2023 epidemic dengue fever outbreak: the experience of a pediatric hospital in the City of Buenos Aires

Autores
Ordoñez, Carolina; Carril, Sofía S.; Espinosa Charris, Elisa; Antonelli Sanz, Antonella; Vergara, Christian; Talarico, Laura Beatriz; Mistchenko, Alicia Susana; López, Eduardo L.
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Introduction. Dengue is a viral infection that may be asymptomatic or include severe manifestations. This study aims to describe the characteristics of a pediatric population during the epidemic outbreak in 2023.Population and methods. This cross-sectional study included patients with probable or confirmed dengue fever who were seen from March 13, 2023, to May 19, 2023, in a pediatric hospital in the Autonomous City of Buenos Aires.Results. A total of 112 patients were included. The median age was 12 years; 58% were male. Seventysix percent of them came from the City of Buenos Aires. Twenty-five percent had cohabitants with symptoms compatible with a suspected case. The most frequent clinical manifestations were fever, headache, retro-ocular pain, myalgia, and arthralgia. The most frequent laboratory alterations were leukopenia (65%) and elevated transaminases (60%). Twenty-one percent (24/112) presented alarm signs and required hospitalization. Leukopenia, plateletopenia, and elevated transaminases were associated with the presence of alarm signs. RT-PCR was detected in fifty-three patients; serotype 2 was the most frequent. Twenty-one patients had positive NS1 tests, 18 patients had positive IgM, and 20 patients with clinical and epidemiological links were assumed to be probable dengue cases. There were no cases of severe dengue.Conclusion. Early clinical suspicion and recognition of laboratory parameters associated with alarm signs are essential for an adequate approach to the disease and early supportive treatment during dengue infection.
Fil: Ordoñez, Carolina. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; Argentina
Fil: Carril, Sofía S.. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; Argentina
Fil: Espinosa Charris, Elisa. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; Argentina
Fil: Antonelli Sanz, Antonella. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; Argentina
Fil: Vergara, Christian. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; Argentina
Fil: Talarico, Laura Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; Argentina
Fil: Mistchenko, Alicia Susana. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez". Laboratorio de Virología; Argentina
Fil: López, Eduardo L.. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; Argentina
Materia
DENGUE
ARBOVIRUS INFECTIONS
PEDIATRICS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/273377
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/273377
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling 2023 epidemic dengue fever outbreak: the experience of a pediatric hospital in the City of Buenos AiresOrdoñez, CarolinaCarril, Sofía S.Espinosa Charris, ElisaAntonelli Sanz, AntonellaVergara, ChristianTalarico, Laura BeatrizMistchenko, Alicia SusanaLópez, Eduardo L.DENGUEARBOVIRUS INFECTIONSPEDIATRICShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Introduction. Dengue is a viral infection that may be asymptomatic or include severe manifestations. This study aims to describe the characteristics of a pediatric population during the epidemic outbreak in 2023.Population and methods. This cross-sectional study included patients with probable or confirmed dengue fever who were seen from March 13, 2023, to May 19, 2023, in a pediatric hospital in the Autonomous City of Buenos Aires.Results. A total of 112 patients were included. The median age was 12 years; 58% were male. Seventysix percent of them came from the City of Buenos Aires. Twenty-five percent had cohabitants with symptoms compatible with a suspected case. The most frequent clinical manifestations were fever, headache, retro-ocular pain, myalgia, and arthralgia. The most frequent laboratory alterations were leukopenia (65%) and elevated transaminases (60%). Twenty-one percent (24/112) presented alarm signs and required hospitalization. Leukopenia, plateletopenia, and elevated transaminases were associated with the presence of alarm signs. RT-PCR was detected in fifty-three patients; serotype 2 was the most frequent. Twenty-one patients had positive NS1 tests, 18 patients had positive IgM, and 20 patients with clinical and epidemiological links were assumed to be probable dengue cases. There were no cases of severe dengue.Conclusion. Early clinical suspicion and recognition of laboratory parameters associated with alarm signs are essential for an adequate approach to the disease and early supportive treatment during dengue infection.Fil: Ordoñez, Carolina. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; ArgentinaFil: Carril, Sofía S.. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; ArgentinaFil: Espinosa Charris, Elisa. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; ArgentinaFil: Antonelli Sanz, Antonella. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; ArgentinaFil: Vergara, Christian. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; ArgentinaFil: Talarico, Laura Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; ArgentinaFil: Mistchenko, Alicia Susana. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez". Laboratorio de Virología; ArgentinaFil: López, Eduardo L.. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; ArgentinaSociedad Argentina de Pediatría2025-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/273377Ordoñez, Carolina; Carril, Sofía S.; Espinosa Charris, Elisa; Antonelli Sanz, Antonella; Vergara, Christian; et al.; 2023 epidemic dengue fever outbreak: the experience of a pediatric hospital in the City of Buenos Aires; Sociedad Argentina de Pediatría; Archivos Argentinos de Pediatría; 123; 1; 2-2025; 1-60325-00751668-3501CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sap.org.ar/docs/publicaciones/archivosarg/2025/v123n1a17e.pdfinfo:eu-repo/semantics/altIdentifier/doi/10.5546/aap.2024-10417.enginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:13:54Zoai:ri.conicet.gov.ar:11336/273377instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:13:54.716CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv 2023 epidemic dengue fever outbreak: the experience of a pediatric hospital in the City of Buenos Aires
title 2023 epidemic dengue fever outbreak: the experience of a pediatric hospital in the City of Buenos Aires
spellingShingle 2023 epidemic dengue fever outbreak: the experience of a pediatric hospital in the City of Buenos Aires
Ordoñez, Carolina
DENGUE
ARBOVIRUS INFECTIONS
PEDIATRICS
title_short 2023 epidemic dengue fever outbreak: the experience of a pediatric hospital in the City of Buenos Aires
title_full 2023 epidemic dengue fever outbreak: the experience of a pediatric hospital in the City of Buenos Aires
title_fullStr 2023 epidemic dengue fever outbreak: the experience of a pediatric hospital in the City of Buenos Aires
title_full_unstemmed 2023 epidemic dengue fever outbreak: the experience of a pediatric hospital in the City of Buenos Aires
title_sort 2023 epidemic dengue fever outbreak: the experience of a pediatric hospital in the City of Buenos Aires
dc.creator.none.fl_str_mv Ordoñez, Carolina
Carril, Sofía S.
Espinosa Charris, Elisa
Antonelli Sanz, Antonella
Vergara, Christian
Talarico, Laura Beatriz
Mistchenko, Alicia Susana
López, Eduardo L.
author Ordoñez, Carolina
author_facet Ordoñez, Carolina
Carril, Sofía S.
Espinosa Charris, Elisa
Antonelli Sanz, Antonella
Vergara, Christian
Talarico, Laura Beatriz
Mistchenko, Alicia Susana
López, Eduardo L.
author_role author
author2 Carril, Sofía S.
Espinosa Charris, Elisa
Antonelli Sanz, Antonella
Vergara, Christian
Talarico, Laura Beatriz
Mistchenko, Alicia Susana
López, Eduardo L.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv DENGUE
ARBOVIRUS INFECTIONS
PEDIATRICS
topic DENGUE
ARBOVIRUS INFECTIONS
PEDIATRICS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Introduction. Dengue is a viral infection that may be asymptomatic or include severe manifestations. This study aims to describe the characteristics of a pediatric population during the epidemic outbreak in 2023.Population and methods. This cross-sectional study included patients with probable or confirmed dengue fever who were seen from March 13, 2023, to May 19, 2023, in a pediatric hospital in the Autonomous City of Buenos Aires.Results. A total of 112 patients were included. The median age was 12 years; 58% were male. Seventysix percent of them came from the City of Buenos Aires. Twenty-five percent had cohabitants with symptoms compatible with a suspected case. The most frequent clinical manifestations were fever, headache, retro-ocular pain, myalgia, and arthralgia. The most frequent laboratory alterations were leukopenia (65%) and elevated transaminases (60%). Twenty-one percent (24/112) presented alarm signs and required hospitalization. Leukopenia, plateletopenia, and elevated transaminases were associated with the presence of alarm signs. RT-PCR was detected in fifty-three patients; serotype 2 was the most frequent. Twenty-one patients had positive NS1 tests, 18 patients had positive IgM, and 20 patients with clinical and epidemiological links were assumed to be probable dengue cases. There were no cases of severe dengue.Conclusion. Early clinical suspicion and recognition of laboratory parameters associated with alarm signs are essential for an adequate approach to the disease and early supportive treatment during dengue infection.
Fil: Ordoñez, Carolina. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; Argentina
Fil: Carril, Sofía S.. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; Argentina
Fil: Espinosa Charris, Elisa. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; Argentina
Fil: Antonelli Sanz, Antonella. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; Argentina
Fil: Vergara, Christian. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; Argentina
Fil: Talarico, Laura Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; Argentina
Fil: Mistchenko, Alicia Susana. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez". Laboratorio de Virología; Argentina
Fil: López, Eduardo L.. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Niños "ricardo Gutierrez". Departamento de Medicina.; Argentina
description Introduction. Dengue is a viral infection that may be asymptomatic or include severe manifestations. This study aims to describe the characteristics of a pediatric population during the epidemic outbreak in 2023.Population and methods. This cross-sectional study included patients with probable or confirmed dengue fever who were seen from March 13, 2023, to May 19, 2023, in a pediatric hospital in the Autonomous City of Buenos Aires.Results. A total of 112 patients were included. The median age was 12 years; 58% were male. Seventysix percent of them came from the City of Buenos Aires. Twenty-five percent had cohabitants with symptoms compatible with a suspected case. The most frequent clinical manifestations were fever, headache, retro-ocular pain, myalgia, and arthralgia. The most frequent laboratory alterations were leukopenia (65%) and elevated transaminases (60%). Twenty-one percent (24/112) presented alarm signs and required hospitalization. Leukopenia, plateletopenia, and elevated transaminases were associated with the presence of alarm signs. RT-PCR was detected in fifty-three patients; serotype 2 was the most frequent. Twenty-one patients had positive NS1 tests, 18 patients had positive IgM, and 20 patients with clinical and epidemiological links were assumed to be probable dengue cases. There were no cases of severe dengue.Conclusion. Early clinical suspicion and recognition of laboratory parameters associated with alarm signs are essential for an adequate approach to the disease and early supportive treatment during dengue infection.
publishDate 2025
dc.date.none.fl_str_mv 2025-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/273377
Ordoñez, Carolina; Carril, Sofía S.; Espinosa Charris, Elisa; Antonelli Sanz, Antonella; Vergara, Christian; et al.; 2023 epidemic dengue fever outbreak: the experience of a pediatric hospital in the City of Buenos Aires; Sociedad Argentina de Pediatría; Archivos Argentinos de Pediatría; 123; 1; 2-2025; 1-6
0325-0075
1668-3501
CONICET Digital
CONICET
url http://hdl.handle.net/11336/273377
identifier_str_mv Ordoñez, Carolina; Carril, Sofía S.; Espinosa Charris, Elisa; Antonelli Sanz, Antonella; Vergara, Christian; et al.; 2023 epidemic dengue fever outbreak: the experience of a pediatric hospital in the City of Buenos Aires; Sociedad Argentina de Pediatría; Archivos Argentinos de Pediatría; 123; 1; 2-2025; 1-6
0325-0075
1668-3501
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sap.org.ar/docs/publicaciones/archivosarg/2025/v123n1a17e.pdf
info:eu-repo/semantics/altIdentifier/doi/10.5546/aap.2024-10417.eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Sociedad Argentina de Pediatría
publisher.none.fl_str_mv Sociedad Argentina de Pediatría
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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