Vascular galectins: regulators of tumour progression and targets for cancer therapy

Autores
Thijssen, Victor L.; Rabinovich, Gabriel Adrián; Griffioen, Arjan W.
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Galectins are a family of carbohydrate binding proteins with a broad range of cytokine and growth factor-like functions in multiple steps of cancer progression. They contribute to tumor cell transformation, promote tumor angiogenesis, hamper the anti-tumor immune response, and facilitate tumor metastasis. Consequently, galectins are considered as multifunctional targets for cancer therapy. Interestingly, many of the functions related to tumor progression can be linked to galectins expressed by endothelial cells in the tumor vascular bed. Since the tumor vasculature is an easily accessible target for cancer therapy, understanding how galectins in the tumor endothelium influence cancer progression is important for the translational development of galectin-targeting therapies.
Fil: Thijssen, Victor L.. VU University Medical Center; Países Bajos
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Griffioen, Arjan W.. VU University Medical Center; Países Bajos
Materia
ANGIOGENESIS
ENDOTHELIAL CELLS
ENDOTHELIUM
IMMUNE RESPONSE
METASTASIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/2353
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/2353
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Vascular galectins: regulators of tumour progression and targets for cancer therapyThijssen, Victor L.Rabinovich, Gabriel AdriánGriffioen, Arjan W.ANGIOGENESISENDOTHELIAL CELLSENDOTHELIUMIMMUNE RESPONSEMETASTASIShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Galectins are a family of carbohydrate binding proteins with a broad range of cytokine and growth factor-like functions in multiple steps of cancer progression. They contribute to tumor cell transformation, promote tumor angiogenesis, hamper the anti-tumor immune response, and facilitate tumor metastasis. Consequently, galectins are considered as multifunctional targets for cancer therapy. Interestingly, many of the functions related to tumor progression can be linked to galectins expressed by endothelial cells in the tumor vascular bed. Since the tumor vasculature is an easily accessible target for cancer therapy, understanding how galectins in the tumor endothelium influence cancer progression is important for the translational development of galectin-targeting therapies.Fil: Thijssen, Victor L.. VU University Medical Center; Países BajosFil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaFil: Griffioen, Arjan W.. VU University Medical Center; Países BajosElsevier2013-08-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/2353Thijssen, Victor L.; Rabinovich, Gabriel Adrián; Griffioen, Arjan W.; Vascular galectins: regulators of tumour progression and targets for cancer therapy; Elsevier; Cytokine & Growth Factor Reviews; 24; 6; 12-8-2013; 547-5581359-61011879-0305enginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.cytogfr.2013.07.003info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1359610113000646info:eu-repo/semantics/altIdentifier/url/http://www.cgfr.co.uk/article/S1359-6101(13)00064-6/abstractinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:06:16Zoai:ri.conicet.gov.ar:11336/2353instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:06:16.34CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Vascular galectins: regulators of tumour progression and targets for cancer therapy
title Vascular galectins: regulators of tumour progression and targets for cancer therapy
spellingShingle Vascular galectins: regulators of tumour progression and targets for cancer therapy
Thijssen, Victor L.
ANGIOGENESIS
ENDOTHELIAL CELLS
ENDOTHELIUM
IMMUNE RESPONSE
METASTASIS
title_short Vascular galectins: regulators of tumour progression and targets for cancer therapy
title_full Vascular galectins: regulators of tumour progression and targets for cancer therapy
title_fullStr Vascular galectins: regulators of tumour progression and targets for cancer therapy
title_full_unstemmed Vascular galectins: regulators of tumour progression and targets for cancer therapy
title_sort Vascular galectins: regulators of tumour progression and targets for cancer therapy
dc.creator.none.fl_str_mv Thijssen, Victor L.
Rabinovich, Gabriel Adrián
Griffioen, Arjan W.
author Thijssen, Victor L.
author_facet Thijssen, Victor L.
Rabinovich, Gabriel Adrián
Griffioen, Arjan W.
author_role author
author2 Rabinovich, Gabriel Adrián
Griffioen, Arjan W.
author2_role author
author
dc.subject.none.fl_str_mv ANGIOGENESIS
ENDOTHELIAL CELLS
ENDOTHELIUM
IMMUNE RESPONSE
METASTASIS
topic ANGIOGENESIS
ENDOTHELIAL CELLS
ENDOTHELIUM
IMMUNE RESPONSE
METASTASIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Galectins are a family of carbohydrate binding proteins with a broad range of cytokine and growth factor-like functions in multiple steps of cancer progression. They contribute to tumor cell transformation, promote tumor angiogenesis, hamper the anti-tumor immune response, and facilitate tumor metastasis. Consequently, galectins are considered as multifunctional targets for cancer therapy. Interestingly, many of the functions related to tumor progression can be linked to galectins expressed by endothelial cells in the tumor vascular bed. Since the tumor vasculature is an easily accessible target for cancer therapy, understanding how galectins in the tumor endothelium influence cancer progression is important for the translational development of galectin-targeting therapies.
Fil: Thijssen, Victor L.. VU University Medical Center; Países Bajos
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Griffioen, Arjan W.. VU University Medical Center; Países Bajos
description Galectins are a family of carbohydrate binding proteins with a broad range of cytokine and growth factor-like functions in multiple steps of cancer progression. They contribute to tumor cell transformation, promote tumor angiogenesis, hamper the anti-tumor immune response, and facilitate tumor metastasis. Consequently, galectins are considered as multifunctional targets for cancer therapy. Interestingly, many of the functions related to tumor progression can be linked to galectins expressed by endothelial cells in the tumor vascular bed. Since the tumor vasculature is an easily accessible target for cancer therapy, understanding how galectins in the tumor endothelium influence cancer progression is important for the translational development of galectin-targeting therapies.
publishDate 2013
dc.date.none.fl_str_mv 2013-08-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/2353
Thijssen, Victor L.; Rabinovich, Gabriel Adrián; Griffioen, Arjan W.; Vascular galectins: regulators of tumour progression and targets for cancer therapy; Elsevier; Cytokine & Growth Factor Reviews; 24; 6; 12-8-2013; 547-558
1359-6101
1879-0305
url http://hdl.handle.net/11336/2353
identifier_str_mv Thijssen, Victor L.; Rabinovich, Gabriel Adrián; Griffioen, Arjan W.; Vascular galectins: regulators of tumour progression and targets for cancer therapy; Elsevier; Cytokine & Growth Factor Reviews; 24; 6; 12-8-2013; 547-558
1359-6101
1879-0305
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cytogfr.2013.07.003
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1359610113000646
info:eu-repo/semantics/altIdentifier/url/http://www.cgfr.co.uk/article/S1359-6101(13)00064-6/abstract
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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