Assessment of Calcium Alginate Gels As Wall Materials For Encapsulation Systems
- Autores
- Orona, Jesica Daiana; Zorrilla, Susana; Peralta, Juan Manuel
- Año de publicación
- 2023
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- BACKGROUND: Calcium alginate gels are widely used to encapsulate active compounds. Some characteristic parameters of these gels are necessary to describe the release of active compounds through mechanistic mathematical models. In this work, transport and kinetics properties of calcium alginate gels were determined through simple experimental techniques. RESULTS: The weight-average molecular weight ((Formula presented.) = 192 × 103 Da) and the fraction of residues of α-l-guluronic acid ((Formula presented.) = 0.356) of sodium alginate were determined by capillary viscometry and 1H-nuclear magnetic resonance at 25 °C, respectively. Considering the half egg-box model, both values were used to estimate the molecular weight of calcium alginate as (Formula presented.) = 2.02 × 105 Da. An effective diffusion coefficient of water ((Formula presented.) = 2.256 × 10−9 m2 s−1) in calcium alginate was determined using a diffusion cell at 37 °C. Finally, a kinetics constant of depolymerization ((Formula presented.) = 9.72 × 10−9 m3 mol−1 s−1) of calcium alginate was obtained considering dissolution of calcium to a medium under intestinal conditions. CONCLUSION: The experimental techniques used are simple and easily reproducible. The obtained values may be useful in the design, production, and optimization of the alginate-based delivery systems that require specific release kinetics of the encapsulated active compounds.
Fil: Orona, Jesica Daiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Zorrilla, Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Peralta, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina - Materia
-
CALCIUM ALGINATE GEL
KINETICS CONSTANT OF DEPOLYMERIZATION
MOLECULAR WEIGHT
WATER EFFECTIVE DIFFUSION COEFFICIENT - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/225719
Ver los metadatos del registro completo
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oai:ri.conicet.gov.ar:11336/225719 |
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3498 |
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CONICET Digital (CONICET) |
spelling |
Assessment of Calcium Alginate Gels As Wall Materials For Encapsulation SystemsOrona, Jesica DaianaZorrilla, SusanaPeralta, Juan ManuelCALCIUM ALGINATE GELKINETICS CONSTANT OF DEPOLYMERIZATIONMOLECULAR WEIGHTWATER EFFECTIVE DIFFUSION COEFFICIENThttps://purl.org/becyt/ford/2.11https://purl.org/becyt/ford/2BACKGROUND: Calcium alginate gels are widely used to encapsulate active compounds. Some characteristic parameters of these gels are necessary to describe the release of active compounds through mechanistic mathematical models. In this work, transport and kinetics properties of calcium alginate gels were determined through simple experimental techniques. RESULTS: The weight-average molecular weight ((Formula presented.) = 192 × 103 Da) and the fraction of residues of α-l-guluronic acid ((Formula presented.) = 0.356) of sodium alginate were determined by capillary viscometry and 1H-nuclear magnetic resonance at 25 °C, respectively. Considering the half egg-box model, both values were used to estimate the molecular weight of calcium alginate as (Formula presented.) = 2.02 × 105 Da. An effective diffusion coefficient of water ((Formula presented.) = 2.256 × 10−9 m2 s−1) in calcium alginate was determined using a diffusion cell at 37 °C. Finally, a kinetics constant of depolymerization ((Formula presented.) = 9.72 × 10−9 m3 mol−1 s−1) of calcium alginate was obtained considering dissolution of calcium to a medium under intestinal conditions. CONCLUSION: The experimental techniques used are simple and easily reproducible. The obtained values may be useful in the design, production, and optimization of the alginate-based delivery systems that require specific release kinetics of the encapsulated active compounds.Fil: Orona, Jesica Daiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Zorrilla, Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Peralta, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaJohn Wiley & Sons Ltd2023-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/225719Orona, Jesica Daiana; Zorrilla, Susana; Peralta, Juan Manuel; Assessment of Calcium Alginate Gels As Wall Materials For Encapsulation Systems; John Wiley & Sons Ltd; Journal of the Science of Food and Agriculture; 11-2023; 1-270022-5142CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/jsfa.13131info:eu-repo/semantics/altIdentifier/doi/10.1002/jsfa.13131info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:24:19Zoai:ri.conicet.gov.ar:11336/225719instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:24:19.41CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Assessment of Calcium Alginate Gels As Wall Materials For Encapsulation Systems |
title |
Assessment of Calcium Alginate Gels As Wall Materials For Encapsulation Systems |
spellingShingle |
Assessment of Calcium Alginate Gels As Wall Materials For Encapsulation Systems Orona, Jesica Daiana CALCIUM ALGINATE GEL KINETICS CONSTANT OF DEPOLYMERIZATION MOLECULAR WEIGHT WATER EFFECTIVE DIFFUSION COEFFICIENT |
title_short |
Assessment of Calcium Alginate Gels As Wall Materials For Encapsulation Systems |
title_full |
Assessment of Calcium Alginate Gels As Wall Materials For Encapsulation Systems |
title_fullStr |
Assessment of Calcium Alginate Gels As Wall Materials For Encapsulation Systems |
title_full_unstemmed |
Assessment of Calcium Alginate Gels As Wall Materials For Encapsulation Systems |
title_sort |
Assessment of Calcium Alginate Gels As Wall Materials For Encapsulation Systems |
dc.creator.none.fl_str_mv |
Orona, Jesica Daiana Zorrilla, Susana Peralta, Juan Manuel |
author |
Orona, Jesica Daiana |
author_facet |
Orona, Jesica Daiana Zorrilla, Susana Peralta, Juan Manuel |
author_role |
author |
author2 |
Zorrilla, Susana Peralta, Juan Manuel |
author2_role |
author author |
dc.subject.none.fl_str_mv |
CALCIUM ALGINATE GEL KINETICS CONSTANT OF DEPOLYMERIZATION MOLECULAR WEIGHT WATER EFFECTIVE DIFFUSION COEFFICIENT |
topic |
CALCIUM ALGINATE GEL KINETICS CONSTANT OF DEPOLYMERIZATION MOLECULAR WEIGHT WATER EFFECTIVE DIFFUSION COEFFICIENT |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/2.11 https://purl.org/becyt/ford/2 |
dc.description.none.fl_txt_mv |
BACKGROUND: Calcium alginate gels are widely used to encapsulate active compounds. Some characteristic parameters of these gels are necessary to describe the release of active compounds through mechanistic mathematical models. In this work, transport and kinetics properties of calcium alginate gels were determined through simple experimental techniques. RESULTS: The weight-average molecular weight ((Formula presented.) = 192 × 103 Da) and the fraction of residues of α-l-guluronic acid ((Formula presented.) = 0.356) of sodium alginate were determined by capillary viscometry and 1H-nuclear magnetic resonance at 25 °C, respectively. Considering the half egg-box model, both values were used to estimate the molecular weight of calcium alginate as (Formula presented.) = 2.02 × 105 Da. An effective diffusion coefficient of water ((Formula presented.) = 2.256 × 10−9 m2 s−1) in calcium alginate was determined using a diffusion cell at 37 °C. Finally, a kinetics constant of depolymerization ((Formula presented.) = 9.72 × 10−9 m3 mol−1 s−1) of calcium alginate was obtained considering dissolution of calcium to a medium under intestinal conditions. CONCLUSION: The experimental techniques used are simple and easily reproducible. The obtained values may be useful in the design, production, and optimization of the alginate-based delivery systems that require specific release kinetics of the encapsulated active compounds. Fil: Orona, Jesica Daiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina Fil: Zorrilla, Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina Fil: Peralta, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina |
description |
BACKGROUND: Calcium alginate gels are widely used to encapsulate active compounds. Some characteristic parameters of these gels are necessary to describe the release of active compounds through mechanistic mathematical models. In this work, transport and kinetics properties of calcium alginate gels were determined through simple experimental techniques. RESULTS: The weight-average molecular weight ((Formula presented.) = 192 × 103 Da) and the fraction of residues of α-l-guluronic acid ((Formula presented.) = 0.356) of sodium alginate were determined by capillary viscometry and 1H-nuclear magnetic resonance at 25 °C, respectively. Considering the half egg-box model, both values were used to estimate the molecular weight of calcium alginate as (Formula presented.) = 2.02 × 105 Da. An effective diffusion coefficient of water ((Formula presented.) = 2.256 × 10−9 m2 s−1) in calcium alginate was determined using a diffusion cell at 37 °C. Finally, a kinetics constant of depolymerization ((Formula presented.) = 9.72 × 10−9 m3 mol−1 s−1) of calcium alginate was obtained considering dissolution of calcium to a medium under intestinal conditions. CONCLUSION: The experimental techniques used are simple and easily reproducible. The obtained values may be useful in the design, production, and optimization of the alginate-based delivery systems that require specific release kinetics of the encapsulated active compounds. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-11 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/225719 Orona, Jesica Daiana; Zorrilla, Susana; Peralta, Juan Manuel; Assessment of Calcium Alginate Gels As Wall Materials For Encapsulation Systems; John Wiley & Sons Ltd; Journal of the Science of Food and Agriculture; 11-2023; 1-27 0022-5142 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/225719 |
identifier_str_mv |
Orona, Jesica Daiana; Zorrilla, Susana; Peralta, Juan Manuel; Assessment of Calcium Alginate Gels As Wall Materials For Encapsulation Systems; John Wiley & Sons Ltd; Journal of the Science of Food and Agriculture; 11-2023; 1-27 0022-5142 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/jsfa.13131 info:eu-repo/semantics/altIdentifier/doi/10.1002/jsfa.13131 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
John Wiley & Sons Ltd |
publisher.none.fl_str_mv |
John Wiley & Sons Ltd |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614239707201536 |
score |
13.070432 |