Mechanism of action of drugs with activity against multicellular parasites

Autores
Giordani, C.; Marin, Gustavo Horacio; Perez, D.; Soraci, Alejandro Luis; Errecalde, J.
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Parasiticides have been the most valuable weapons to combat parasites for almost half a century, constituting more than 50 % of veterinary pharmaceuticals and a good part of the products destined for human health. However, in many parts of the world, parasites develop resistance to these drugs, and it is now a major health problem. One way to avoid this inconvenience is the in-depth knowledge of its mechanisms of action, which will allow a more appropriate use. This work is a review of the different physiological aspects of parasite species and an explanation of the different mechanisms of action of antiparasitic agents. Once these drugs are ingested or absorbed by parasites the agents come into contact with the parasites structures, and according to the drug's properties it will define the antiparasitic activity either by altering tegument, carbohydrates, protein and lipid metabolism, or motility of the multicellular parasites.
Fil: Giordani, C.. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Marin, Gustavo Horacio. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Perez, D.. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Soraci, Alejandro Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Errecalde, J.. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; Argentina
Materia
Mechanism of Action, Pharmacodynamics, Antiparasitic Agents
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/58597
Acceder
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spelling Mechanism of action of drugs with activity against multicellular parasitesGiordani, C.Marin, Gustavo HoracioPerez, D.Soraci, Alejandro LuisErrecalde, J.Mechanism of Action, Pharmacodynamics, Antiparasitic Agentshttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Parasiticides have been the most valuable weapons to combat parasites for almost half a century, constituting more than 50 % of veterinary pharmaceuticals and a good part of the products destined for human health. However, in many parts of the world, parasites develop resistance to these drugs, and it is now a major health problem. One way to avoid this inconvenience is the in-depth knowledge of its mechanisms of action, which will allow a more appropriate use. This work is a review of the different physiological aspects of parasite species and an explanation of the different mechanisms of action of antiparasitic agents. Once these drugs are ingested or absorbed by parasites the agents come into contact with the parasites structures, and according to the drug's properties it will define the antiparasitic activity either by altering tegument, carbohydrates, protein and lipid metabolism, or motility of the multicellular parasites.Fil: Giordani, C.. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Marin, Gustavo Horacio. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Perez, D.. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Soraci, Alejandro Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Errecalde, J.. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; ArgentinaNauka2017-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/58597Giordani, C.; Marin, Gustavo Horacio; Perez, D.; Soraci, Alejandro Luis; Errecalde, J.; Mechanism of action of drugs with activity against multicellular parasites; Nauka; Parazitologiia Parazitology; 51; 4; 3-2017; 294-3160031-1847CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.zin.ru/journals/parazitologiya/content/2017/prz_2017_4_3_Giordani.pdfinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-06-17T09:40:17Zoai:ri.conicet.gov.ar:11336/58597instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-06-17 09:40:17.964CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Mechanism of action of drugs with activity against multicellular parasites
title Mechanism of action of drugs with activity against multicellular parasites
spellingShingle Mechanism of action of drugs with activity against multicellular parasites
Giordani, C.
Mechanism of Action, Pharmacodynamics, Antiparasitic Agents
title_short Mechanism of action of drugs with activity against multicellular parasites
title_full Mechanism of action of drugs with activity against multicellular parasites
title_fullStr Mechanism of action of drugs with activity against multicellular parasites
title_full_unstemmed Mechanism of action of drugs with activity against multicellular parasites
title_sort Mechanism of action of drugs with activity against multicellular parasites
dc.creator.none.fl_str_mv Giordani, C.
Marin, Gustavo Horacio
Perez, D.
Soraci, Alejandro Luis
Errecalde, J.
author Giordani, C.
author_facet Giordani, C.
Marin, Gustavo Horacio
Perez, D.
Soraci, Alejandro Luis
Errecalde, J.
author_role author
author2 Marin, Gustavo Horacio
Perez, D.
Soraci, Alejandro Luis
Errecalde, J.
author2_role author
author
author
author
dc.subject.none.fl_str_mv Mechanism of Action, Pharmacodynamics, Antiparasitic Agents
topic Mechanism of Action, Pharmacodynamics, Antiparasitic Agents
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Parasiticides have been the most valuable weapons to combat parasites for almost half a century, constituting more than 50 % of veterinary pharmaceuticals and a good part of the products destined for human health. However, in many parts of the world, parasites develop resistance to these drugs, and it is now a major health problem. One way to avoid this inconvenience is the in-depth knowledge of its mechanisms of action, which will allow a more appropriate use. This work is a review of the different physiological aspects of parasite species and an explanation of the different mechanisms of action of antiparasitic agents. Once these drugs are ingested or absorbed by parasites the agents come into contact with the parasites structures, and according to the drug's properties it will define the antiparasitic activity either by altering tegument, carbohydrates, protein and lipid metabolism, or motility of the multicellular parasites.
Fil: Giordani, C.. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Marin, Gustavo Horacio. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Perez, D.. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Soraci, Alejandro Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Errecalde, J.. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; Argentina
description Parasiticides have been the most valuable weapons to combat parasites for almost half a century, constituting more than 50 % of veterinary pharmaceuticals and a good part of the products destined for human health. However, in many parts of the world, parasites develop resistance to these drugs, and it is now a major health problem. One way to avoid this inconvenience is the in-depth knowledge of its mechanisms of action, which will allow a more appropriate use. This work is a review of the different physiological aspects of parasite species and an explanation of the different mechanisms of action of antiparasitic agents. Once these drugs are ingested or absorbed by parasites the agents come into contact with the parasites structures, and according to the drug's properties it will define the antiparasitic activity either by altering tegument, carbohydrates, protein and lipid metabolism, or motility of the multicellular parasites.
publishDate 2017
dc.date.none.fl_str_mv 2017-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/58597
Giordani, C.; Marin, Gustavo Horacio; Perez, D.; Soraci, Alejandro Luis; Errecalde, J.; Mechanism of action of drugs with activity against multicellular parasites; Nauka; Parazitologiia Parazitology; 51; 4; 3-2017; 294-316
0031-1847
CONICET Digital
CONICET
url http://hdl.handle.net/11336/58597
identifier_str_mv Giordani, C.; Marin, Gustavo Horacio; Perez, D.; Soraci, Alejandro Luis; Errecalde, J.; Mechanism of action of drugs with activity against multicellular parasites; Nauka; Parazitologiia Parazitology; 51; 4; 3-2017; 294-316
0031-1847
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.zin.ru/journals/parazitologiya/content/2017/prz_2017_4_3_Giordani.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nauka
publisher.none.fl_str_mv Nauka
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.040872

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