State of the Art on Plant-Made Single-Domain Antibodies

Autores
Marconi, Patricia Laura; Alvarez, Maria Alejandra
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In addition to conventional antibodies (with heavy and light chains), camelids also produce functional antibodies devoid of light chains (HCAbs) without the first constant domain (CH1). Their variable domains (VHH) have binding properties, high stability and solubility, and are considered the smallest available intact antigen–binding fragment derived from a functional immunoglobulin. For their practical utilities VHHs have been expressed in different platforms. This review aims to provide an update in the field of plant-made VHHs, their applications and limitations, and a discussion about the challenges for the near future in this field.
Fil: Marconi, Patricia Laura. Universidad Maimónides; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Alvarez, Maria Alejandra. Universidad Maimónides; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Molecular Farming
Plantibodies
Single-Domain Antibodies
Tobacco
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/36142
Acceder
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network_name_str CONICET Digital (CONICET)
spelling State of the Art on Plant-Made Single-Domain AntibodiesMarconi, Patricia LauraAlvarez, Maria AlejandraMolecular FarmingPlantibodiesSingle-Domain AntibodiesTobaccohttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1In addition to conventional antibodies (with heavy and light chains), camelids also produce functional antibodies devoid of light chains (HCAbs) without the first constant domain (CH1). Their variable domains (VHH) have binding properties, high stability and solubility, and are considered the smallest available intact antigen–binding fragment derived from a functional immunoglobulin. For their practical utilities VHHs have been expressed in different platforms. This review aims to provide an update in the field of plant-made VHHs, their applications and limitations, and a discussion about the challenges for the near future in this field.Fil: Marconi, Patricia Laura. Universidad Maimónides; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Alvarez, Maria Alejandra. Universidad Maimónides; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaSciTechnol2014-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/36142Marconi, Patricia Laura; Alvarez, Maria Alejandra; State of the Art on Plant-Made Single-Domain Antibodies; SciTechnol; Journal of Immunological Techniques in Infectious Diseases; 3; 2; 8-2014; 1-62329-9541CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.4172/2329-9541.1000125info:eu-repo/semantics/altIdentifier/url/https://www.scitechnol.com/state-of-the-art-on-plantmade-singledomain-antibodies-7Lg8.php?article_id=2033info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:24:00Zoai:ri.conicet.gov.ar:11336/36142instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:24:00.842CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv State of the Art on Plant-Made Single-Domain Antibodies
title State of the Art on Plant-Made Single-Domain Antibodies
spellingShingle State of the Art on Plant-Made Single-Domain Antibodies
Marconi, Patricia Laura
Molecular Farming
Plantibodies
Single-Domain Antibodies
Tobacco
title_short State of the Art on Plant-Made Single-Domain Antibodies
title_full State of the Art on Plant-Made Single-Domain Antibodies
title_fullStr State of the Art on Plant-Made Single-Domain Antibodies
title_full_unstemmed State of the Art on Plant-Made Single-Domain Antibodies
title_sort State of the Art on Plant-Made Single-Domain Antibodies
dc.creator.none.fl_str_mv Marconi, Patricia Laura
Alvarez, Maria Alejandra
author Marconi, Patricia Laura
author_facet Marconi, Patricia Laura
Alvarez, Maria Alejandra
author_role author
author2 Alvarez, Maria Alejandra
author2_role author
dc.subject.none.fl_str_mv Molecular Farming
Plantibodies
Single-Domain Antibodies
Tobacco
topic Molecular Farming
Plantibodies
Single-Domain Antibodies
Tobacco
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv In addition to conventional antibodies (with heavy and light chains), camelids also produce functional antibodies devoid of light chains (HCAbs) without the first constant domain (CH1). Their variable domains (VHH) have binding properties, high stability and solubility, and are considered the smallest available intact antigen–binding fragment derived from a functional immunoglobulin. For their practical utilities VHHs have been expressed in different platforms. This review aims to provide an update in the field of plant-made VHHs, their applications and limitations, and a discussion about the challenges for the near future in this field.
Fil: Marconi, Patricia Laura. Universidad Maimónides; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Alvarez, Maria Alejandra. Universidad Maimónides; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description In addition to conventional antibodies (with heavy and light chains), camelids also produce functional antibodies devoid of light chains (HCAbs) without the first constant domain (CH1). Their variable domains (VHH) have binding properties, high stability and solubility, and are considered the smallest available intact antigen–binding fragment derived from a functional immunoglobulin. For their practical utilities VHHs have been expressed in different platforms. This review aims to provide an update in the field of plant-made VHHs, their applications and limitations, and a discussion about the challenges for the near future in this field.
publishDate 2014
dc.date.none.fl_str_mv 2014-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/36142
Marconi, Patricia Laura; Alvarez, Maria Alejandra; State of the Art on Plant-Made Single-Domain Antibodies; SciTechnol; Journal of Immunological Techniques in Infectious Diseases; 3; 2; 8-2014; 1-6
2329-9541
CONICET Digital
CONICET
url http://hdl.handle.net/11336/36142
identifier_str_mv Marconi, Patricia Laura; Alvarez, Maria Alejandra; State of the Art on Plant-Made Single-Domain Antibodies; SciTechnol; Journal of Immunological Techniques in Infectious Diseases; 3; 2; 8-2014; 1-6
2329-9541
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.4172/2329-9541.1000125
info:eu-repo/semantics/altIdentifier/url/https://www.scitechnol.com/state-of-the-art-on-plantmade-singledomain-antibodies-7Lg8.php?article_id=2033
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv SciTechnol
publisher.none.fl_str_mv SciTechnol
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846082656861683712
score 13.22299

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