Risk of chronic arthralgia and impact of pain on daily activities in a cohort of patients with chikungunya virus infection from Brazil

Autores
Silva, Monaíse M. O.; Kikuti, Mariana; Anjos, Rosângela O.; Portilho, Moyra M.; Santos, Viviane C.; Gonçalves, Thaiza S.F.; Tauro, Laura Beatriz; Moreira, Patrícia S. S.; Jacob Nascimento, Leile C.; Santana, Perla M.; Campos, Gúbio S.; Siqueira, André M.; Kitron, Uriel D.; Reis, Mitermayer G.; Ribeiro, Guilherme S.
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objectives: To investigate risk factors for persistent arthralgia in patients with chikungunya, and describe its impact on daily activities. Methods: From September 2014 to July 2016, a surveillance study enrolled patients with acute febrile illness in Salvador, Brazil, and detected those with chikungunya virus infection using IgM enzyme-linked immunosorbent assay or reverse transcriptase polymerase chain reaction. Telephone follow-ups were performed to ascertain the progression of disease. Results: Of 153 followed cases, 65 (42.5%) reported chronic arthralgia that lasted >3 months, and 47 (30.7%) were still symptomatic at the time of the interview (approximately 1.5 years after symptom onset). Limitations in daily activities and mental distress were reported by 93.8% and 61.5% of those with chronic arthralgia, respectively. Female sex [risk ratio (RR) 1.79, 95% confidence interval (CI) 1.95–2.69] and age (RR 1.02 for each 1-year increase, 95% CI 1.01–1.03) were independent risk factors for chronic arthralgia. Chronic arthralgia was not associated with co-infection with dengue virus (RR 0.97, 95% CI 0.48–1.94) or chikungunya viral load at diagnosis (median chikungunya virus RNA of 5.60 and 5.52 log10 copies/μL for those with and without chronic arthralgia, respectively; P = 0.75). Conclusions: These findings reinforce the high frequency of chronic chikungunya arthralgia, and highlight the substantial disability associated with the persistence of pain. Development of novel strategies to mitigate the transmission of chikungunya virus and to provide long-term medical assistance for patients with chikungunya are needed urgently.
Fil: Silva, Monaíse M. O.. Fundación Oswaldo Cruz; Brasil
Fil: Kikuti, Mariana. Universidade Federal da Bahia; Brasil. Fundación Oswaldo Cruz; Brasil
Fil: Anjos, Rosângela O.. Fundación Oswaldo Cruz; Brasil
Fil: Portilho, Moyra M.. Fundación Oswaldo Cruz; Brasil
Fil: Santos, Viviane C.. Fundación Oswaldo Cruz; Brasil
Fil: Gonçalves, Thaiza S.F.. Fundación Oswaldo Cruz; Brasil
Fil: Tauro, Laura Beatriz. Fundación Oswaldo Cruz; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Puerto Iguazú | Universidad Nacional de Misiones. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Puerto Iguazú; Argentina
Fil: Moreira, Patrícia S. S.. Fundación Oswaldo Cruz; Brasil
Fil: Jacob Nascimento, Leile C.. Fundación Oswaldo Cruz; Brasil
Fil: Santana, Perla M.. Fundación Oswaldo Cruz; Brasil
Fil: Campos, Gúbio S.. Universidade Federal da Bahia; Brasil
Fil: Siqueira, André M.. Fundación Oswaldo Cruz; Brasil
Fil: Kitron, Uriel D.. University of Emory; Estados Unidos. Fundación Oswaldo Cruz; Brasil
Fil: Reis, Mitermayer G.. University of Yale; Estados Unidos. Fundación Oswaldo Cruz; Brasil. Universidade Federal da Bahia; Brasil
Fil: Ribeiro, Guilherme S.. Fundación Oswaldo Cruz; Brasil. Universidade Federal da Bahia; Brasil
Materia
CHIKUNGUNYA VIRUS
CHRONIC ARTHRALGIA
COHORT
DISABILITY
RISK FACTOR
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/178650
Acceder
id CONICETDig_08d4c2b7109e9ab785833dd002462969
oai_identifier_str oai:ri.conicet.gov.ar:11336/178650
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Risk of chronic arthralgia and impact of pain on daily activities in a cohort of patients with chikungunya virus infection from BrazilSilva, Monaíse M. O.Kikuti, MarianaAnjos, Rosângela O.Portilho, Moyra M.Santos, Viviane C.Gonçalves, Thaiza S.F.Tauro, Laura BeatrizMoreira, Patrícia S. S.Jacob Nascimento, Leile C.Santana, Perla M.Campos, Gúbio S.Siqueira, André M.Kitron, Uriel D.Reis, Mitermayer G.Ribeiro, Guilherme S.CHIKUNGUNYA VIRUSCHRONIC ARTHRALGIACOHORTDISABILITYRISK FACTORhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Objectives: To investigate risk factors for persistent arthralgia in patients with chikungunya, and describe its impact on daily activities. Methods: From September 2014 to July 2016, a surveillance study enrolled patients with acute febrile illness in Salvador, Brazil, and detected those with chikungunya virus infection using IgM enzyme-linked immunosorbent assay or reverse transcriptase polymerase chain reaction. Telephone follow-ups were performed to ascertain the progression of disease. Results: Of 153 followed cases, 65 (42.5%) reported chronic arthralgia that lasted >3 months, and 47 (30.7%) were still symptomatic at the time of the interview (approximately 1.5 years after symptom onset). Limitations in daily activities and mental distress were reported by 93.8% and 61.5% of those with chronic arthralgia, respectively. Female sex [risk ratio (RR) 1.79, 95% confidence interval (CI) 1.95–2.69] and age (RR 1.02 for each 1-year increase, 95% CI 1.01–1.03) were independent risk factors for chronic arthralgia. Chronic arthralgia was not associated with co-infection with dengue virus (RR 0.97, 95% CI 0.48–1.94) or chikungunya viral load at diagnosis (median chikungunya virus RNA of 5.60 and 5.52 log10 copies/μL for those with and without chronic arthralgia, respectively; P = 0.75). Conclusions: These findings reinforce the high frequency of chronic chikungunya arthralgia, and highlight the substantial disability associated with the persistence of pain. Development of novel strategies to mitigate the transmission of chikungunya virus and to provide long-term medical assistance for patients with chikungunya are needed urgently.Fil: Silva, Monaíse M. O.. Fundación Oswaldo Cruz; BrasilFil: Kikuti, Mariana. Universidade Federal da Bahia; Brasil. Fundación Oswaldo Cruz; BrasilFil: Anjos, Rosângela O.. Fundación Oswaldo Cruz; BrasilFil: Portilho, Moyra M.. Fundación Oswaldo Cruz; BrasilFil: Santos, Viviane C.. Fundación Oswaldo Cruz; BrasilFil: Gonçalves, Thaiza S.F.. Fundación Oswaldo Cruz; BrasilFil: Tauro, Laura Beatriz. Fundación Oswaldo Cruz; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Puerto Iguazú | Universidad Nacional de Misiones. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Puerto Iguazú; ArgentinaFil: Moreira, Patrícia S. S.. Fundación Oswaldo Cruz; BrasilFil: Jacob Nascimento, Leile C.. Fundación Oswaldo Cruz; BrasilFil: Santana, Perla M.. Fundación Oswaldo Cruz; BrasilFil: Campos, Gúbio S.. Universidade Federal da Bahia; BrasilFil: Siqueira, André M.. Fundación Oswaldo Cruz; BrasilFil: Kitron, Uriel D.. University of Emory; Estados Unidos. Fundación Oswaldo Cruz; BrasilFil: Reis, Mitermayer G.. University of Yale; Estados Unidos. Fundación Oswaldo Cruz; Brasil. Universidade Federal da Bahia; BrasilFil: Ribeiro, Guilherme S.. Fundación Oswaldo Cruz; Brasil. Universidade Federal da Bahia; BrasilElsevier2021-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/178650Silva, Monaíse M. O.; Kikuti, Mariana; Anjos, Rosângela O.; Portilho, Moyra M.; Santos, Viviane C.; et al.; Risk of chronic arthralgia and impact of pain on daily activities in a cohort of patients with chikungunya virus infection from Brazil; Elsevier; International Journal of Infectious Diseases; 105; 4-2021; 608-6161201-9712CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.ijid.2021.03.003info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1201971221002083info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:58:32Zoai:ri.conicet.gov.ar:11336/178650instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:58:32.687CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Risk of chronic arthralgia and impact of pain on daily activities in a cohort of patients with chikungunya virus infection from Brazil
title Risk of chronic arthralgia and impact of pain on daily activities in a cohort of patients with chikungunya virus infection from Brazil
spellingShingle Risk of chronic arthralgia and impact of pain on daily activities in a cohort of patients with chikungunya virus infection from Brazil
Silva, Monaíse M. O.
CHIKUNGUNYA VIRUS
CHRONIC ARTHRALGIA
COHORT
DISABILITY
RISK FACTOR
title_short Risk of chronic arthralgia and impact of pain on daily activities in a cohort of patients with chikungunya virus infection from Brazil
title_full Risk of chronic arthralgia and impact of pain on daily activities in a cohort of patients with chikungunya virus infection from Brazil
title_fullStr Risk of chronic arthralgia and impact of pain on daily activities in a cohort of patients with chikungunya virus infection from Brazil
title_full_unstemmed Risk of chronic arthralgia and impact of pain on daily activities in a cohort of patients with chikungunya virus infection from Brazil
title_sort Risk of chronic arthralgia and impact of pain on daily activities in a cohort of patients with chikungunya virus infection from Brazil
dc.creator.none.fl_str_mv Silva, Monaíse M. O.
Kikuti, Mariana
Anjos, Rosângela O.
Portilho, Moyra M.
Santos, Viviane C.
Gonçalves, Thaiza S.F.
Tauro, Laura Beatriz
Moreira, Patrícia S. S.
Jacob Nascimento, Leile C.
Santana, Perla M.
Campos, Gúbio S.
Siqueira, André M.
Kitron, Uriel D.
Reis, Mitermayer G.
Ribeiro, Guilherme S.
author Silva, Monaíse M. O.
author_facet Silva, Monaíse M. O.
Kikuti, Mariana
Anjos, Rosângela O.
Portilho, Moyra M.
Santos, Viviane C.
Gonçalves, Thaiza S.F.
Tauro, Laura Beatriz
Moreira, Patrícia S. S.
Jacob Nascimento, Leile C.
Santana, Perla M.
Campos, Gúbio S.
Siqueira, André M.
Kitron, Uriel D.
Reis, Mitermayer G.
Ribeiro, Guilherme S.
author_role author
author2 Kikuti, Mariana
Anjos, Rosângela O.
Portilho, Moyra M.
Santos, Viviane C.
Gonçalves, Thaiza S.F.
Tauro, Laura Beatriz
Moreira, Patrícia S. S.
Jacob Nascimento, Leile C.
Santana, Perla M.
Campos, Gúbio S.
Siqueira, André M.
Kitron, Uriel D.
Reis, Mitermayer G.
Ribeiro, Guilherme S.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CHIKUNGUNYA VIRUS
CHRONIC ARTHRALGIA
COHORT
DISABILITY
RISK FACTOR
topic CHIKUNGUNYA VIRUS
CHRONIC ARTHRALGIA
COHORT
DISABILITY
RISK FACTOR
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Objectives: To investigate risk factors for persistent arthralgia in patients with chikungunya, and describe its impact on daily activities. Methods: From September 2014 to July 2016, a surveillance study enrolled patients with acute febrile illness in Salvador, Brazil, and detected those with chikungunya virus infection using IgM enzyme-linked immunosorbent assay or reverse transcriptase polymerase chain reaction. Telephone follow-ups were performed to ascertain the progression of disease. Results: Of 153 followed cases, 65 (42.5%) reported chronic arthralgia that lasted >3 months, and 47 (30.7%) were still symptomatic at the time of the interview (approximately 1.5 years after symptom onset). Limitations in daily activities and mental distress were reported by 93.8% and 61.5% of those with chronic arthralgia, respectively. Female sex [risk ratio (RR) 1.79, 95% confidence interval (CI) 1.95–2.69] and age (RR 1.02 for each 1-year increase, 95% CI 1.01–1.03) were independent risk factors for chronic arthralgia. Chronic arthralgia was not associated with co-infection with dengue virus (RR 0.97, 95% CI 0.48–1.94) or chikungunya viral load at diagnosis (median chikungunya virus RNA of 5.60 and 5.52 log10 copies/μL for those with and without chronic arthralgia, respectively; P = 0.75). Conclusions: These findings reinforce the high frequency of chronic chikungunya arthralgia, and highlight the substantial disability associated with the persistence of pain. Development of novel strategies to mitigate the transmission of chikungunya virus and to provide long-term medical assistance for patients with chikungunya are needed urgently.
Fil: Silva, Monaíse M. O.. Fundación Oswaldo Cruz; Brasil
Fil: Kikuti, Mariana. Universidade Federal da Bahia; Brasil. Fundación Oswaldo Cruz; Brasil
Fil: Anjos, Rosângela O.. Fundación Oswaldo Cruz; Brasil
Fil: Portilho, Moyra M.. Fundación Oswaldo Cruz; Brasil
Fil: Santos, Viviane C.. Fundación Oswaldo Cruz; Brasil
Fil: Gonçalves, Thaiza S.F.. Fundación Oswaldo Cruz; Brasil
Fil: Tauro, Laura Beatriz. Fundación Oswaldo Cruz; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Puerto Iguazú | Universidad Nacional de Misiones. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Puerto Iguazú; Argentina
Fil: Moreira, Patrícia S. S.. Fundación Oswaldo Cruz; Brasil
Fil: Jacob Nascimento, Leile C.. Fundación Oswaldo Cruz; Brasil
Fil: Santana, Perla M.. Fundación Oswaldo Cruz; Brasil
Fil: Campos, Gúbio S.. Universidade Federal da Bahia; Brasil
Fil: Siqueira, André M.. Fundación Oswaldo Cruz; Brasil
Fil: Kitron, Uriel D.. University of Emory; Estados Unidos. Fundación Oswaldo Cruz; Brasil
Fil: Reis, Mitermayer G.. University of Yale; Estados Unidos. Fundación Oswaldo Cruz; Brasil. Universidade Federal da Bahia; Brasil
Fil: Ribeiro, Guilherme S.. Fundación Oswaldo Cruz; Brasil. Universidade Federal da Bahia; Brasil
description Objectives: To investigate risk factors for persistent arthralgia in patients with chikungunya, and describe its impact on daily activities. Methods: From September 2014 to July 2016, a surveillance study enrolled patients with acute febrile illness in Salvador, Brazil, and detected those with chikungunya virus infection using IgM enzyme-linked immunosorbent assay or reverse transcriptase polymerase chain reaction. Telephone follow-ups were performed to ascertain the progression of disease. Results: Of 153 followed cases, 65 (42.5%) reported chronic arthralgia that lasted >3 months, and 47 (30.7%) were still symptomatic at the time of the interview (approximately 1.5 years after symptom onset). Limitations in daily activities and mental distress were reported by 93.8% and 61.5% of those with chronic arthralgia, respectively. Female sex [risk ratio (RR) 1.79, 95% confidence interval (CI) 1.95–2.69] and age (RR 1.02 for each 1-year increase, 95% CI 1.01–1.03) were independent risk factors for chronic arthralgia. Chronic arthralgia was not associated with co-infection with dengue virus (RR 0.97, 95% CI 0.48–1.94) or chikungunya viral load at diagnosis (median chikungunya virus RNA of 5.60 and 5.52 log10 copies/μL for those with and without chronic arthralgia, respectively; P = 0.75). Conclusions: These findings reinforce the high frequency of chronic chikungunya arthralgia, and highlight the substantial disability associated with the persistence of pain. Development of novel strategies to mitigate the transmission of chikungunya virus and to provide long-term medical assistance for patients with chikungunya are needed urgently.
publishDate 2021
dc.date.none.fl_str_mv 2021-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/178650
Silva, Monaíse M. O.; Kikuti, Mariana; Anjos, Rosângela O.; Portilho, Moyra M.; Santos, Viviane C.; et al.; Risk of chronic arthralgia and impact of pain on daily activities in a cohort of patients with chikungunya virus infection from Brazil; Elsevier; International Journal of Infectious Diseases; 105; 4-2021; 608-616
1201-9712
CONICET Digital
CONICET
url http://hdl.handle.net/11336/178650
identifier_str_mv Silva, Monaíse M. O.; Kikuti, Mariana; Anjos, Rosângela O.; Portilho, Moyra M.; Santos, Viviane C.; et al.; Risk of chronic arthralgia and impact of pain on daily activities in a cohort of patients with chikungunya virus infection from Brazil; Elsevier; International Journal of Infectious Diseases; 105; 4-2021; 608-616
1201-9712
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ijid.2021.03.003
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1201971221002083
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083126040723456
score 13.22299

Publicaciones similares