An Antibody Recognizing the Apical Domain of Human Transferrin Receptor 1 Efficiently Inhibits the Entry of All New World Hemorrhagic Fever Arenaviruses

Autores
Helguera, Gustavo Fernando; Jemielity, Stephanie; Abraham, Jonathan; Cordo, Sandra Myriam; Martinez, María Guadalupe; Rodríguez, José A.; Bregni, Carlos; Wang, Jinyize J.; Farzan, Michael; Penichet, Manuel L.; Candurra, Nélida Alicia; Choe, Hyeryun
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Five New World (NW) arenaviruses cause human hemorrhagic fevers. Four of these arenaviruses are known to enter cells bybinding human transferrin receptor 1 (hTfR1). Here we show that the fifth arenavirus, Chapare virus, similarly uses hTfR1. Wealso identify an anti-hTfR1 antibody, ch128.1, which efficiently inhibits entry mediated by the glycoproteins of all five viruses, aswell as replication of infectious Junín virus. Our data indicate that allNWhemorrhagic fever arenaviruses utilize a commonhTfR1 apical-domain epitope and suggest that therapeutic agents targeting this epitope, including ch128.1 itself, can be broadlyeffective in treating South American hemorrhagic fevers.
Fil: Helguera, Gustavo Fernando. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Jemielity, Stephanie. Harvard Medical School; Estados Unidos
Fil: Abraham, Jonathan. Harvard Medical School; Estados Unidos
Fil: Cordo, Sandra Myriam. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Martinez, María Guadalupe. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rodríguez, José A.. University of California; Estados Unidos
Fil: Bregni, Carlos. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
Fil: Wang, Jinyize J.. Harvard Medical School; Estados Unidos
Fil: Farzan, Michael. Harvard Medical School; Estados Unidos
Fil: Penichet, Manuel L.. University of California; Estados Unidos
Fil: Candurra, Nélida Alicia. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Choe, Hyeryun. Harvard Medical School; Estados Unidos
Materia
JUNV
transferrin receptor
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/269438
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/269438
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling An Antibody Recognizing the Apical Domain of Human Transferrin Receptor 1 Efficiently Inhibits the Entry of All New World Hemorrhagic Fever ArenavirusesHelguera, Gustavo FernandoJemielity, StephanieAbraham, JonathanCordo, Sandra MyriamMartinez, María GuadalupeRodríguez, José A.Bregni, CarlosWang, Jinyize J.Farzan, MichaelPenichet, Manuel L.Candurra, Nélida AliciaChoe, HyeryunJUNVtransferrin receptorhttps://purl.org/becyt/ford/1.7https://purl.org/becyt/ford/1Five New World (NW) arenaviruses cause human hemorrhagic fevers. Four of these arenaviruses are known to enter cells bybinding human transferrin receptor 1 (hTfR1). Here we show that the fifth arenavirus, Chapare virus, similarly uses hTfR1. Wealso identify an anti-hTfR1 antibody, ch128.1, which efficiently inhibits entry mediated by the glycoproteins of all five viruses, aswell as replication of infectious Junín virus. Our data indicate that allNWhemorrhagic fever arenaviruses utilize a commonhTfR1 apical-domain epitope and suggest that therapeutic agents targeting this epitope, including ch128.1 itself, can be broadlyeffective in treating South American hemorrhagic fevers.Fil: Helguera, Gustavo Fernando. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Jemielity, Stephanie. Harvard Medical School; Estados UnidosFil: Abraham, Jonathan. Harvard Medical School; Estados UnidosFil: Cordo, Sandra Myriam. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Martinez, María Guadalupe. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Rodríguez, José A.. University of California; Estados UnidosFil: Bregni, Carlos. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; ArgentinaFil: Wang, Jinyize J.. Harvard Medical School; Estados UnidosFil: Farzan, Michael. Harvard Medical School; Estados UnidosFil: Penichet, Manuel L.. University of California; Estados UnidosFil: Candurra, Nélida Alicia. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaFil: Choe, Hyeryun. Harvard Medical School; Estados UnidosAmerican Society for Microbiology2012-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/269438Helguera, Gustavo Fernando; Jemielity, Stephanie; Abraham, Jonathan; Cordo, Sandra Myriam; Martinez, María Guadalupe; et al.; An Antibody Recognizing the Apical Domain of Human Transferrin Receptor 1 Efficiently Inhibits the Entry of All New World Hemorrhagic Fever Arenaviruses; American Society for Microbiology; Journal of Virology; 86; 7; 4-2012; 4024-40280022-538XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://journals.asm.org/doi/10.1128/jvi.06397-11info:eu-repo/semantics/altIdentifier/doi/10.1128/jvi.06397-11info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:35:39Zoai:ri.conicet.gov.ar:11336/269438instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:35:40.134CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv An Antibody Recognizing the Apical Domain of Human Transferrin Receptor 1 Efficiently Inhibits the Entry of All New World Hemorrhagic Fever Arenaviruses
title An Antibody Recognizing the Apical Domain of Human Transferrin Receptor 1 Efficiently Inhibits the Entry of All New World Hemorrhagic Fever Arenaviruses
spellingShingle An Antibody Recognizing the Apical Domain of Human Transferrin Receptor 1 Efficiently Inhibits the Entry of All New World Hemorrhagic Fever Arenaviruses
Helguera, Gustavo Fernando
JUNV
transferrin receptor
title_short An Antibody Recognizing the Apical Domain of Human Transferrin Receptor 1 Efficiently Inhibits the Entry of All New World Hemorrhagic Fever Arenaviruses
title_full An Antibody Recognizing the Apical Domain of Human Transferrin Receptor 1 Efficiently Inhibits the Entry of All New World Hemorrhagic Fever Arenaviruses
title_fullStr An Antibody Recognizing the Apical Domain of Human Transferrin Receptor 1 Efficiently Inhibits the Entry of All New World Hemorrhagic Fever Arenaviruses
title_full_unstemmed An Antibody Recognizing the Apical Domain of Human Transferrin Receptor 1 Efficiently Inhibits the Entry of All New World Hemorrhagic Fever Arenaviruses
title_sort An Antibody Recognizing the Apical Domain of Human Transferrin Receptor 1 Efficiently Inhibits the Entry of All New World Hemorrhagic Fever Arenaviruses
dc.creator.none.fl_str_mv Helguera, Gustavo Fernando
Jemielity, Stephanie
Abraham, Jonathan
Cordo, Sandra Myriam
Martinez, María Guadalupe
Rodríguez, José A.
Bregni, Carlos
Wang, Jinyize J.
Farzan, Michael
Penichet, Manuel L.
Candurra, Nélida Alicia
Choe, Hyeryun
author Helguera, Gustavo Fernando
author_facet Helguera, Gustavo Fernando
Jemielity, Stephanie
Abraham, Jonathan
Cordo, Sandra Myriam
Martinez, María Guadalupe
Rodríguez, José A.
Bregni, Carlos
Wang, Jinyize J.
Farzan, Michael
Penichet, Manuel L.
Candurra, Nélida Alicia
Choe, Hyeryun
author_role author
author2 Jemielity, Stephanie
Abraham, Jonathan
Cordo, Sandra Myriam
Martinez, María Guadalupe
Rodríguez, José A.
Bregni, Carlos
Wang, Jinyize J.
Farzan, Michael
Penichet, Manuel L.
Candurra, Nélida Alicia
Choe, Hyeryun
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv JUNV
transferrin receptor
topic JUNV
transferrin receptor
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.7
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Five New World (NW) arenaviruses cause human hemorrhagic fevers. Four of these arenaviruses are known to enter cells bybinding human transferrin receptor 1 (hTfR1). Here we show that the fifth arenavirus, Chapare virus, similarly uses hTfR1. Wealso identify an anti-hTfR1 antibody, ch128.1, which efficiently inhibits entry mediated by the glycoproteins of all five viruses, aswell as replication of infectious Junín virus. Our data indicate that allNWhemorrhagic fever arenaviruses utilize a commonhTfR1 apical-domain epitope and suggest that therapeutic agents targeting this epitope, including ch128.1 itself, can be broadlyeffective in treating South American hemorrhagic fevers.
Fil: Helguera, Gustavo Fernando. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Jemielity, Stephanie. Harvard Medical School; Estados Unidos
Fil: Abraham, Jonathan. Harvard Medical School; Estados Unidos
Fil: Cordo, Sandra Myriam. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Martinez, María Guadalupe. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rodríguez, José A.. University of California; Estados Unidos
Fil: Bregni, Carlos. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
Fil: Wang, Jinyize J.. Harvard Medical School; Estados Unidos
Fil: Farzan, Michael. Harvard Medical School; Estados Unidos
Fil: Penichet, Manuel L.. University of California; Estados Unidos
Fil: Candurra, Nélida Alicia. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Choe, Hyeryun. Harvard Medical School; Estados Unidos
description Five New World (NW) arenaviruses cause human hemorrhagic fevers. Four of these arenaviruses are known to enter cells bybinding human transferrin receptor 1 (hTfR1). Here we show that the fifth arenavirus, Chapare virus, similarly uses hTfR1. Wealso identify an anti-hTfR1 antibody, ch128.1, which efficiently inhibits entry mediated by the glycoproteins of all five viruses, aswell as replication of infectious Junín virus. Our data indicate that allNWhemorrhagic fever arenaviruses utilize a commonhTfR1 apical-domain epitope and suggest that therapeutic agents targeting this epitope, including ch128.1 itself, can be broadlyeffective in treating South American hemorrhagic fevers.
publishDate 2012
dc.date.none.fl_str_mv 2012-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/269438
Helguera, Gustavo Fernando; Jemielity, Stephanie; Abraham, Jonathan; Cordo, Sandra Myriam; Martinez, María Guadalupe; et al.; An Antibody Recognizing the Apical Domain of Human Transferrin Receptor 1 Efficiently Inhibits the Entry of All New World Hemorrhagic Fever Arenaviruses; American Society for Microbiology; Journal of Virology; 86; 7; 4-2012; 4024-4028
0022-538X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/269438
identifier_str_mv Helguera, Gustavo Fernando; Jemielity, Stephanie; Abraham, Jonathan; Cordo, Sandra Myriam; Martinez, María Guadalupe; et al.; An Antibody Recognizing the Apical Domain of Human Transferrin Receptor 1 Efficiently Inhibits the Entry of All New World Hemorrhagic Fever Arenaviruses; American Society for Microbiology; Journal of Virology; 86; 7; 4-2012; 4024-4028
0022-538X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://journals.asm.org/doi/10.1128/jvi.06397-11
info:eu-repo/semantics/altIdentifier/doi/10.1128/jvi.06397-11
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846082817562247168
score 13.22299

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