on the relationship between the pharmacological activities and its phytochemical compounds. Objective: This study investigates for the first time the acute toxicity and the gastroprotective effect of the aqueous extract from inflorescences of S. chilensis. Materials and methods: The gastroprotective activity was evaluated in mice subjected to ethanol-induced gastric ulcer model at 125, 250, 400, 800, 1200, and 2000mg/kg doses. Acute toxicity study was performed at one dose of 2000mg/kg. At the end of the exposure behavioral and functional parameters and motor activity were assessed in all animals. Results: Results demonstrated that the extract exhibited a significant antiulcer activity when given at 125-2000mg/kg (P<0.05), but did not show acute toxicity in mice treated with 2000mg/kg p.o. Discussion and conclusion: This study demonstrated that the oral administration of S. chilensis aqueous extract prevents the formation of gastric lesions caused by an aggressive factor as ethanol but does not produce toxicity by acute exposure in mice. These promising results support a better pharmacological study of S. chilensis as a potential antiulcerogenic species for studies targeted towards the development of antiulcerogenic agents. © 2010 Informa Healthcare USA, Inc.
Fil: Bucciarelli, Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Laboratorio de Farmacognosia; Argentina
Fil: Minetti, Alejandra. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Milczakowskyg, Cristina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Laboratorio de Farmacognosia; Argentina
Fil: Skliar, Mario Ignacio. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Laboratorio de Farmacognosia; Argentina
description Context: Solidago chilensis Meyen (Asteraceae) is widely used in South America in traditional medicine as an anti-inflammatory and diuretic, and to treat gastrointestinal disorders. However, no scientific evidence exists in literature to corroborate the therapeutic use of the plant. Despite its traditional uses, no reports are available on the safety of this utilization or on the relationship between the pharmacological activities and its phytochemical compounds. Objective: This study investigates for the first time the acute toxicity and the gastroprotective effect of the aqueous extract from inflorescences of S. chilensis. Materials and methods: The gastroprotective activity was evaluated in mice subjected to ethanol-induced gastric ulcer model at 125, 250, 400, 800, 1200, and 2000mg/kg doses. Acute toxicity study was performed at one dose of 2000mg/kg. At the end of the exposure behavioral and functional parameters and motor activity were assessed in all animals. Results: Results demonstrated that the extract exhibited a significant antiulcer activity when given at 125-2000mg/kg (P<0.05), but did not show acute toxicity in mice treated with 2000mg/kg p.o. Discussion and conclusion: This study demonstrated that the oral administration of S. chilensis aqueous extract prevents the formation of gastric lesions caused by an aggressive factor as ethanol but does not produce toxicity by acute exposure in mice. These promising results support a better pharmacological study of S. chilensis as a potential antiulcerogenic species for studies targeted towards the development of antiulcerogenic agents. © 2010 Informa Healthcare USA, Inc.
publishDate 2010
dc.date.none.fl_str_mv 2010-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/67656
Bucciarelli, Alejandro; Minetti, Alejandra; Milczakowskyg, Cristina; Skliar, Mario Ignacio; Evaluation of gastroprotective activity and acute toxicity of Solidago chilensis Meyen (Asteraceae); Taylor ; Pharmaceutical Biology; 48; 9; 9-2010; 1025-1030
1388-0209
CONICET Digital
CONICET
url http://hdl.handle.net/11336/67656
identifier_str_mv Bucciarelli, Alejandro; Minetti, Alejandra; Milczakowskyg, Cristina; Skliar, Mario Ignacio; Evaluation of gastroprotective activity and acute toxicity of Solidago chilensis Meyen (Asteraceae); Taylor ; Pharmaceutical Biology; 48; 9; 9-2010; 1025-1030
1388-0209
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3109/13880200903453131
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.3109/13880200903453131
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor
publisher.none.fl_str_mv Taylor
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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