An Antibody Recognizing the Apical Domain of Human Transferrin Receptor 1 Efficiently Inhibits the Entry of All New World Hemorrhagic Fever Arenaviruses
- Autores
- Helguera, Gustavo Fernando; Jemielity, Stephanie; Abraham, Jonathan; Cordo, Sandra Myriam; Martinez, María Guadalupe; Rodríguez, José A.; Bregni, Carlos; Wang, Jinyize J.; Farzan, Michael; Penichet, Manuel L.; Candurra, Nélida Alicia; Choe, Hyeryun
- Año de publicación
- 2012
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Five New World (NW) arenaviruses cause human hemorrhagic fevers. Four of these arenaviruses are known to enter cells bybinding human transferrin receptor 1 (hTfR1). Here we show that the fifth arenavirus, Chapare virus, similarly uses hTfR1. Wealso identify an anti-hTfR1 antibody, ch128.1, which efficiently inhibits entry mediated by the glycoproteins of all five viruses, aswell as replication of infectious Junín virus. Our data indicate that allNWhemorrhagic fever arenaviruses utilize a commonhTfR1 apical-domain epitope and suggest that therapeutic agents targeting this epitope, including ch128.1 itself, can be broadlyeffective in treating South American hemorrhagic fevers.
Fil: Helguera, Gustavo Fernando. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Jemielity, Stephanie. Harvard Medical School; Estados Unidos
Fil: Abraham, Jonathan. Harvard Medical School; Estados Unidos
Fil: Cordo, Sandra Myriam. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Martinez, María Guadalupe. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rodríguez, José A.. University of California; Estados Unidos
Fil: Bregni, Carlos. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
Fil: Wang, Jinyize J.. Harvard Medical School; Estados Unidos
Fil: Farzan, Michael. Harvard Medical School; Estados Unidos
Fil: Penichet, Manuel L.. University of California; Estados Unidos
Fil: Candurra, Nélida Alicia. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Choe, Hyeryun. Harvard Medical School; Estados Unidos - Materia
-
JUNV
transferrin receptor - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/269438
Ver los metadatos del registro completo
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CONICET Digital (CONICET) |
spelling |
An Antibody Recognizing the Apical Domain of Human Transferrin Receptor 1 Efficiently Inhibits the Entry of All New World Hemorrhagic Fever ArenavirusesHelguera, Gustavo FernandoJemielity, StephanieAbraham, JonathanCordo, Sandra MyriamMartinez, María GuadalupeRodríguez, José A.Bregni, CarlosWang, Jinyize J.Farzan, MichaelPenichet, Manuel L.Candurra, Nélida AliciaChoe, HyeryunJUNVtransferrin receptorhttps://purl.org/becyt/ford/1.7https://purl.org/becyt/ford/1Five New World (NW) arenaviruses cause human hemorrhagic fevers. Four of these arenaviruses are known to enter cells bybinding human transferrin receptor 1 (hTfR1). Here we show that the fifth arenavirus, Chapare virus, similarly uses hTfR1. Wealso identify an anti-hTfR1 antibody, ch128.1, which efficiently inhibits entry mediated by the glycoproteins of all five viruses, aswell as replication of infectious Junín virus. Our data indicate that allNWhemorrhagic fever arenaviruses utilize a commonhTfR1 apical-domain epitope and suggest that therapeutic agents targeting this epitope, including ch128.1 itself, can be broadlyeffective in treating South American hemorrhagic fevers.Fil: Helguera, Gustavo Fernando. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Jemielity, Stephanie. Harvard Medical School; Estados UnidosFil: Abraham, Jonathan. Harvard Medical School; Estados UnidosFil: Cordo, Sandra Myriam. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Martinez, María Guadalupe. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Rodríguez, José A.. University of California; Estados UnidosFil: Bregni, Carlos. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; ArgentinaFil: Wang, Jinyize J.. Harvard Medical School; Estados UnidosFil: Farzan, Michael. Harvard Medical School; Estados UnidosFil: Penichet, Manuel L.. University of California; Estados UnidosFil: Candurra, Nélida Alicia. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaFil: Choe, Hyeryun. Harvard Medical School; Estados UnidosAmerican Society for Microbiology2012-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/269438Helguera, Gustavo Fernando; Jemielity, Stephanie; Abraham, Jonathan; Cordo, Sandra Myriam; Martinez, María Guadalupe; et al.; An Antibody Recognizing the Apical Domain of Human Transferrin Receptor 1 Efficiently Inhibits the Entry of All New World Hemorrhagic Fever Arenaviruses; American Society for Microbiology; Journal of Virology; 86; 7; 4-2012; 4024-40280022-538XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://journals.asm.org/doi/10.1128/jvi.06397-11info:eu-repo/semantics/altIdentifier/doi/10.1128/jvi.06397-11info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:42:35Zoai:ri.conicet.gov.ar:11336/269438instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:42:35.769CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
An Antibody Recognizing the Apical Domain of Human Transferrin Receptor 1 Efficiently Inhibits the Entry of All New World Hemorrhagic Fever Arenaviruses |
title |
An Antibody Recognizing the Apical Domain of Human Transferrin Receptor 1 Efficiently Inhibits the Entry of All New World Hemorrhagic Fever Arenaviruses |
spellingShingle |
An Antibody Recognizing the Apical Domain of Human Transferrin Receptor 1 Efficiently Inhibits the Entry of All New World Hemorrhagic Fever Arenaviruses Helguera, Gustavo Fernando JUNV transferrin receptor |
title_short |
An Antibody Recognizing the Apical Domain of Human Transferrin Receptor 1 Efficiently Inhibits the Entry of All New World Hemorrhagic Fever Arenaviruses |
title_full |
An Antibody Recognizing the Apical Domain of Human Transferrin Receptor 1 Efficiently Inhibits the Entry of All New World Hemorrhagic Fever Arenaviruses |
title_fullStr |
An Antibody Recognizing the Apical Domain of Human Transferrin Receptor 1 Efficiently Inhibits the Entry of All New World Hemorrhagic Fever Arenaviruses |
title_full_unstemmed |
An Antibody Recognizing the Apical Domain of Human Transferrin Receptor 1 Efficiently Inhibits the Entry of All New World Hemorrhagic Fever Arenaviruses |
title_sort |
An Antibody Recognizing the Apical Domain of Human Transferrin Receptor 1 Efficiently Inhibits the Entry of All New World Hemorrhagic Fever Arenaviruses |
dc.creator.none.fl_str_mv |
Helguera, Gustavo Fernando Jemielity, Stephanie Abraham, Jonathan Cordo, Sandra Myriam Martinez, María Guadalupe Rodríguez, José A. Bregni, Carlos Wang, Jinyize J. Farzan, Michael Penichet, Manuel L. Candurra, Nélida Alicia Choe, Hyeryun |
author |
Helguera, Gustavo Fernando |
author_facet |
Helguera, Gustavo Fernando Jemielity, Stephanie Abraham, Jonathan Cordo, Sandra Myriam Martinez, María Guadalupe Rodríguez, José A. Bregni, Carlos Wang, Jinyize J. Farzan, Michael Penichet, Manuel L. Candurra, Nélida Alicia Choe, Hyeryun |
author_role |
author |
author2 |
Jemielity, Stephanie Abraham, Jonathan Cordo, Sandra Myriam Martinez, María Guadalupe Rodríguez, José A. Bregni, Carlos Wang, Jinyize J. Farzan, Michael Penichet, Manuel L. Candurra, Nélida Alicia Choe, Hyeryun |
author2_role |
author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
JUNV transferrin receptor |
topic |
JUNV transferrin receptor |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.7 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Five New World (NW) arenaviruses cause human hemorrhagic fevers. Four of these arenaviruses are known to enter cells bybinding human transferrin receptor 1 (hTfR1). Here we show that the fifth arenavirus, Chapare virus, similarly uses hTfR1. Wealso identify an anti-hTfR1 antibody, ch128.1, which efficiently inhibits entry mediated by the glycoproteins of all five viruses, aswell as replication of infectious Junín virus. Our data indicate that allNWhemorrhagic fever arenaviruses utilize a commonhTfR1 apical-domain epitope and suggest that therapeutic agents targeting this epitope, including ch128.1 itself, can be broadlyeffective in treating South American hemorrhagic fevers. Fil: Helguera, Gustavo Fernando. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Jemielity, Stephanie. Harvard Medical School; Estados Unidos Fil: Abraham, Jonathan. Harvard Medical School; Estados Unidos Fil: Cordo, Sandra Myriam. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Martinez, María Guadalupe. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Rodríguez, José A.. University of California; Estados Unidos Fil: Bregni, Carlos. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina Fil: Wang, Jinyize J.. Harvard Medical School; Estados Unidos Fil: Farzan, Michael. Harvard Medical School; Estados Unidos Fil: Penichet, Manuel L.. University of California; Estados Unidos Fil: Candurra, Nélida Alicia. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina Fil: Choe, Hyeryun. Harvard Medical School; Estados Unidos |
description |
Five New World (NW) arenaviruses cause human hemorrhagic fevers. Four of these arenaviruses are known to enter cells bybinding human transferrin receptor 1 (hTfR1). Here we show that the fifth arenavirus, Chapare virus, similarly uses hTfR1. Wealso identify an anti-hTfR1 antibody, ch128.1, which efficiently inhibits entry mediated by the glycoproteins of all five viruses, aswell as replication of infectious Junín virus. Our data indicate that allNWhemorrhagic fever arenaviruses utilize a commonhTfR1 apical-domain epitope and suggest that therapeutic agents targeting this epitope, including ch128.1 itself, can be broadlyeffective in treating South American hemorrhagic fevers. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-04 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/269438 Helguera, Gustavo Fernando; Jemielity, Stephanie; Abraham, Jonathan; Cordo, Sandra Myriam; Martinez, María Guadalupe; et al.; An Antibody Recognizing the Apical Domain of Human Transferrin Receptor 1 Efficiently Inhibits the Entry of All New World Hemorrhagic Fever Arenaviruses; American Society for Microbiology; Journal of Virology; 86; 7; 4-2012; 4024-4028 0022-538X CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/269438 |
identifier_str_mv |
Helguera, Gustavo Fernando; Jemielity, Stephanie; Abraham, Jonathan; Cordo, Sandra Myriam; Martinez, María Guadalupe; et al.; An Antibody Recognizing the Apical Domain of Human Transferrin Receptor 1 Efficiently Inhibits the Entry of All New World Hemorrhagic Fever Arenaviruses; American Society for Microbiology; Journal of Virology; 86; 7; 4-2012; 4024-4028 0022-538X CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://journals.asm.org/doi/10.1128/jvi.06397-11 info:eu-repo/semantics/altIdentifier/doi/10.1128/jvi.06397-11 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
American Society for Microbiology |
publisher.none.fl_str_mv |
American Society for Microbiology |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |