Overexpressed S100A7 in the progression of oral lichen planus: From moderate dysplasia to oral squamous cell carcinoma

Autores
Gandolfo, Mariana Silvia; Denninghoff, Valeria Cecilia; Avagnina, Alejandra; Scola Horisberger, María José; Turon, Pablo; Adler, Lidia Isabel
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The S100A7 protein plays an essential role in tumor progression and is found to be overexpressed or deregulated in oral mucosal dysplasia and several cancers. However, its expression in oral lichen planus remains unknown. Early detection of malignancy in lichen is a challenge because the histopathological diagnosis of dysplasia is subjective and is dependent on the personal assessment of each observer and there are intra and interobserver variability. In this context, using biological markers such as S100A7 could estimate its capacity for malignant transformation. The objective is to describe the immunohistochemical expression of S100A7 in a case of malignant transformation of oral lichen planus in a 62-year-old woman, in whom several foci of mild and moderate dysplasia and micro-invasive carcinoma were detected and monitored during her clinical follow-up. Immunohistochemistry of S100A7 determined increased protein expression in moderate dysplasia and micro-invasive carcinoma of oral lichen planus.
Fil: Gandolfo, Mariana Silvia. Universidad de Buenos Aires; Argentina
Fil: Denninghoff, Valeria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina. Universidad de Granada; España
Fil: Avagnina, Alejandra. Universidad de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Scola Horisberger, María José. Universidad de Buenos Aires; Argentina
Fil: Turon, Pablo. Universidad de Buenos Aires; Argentina
Fil: Adler, Lidia Isabel. Universidad de Buenos Aires; Argentina
Materia
ORAL LICHEN PLANUS
MALIGNANT TRANSFORMATION
S100A7 PROTEIN
EARLY DIAGNOSIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/236935
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Overexpressed S100A7 in the progression of oral lichen planus: From moderate dysplasia to oral squamous cell carcinomaGandolfo, Mariana SilviaDenninghoff, Valeria CeciliaAvagnina, AlejandraScola Horisberger, María JoséTuron, PabloAdler, Lidia IsabelORAL LICHEN PLANUSMALIGNANT TRANSFORMATIONS100A7 PROTEINEARLY DIAGNOSIShttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3The S100A7 protein plays an essential role in tumor progression and is found to be overexpressed or deregulated in oral mucosal dysplasia and several cancers. However, its expression in oral lichen planus remains unknown. Early detection of malignancy in lichen is a challenge because the histopathological diagnosis of dysplasia is subjective and is dependent on the personal assessment of each observer and there are intra and interobserver variability. In this context, using biological markers such as S100A7 could estimate its capacity for malignant transformation. The objective is to describe the immunohistochemical expression of S100A7 in a case of malignant transformation of oral lichen planus in a 62-year-old woman, in whom several foci of mild and moderate dysplasia and micro-invasive carcinoma were detected and monitored during her clinical follow-up. Immunohistochemistry of S100A7 determined increased protein expression in moderate dysplasia and micro-invasive carcinoma of oral lichen planus.Fil: Gandolfo, Mariana Silvia. Universidad de Buenos Aires; ArgentinaFil: Denninghoff, Valeria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina. Universidad de Granada; EspañaFil: Avagnina, Alejandra. Universidad de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Scola Horisberger, María José. Universidad de Buenos Aires; ArgentinaFil: Turon, Pablo. Universidad de Buenos Aires; ArgentinaFil: Adler, Lidia Isabel. Universidad de Buenos Aires; ArgentinaJournal of Clinical Images and Medical Case Reports2023-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/236935Gandolfo, Mariana Silvia; Denninghoff, Valeria Cecilia; Avagnina, Alejandra; Scola Horisberger, María José; Turon, Pablo; et al.; Overexpressed S100A7 in the progression of oral lichen planus: From moderate dysplasia to oral squamous cell carcinoma; Journal of Clinical Images and Medical Case Reports; Journal of Clinical Images and Medical Case Reports; 4; 12; 12-2023; 1-42766-7820CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://jcimcr.org/articles/JCIMCR-V4-2737.htmlinfo:eu-repo/semantics/altIdentifier/doi/10.52768/2766-7820/2737info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:35:08Zoai:ri.conicet.gov.ar:11336/236935instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:35:08.349CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Overexpressed S100A7 in the progression of oral lichen planus: From moderate dysplasia to oral squamous cell carcinoma
title Overexpressed S100A7 in the progression of oral lichen planus: From moderate dysplasia to oral squamous cell carcinoma
spellingShingle Overexpressed S100A7 in the progression of oral lichen planus: From moderate dysplasia to oral squamous cell carcinoma
Gandolfo, Mariana Silvia
ORAL LICHEN PLANUS
MALIGNANT TRANSFORMATION
S100A7 PROTEIN
EARLY DIAGNOSIS
title_short Overexpressed S100A7 in the progression of oral lichen planus: From moderate dysplasia to oral squamous cell carcinoma
title_full Overexpressed S100A7 in the progression of oral lichen planus: From moderate dysplasia to oral squamous cell carcinoma
title_fullStr Overexpressed S100A7 in the progression of oral lichen planus: From moderate dysplasia to oral squamous cell carcinoma
title_full_unstemmed Overexpressed S100A7 in the progression of oral lichen planus: From moderate dysplasia to oral squamous cell carcinoma
title_sort Overexpressed S100A7 in the progression of oral lichen planus: From moderate dysplasia to oral squamous cell carcinoma
dc.creator.none.fl_str_mv Gandolfo, Mariana Silvia
Denninghoff, Valeria Cecilia
Avagnina, Alejandra
Scola Horisberger, María José
Turon, Pablo
Adler, Lidia Isabel
author Gandolfo, Mariana Silvia
author_facet Gandolfo, Mariana Silvia
Denninghoff, Valeria Cecilia
Avagnina, Alejandra
Scola Horisberger, María José
Turon, Pablo
Adler, Lidia Isabel
author_role author
author2 Denninghoff, Valeria Cecilia
Avagnina, Alejandra
Scola Horisberger, María José
Turon, Pablo
Adler, Lidia Isabel
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv ORAL LICHEN PLANUS
MALIGNANT TRANSFORMATION
S100A7 PROTEIN
EARLY DIAGNOSIS
topic ORAL LICHEN PLANUS
MALIGNANT TRANSFORMATION
S100A7 PROTEIN
EARLY DIAGNOSIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The S100A7 protein plays an essential role in tumor progression and is found to be overexpressed or deregulated in oral mucosal dysplasia and several cancers. However, its expression in oral lichen planus remains unknown. Early detection of malignancy in lichen is a challenge because the histopathological diagnosis of dysplasia is subjective and is dependent on the personal assessment of each observer and there are intra and interobserver variability. In this context, using biological markers such as S100A7 could estimate its capacity for malignant transformation. The objective is to describe the immunohistochemical expression of S100A7 in a case of malignant transformation of oral lichen planus in a 62-year-old woman, in whom several foci of mild and moderate dysplasia and micro-invasive carcinoma were detected and monitored during her clinical follow-up. Immunohistochemistry of S100A7 determined increased protein expression in moderate dysplasia and micro-invasive carcinoma of oral lichen planus.
Fil: Gandolfo, Mariana Silvia. Universidad de Buenos Aires; Argentina
Fil: Denninghoff, Valeria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina. Universidad de Granada; España
Fil: Avagnina, Alejandra. Universidad de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Scola Horisberger, María José. Universidad de Buenos Aires; Argentina
Fil: Turon, Pablo. Universidad de Buenos Aires; Argentina
Fil: Adler, Lidia Isabel. Universidad de Buenos Aires; Argentina
description The S100A7 protein plays an essential role in tumor progression and is found to be overexpressed or deregulated in oral mucosal dysplasia and several cancers. However, its expression in oral lichen planus remains unknown. Early detection of malignancy in lichen is a challenge because the histopathological diagnosis of dysplasia is subjective and is dependent on the personal assessment of each observer and there are intra and interobserver variability. In this context, using biological markers such as S100A7 could estimate its capacity for malignant transformation. The objective is to describe the immunohistochemical expression of S100A7 in a case of malignant transformation of oral lichen planus in a 62-year-old woman, in whom several foci of mild and moderate dysplasia and micro-invasive carcinoma were detected and monitored during her clinical follow-up. Immunohistochemistry of S100A7 determined increased protein expression in moderate dysplasia and micro-invasive carcinoma of oral lichen planus.
publishDate 2023
dc.date.none.fl_str_mv 2023-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/236935
Gandolfo, Mariana Silvia; Denninghoff, Valeria Cecilia; Avagnina, Alejandra; Scola Horisberger, María José; Turon, Pablo; et al.; Overexpressed S100A7 in the progression of oral lichen planus: From moderate dysplasia to oral squamous cell carcinoma; Journal of Clinical Images and Medical Case Reports; Journal of Clinical Images and Medical Case Reports; 4; 12; 12-2023; 1-4
2766-7820
CONICET Digital
CONICET
url http://hdl.handle.net/11336/236935
identifier_str_mv Gandolfo, Mariana Silvia; Denninghoff, Valeria Cecilia; Avagnina, Alejandra; Scola Horisberger, María José; Turon, Pablo; et al.; Overexpressed S100A7 in the progression of oral lichen planus: From moderate dysplasia to oral squamous cell carcinoma; Journal of Clinical Images and Medical Case Reports; Journal of Clinical Images and Medical Case Reports; 4; 12; 12-2023; 1-4
2766-7820
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://jcimcr.org/articles/JCIMCR-V4-2737.html
info:eu-repo/semantics/altIdentifier/doi/10.52768/2766-7820/2737
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Journal of Clinical Images and Medical Case Reports
publisher.none.fl_str_mv Journal of Clinical Images and Medical Case Reports
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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