Assessment of Calcium Alginate Gels As Wall Materials For Encapsulation Systems

Autores
Orona, Jesica Daiana; Zorrilla, Susana; Peralta, Juan Manuel
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
BACKGROUND: Calcium alginate gels are widely used to encapsulate active compounds. Some characteristic parameters of these gels are necessary to describe the release of active compounds through mechanistic mathematical models. In this work, transport and kinetics properties of calcium alginate gels were determined through simple experimental techniques. RESULTS: The weight-average molecular weight ((Formula presented.) = 192 × 103 Da) and the fraction of residues of α-l-guluronic acid ((Formula presented.) = 0.356) of sodium alginate were determined by capillary viscometry and 1H-nuclear magnetic resonance at 25 °C, respectively. Considering the half egg-box model, both values were used to estimate the molecular weight of calcium alginate as (Formula presented.) = 2.02 × 105 Da. An effective diffusion coefficient of water ((Formula presented.) = 2.256 × 10−9 m2 s−1) in calcium alginate was determined using a diffusion cell at 37 °C. Finally, a kinetics constant of depolymerization ((Formula presented.) = 9.72 × 10−9 m3 mol−1 s−1) of calcium alginate was obtained considering dissolution of calcium to a medium under intestinal conditions. CONCLUSION: The experimental techniques used are simple and easily reproducible. The obtained values may be useful in the design, production, and optimization of the alginate-based delivery systems that require specific release kinetics of the encapsulated active compounds.
Fil: Orona, Jesica Daiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Zorrilla, Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Peralta, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Materia
CALCIUM ALGINATE GEL
KINETICS CONSTANT OF DEPOLYMERIZATION
MOLECULAR WEIGHT
WATER EFFECTIVE DIFFUSION COEFFICIENT
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/225719
Acceder
id CONICETDig_08d10c8aabe8e9ebf77111beaf3a2412
oai_identifier_str oai:ri.conicet.gov.ar:11336/225719
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Assessment of Calcium Alginate Gels As Wall Materials For Encapsulation SystemsOrona, Jesica DaianaZorrilla, SusanaPeralta, Juan ManuelCALCIUM ALGINATE GELKINETICS CONSTANT OF DEPOLYMERIZATIONMOLECULAR WEIGHTWATER EFFECTIVE DIFFUSION COEFFICIENThttps://purl.org/becyt/ford/2.11https://purl.org/becyt/ford/2BACKGROUND: Calcium alginate gels are widely used to encapsulate active compounds. Some characteristic parameters of these gels are necessary to describe the release of active compounds through mechanistic mathematical models. In this work, transport and kinetics properties of calcium alginate gels were determined through simple experimental techniques. RESULTS: The weight-average molecular weight ((Formula presented.) = 192 × 103 Da) and the fraction of residues of α-l-guluronic acid ((Formula presented.) = 0.356) of sodium alginate were determined by capillary viscometry and 1H-nuclear magnetic resonance at 25 °C, respectively. Considering the half egg-box model, both values were used to estimate the molecular weight of calcium alginate as (Formula presented.) = 2.02 × 105 Da. An effective diffusion coefficient of water ((Formula presented.) = 2.256 × 10−9 m2 s−1) in calcium alginate was determined using a diffusion cell at 37 °C. Finally, a kinetics constant of depolymerization ((Formula presented.) = 9.72 × 10−9 m3 mol−1 s−1) of calcium alginate was obtained considering dissolution of calcium to a medium under intestinal conditions. CONCLUSION: The experimental techniques used are simple and easily reproducible. The obtained values may be useful in the design, production, and optimization of the alginate-based delivery systems that require specific release kinetics of the encapsulated active compounds.Fil: Orona, Jesica Daiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Zorrilla, Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Peralta, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaJohn Wiley & Sons Ltd2023-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/225719Orona, Jesica Daiana; Zorrilla, Susana; Peralta, Juan Manuel; Assessment of Calcium Alginate Gels As Wall Materials For Encapsulation Systems; John Wiley & Sons Ltd; Journal of the Science of Food and Agriculture; 11-2023; 1-270022-5142CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/jsfa.13131info:eu-repo/semantics/altIdentifier/doi/10.1002/jsfa.13131info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:21:29Zoai:ri.conicet.gov.ar:11336/225719instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:21:30.03CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Assessment of Calcium Alginate Gels As Wall Materials For Encapsulation Systems
title Assessment of Calcium Alginate Gels As Wall Materials For Encapsulation Systems
spellingShingle Assessment of Calcium Alginate Gels As Wall Materials For Encapsulation Systems
Orona, Jesica Daiana
CALCIUM ALGINATE GEL
KINETICS CONSTANT OF DEPOLYMERIZATION
MOLECULAR WEIGHT
WATER EFFECTIVE DIFFUSION COEFFICIENT
title_short Assessment of Calcium Alginate Gels As Wall Materials For Encapsulation Systems
title_full Assessment of Calcium Alginate Gels As Wall Materials For Encapsulation Systems
title_fullStr Assessment of Calcium Alginate Gels As Wall Materials For Encapsulation Systems
title_full_unstemmed Assessment of Calcium Alginate Gels As Wall Materials For Encapsulation Systems
title_sort Assessment of Calcium Alginate Gels As Wall Materials For Encapsulation Systems
dc.creator.none.fl_str_mv Orona, Jesica Daiana
Zorrilla, Susana
Peralta, Juan Manuel
author Orona, Jesica Daiana
author_facet Orona, Jesica Daiana
Zorrilla, Susana
Peralta, Juan Manuel
author_role author
author2 Zorrilla, Susana
Peralta, Juan Manuel
author2_role author
author
dc.subject.none.fl_str_mv CALCIUM ALGINATE GEL
KINETICS CONSTANT OF DEPOLYMERIZATION
MOLECULAR WEIGHT
WATER EFFECTIVE DIFFUSION COEFFICIENT
topic CALCIUM ALGINATE GEL
KINETICS CONSTANT OF DEPOLYMERIZATION
MOLECULAR WEIGHT
WATER EFFECTIVE DIFFUSION COEFFICIENT
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.11
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv BACKGROUND: Calcium alginate gels are widely used to encapsulate active compounds. Some characteristic parameters of these gels are necessary to describe the release of active compounds through mechanistic mathematical models. In this work, transport and kinetics properties of calcium alginate gels were determined through simple experimental techniques. RESULTS: The weight-average molecular weight ((Formula presented.) = 192 × 103 Da) and the fraction of residues of α-l-guluronic acid ((Formula presented.) = 0.356) of sodium alginate were determined by capillary viscometry and 1H-nuclear magnetic resonance at 25 °C, respectively. Considering the half egg-box model, both values were used to estimate the molecular weight of calcium alginate as (Formula presented.) = 2.02 × 105 Da. An effective diffusion coefficient of water ((Formula presented.) = 2.256 × 10−9 m2 s−1) in calcium alginate was determined using a diffusion cell at 37 °C. Finally, a kinetics constant of depolymerization ((Formula presented.) = 9.72 × 10−9 m3 mol−1 s−1) of calcium alginate was obtained considering dissolution of calcium to a medium under intestinal conditions. CONCLUSION: The experimental techniques used are simple and easily reproducible. The obtained values may be useful in the design, production, and optimization of the alginate-based delivery systems that require specific release kinetics of the encapsulated active compounds.
Fil: Orona, Jesica Daiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Zorrilla, Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Peralta, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
description BACKGROUND: Calcium alginate gels are widely used to encapsulate active compounds. Some characteristic parameters of these gels are necessary to describe the release of active compounds through mechanistic mathematical models. In this work, transport and kinetics properties of calcium alginate gels were determined through simple experimental techniques. RESULTS: The weight-average molecular weight ((Formula presented.) = 192 × 103 Da) and the fraction of residues of α-l-guluronic acid ((Formula presented.) = 0.356) of sodium alginate were determined by capillary viscometry and 1H-nuclear magnetic resonance at 25 °C, respectively. Considering the half egg-box model, both values were used to estimate the molecular weight of calcium alginate as (Formula presented.) = 2.02 × 105 Da. An effective diffusion coefficient of water ((Formula presented.) = 2.256 × 10−9 m2 s−1) in calcium alginate was determined using a diffusion cell at 37 °C. Finally, a kinetics constant of depolymerization ((Formula presented.) = 9.72 × 10−9 m3 mol−1 s−1) of calcium alginate was obtained considering dissolution of calcium to a medium under intestinal conditions. CONCLUSION: The experimental techniques used are simple and easily reproducible. The obtained values may be useful in the design, production, and optimization of the alginate-based delivery systems that require specific release kinetics of the encapsulated active compounds.
publishDate 2023
dc.date.none.fl_str_mv 2023-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/225719
Orona, Jesica Daiana; Zorrilla, Susana; Peralta, Juan Manuel; Assessment of Calcium Alginate Gels As Wall Materials For Encapsulation Systems; John Wiley & Sons Ltd; Journal of the Science of Food and Agriculture; 11-2023; 1-27
0022-5142
CONICET Digital
CONICET
url http://hdl.handle.net/11336/225719
identifier_str_mv Orona, Jesica Daiana; Zorrilla, Susana; Peralta, Juan Manuel; Assessment of Calcium Alginate Gels As Wall Materials For Encapsulation Systems; John Wiley & Sons Ltd; Journal of the Science of Food and Agriculture; 11-2023; 1-27
0022-5142
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/jsfa.13131
info:eu-repo/semantics/altIdentifier/doi/10.1002/jsfa.13131
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons Ltd
publisher.none.fl_str_mv John Wiley & Sons Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083362686500864
score 13.22299

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