IL-1β, IL-2 and IL-4 concentration during porcine gestation

Autores
Vélez, Carolina; Clauzure, Mariángeles; Williamson, Delia; Koncurat, Mirta A.; Santa Coloma, Tomás Antonio; Barbeito, Claudio
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Vélez, Carolina. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina
Fil: Vélez, Carolina. Consejo Nacional de Investigaciones Científicas y Ténicas; Argentina
Fil: Clauzure, Mariángeles. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Biología Celular y Molecular; Argentina
Fil: Clauzure, Mariángeles. Consejo Nacional de Investigaciones Científicas y Ténicas; Argentina
Fil: Williamson, Delia. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina
Fil: Koncurat, Mirta A. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina
Fil: Santa Coloma, Tomás Antonio. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Biología Celular y Molecular; Argentina
Fil: Santa Coloma, Tomás Antonio. Consejo Nacional de Investigaciones Científicas y Ténicas; Argentina
Fil: Barbeito, Claudio. Consejo Nacional de Investigaciones Científicas y Ténicas; Argentina
Fil: Barbeito, Claudio. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Laboratorio de Embriología e Histología Descriptiva, Comparativa y Experimental; Argentina
Abstract: In pigs, given the type of epitheliochorial and non-invasive placenta, the trophoblast is in intimate contact with maternal tissues. The dialogue established between the conceptus and the endometrium involves, among others, the immune system, which minimizes the chances of rejection of the embryo and promotes the establishment of pregnancy. The aim of this work was to determine the concentration of IL-1β, IL-2 and IL-4 in sera and in extracts of maternal and fetal placenta from sows of different gestational periods. Reproductive tracts from 23 crossbreed sows, between 30 and 114 days of gestation (dg), and from 8 non-pregnant sows were used. The concentration of the cytokines was determined by ELISA. IL-1β, IL-2 and IL-4 demonstrated a similar pattern of concentration at the placental interface and serum; they were found elevated in tissues at 30 and 60-70 dg, and significantly decreased at term, period in which the cytokines were significantly increased in serum. These results show that IL-1β, IL-2, and IL-4 are differentially modulated during pregnancy and at term, and suggest an important role of these cytokines in defining the proinflammatory stage of these periods.
Fuente
Theriogenology. 2019, 128
Materia
ENDOMETRIO
CITOQUINAS
PORCINOS
PLACENTA
IL-2
IL-1β
IL-4
EMBARAZO
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Repositorio Institucional (UCA)
Institución
Pontificia Universidad Católica Argentina
OAI Identificador
oai:ucacris:123456789/14303
Acceder
id RIUCA_b81ba3318a42d986c5c673da086e0b5e
oai_identifier_str oai:ucacris:123456789/14303
network_acronym_str RIUCA
repository_id_str 2585
network_name_str Repositorio Institucional (UCA)
spelling IL-1β, IL-2 and IL-4 concentration during porcine gestationVélez, CarolinaClauzure, MariángelesWilliamson, DeliaKoncurat, Mirta A.Santa Coloma, Tomás AntonioBarbeito, ClaudioENDOMETRIOCITOQUINASPORCINOSPLACENTAIL-2IL-1βIL-4EMBARAZOFil: Vélez, Carolina. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; ArgentinaFil: Vélez, Carolina. Consejo Nacional de Investigaciones Científicas y Ténicas; ArgentinaFil: Clauzure, Mariángeles. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Biología Celular y Molecular; ArgentinaFil: Clauzure, Mariángeles. Consejo Nacional de Investigaciones Científicas y Ténicas; ArgentinaFil: Williamson, Delia. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; ArgentinaFil: Koncurat, Mirta A. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; ArgentinaFil: Santa Coloma, Tomás Antonio. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Biología Celular y Molecular; ArgentinaFil: Santa Coloma, Tomás Antonio. Consejo Nacional de Investigaciones Científicas y Ténicas; ArgentinaFil: Barbeito, Claudio. Consejo Nacional de Investigaciones Científicas y Ténicas; ArgentinaFil: Barbeito, Claudio. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Laboratorio de Embriología e Histología Descriptiva, Comparativa y Experimental; ArgentinaAbstract: In pigs, given the type of epitheliochorial and non-invasive placenta, the trophoblast is in intimate contact with maternal tissues. The dialogue established between the conceptus and the endometrium involves, among others, the immune system, which minimizes the chances of rejection of the embryo and promotes the establishment of pregnancy. The aim of this work was to determine the concentration of IL-1β, IL-2 and IL-4 in sera and in extracts of maternal and fetal placenta from sows of different gestational periods. Reproductive tracts from 23 crossbreed sows, between 30 and 114 days of gestation (dg), and from 8 non-pregnant sows were used. The concentration of the cytokines was determined by ELISA. IL-1β, IL-2 and IL-4 demonstrated a similar pattern of concentration at the placental interface and serum; they were found elevated in tissues at 30 and 60-70 dg, and significantly decreased at term, period in which the cytokines were significantly increased in serum. These results show that IL-1β, IL-2, and IL-4 are differentially modulated during pregnancy and at term, and suggest an important role of these cytokines in defining the proinflammatory stage of these periods.Elsevier2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/143030093-691X10.1016/j.theriogenology.2019.01.01730743102Vélez, C., et al. IL-1β, IL-2 and IL-4 concentration during porcine gestation [en línea]. Theriogenology. 2019, 128 doi:10.1016/j.theriogenology.2019.01.017 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14303Theriogenology. 2019, 128reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:58:38Zoai:ucacris:123456789/14303instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:58:38.562Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv IL-1β, IL-2 and IL-4 concentration during porcine gestation
title IL-1β, IL-2 and IL-4 concentration during porcine gestation
spellingShingle IL-1β, IL-2 and IL-4 concentration during porcine gestation
Vélez, Carolina
ENDOMETRIO
CITOQUINAS
PORCINOS
PLACENTA
IL-2
IL-1β
IL-4
EMBARAZO
title_short IL-1β, IL-2 and IL-4 concentration during porcine gestation
title_full IL-1β, IL-2 and IL-4 concentration during porcine gestation
title_fullStr IL-1β, IL-2 and IL-4 concentration during porcine gestation
title_full_unstemmed IL-1β, IL-2 and IL-4 concentration during porcine gestation
title_sort IL-1β, IL-2 and IL-4 concentration during porcine gestation
dc.creator.none.fl_str_mv Vélez, Carolina
Clauzure, Mariángeles
Williamson, Delia
Koncurat, Mirta A.
Santa Coloma, Tomás Antonio
Barbeito, Claudio
author Vélez, Carolina
author_facet Vélez, Carolina
Clauzure, Mariángeles
Williamson, Delia
Koncurat, Mirta A.
Santa Coloma, Tomás Antonio
Barbeito, Claudio
author_role author
author2 Clauzure, Mariángeles
Williamson, Delia
Koncurat, Mirta A.
Santa Coloma, Tomás Antonio
Barbeito, Claudio
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv ENDOMETRIO
CITOQUINAS
PORCINOS
PLACENTA
IL-2
IL-1β
IL-4
EMBARAZO
topic ENDOMETRIO
CITOQUINAS
PORCINOS
PLACENTA
IL-2
IL-1β
IL-4
EMBARAZO
dc.description.none.fl_txt_mv Fil: Vélez, Carolina. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina
Fil: Vélez, Carolina. Consejo Nacional de Investigaciones Científicas y Ténicas; Argentina
Fil: Clauzure, Mariángeles. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Biología Celular y Molecular; Argentina
Fil: Clauzure, Mariángeles. Consejo Nacional de Investigaciones Científicas y Ténicas; Argentina
Fil: Williamson, Delia. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina
Fil: Koncurat, Mirta A. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina
Fil: Santa Coloma, Tomás Antonio. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Biología Celular y Molecular; Argentina
Fil: Santa Coloma, Tomás Antonio. Consejo Nacional de Investigaciones Científicas y Ténicas; Argentina
Fil: Barbeito, Claudio. Consejo Nacional de Investigaciones Científicas y Ténicas; Argentina
Fil: Barbeito, Claudio. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Laboratorio de Embriología e Histología Descriptiva, Comparativa y Experimental; Argentina
Abstract: In pigs, given the type of epitheliochorial and non-invasive placenta, the trophoblast is in intimate contact with maternal tissues. The dialogue established between the conceptus and the endometrium involves, among others, the immune system, which minimizes the chances of rejection of the embryo and promotes the establishment of pregnancy. The aim of this work was to determine the concentration of IL-1β, IL-2 and IL-4 in sera and in extracts of maternal and fetal placenta from sows of different gestational periods. Reproductive tracts from 23 crossbreed sows, between 30 and 114 days of gestation (dg), and from 8 non-pregnant sows were used. The concentration of the cytokines was determined by ELISA. IL-1β, IL-2 and IL-4 demonstrated a similar pattern of concentration at the placental interface and serum; they were found elevated in tissues at 30 and 60-70 dg, and significantly decreased at term, period in which the cytokines were significantly increased in serum. These results show that IL-1β, IL-2, and IL-4 are differentially modulated during pregnancy and at term, and suggest an important role of these cytokines in defining the proinflammatory stage of these periods.
description Fil: Vélez, Carolina. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/14303
0093-691X
10.1016/j.theriogenology.2019.01.017
30743102
Vélez, C., et al. IL-1β, IL-2 and IL-4 concentration during porcine gestation [en línea]. Theriogenology. 2019, 128 doi:10.1016/j.theriogenology.2019.01.017 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14303
url https://repositorio.uca.edu.ar/handle/123456789/14303
identifier_str_mv 0093-691X
10.1016/j.theriogenology.2019.01.017
30743102
Vélez, C., et al. IL-1β, IL-2 and IL-4 concentration during porcine gestation [en línea]. Theriogenology. 2019, 128 doi:10.1016/j.theriogenology.2019.01.017 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14303
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Theriogenology. 2019, 128
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
instname_str Pontificia Universidad Católica Argentina
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
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score 13.13397

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