An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes
- Autores
- López Zeballos, Noelia del Carmen; Garcia Vior, María Cecilia; Awruch, Josefina; Dicelio, Lelia Elina
- Año de publicación
- 2012
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The lipophilic tetrasubstituted sensitizer 2,9(10),16(17),23(24)-tetrakis-(1-adamantylsulfanyl)phthalocyaninatozinc(II) (ZnPc) was incorporated into different liposomal formulations in orderto evaluate its photophysical properties, as well as the size, incorporation efficiency, thermotropicproperties and stability of liposomes during a time period. Liposomes were prepared by the thin-layerevaporation technique followed by hydratation with buffer at pH 7.4 and 0.15 M NaCl. Small unilamellarvesicles (SUV) were obtained after sonicating the mixture. Phthalocyanine was incorporated efficientlyinto all the liposomal formulations. The shape of ZnPc spectra depended on the environment. The S-PEGliposomal formulation showed the lowest aggregation value. The average diameter of liposomes withdifferent lipid compositions varied from 49.70 ± 0.09 to 223.10 ± 0.36 nm, with significant differencesbetween the various liposomal preparations. The inclusion of cholesterol (CHOL) and polyethylene glycol(PEG) on the lipid bilayer did not influence the size of the particles. The formulations with PEG increasedthe stability of liposomes for at least 9 months. After a long storage, the most stable formulations werethose without CHOL. Singlet molecular oxygen values ranged between 0.10 and 0.26. These values werehigher than other zinc(II) phthalocyanines incorporated into dimyristoyl phosphatidylcholine (DMPC)liposomes or Tween 80
Fil: López Zeballos, Noelia del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina
Fil: Garcia Vior, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica; Argentina
Fil: Awruch, Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica; Argentina
Fil: Dicelio, Lelia Elina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina - Materia
-
Liposomes
Phthalocyanines
Singlet oxygen
Stability - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/108967
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An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomesLópez Zeballos, Noelia del CarmenGarcia Vior, María CeciliaAwruch, JosefinaDicelio, Lelia ElinaLiposomesPhthalocyaninesSinglet oxygenStabilityhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The lipophilic tetrasubstituted sensitizer 2,9(10),16(17),23(24)-tetrakis-(1-adamantylsulfanyl)phthalocyaninatozinc(II) (ZnPc) was incorporated into different liposomal formulations in orderto evaluate its photophysical properties, as well as the size, incorporation efficiency, thermotropicproperties and stability of liposomes during a time period. Liposomes were prepared by the thin-layerevaporation technique followed by hydratation with buffer at pH 7.4 and 0.15 M NaCl. Small unilamellarvesicles (SUV) were obtained after sonicating the mixture. Phthalocyanine was incorporated efficientlyinto all the liposomal formulations. The shape of ZnPc spectra depended on the environment. The S-PEGliposomal formulation showed the lowest aggregation value. The average diameter of liposomes withdifferent lipid compositions varied from 49.70 ± 0.09 to 223.10 ± 0.36 nm, with significant differencesbetween the various liposomal preparations. The inclusion of cholesterol (CHOL) and polyethylene glycol(PEG) on the lipid bilayer did not influence the size of the particles. The formulations with PEG increasedthe stability of liposomes for at least 9 months. After a long storage, the most stable formulations werethose without CHOL. Singlet molecular oxygen values ranged between 0.10 and 0.26. These values werehigher than other zinc(II) phthalocyanines incorporated into dimyristoyl phosphatidylcholine (DMPC)liposomes or Tween 80Fil: López Zeballos, Noelia del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; ArgentinaFil: Garcia Vior, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica; ArgentinaFil: Awruch, Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica; ArgentinaFil: Dicelio, Lelia Elina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; ArgentinaElsevier Science Sa2012-05-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/108967López Zeballos, Noelia del Carmen; Garcia Vior, María Cecilia; Awruch, Josefina; Dicelio, Lelia Elina; An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes; Elsevier Science Sa; Journal of Photochemistry and Photobiology A: Chemistry; 235; 5-5-2012; 7-131010-6030CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1010603012000962info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jphotochem.2012.02.022info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:46:03Zoai:ri.conicet.gov.ar:11336/108967instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:46:03.879CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes |
title |
An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes |
spellingShingle |
An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes López Zeballos, Noelia del Carmen Liposomes Phthalocyanines Singlet oxygen Stability |
title_short |
An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes |
title_full |
An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes |
title_fullStr |
An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes |
title_full_unstemmed |
An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes |
title_sort |
An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes |
dc.creator.none.fl_str_mv |
López Zeballos, Noelia del Carmen Garcia Vior, María Cecilia Awruch, Josefina Dicelio, Lelia Elina |
author |
López Zeballos, Noelia del Carmen |
author_facet |
López Zeballos, Noelia del Carmen Garcia Vior, María Cecilia Awruch, Josefina Dicelio, Lelia Elina |
author_role |
author |
author2 |
Garcia Vior, María Cecilia Awruch, Josefina Dicelio, Lelia Elina |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
Liposomes Phthalocyanines Singlet oxygen Stability |
topic |
Liposomes Phthalocyanines Singlet oxygen Stability |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
The lipophilic tetrasubstituted sensitizer 2,9(10),16(17),23(24)-tetrakis-(1-adamantylsulfanyl)phthalocyaninatozinc(II) (ZnPc) was incorporated into different liposomal formulations in orderto evaluate its photophysical properties, as well as the size, incorporation efficiency, thermotropicproperties and stability of liposomes during a time period. Liposomes were prepared by the thin-layerevaporation technique followed by hydratation with buffer at pH 7.4 and 0.15 M NaCl. Small unilamellarvesicles (SUV) were obtained after sonicating the mixture. Phthalocyanine was incorporated efficientlyinto all the liposomal formulations. The shape of ZnPc spectra depended on the environment. The S-PEGliposomal formulation showed the lowest aggregation value. The average diameter of liposomes withdifferent lipid compositions varied from 49.70 ± 0.09 to 223.10 ± 0.36 nm, with significant differencesbetween the various liposomal preparations. The inclusion of cholesterol (CHOL) and polyethylene glycol(PEG) on the lipid bilayer did not influence the size of the particles. The formulations with PEG increasedthe stability of liposomes for at least 9 months. After a long storage, the most stable formulations werethose without CHOL. Singlet molecular oxygen values ranged between 0.10 and 0.26. These values werehigher than other zinc(II) phthalocyanines incorporated into dimyristoyl phosphatidylcholine (DMPC)liposomes or Tween 80 Fil: López Zeballos, Noelia del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina Fil: Garcia Vior, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica; Argentina Fil: Awruch, Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica; Argentina Fil: Dicelio, Lelia Elina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina |
description |
The lipophilic tetrasubstituted sensitizer 2,9(10),16(17),23(24)-tetrakis-(1-adamantylsulfanyl)phthalocyaninatozinc(II) (ZnPc) was incorporated into different liposomal formulations in orderto evaluate its photophysical properties, as well as the size, incorporation efficiency, thermotropicproperties and stability of liposomes during a time period. Liposomes were prepared by the thin-layerevaporation technique followed by hydratation with buffer at pH 7.4 and 0.15 M NaCl. Small unilamellarvesicles (SUV) were obtained after sonicating the mixture. Phthalocyanine was incorporated efficientlyinto all the liposomal formulations. The shape of ZnPc spectra depended on the environment. The S-PEGliposomal formulation showed the lowest aggregation value. The average diameter of liposomes withdifferent lipid compositions varied from 49.70 ± 0.09 to 223.10 ± 0.36 nm, with significant differencesbetween the various liposomal preparations. The inclusion of cholesterol (CHOL) and polyethylene glycol(PEG) on the lipid bilayer did not influence the size of the particles. The formulations with PEG increasedthe stability of liposomes for at least 9 months. After a long storage, the most stable formulations werethose without CHOL. Singlet molecular oxygen values ranged between 0.10 and 0.26. These values werehigher than other zinc(II) phthalocyanines incorporated into dimyristoyl phosphatidylcholine (DMPC)liposomes or Tween 80 |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-05-05 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/108967 López Zeballos, Noelia del Carmen; Garcia Vior, María Cecilia; Awruch, Josefina; Dicelio, Lelia Elina; An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes; Elsevier Science Sa; Journal of Photochemistry and Photobiology A: Chemistry; 235; 5-5-2012; 7-13 1010-6030 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/108967 |
identifier_str_mv |
López Zeballos, Noelia del Carmen; Garcia Vior, María Cecilia; Awruch, Josefina; Dicelio, Lelia Elina; An exhaustive study of a novel sulfur-linked adamantane tetrasubstituted zinc(II) phthalocyanine incorporated into liposomes; Elsevier Science Sa; Journal of Photochemistry and Photobiology A: Chemistry; 235; 5-5-2012; 7-13 1010-6030 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1010603012000962 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jphotochem.2012.02.022 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Science Sa |
publisher.none.fl_str_mv |
Elsevier Science Sa |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842268770889891840 |
score |
13.13397 |