An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes

Autores
López Zeballos, Noelia del Carmen; Garcia Vior, María Cecilia; Awruch, Josefina; Dicelio, Lelia Elina
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The lipophilic tetrasubstituted sensitizer 2,9(10),16(17),23(24)-tetrakis-(1-adamantylsulfanyl)phthalocyaninatozinc(II) (ZnPc) was incorporated into different liposomal formulations in orderto evaluate its photophysical properties, as well as the size, incorporation efficiency, thermotropicproperties and stability of liposomes during a time period. Liposomes were prepared by the thin-layerevaporation technique followed by hydratation with buffer at pH 7.4 and 0.15 M NaCl. Small unilamellarvesicles (SUV) were obtained after sonicating the mixture. Phthalocyanine was incorporated efficientlyinto all the liposomal formulations. The shape of ZnPc spectra depended on the environment. The S-PEGliposomal formulation showed the lowest aggregation value. The average diameter of liposomes withdifferent lipid compositions varied from 49.70 ± 0.09 to 223.10 ± 0.36 nm, with significant differencesbetween the various liposomal preparations. The inclusion of cholesterol (CHOL) and polyethylene glycol(PEG) on the lipid bilayer did not influence the size of the particles. The formulations with PEG increasedthe stability of liposomes for at least 9 months. After a long storage, the most stable formulations werethose without CHOL. Singlet molecular oxygen values ranged between 0.10 and 0.26. These values werehigher than other zinc(II) phthalocyanines incorporated into dimyristoyl phosphatidylcholine (DMPC)liposomes or Tween 80
Fil: López Zeballos, Noelia del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina
Fil: Garcia Vior, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica; Argentina
Fil: Awruch, Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica; Argentina
Fil: Dicelio, Lelia Elina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina
Materia
Liposomes
Phthalocyanines
Singlet oxygen
Stability
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/108967
Acceder
id CONICETDig_09b5a439ff00b1376a4f58462b37cea6
oai_identifier_str oai:ri.conicet.gov.ar:11336/108967
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomesLópez Zeballos, Noelia del CarmenGarcia Vior, María CeciliaAwruch, JosefinaDicelio, Lelia ElinaLiposomesPhthalocyaninesSinglet oxygenStabilityhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The lipophilic tetrasubstituted sensitizer 2,9(10),16(17),23(24)-tetrakis-(1-adamantylsulfanyl)phthalocyaninatozinc(II) (ZnPc) was incorporated into different liposomal formulations in orderto evaluate its photophysical properties, as well as the size, incorporation efficiency, thermotropicproperties and stability of liposomes during a time period. Liposomes were prepared by the thin-layerevaporation technique followed by hydratation with buffer at pH 7.4 and 0.15 M NaCl. Small unilamellarvesicles (SUV) were obtained after sonicating the mixture. Phthalocyanine was incorporated efficientlyinto all the liposomal formulations. The shape of ZnPc spectra depended on the environment. The S-PEGliposomal formulation showed the lowest aggregation value. The average diameter of liposomes withdifferent lipid compositions varied from 49.70 ± 0.09 to 223.10 ± 0.36 nm, with significant differencesbetween the various liposomal preparations. The inclusion of cholesterol (CHOL) and polyethylene glycol(PEG) on the lipid bilayer did not influence the size of the particles. The formulations with PEG increasedthe stability of liposomes for at least 9 months. After a long storage, the most stable formulations werethose without CHOL. Singlet molecular oxygen values ranged between 0.10 and 0.26. These values werehigher than other zinc(II) phthalocyanines incorporated into dimyristoyl phosphatidylcholine (DMPC)liposomes or Tween 80Fil: López Zeballos, Noelia del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; ArgentinaFil: Garcia Vior, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica; ArgentinaFil: Awruch, Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica; ArgentinaFil: Dicelio, Lelia Elina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; ArgentinaElsevier Science Sa2012-05-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/108967López Zeballos, Noelia del Carmen; Garcia Vior, María Cecilia; Awruch, Josefina; Dicelio, Lelia Elina; An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes; Elsevier Science Sa; Journal of Photochemistry and Photobiology A: Chemistry; 235; 5-5-2012; 7-131010-6030CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1010603012000962info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jphotochem.2012.02.022info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:37:01Zoai:ri.conicet.gov.ar:11336/108967instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:37:01.269CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes
title An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes
spellingShingle An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes
López Zeballos, Noelia del Carmen
Liposomes
Phthalocyanines
Singlet oxygen
Stability
title_short An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes
title_full An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes
title_fullStr An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes
title_full_unstemmed An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes
title_sort An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes
dc.creator.none.fl_str_mv López Zeballos, Noelia del Carmen
Garcia Vior, María Cecilia
Awruch, Josefina
Dicelio, Lelia Elina
author López Zeballos, Noelia del Carmen
author_facet López Zeballos, Noelia del Carmen
Garcia Vior, María Cecilia
Awruch, Josefina
Dicelio, Lelia Elina
author_role author
author2 Garcia Vior, María Cecilia
Awruch, Josefina
Dicelio, Lelia Elina
author2_role author
author
author
dc.subject.none.fl_str_mv Liposomes
Phthalocyanines
Singlet oxygen
Stability
topic Liposomes
Phthalocyanines
Singlet oxygen
Stability
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The lipophilic tetrasubstituted sensitizer 2,9(10),16(17),23(24)-tetrakis-(1-adamantylsulfanyl)phthalocyaninatozinc(II) (ZnPc) was incorporated into different liposomal formulations in orderto evaluate its photophysical properties, as well as the size, incorporation efficiency, thermotropicproperties and stability of liposomes during a time period. Liposomes were prepared by the thin-layerevaporation technique followed by hydratation with buffer at pH 7.4 and 0.15 M NaCl. Small unilamellarvesicles (SUV) were obtained after sonicating the mixture. Phthalocyanine was incorporated efficientlyinto all the liposomal formulations. The shape of ZnPc spectra depended on the environment. The S-PEGliposomal formulation showed the lowest aggregation value. The average diameter of liposomes withdifferent lipid compositions varied from 49.70 ± 0.09 to 223.10 ± 0.36 nm, with significant differencesbetween the various liposomal preparations. The inclusion of cholesterol (CHOL) and polyethylene glycol(PEG) on the lipid bilayer did not influence the size of the particles. The formulations with PEG increasedthe stability of liposomes for at least 9 months. After a long storage, the most stable formulations werethose without CHOL. Singlet molecular oxygen values ranged between 0.10 and 0.26. These values werehigher than other zinc(II) phthalocyanines incorporated into dimyristoyl phosphatidylcholine (DMPC)liposomes or Tween 80
Fil: López Zeballos, Noelia del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina
Fil: Garcia Vior, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica; Argentina
Fil: Awruch, Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica; Argentina
Fil: Dicelio, Lelia Elina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina
description The lipophilic tetrasubstituted sensitizer 2,9(10),16(17),23(24)-tetrakis-(1-adamantylsulfanyl)phthalocyaninatozinc(II) (ZnPc) was incorporated into different liposomal formulations in orderto evaluate its photophysical properties, as well as the size, incorporation efficiency, thermotropicproperties and stability of liposomes during a time period. Liposomes were prepared by the thin-layerevaporation technique followed by hydratation with buffer at pH 7.4 and 0.15 M NaCl. Small unilamellarvesicles (SUV) were obtained after sonicating the mixture. Phthalocyanine was incorporated efficientlyinto all the liposomal formulations. The shape of ZnPc spectra depended on the environment. The S-PEGliposomal formulation showed the lowest aggregation value. The average diameter of liposomes withdifferent lipid compositions varied from 49.70 ± 0.09 to 223.10 ± 0.36 nm, with significant differencesbetween the various liposomal preparations. The inclusion of cholesterol (CHOL) and polyethylene glycol(PEG) on the lipid bilayer did not influence the size of the particles. The formulations with PEG increasedthe stability of liposomes for at least 9 months. After a long storage, the most stable formulations werethose without CHOL. Singlet molecular oxygen values ranged between 0.10 and 0.26. These values werehigher than other zinc(II) phthalocyanines incorporated into dimyristoyl phosphatidylcholine (DMPC)liposomes or Tween 80
publishDate 2012
dc.date.none.fl_str_mv 2012-05-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/108967
López Zeballos, Noelia del Carmen; Garcia Vior, María Cecilia; Awruch, Josefina; Dicelio, Lelia Elina; An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes; Elsevier Science Sa; Journal of Photochemistry and Photobiology A: Chemistry; 235; 5-5-2012; 7-13
1010-6030
CONICET Digital
CONICET
url http://hdl.handle.net/11336/108967
identifier_str_mv López Zeballos, Noelia del Carmen; Garcia Vior, María Cecilia; Awruch, Josefina; Dicelio, Lelia Elina; An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes; Elsevier Science Sa; Journal of Photochemistry and Photobiology A: Chemistry; 235; 5-5-2012; 7-13
1010-6030
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1010603012000962
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jphotochem.2012.02.022
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Sa
publisher.none.fl_str_mv Elsevier Science Sa
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613164470108160
score 13.069144

Publicaciones similares