Acute-Phase Levels of CXCL8 as Risk Factor for Chronic Arthralgia Following Chikungunya Virus Infection
- Autores
- Jacob Nascimento, Leile Camila; Carvalho, Caroline Xavier; Oliveira Silva, Monaíse Madalena; Kikuti, Mariana; Oliveira Anjos, Rosângela; Rodrigues Barbosa Fradico, Jordana; Campi Azevedo, Ana Carolina; Tauro, Laura Beatriz; Soares Campos, Gúbio; Sousa dos Santos Moreira, Patricia; Machado Portilho, Moyra; Assis Martins Filho, Olindo; Sousa Ribeiro, Guilherme; Galvão Reis, Mitermayer
- Año de publicación
- 2021
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The immunopathogenesis of chikungunya virus (CHIKV) infection and the role of acute-phase immune response on joint pain persistence is not fully understood. We investigated the profile of serum chemokine and cytokine in CHIKV-infected patients with acute disease, compared the levels of these biomarkers to those of patients with other acute febrile diseases (OAFD) and healthy controls (HC), and evaluated their role as predictors of chronic arthralgia development. Chemokines and cytokines were measured by flow Cytometric Bead Array. Patients with CHIKV infection were further categorized according to duration of arthralgia (≤ 3 months vs >3 months), presence of anti-CHIKV IgM at acute-phase sample, and number of days of symptoms at sample collection (1 vs 2-3 vs ≥4). Patients with acute CHIKV infection had significantly higher levels of CXCL8, CCL2, CXCL9, CCL5, CXCL10, IL-1β, IL-6, IL-12, and IL-10 as compared to HC. CCL2, CCL5, and CXCL10 levels were also significantly higher in patients with CHIKV infection compared to patients with OAFD. Patients whose arthralgia lasted > 3 months had increased CXCL8 levels compared to patients whose arthralgia did not (p<0.05). Multivariable analyses further indicated that high levels of CXCL8 and female sex were associated with arthralgia lasting >3 months. Patients with chikungunya and OAFD had similar cytokine kinetics for IL-1β, IL-12, TNF, IFN-γ, IL-2, and IL-4, although the levels were lower for CHIKV patients. This study suggests that chemokines may have an important role in the immunopathogenesis of chronic chikungunya-related arthralgia.
Fil: Jacob Nascimento, Leile Camila. Fundación Oswaldo Cruz; Brasil
Fil: Carvalho, Caroline Xavier. Fundación Oswaldo Cruz; Brasil
Fil: Oliveira Silva, Monaíse Madalena. Fundación Oswaldo Cruz; Brasil
Fil: Kikuti, Mariana. Fundación Oswaldo Cruz; Brasil. Universidade Federal da Bahia; Brasil
Fil: Oliveira Anjos, Rosângela. Fundación Oswaldo Cruz; Brasil
Fil: Rodrigues Barbosa Fradico, Jordana. Fundación Oswaldo Cruz; Brasil
Fil: Campi Azevedo, Ana Carolina. Fundación Oswaldo Cruz; Brasil
Fil: Tauro, Laura Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Puerto Iguazú | Universidad Nacional de Misiones. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Puerto Iguazú; Argentina
Fil: Soares Campos, Gúbio. Universidade Federal da Bahia; Brasil
Fil: Sousa dos Santos Moreira, Patricia. Fundación Oswaldo Cruz; Brasil
Fil: Machado Portilho, Moyra. Fundación Oswaldo Cruz; Brasil
Fil: Assis Martins Filho, Olindo. Fundación Oswaldo Cruz; Brasil
Fil: Sousa Ribeiro, Guilherme. Universidade Federal da Bahia; Brasil. Fundación Oswaldo Cruz; Brasil
Fil: Galvão Reis, Mitermayer. Fundación Oswaldo Cruz; Brasil. University of Yale; Estados Unidos. Universidade Federal da Bahia; Brasil - Materia
-
CHEMOKINES
CHIKUNGUNYA
CHRONIC ARTHRALGIA
COHORT
CYTOKINES
SERUM BIOMARKERS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/158779
Ver los metadatos del registro completo
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Acute-Phase Levels of CXCL8 as Risk Factor for Chronic Arthralgia Following Chikungunya Virus InfectionJacob Nascimento, Leile CamilaCarvalho, Caroline XavierOliveira Silva, Monaíse MadalenaKikuti, MarianaOliveira Anjos, RosângelaRodrigues Barbosa Fradico, JordanaCampi Azevedo, Ana CarolinaTauro, Laura BeatrizSoares Campos, GúbioSousa dos Santos Moreira, PatriciaMachado Portilho, MoyraAssis Martins Filho, OlindoSousa Ribeiro, GuilhermeGalvão Reis, MitermayerCHEMOKINESCHIKUNGUNYACHRONIC ARTHRALGIACOHORTCYTOKINESSERUM BIOMARKERShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The immunopathogenesis of chikungunya virus (CHIKV) infection and the role of acute-phase immune response on joint pain persistence is not fully understood. We investigated the profile of serum chemokine and cytokine in CHIKV-infected patients with acute disease, compared the levels of these biomarkers to those of patients with other acute febrile diseases (OAFD) and healthy controls (HC), and evaluated their role as predictors of chronic arthralgia development. Chemokines and cytokines were measured by flow Cytometric Bead Array. Patients with CHIKV infection were further categorized according to duration of arthralgia (≤ 3 months vs >3 months), presence of anti-CHIKV IgM at acute-phase sample, and number of days of symptoms at sample collection (1 vs 2-3 vs ≥4). Patients with acute CHIKV infection had significantly higher levels of CXCL8, CCL2, CXCL9, CCL5, CXCL10, IL-1β, IL-6, IL-12, and IL-10 as compared to HC. CCL2, CCL5, and CXCL10 levels were also significantly higher in patients with CHIKV infection compared to patients with OAFD. Patients whose arthralgia lasted > 3 months had increased CXCL8 levels compared to patients whose arthralgia did not (p<0.05). Multivariable analyses further indicated that high levels of CXCL8 and female sex were associated with arthralgia lasting >3 months. Patients with chikungunya and OAFD had similar cytokine kinetics for IL-1β, IL-12, TNF, IFN-γ, IL-2, and IL-4, although the levels were lower for CHIKV patients. This study suggests that chemokines may have an important role in the immunopathogenesis of chronic chikungunya-related arthralgia.Fil: Jacob Nascimento, Leile Camila. Fundación Oswaldo Cruz; BrasilFil: Carvalho, Caroline Xavier. Fundación Oswaldo Cruz; BrasilFil: Oliveira Silva, Monaíse Madalena. Fundación Oswaldo Cruz; BrasilFil: Kikuti, Mariana. Fundación Oswaldo Cruz; Brasil. Universidade Federal da Bahia; BrasilFil: Oliveira Anjos, Rosângela. Fundación Oswaldo Cruz; BrasilFil: Rodrigues Barbosa Fradico, Jordana. Fundación Oswaldo Cruz; BrasilFil: Campi Azevedo, Ana Carolina. Fundación Oswaldo Cruz; BrasilFil: Tauro, Laura Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Puerto Iguazú | Universidad Nacional de Misiones. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Puerto Iguazú; ArgentinaFil: Soares Campos, Gúbio. Universidade Federal da Bahia; BrasilFil: Sousa dos Santos Moreira, Patricia. Fundación Oswaldo Cruz; BrasilFil: Machado Portilho, Moyra. Fundación Oswaldo Cruz; BrasilFil: Assis Martins Filho, Olindo. Fundación Oswaldo Cruz; BrasilFil: Sousa Ribeiro, Guilherme. Universidade Federal da Bahia; Brasil. Fundación Oswaldo Cruz; BrasilFil: Galvão Reis, Mitermayer. Fundación Oswaldo Cruz; Brasil. University of Yale; Estados Unidos. Universidade Federal da Bahia; BrasilFrontiers Media2021-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/158779Jacob Nascimento, Leile Camila; Carvalho, Caroline Xavier; Oliveira Silva, Monaíse Madalena; Kikuti, Mariana; Oliveira Anjos, Rosângela; et al.; Acute-Phase Levels of CXCL8 as Risk Factor for Chronic Arthralgia Following Chikungunya Virus Infection; Frontiers Media; Frontiers in Immunology; 12; 10-2021; 1-101664-3224CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2021.744183info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fimmu.2021.744183/fullinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:27:24Zoai:ri.conicet.gov.ar:11336/158779instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:27:24.666CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Acute-Phase Levels of CXCL8 as Risk Factor for Chronic Arthralgia Following Chikungunya Virus Infection |
| title |
Acute-Phase Levels of CXCL8 as Risk Factor for Chronic Arthralgia Following Chikungunya Virus Infection |
| spellingShingle |
Acute-Phase Levels of CXCL8 as Risk Factor for Chronic Arthralgia Following Chikungunya Virus Infection Jacob Nascimento, Leile Camila CHEMOKINES CHIKUNGUNYA CHRONIC ARTHRALGIA COHORT CYTOKINES SERUM BIOMARKERS |
| title_short |
Acute-Phase Levels of CXCL8 as Risk Factor for Chronic Arthralgia Following Chikungunya Virus Infection |
| title_full |
Acute-Phase Levels of CXCL8 as Risk Factor for Chronic Arthralgia Following Chikungunya Virus Infection |
| title_fullStr |
Acute-Phase Levels of CXCL8 as Risk Factor for Chronic Arthralgia Following Chikungunya Virus Infection |
| title_full_unstemmed |
Acute-Phase Levels of CXCL8 as Risk Factor for Chronic Arthralgia Following Chikungunya Virus Infection |
| title_sort |
Acute-Phase Levels of CXCL8 as Risk Factor for Chronic Arthralgia Following Chikungunya Virus Infection |
| dc.creator.none.fl_str_mv |
Jacob Nascimento, Leile Camila Carvalho, Caroline Xavier Oliveira Silva, Monaíse Madalena Kikuti, Mariana Oliveira Anjos, Rosângela Rodrigues Barbosa Fradico, Jordana Campi Azevedo, Ana Carolina Tauro, Laura Beatriz Soares Campos, Gúbio Sousa dos Santos Moreira, Patricia Machado Portilho, Moyra Assis Martins Filho, Olindo Sousa Ribeiro, Guilherme Galvão Reis, Mitermayer |
| author |
Jacob Nascimento, Leile Camila |
| author_facet |
Jacob Nascimento, Leile Camila Carvalho, Caroline Xavier Oliveira Silva, Monaíse Madalena Kikuti, Mariana Oliveira Anjos, Rosângela Rodrigues Barbosa Fradico, Jordana Campi Azevedo, Ana Carolina Tauro, Laura Beatriz Soares Campos, Gúbio Sousa dos Santos Moreira, Patricia Machado Portilho, Moyra Assis Martins Filho, Olindo Sousa Ribeiro, Guilherme Galvão Reis, Mitermayer |
| author_role |
author |
| author2 |
Carvalho, Caroline Xavier Oliveira Silva, Monaíse Madalena Kikuti, Mariana Oliveira Anjos, Rosângela Rodrigues Barbosa Fradico, Jordana Campi Azevedo, Ana Carolina Tauro, Laura Beatriz Soares Campos, Gúbio Sousa dos Santos Moreira, Patricia Machado Portilho, Moyra Assis Martins Filho, Olindo Sousa Ribeiro, Guilherme Galvão Reis, Mitermayer |
| author2_role |
author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
CHEMOKINES CHIKUNGUNYA CHRONIC ARTHRALGIA COHORT CYTOKINES SERUM BIOMARKERS |
| topic |
CHEMOKINES CHIKUNGUNYA CHRONIC ARTHRALGIA COHORT CYTOKINES SERUM BIOMARKERS |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
| dc.description.none.fl_txt_mv |
The immunopathogenesis of chikungunya virus (CHIKV) infection and the role of acute-phase immune response on joint pain persistence is not fully understood. We investigated the profile of serum chemokine and cytokine in CHIKV-infected patients with acute disease, compared the levels of these biomarkers to those of patients with other acute febrile diseases (OAFD) and healthy controls (HC), and evaluated their role as predictors of chronic arthralgia development. Chemokines and cytokines were measured by flow Cytometric Bead Array. Patients with CHIKV infection were further categorized according to duration of arthralgia (≤ 3 months vs >3 months), presence of anti-CHIKV IgM at acute-phase sample, and number of days of symptoms at sample collection (1 vs 2-3 vs ≥4). Patients with acute CHIKV infection had significantly higher levels of CXCL8, CCL2, CXCL9, CCL5, CXCL10, IL-1β, IL-6, IL-12, and IL-10 as compared to HC. CCL2, CCL5, and CXCL10 levels were also significantly higher in patients with CHIKV infection compared to patients with OAFD. Patients whose arthralgia lasted > 3 months had increased CXCL8 levels compared to patients whose arthralgia did not (p<0.05). Multivariable analyses further indicated that high levels of CXCL8 and female sex were associated with arthralgia lasting >3 months. Patients with chikungunya and OAFD had similar cytokine kinetics for IL-1β, IL-12, TNF, IFN-γ, IL-2, and IL-4, although the levels were lower for CHIKV patients. This study suggests that chemokines may have an important role in the immunopathogenesis of chronic chikungunya-related arthralgia. Fil: Jacob Nascimento, Leile Camila. Fundación Oswaldo Cruz; Brasil Fil: Carvalho, Caroline Xavier. Fundación Oswaldo Cruz; Brasil Fil: Oliveira Silva, Monaíse Madalena. Fundación Oswaldo Cruz; Brasil Fil: Kikuti, Mariana. Fundación Oswaldo Cruz; Brasil. Universidade Federal da Bahia; Brasil Fil: Oliveira Anjos, Rosângela. Fundación Oswaldo Cruz; Brasil Fil: Rodrigues Barbosa Fradico, Jordana. Fundación Oswaldo Cruz; Brasil Fil: Campi Azevedo, Ana Carolina. Fundación Oswaldo Cruz; Brasil Fil: Tauro, Laura Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Puerto Iguazú | Universidad Nacional de Misiones. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Puerto Iguazú; Argentina Fil: Soares Campos, Gúbio. Universidade Federal da Bahia; Brasil Fil: Sousa dos Santos Moreira, Patricia. Fundación Oswaldo Cruz; Brasil Fil: Machado Portilho, Moyra. Fundación Oswaldo Cruz; Brasil Fil: Assis Martins Filho, Olindo. Fundación Oswaldo Cruz; Brasil Fil: Sousa Ribeiro, Guilherme. Universidade Federal da Bahia; Brasil. Fundación Oswaldo Cruz; Brasil Fil: Galvão Reis, Mitermayer. Fundación Oswaldo Cruz; Brasil. University of Yale; Estados Unidos. Universidade Federal da Bahia; Brasil |
| description |
The immunopathogenesis of chikungunya virus (CHIKV) infection and the role of acute-phase immune response on joint pain persistence is not fully understood. We investigated the profile of serum chemokine and cytokine in CHIKV-infected patients with acute disease, compared the levels of these biomarkers to those of patients with other acute febrile diseases (OAFD) and healthy controls (HC), and evaluated their role as predictors of chronic arthralgia development. Chemokines and cytokines were measured by flow Cytometric Bead Array. Patients with CHIKV infection were further categorized according to duration of arthralgia (≤ 3 months vs >3 months), presence of anti-CHIKV IgM at acute-phase sample, and number of days of symptoms at sample collection (1 vs 2-3 vs ≥4). Patients with acute CHIKV infection had significantly higher levels of CXCL8, CCL2, CXCL9, CCL5, CXCL10, IL-1β, IL-6, IL-12, and IL-10 as compared to HC. CCL2, CCL5, and CXCL10 levels were also significantly higher in patients with CHIKV infection compared to patients with OAFD. Patients whose arthralgia lasted > 3 months had increased CXCL8 levels compared to patients whose arthralgia did not (p<0.05). Multivariable analyses further indicated that high levels of CXCL8 and female sex were associated with arthralgia lasting >3 months. Patients with chikungunya and OAFD had similar cytokine kinetics for IL-1β, IL-12, TNF, IFN-γ, IL-2, and IL-4, although the levels were lower for CHIKV patients. This study suggests that chemokines may have an important role in the immunopathogenesis of chronic chikungunya-related arthralgia. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021-10 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/158779 Jacob Nascimento, Leile Camila; Carvalho, Caroline Xavier; Oliveira Silva, Monaíse Madalena; Kikuti, Mariana; Oliveira Anjos, Rosângela; et al.; Acute-Phase Levels of CXCL8 as Risk Factor for Chronic Arthralgia Following Chikungunya Virus Infection; Frontiers Media; Frontiers in Immunology; 12; 10-2021; 1-10 1664-3224 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/158779 |
| identifier_str_mv |
Jacob Nascimento, Leile Camila; Carvalho, Caroline Xavier; Oliveira Silva, Monaíse Madalena; Kikuti, Mariana; Oliveira Anjos, Rosângela; et al.; Acute-Phase Levels of CXCL8 as Risk Factor for Chronic Arthralgia Following Chikungunya Virus Infection; Frontiers Media; Frontiers in Immunology; 12; 10-2021; 1-10 1664-3224 CONICET Digital CONICET |
| dc.language.none.fl_str_mv |
eng |
| language |
eng |
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info:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2021.744183 info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fimmu.2021.744183/full |
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info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
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openAccess |
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Frontiers Media |
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Frontiers Media |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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