Opioid receptors modulate recovery from consummatory successive negative contrast

Autores
Pellegrini, Santiago; Wood, Michael; Daniel, Alan M.; Papini, Mauricio Roberto
Año de publicación
2005
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Three experiments explored the role of the opioid system in consummatory successive negative contrast. In Experiment 1, rats treated with the nonspecific opioid-receptor antagonist naloxone (2 mg/kg) exhibited increased suppression after a shift from 32% to 6% sucrose solution (32 → 6), relative to 6 → 6 unshifted controls. A similar but shorter effect was observed with the delta-opioid receptor antagonist naltrindole (1 mg/kg). In Experiment 2, naloxone increased suppression after a more conventional 32 → 4 sucrose shift. In Experiment 3, rats classified as expressing slow recovery from contrast (after a 32 → 4 sucrose downshift) were more sensitive to naloxone in an activity test than fast-recovery rats. Whereas it was previously known that contrast was reduced by the extrinsic administration of opioid agonists, the effects reported here with antagonists provide the first evidence that the opioid system is intrinsically engaged by situations involving surprising reward loss.
Fil: Pellegrini, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Wood, Michael. Texas Christian University; Estados Unidos
Fil: Daniel, Alan M.. Texas Christian University; Estados Unidos
Fil: Papini, Mauricio Roberto. Texas Christian University; Estados Unidos
Materia
CONSUMMATORY SUCCESSIVE NEGATIVE CONTRAST
NALOXONE
NALTRINDOLE
OPIOID RECEPTORS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/182067
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Opioid receptors modulate recovery from consummatory successive negative contrastPellegrini, SantiagoWood, MichaelDaniel, Alan M.Papini, Mauricio RobertoCONSUMMATORY SUCCESSIVE NEGATIVE CONTRASTNALOXONENALTRINDOLEOPIOID RECEPTORShttps://purl.org/becyt/ford/5.1https://purl.org/becyt/ford/5Three experiments explored the role of the opioid system in consummatory successive negative contrast. In Experiment 1, rats treated with the nonspecific opioid-receptor antagonist naloxone (2 mg/kg) exhibited increased suppression after a shift from 32% to 6% sucrose solution (32 → 6), relative to 6 → 6 unshifted controls. A similar but shorter effect was observed with the delta-opioid receptor antagonist naltrindole (1 mg/kg). In Experiment 2, naloxone increased suppression after a more conventional 32 → 4 sucrose shift. In Experiment 3, rats classified as expressing slow recovery from contrast (after a 32 → 4 sucrose downshift) were more sensitive to naloxone in an activity test than fast-recovery rats. Whereas it was previously known that contrast was reduced by the extrinsic administration of opioid agonists, the effects reported here with antagonists provide the first evidence that the opioid system is intrinsically engaged by situations involving surprising reward loss.Fil: Pellegrini, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Wood, Michael. Texas Christian University; Estados UnidosFil: Daniel, Alan M.. Texas Christian University; Estados UnidosFil: Papini, Mauricio Roberto. Texas Christian University; Estados UnidosElsevier Science2005-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/182067Pellegrini, Santiago; Wood, Michael; Daniel, Alan M.; Papini, Mauricio Roberto; Opioid receptors modulate recovery from consummatory successive negative contrast; Elsevier Science; Behavioural Brain Research; 164; 2; 11-2005; 239-2490166-4328CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0166432805003013info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbr.2005.06.035info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:56:17Zoai:ri.conicet.gov.ar:11336/182067instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:56:17.734CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Opioid receptors modulate recovery from consummatory successive negative contrast
title Opioid receptors modulate recovery from consummatory successive negative contrast
spellingShingle Opioid receptors modulate recovery from consummatory successive negative contrast
Pellegrini, Santiago
CONSUMMATORY SUCCESSIVE NEGATIVE CONTRAST
NALOXONE
NALTRINDOLE
OPIOID RECEPTORS
title_short Opioid receptors modulate recovery from consummatory successive negative contrast
title_full Opioid receptors modulate recovery from consummatory successive negative contrast
title_fullStr Opioid receptors modulate recovery from consummatory successive negative contrast
title_full_unstemmed Opioid receptors modulate recovery from consummatory successive negative contrast
title_sort Opioid receptors modulate recovery from consummatory successive negative contrast
dc.creator.none.fl_str_mv Pellegrini, Santiago
Wood, Michael
Daniel, Alan M.
Papini, Mauricio Roberto
author Pellegrini, Santiago
author_facet Pellegrini, Santiago
Wood, Michael
Daniel, Alan M.
Papini, Mauricio Roberto
author_role author
author2 Wood, Michael
Daniel, Alan M.
Papini, Mauricio Roberto
author2_role author
author
author
dc.subject.none.fl_str_mv CONSUMMATORY SUCCESSIVE NEGATIVE CONTRAST
NALOXONE
NALTRINDOLE
OPIOID RECEPTORS
topic CONSUMMATORY SUCCESSIVE NEGATIVE CONTRAST
NALOXONE
NALTRINDOLE
OPIOID RECEPTORS
purl_subject.fl_str_mv https://purl.org/becyt/ford/5.1
https://purl.org/becyt/ford/5
dc.description.none.fl_txt_mv Three experiments explored the role of the opioid system in consummatory successive negative contrast. In Experiment 1, rats treated with the nonspecific opioid-receptor antagonist naloxone (2 mg/kg) exhibited increased suppression after a shift from 32% to 6% sucrose solution (32 → 6), relative to 6 → 6 unshifted controls. A similar but shorter effect was observed with the delta-opioid receptor antagonist naltrindole (1 mg/kg). In Experiment 2, naloxone increased suppression after a more conventional 32 → 4 sucrose shift. In Experiment 3, rats classified as expressing slow recovery from contrast (after a 32 → 4 sucrose downshift) were more sensitive to naloxone in an activity test than fast-recovery rats. Whereas it was previously known that contrast was reduced by the extrinsic administration of opioid agonists, the effects reported here with antagonists provide the first evidence that the opioid system is intrinsically engaged by situations involving surprising reward loss.
Fil: Pellegrini, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Wood, Michael. Texas Christian University; Estados Unidos
Fil: Daniel, Alan M.. Texas Christian University; Estados Unidos
Fil: Papini, Mauricio Roberto. Texas Christian University; Estados Unidos
description Three experiments explored the role of the opioid system in consummatory successive negative contrast. In Experiment 1, rats treated with the nonspecific opioid-receptor antagonist naloxone (2 mg/kg) exhibited increased suppression after a shift from 32% to 6% sucrose solution (32 → 6), relative to 6 → 6 unshifted controls. A similar but shorter effect was observed with the delta-opioid receptor antagonist naltrindole (1 mg/kg). In Experiment 2, naloxone increased suppression after a more conventional 32 → 4 sucrose shift. In Experiment 3, rats classified as expressing slow recovery from contrast (after a 32 → 4 sucrose downshift) were more sensitive to naloxone in an activity test than fast-recovery rats. Whereas it was previously known that contrast was reduced by the extrinsic administration of opioid agonists, the effects reported here with antagonists provide the first evidence that the opioid system is intrinsically engaged by situations involving surprising reward loss.
publishDate 2005
dc.date.none.fl_str_mv 2005-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/182067
Pellegrini, Santiago; Wood, Michael; Daniel, Alan M.; Papini, Mauricio Roberto; Opioid receptors modulate recovery from consummatory successive negative contrast; Elsevier Science; Behavioural Brain Research; 164; 2; 11-2005; 239-249
0166-4328
CONICET Digital
CONICET
url http://hdl.handle.net/11336/182067
identifier_str_mv Pellegrini, Santiago; Wood, Michael; Daniel, Alan M.; Papini, Mauricio Roberto; Opioid receptors modulate recovery from consummatory successive negative contrast; Elsevier Science; Behavioural Brain Research; 164; 2; 11-2005; 239-249
0166-4328
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0166432805003013
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbr.2005.06.035
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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