An extensive analysis of Y-chromosomal microsatellite haplotypes in globally dispersed human populations

Autores
Kayser, Manfred; Krawczak, Michael; Excoffier, Laurent; Dieltjes, Patrick; Corach, Daniel; Pascali, Vincente; Gehrig, Christian; Bernini, Luigi F.; Jespersen, J.; Bakker, Egbert; Roewer, Lutz; De Knijff, Peter
Año de publicación
2001
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The genetic variance at seven Y-chromosomal microsatellite loci (or short tandem repeats [STRs]) was studied among 986 male individuals from 20 globally dispersed human populations. A total of 598 different haplotypes were observed, of which 437 (73.1%) were each found in a single male only. Population-specific haplotype-diversity values were .86-.99. Analyses of haplotype diversity and population-specific haplotypes revealed marked population-structure differences between more-isolated indigenous populations (e.g., Central African Pygmies or Greenland Inuit) and more-admixed populations (e.g., Europeans or Surinamese). Furthermore, male individuals from isolated indigenous populations shared haplotypes mainly with male individuals from their own population. By analysis of molecular variance, we found that 76.8% of the total genetic variance present among these male individuals could be attributed to genetic differences between male individuals who were members of the same population. Haplotype sharing between populations, ΦST statistics, and phylogenetic analysis identified close genetic affinities among European populations and among New Guinean populations. Our data illustrate that Y-chromosomal STR haplotypes are an ideal tool for the study of the genetic affinities between groups of male subjects and for detection of population structure.
Fil: Kayser, Manfred. Max Planck Institute for Evolutionary Anthropology; Alemania
Fil: Krawczak, Michael. University of Wales ; Reino Unido
Fil: Excoffier, Laurent. Universidad de Genova; España
Fil: Dieltjes, Patrick. Leiden University; Países Bajos
Fil: Corach, Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Servicio de Huellas Digitales Genéticas; Argentina
Fil: Pascali, Vincente. Universidad Catolica del Sacre Cuore; Italia
Fil: Gehrig, Christian. Institute of Legal Medicine; Italia
Fil: Bernini, Luigi F.. Leiden University; Países Bajos
Fil: Jespersen, J.. University of South Denmark; Dinamarca
Fil: Bakker, Egbert. Leiden University; Países Bajos
Fil: Roewer, Lutz. Humboldt-Universität zu Berlin; Alemania
Fil: De Knijff, Peter. Leiden University; Países Bajos
Materia
YSTRS
WORLD POPULATIONS
HAPLOTYPES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/138624
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/138624
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling An extensive analysis of Y-chromosomal microsatellite haplotypes in globally dispersed human populationsKayser, ManfredKrawczak, MichaelExcoffier, LaurentDieltjes, PatrickCorach, DanielPascali, VincenteGehrig, ChristianBernini, Luigi F.Jespersen, J.Bakker, EgbertRoewer, LutzDe Knijff, PeterYSTRSWORLD POPULATIONSHAPLOTYPEShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The genetic variance at seven Y-chromosomal microsatellite loci (or short tandem repeats [STRs]) was studied among 986 male individuals from 20 globally dispersed human populations. A total of 598 different haplotypes were observed, of which 437 (73.1%) were each found in a single male only. Population-specific haplotype-diversity values were .86-.99. Analyses of haplotype diversity and population-specific haplotypes revealed marked population-structure differences between more-isolated indigenous populations (e.g., Central African Pygmies or Greenland Inuit) and more-admixed populations (e.g., Europeans or Surinamese). Furthermore, male individuals from isolated indigenous populations shared haplotypes mainly with male individuals from their own population. By analysis of molecular variance, we found that 76.8% of the total genetic variance present among these male individuals could be attributed to genetic differences between male individuals who were members of the same population. Haplotype sharing between populations, ΦST statistics, and phylogenetic analysis identified close genetic affinities among European populations and among New Guinean populations. Our data illustrate that Y-chromosomal STR haplotypes are an ideal tool for the study of the genetic affinities between groups of male subjects and for detection of population structure.Fil: Kayser, Manfred. Max Planck Institute for Evolutionary Anthropology; AlemaniaFil: Krawczak, Michael. University of Wales ; Reino UnidoFil: Excoffier, Laurent. Universidad de Genova; EspañaFil: Dieltjes, Patrick. Leiden University; Países BajosFil: Corach, Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Servicio de Huellas Digitales Genéticas; ArgentinaFil: Pascali, Vincente. Universidad Catolica del Sacre Cuore; ItaliaFil: Gehrig, Christian. Institute of Legal Medicine; ItaliaFil: Bernini, Luigi F.. Leiden University; Países BajosFil: Jespersen, J.. University of South Denmark; DinamarcaFil: Bakker, Egbert. Leiden University; Países BajosFil: Roewer, Lutz. Humboldt-Universität zu Berlin; AlemaniaFil: De Knijff, Peter. Leiden University; Países BajosCell Press2001-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/138624Kayser, Manfred; Krawczak, Michael; Excoffier, Laurent; Dieltjes, Patrick; Corach, Daniel; et al.; An extensive analysis of Y-chromosomal microsatellite haplotypes in globally dispersed human populations; Cell Press; American Journal Of Human Genetics; 68; 4; 4-2001; 990-10180002-9297CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.cell.com/ajhg/fulltext/S0002-9297(07)61425-6info:eu-repo/semantics/altIdentifier/doi/10.1086/319510info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:37:57Zoai:ri.conicet.gov.ar:11336/138624instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:37:57.458CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv An extensive analysis of Y-chromosomal microsatellite haplotypes in globally dispersed human populations
title An extensive analysis of Y-chromosomal microsatellite haplotypes in globally dispersed human populations
spellingShingle An extensive analysis of Y-chromosomal microsatellite haplotypes in globally dispersed human populations
Kayser, Manfred
YSTRS
WORLD POPULATIONS
HAPLOTYPES
title_short An extensive analysis of Y-chromosomal microsatellite haplotypes in globally dispersed human populations
title_full An extensive analysis of Y-chromosomal microsatellite haplotypes in globally dispersed human populations
title_fullStr An extensive analysis of Y-chromosomal microsatellite haplotypes in globally dispersed human populations
title_full_unstemmed An extensive analysis of Y-chromosomal microsatellite haplotypes in globally dispersed human populations
title_sort An extensive analysis of Y-chromosomal microsatellite haplotypes in globally dispersed human populations
dc.creator.none.fl_str_mv Kayser, Manfred
Krawczak, Michael
Excoffier, Laurent
Dieltjes, Patrick
Corach, Daniel
Pascali, Vincente
Gehrig, Christian
Bernini, Luigi F.
Jespersen, J.
Bakker, Egbert
Roewer, Lutz
De Knijff, Peter
author Kayser, Manfred
author_facet Kayser, Manfred
Krawczak, Michael
Excoffier, Laurent
Dieltjes, Patrick
Corach, Daniel
Pascali, Vincente
Gehrig, Christian
Bernini, Luigi F.
Jespersen, J.
Bakker, Egbert
Roewer, Lutz
De Knijff, Peter
author_role author
author2 Krawczak, Michael
Excoffier, Laurent
Dieltjes, Patrick
Corach, Daniel
Pascali, Vincente
Gehrig, Christian
Bernini, Luigi F.
Jespersen, J.
Bakker, Egbert
Roewer, Lutz
De Knijff, Peter
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv YSTRS
WORLD POPULATIONS
HAPLOTYPES
topic YSTRS
WORLD POPULATIONS
HAPLOTYPES
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The genetic variance at seven Y-chromosomal microsatellite loci (or short tandem repeats [STRs]) was studied among 986 male individuals from 20 globally dispersed human populations. A total of 598 different haplotypes were observed, of which 437 (73.1%) were each found in a single male only. Population-specific haplotype-diversity values were .86-.99. Analyses of haplotype diversity and population-specific haplotypes revealed marked population-structure differences between more-isolated indigenous populations (e.g., Central African Pygmies or Greenland Inuit) and more-admixed populations (e.g., Europeans or Surinamese). Furthermore, male individuals from isolated indigenous populations shared haplotypes mainly with male individuals from their own population. By analysis of molecular variance, we found that 76.8% of the total genetic variance present among these male individuals could be attributed to genetic differences between male individuals who were members of the same population. Haplotype sharing between populations, ΦST statistics, and phylogenetic analysis identified close genetic affinities among European populations and among New Guinean populations. Our data illustrate that Y-chromosomal STR haplotypes are an ideal tool for the study of the genetic affinities between groups of male subjects and for detection of population structure.
Fil: Kayser, Manfred. Max Planck Institute for Evolutionary Anthropology; Alemania
Fil: Krawczak, Michael. University of Wales ; Reino Unido
Fil: Excoffier, Laurent. Universidad de Genova; España
Fil: Dieltjes, Patrick. Leiden University; Países Bajos
Fil: Corach, Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Servicio de Huellas Digitales Genéticas; Argentina
Fil: Pascali, Vincente. Universidad Catolica del Sacre Cuore; Italia
Fil: Gehrig, Christian. Institute of Legal Medicine; Italia
Fil: Bernini, Luigi F.. Leiden University; Países Bajos
Fil: Jespersen, J.. University of South Denmark; Dinamarca
Fil: Bakker, Egbert. Leiden University; Países Bajos
Fil: Roewer, Lutz. Humboldt-Universität zu Berlin; Alemania
Fil: De Knijff, Peter. Leiden University; Países Bajos
description The genetic variance at seven Y-chromosomal microsatellite loci (or short tandem repeats [STRs]) was studied among 986 male individuals from 20 globally dispersed human populations. A total of 598 different haplotypes were observed, of which 437 (73.1%) were each found in a single male only. Population-specific haplotype-diversity values were .86-.99. Analyses of haplotype diversity and population-specific haplotypes revealed marked population-structure differences between more-isolated indigenous populations (e.g., Central African Pygmies or Greenland Inuit) and more-admixed populations (e.g., Europeans or Surinamese). Furthermore, male individuals from isolated indigenous populations shared haplotypes mainly with male individuals from their own population. By analysis of molecular variance, we found that 76.8% of the total genetic variance present among these male individuals could be attributed to genetic differences between male individuals who were members of the same population. Haplotype sharing between populations, ΦST statistics, and phylogenetic analysis identified close genetic affinities among European populations and among New Guinean populations. Our data illustrate that Y-chromosomal STR haplotypes are an ideal tool for the study of the genetic affinities between groups of male subjects and for detection of population structure.
publishDate 2001
dc.date.none.fl_str_mv 2001-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/138624
Kayser, Manfred; Krawczak, Michael; Excoffier, Laurent; Dieltjes, Patrick; Corach, Daniel; et al.; An extensive analysis of Y-chromosomal microsatellite haplotypes in globally dispersed human populations; Cell Press; American Journal Of Human Genetics; 68; 4; 4-2001; 990-1018
0002-9297
CONICET Digital
CONICET
url http://hdl.handle.net/11336/138624
identifier_str_mv Kayser, Manfred; Krawczak, Michael; Excoffier, Laurent; Dieltjes, Patrick; Corach, Daniel; et al.; An extensive analysis of Y-chromosomal microsatellite haplotypes in globally dispersed human populations; Cell Press; American Journal Of Human Genetics; 68; 4; 4-2001; 990-1018
0002-9297
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.cell.com/ajhg/fulltext/S0002-9297(07)61425-6
info:eu-repo/semantics/altIdentifier/doi/10.1086/319510
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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