Confirmation of an association between rs6822844 at the IL2-IL21 region and multiple autoimmune diseases: Evidence of a general susceptibility locus

Autores
Maiti, Amit K.; Kim Howard, Xana; Viswanathan, Parvathi; Guillen, Laura Cristina; Rojas Villarraga, Adriana; Deshmukh, Harshal; Direskeneli, Haner; Saruhan Direskeneli, Güher; Cañas, Carlos; Tobón, Gabriel J.; Sawalha, Amr H.; Cherñavsky, Alejandra Claudia; Anaya, Juan Manuel; Nath, Swapan K.
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objective. Autoimmune diseases often have susceptibility genes in common, indicating similar molecular mechanisms. Increasing evidence suggests that rs6822844 at the IL2-IL21 region is strongly associated with multiple autoimmune diseases in individuals of European descent. This study was undertaken to attempt to replicate the association between rs6822844 and 6 different immune-mediated diseases in non-European populations, and to perform disease-specific and overall meta-analyses using data from previously published studies. Methods. We evaluated case-control associations between rs6822844 and celiac disease (CD) in subjects from Argentina; rheumatoid arthritis (RA), type 1 diabetes mellitus (DM), primary Sjögren's syndrome (SS), and systemic lupus erythematosus (SLE) in subjects from Colombia; and Behçet's disease (BD) in subjects from Turkey. Allele and gene distributions were compared between cases and controls. Meta-analyses were performed using data from the present study and previous studies. Results. We detected significant associations of rs6822844 with SLE (P = 0.008), type 1 DM(P = 0.014), RA (P = 0.019), and primary SS (P = 0.033) but not with BD (P = 0.34) or CD (P = 0.98). We identified little evidence of population differentiation (FST = 0.01) within cases and controls from Argentina and Colombia, suggesting that association was not influenced by population substructure. Disease-specific meta-analysis indicated significant association for RA (Pmeta = 3.61 × 10-6), inflammatory bowel disease (IBD; Crohn's disease and ulcerative colitis) (Pmeta = 3.48 × 10-12), type 1 DM (Pmeta = 5.33 × 10-5), and CD (Pmeta = 5.30 × 10-3). Overall meta-analysis across all autoimmune diseases reinforced association with rs6822844 (23 data sets; Pmeta = 2.61 × 10-25, odds ratio 0.73 [95% confidence interval 0.69-0.78]). Conclusion. Our results indicate that there is an association between rs6822844 and multiple autoimmune diseases in non-European populations. Metaanalysis results strongly reinforce this robust association across multiple autoimmune diseases in both European-derived and non-European populations.
Fil: Maiti, Amit K.. Oklahoma Medical Research Foundation; Estados Unidos
Fil: Kim Howard, Xana. Oklahoma Medical Research Foundation; Estados Unidos
Fil: Viswanathan, Parvathi. Oklahoma Medical Research Foundation; Estados Unidos
Fil: Guillen, Laura Cristina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rojas Villarraga, Adriana. Universidad del Rosario; Colombia
Fil: Deshmukh, Harshal. Oklahoma Medical Research Foundation; Estados Unidos
Fil: Direskeneli, Haner. Marmara University; Turquía
Fil: Saruhan Direskeneli, Güher. Istanbul University; Turquía
Fil: Cañas, Carlos. Fundación Valle del Lili; Colombia
Fil: Tobón, Gabriel J.. Fundación Valle del Lili; Colombia
Fil: Sawalha, Amr H.. University of Oklahoma; Estados Unidos
Fil: Cherñavsky, Alejandra Claudia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Anaya, Juan Manuel. Oklahoma Medical Research Foundation; Estados Unidos
Fil: Nath, Swapan K.. Oklahoma Medical Research Foundation; Estados Unidos
Materia
rs6822844
Il2-Il21 REGION
AUTOIMMUNE DISEASES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/67678
Acceder
id CONICETDig_089bb68d46b1854397ca9f07b1a239e2
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Confirmation of an association between rs6822844 at the IL2-IL21 region and multiple autoimmune diseases: Evidence of a general susceptibility locusMaiti, Amit K.Kim Howard, XanaViswanathan, ParvathiGuillen, Laura CristinaRojas Villarraga, AdrianaDeshmukh, HarshalDireskeneli, HanerSaruhan Direskeneli, GüherCañas, CarlosTobón, Gabriel J.Sawalha, Amr H.Cherñavsky, Alejandra ClaudiaAnaya, Juan ManuelNath, Swapan K.rs6822844Il2-Il21 REGIONAUTOIMMUNE DISEASEShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Objective. Autoimmune diseases often have susceptibility genes in common, indicating similar molecular mechanisms. Increasing evidence suggests that rs6822844 at the IL2-IL21 region is strongly associated with multiple autoimmune diseases in individuals of European descent. This study was undertaken to attempt to replicate the association between rs6822844 and 6 different immune-mediated diseases in non-European populations, and to perform disease-specific and overall meta-analyses using data from previously published studies. Methods. We evaluated case-control associations between rs6822844 and celiac disease (CD) in subjects from Argentina; rheumatoid arthritis (RA), type 1 diabetes mellitus (DM), primary Sjögren's syndrome (SS), and systemic lupus erythematosus (SLE) in subjects from Colombia; and Behçet's disease (BD) in subjects from Turkey. Allele and gene distributions were compared between cases and controls. Meta-analyses were performed using data from the present study and previous studies. Results. We detected significant associations of rs6822844 with SLE (P = 0.008), type 1 DM(P = 0.014), RA (P = 0.019), and primary SS (P = 0.033) but not with BD (P = 0.34) or CD (P = 0.98). We identified little evidence of population differentiation (FST = 0.01) within cases and controls from Argentina and Colombia, suggesting that association was not influenced by population substructure. Disease-specific meta-analysis indicated significant association for RA (Pmeta = 3.61 × 10-6), inflammatory bowel disease (IBD; Crohn's disease and ulcerative colitis) (Pmeta = 3.48 × 10-12), type 1 DM (Pmeta = 5.33 × 10-5), and CD (Pmeta = 5.30 × 10-3). Overall meta-analysis across all autoimmune diseases reinforced association with rs6822844 (23 data sets; Pmeta = 2.61 × 10-25, odds ratio 0.73 [95% confidence interval 0.69-0.78]). Conclusion. Our results indicate that there is an association between rs6822844 and multiple autoimmune diseases in non-European populations. Metaanalysis results strongly reinforce this robust association across multiple autoimmune diseases in both European-derived and non-European populations.Fil: Maiti, Amit K.. Oklahoma Medical Research Foundation; Estados UnidosFil: Kim Howard, Xana. Oklahoma Medical Research Foundation; Estados UnidosFil: Viswanathan, Parvathi. Oklahoma Medical Research Foundation; Estados UnidosFil: Guillen, Laura Cristina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Rojas Villarraga, Adriana. Universidad del Rosario; ColombiaFil: Deshmukh, Harshal. Oklahoma Medical Research Foundation; Estados UnidosFil: Direskeneli, Haner. Marmara University; TurquíaFil: Saruhan Direskeneli, Güher. Istanbul University; TurquíaFil: Cañas, Carlos. Fundación Valle del Lili; ColombiaFil: Tobón, Gabriel J.. Fundación Valle del Lili; ColombiaFil: Sawalha, Amr H.. University of Oklahoma; Estados UnidosFil: Cherñavsky, Alejandra Claudia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Anaya, Juan Manuel. Oklahoma Medical Research Foundation; Estados UnidosFil: Nath, Swapan K.. Oklahoma Medical Research Foundation; Estados UnidosWiley-liss, Div John Wiley & Sons Inc2010-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/67678Maiti, Amit K.; Kim Howard, Xana; Viswanathan, Parvathi; Guillen, Laura Cristina; Rojas Villarraga, Adriana; et al.; Confirmation of an association between rs6822844 at the IL2-IL21 region and multiple autoimmune diseases: Evidence of a general susceptibility locus; Wiley-liss, Div John Wiley & Sons Inc; Arthritis And Rheumatism; 62; 2; 2-2010; 323-3290004-3591CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/art.27222info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1002/art.27222info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028384/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:48:43Zoai:ri.conicet.gov.ar:11336/67678instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:48:43.608CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Confirmation of an association between rs6822844 at the IL2-IL21 region and multiple autoimmune diseases: Evidence of a general susceptibility locus
title Confirmation of an association between rs6822844 at the IL2-IL21 region and multiple autoimmune diseases: Evidence of a general susceptibility locus
spellingShingle Confirmation of an association between rs6822844 at the IL2-IL21 region and multiple autoimmune diseases: Evidence of a general susceptibility locus
Maiti, Amit K.
rs6822844
Il2-Il21 REGION
AUTOIMMUNE DISEASES
title_short Confirmation of an association between rs6822844 at the IL2-IL21 region and multiple autoimmune diseases: Evidence of a general susceptibility locus
title_full Confirmation of an association between rs6822844 at the IL2-IL21 region and multiple autoimmune diseases: Evidence of a general susceptibility locus
title_fullStr Confirmation of an association between rs6822844 at the IL2-IL21 region and multiple autoimmune diseases: Evidence of a general susceptibility locus
title_full_unstemmed Confirmation of an association between rs6822844 at the IL2-IL21 region and multiple autoimmune diseases: Evidence of a general susceptibility locus
title_sort Confirmation of an association between rs6822844 at the IL2-IL21 region and multiple autoimmune diseases: Evidence of a general susceptibility locus
dc.creator.none.fl_str_mv Maiti, Amit K.
Kim Howard, Xana
Viswanathan, Parvathi
Guillen, Laura Cristina
Rojas Villarraga, Adriana
Deshmukh, Harshal
Direskeneli, Haner
Saruhan Direskeneli, Güher
Cañas, Carlos
Tobón, Gabriel J.
Sawalha, Amr H.
Cherñavsky, Alejandra Claudia
Anaya, Juan Manuel
Nath, Swapan K.
author Maiti, Amit K.
author_facet Maiti, Amit K.
Kim Howard, Xana
Viswanathan, Parvathi
Guillen, Laura Cristina
Rojas Villarraga, Adriana
Deshmukh, Harshal
Direskeneli, Haner
Saruhan Direskeneli, Güher
Cañas, Carlos
Tobón, Gabriel J.
Sawalha, Amr H.
Cherñavsky, Alejandra Claudia
Anaya, Juan Manuel
Nath, Swapan K.
author_role author
author2 Kim Howard, Xana
Viswanathan, Parvathi
Guillen, Laura Cristina
Rojas Villarraga, Adriana
Deshmukh, Harshal
Direskeneli, Haner
Saruhan Direskeneli, Güher
Cañas, Carlos
Tobón, Gabriel J.
Sawalha, Amr H.
Cherñavsky, Alejandra Claudia
Anaya, Juan Manuel
Nath, Swapan K.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv rs6822844
Il2-Il21 REGION
AUTOIMMUNE DISEASES
topic rs6822844
Il2-Il21 REGION
AUTOIMMUNE DISEASES
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objective. Autoimmune diseases often have susceptibility genes in common, indicating similar molecular mechanisms. Increasing evidence suggests that rs6822844 at the IL2-IL21 region is strongly associated with multiple autoimmune diseases in individuals of European descent. This study was undertaken to attempt to replicate the association between rs6822844 and 6 different immune-mediated diseases in non-European populations, and to perform disease-specific and overall meta-analyses using data from previously published studies. Methods. We evaluated case-control associations between rs6822844 and celiac disease (CD) in subjects from Argentina; rheumatoid arthritis (RA), type 1 diabetes mellitus (DM), primary Sjögren's syndrome (SS), and systemic lupus erythematosus (SLE) in subjects from Colombia; and Behçet's disease (BD) in subjects from Turkey. Allele and gene distributions were compared between cases and controls. Meta-analyses were performed using data from the present study and previous studies. Results. We detected significant associations of rs6822844 with SLE (P = 0.008), type 1 DM(P = 0.014), RA (P = 0.019), and primary SS (P = 0.033) but not with BD (P = 0.34) or CD (P = 0.98). We identified little evidence of population differentiation (FST = 0.01) within cases and controls from Argentina and Colombia, suggesting that association was not influenced by population substructure. Disease-specific meta-analysis indicated significant association for RA (Pmeta = 3.61 × 10-6), inflammatory bowel disease (IBD; Crohn's disease and ulcerative colitis) (Pmeta = 3.48 × 10-12), type 1 DM (Pmeta = 5.33 × 10-5), and CD (Pmeta = 5.30 × 10-3). Overall meta-analysis across all autoimmune diseases reinforced association with rs6822844 (23 data sets; Pmeta = 2.61 × 10-25, odds ratio 0.73 [95% confidence interval 0.69-0.78]). Conclusion. Our results indicate that there is an association between rs6822844 and multiple autoimmune diseases in non-European populations. Metaanalysis results strongly reinforce this robust association across multiple autoimmune diseases in both European-derived and non-European populations.
Fil: Maiti, Amit K.. Oklahoma Medical Research Foundation; Estados Unidos
Fil: Kim Howard, Xana. Oklahoma Medical Research Foundation; Estados Unidos
Fil: Viswanathan, Parvathi. Oklahoma Medical Research Foundation; Estados Unidos
Fil: Guillen, Laura Cristina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rojas Villarraga, Adriana. Universidad del Rosario; Colombia
Fil: Deshmukh, Harshal. Oklahoma Medical Research Foundation; Estados Unidos
Fil: Direskeneli, Haner. Marmara University; Turquía
Fil: Saruhan Direskeneli, Güher. Istanbul University; Turquía
Fil: Cañas, Carlos. Fundación Valle del Lili; Colombia
Fil: Tobón, Gabriel J.. Fundación Valle del Lili; Colombia
Fil: Sawalha, Amr H.. University of Oklahoma; Estados Unidos
Fil: Cherñavsky, Alejandra Claudia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Anaya, Juan Manuel. Oklahoma Medical Research Foundation; Estados Unidos
Fil: Nath, Swapan K.. Oklahoma Medical Research Foundation; Estados Unidos
description Objective. Autoimmune diseases often have susceptibility genes in common, indicating similar molecular mechanisms. Increasing evidence suggests that rs6822844 at the IL2-IL21 region is strongly associated with multiple autoimmune diseases in individuals of European descent. This study was undertaken to attempt to replicate the association between rs6822844 and 6 different immune-mediated diseases in non-European populations, and to perform disease-specific and overall meta-analyses using data from previously published studies. Methods. We evaluated case-control associations between rs6822844 and celiac disease (CD) in subjects from Argentina; rheumatoid arthritis (RA), type 1 diabetes mellitus (DM), primary Sjögren's syndrome (SS), and systemic lupus erythematosus (SLE) in subjects from Colombia; and Behçet's disease (BD) in subjects from Turkey. Allele and gene distributions were compared between cases and controls. Meta-analyses were performed using data from the present study and previous studies. Results. We detected significant associations of rs6822844 with SLE (P = 0.008), type 1 DM(P = 0.014), RA (P = 0.019), and primary SS (P = 0.033) but not with BD (P = 0.34) or CD (P = 0.98). We identified little evidence of population differentiation (FST = 0.01) within cases and controls from Argentina and Colombia, suggesting that association was not influenced by population substructure. Disease-specific meta-analysis indicated significant association for RA (Pmeta = 3.61 × 10-6), inflammatory bowel disease (IBD; Crohn's disease and ulcerative colitis) (Pmeta = 3.48 × 10-12), type 1 DM (Pmeta = 5.33 × 10-5), and CD (Pmeta = 5.30 × 10-3). Overall meta-analysis across all autoimmune diseases reinforced association with rs6822844 (23 data sets; Pmeta = 2.61 × 10-25, odds ratio 0.73 [95% confidence interval 0.69-0.78]). Conclusion. Our results indicate that there is an association between rs6822844 and multiple autoimmune diseases in non-European populations. Metaanalysis results strongly reinforce this robust association across multiple autoimmune diseases in both European-derived and non-European populations.
publishDate 2010
dc.date.none.fl_str_mv 2010-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/67678
Maiti, Amit K.; Kim Howard, Xana; Viswanathan, Parvathi; Guillen, Laura Cristina; Rojas Villarraga, Adriana; et al.; Confirmation of an association between rs6822844 at the IL2-IL21 region and multiple autoimmune diseases: Evidence of a general susceptibility locus; Wiley-liss, Div John Wiley & Sons Inc; Arthritis And Rheumatism; 62; 2; 2-2010; 323-329
0004-3591
CONICET Digital
CONICET
url http://hdl.handle.net/11336/67678
identifier_str_mv Maiti, Amit K.; Kim Howard, Xana; Viswanathan, Parvathi; Guillen, Laura Cristina; Rojas Villarraga, Adriana; et al.; Confirmation of an association between rs6822844 at the IL2-IL21 region and multiple autoimmune diseases: Evidence of a general susceptibility locus; Wiley-liss, Div John Wiley & Sons Inc; Arthritis And Rheumatism; 62; 2; 2-2010; 323-329
0004-3591
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1002/art.27222
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1002/art.27222
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028384/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
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rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley-liss, Div John Wiley & Sons Inc
publisher.none.fl_str_mv Wiley-liss, Div John Wiley & Sons Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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