BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions.

Autores
Salcedo, Suzana P.; Marchesini, Maria Ines; Degos, Clara; Terwagne, Matthiew; Von Bargen, Kristine; Lepidi, Hubert; Herrmann, Claudia Karina; Santos Lacerda, Thais L.; Imbert, Paul R. C.; Pierre, Philippe; Alexopoulou, Lena; Letesson, Jean Jacques; Comerci, Diego José; Gorvel, Jean Pierre
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Several bacterial pathogens have TIR domain-containing proteins that contribute to their pathogenesis. We identified a second TIR-containing protein in Brucella spp. that we have designated BtpB. We show it is a potent inhibitor of TLR signaling, probably via MyD88. BtpB is a novel Brucella effector that is translocated into host cells and interferes with activation of dendritic cells. In vivo mouse studies revealed that BtpB is contributing to virulence and control of local inflammatory responses with relevance in the establishment of chronic brucellosis. Together, our results show that BtpB is a novel Brucella effector that plays a major role in the modulation of host innate immune response during infection.
Fil: Salcedo, Suzana P.. Centre d’Immunologie de Marseille-Luminy; Francia. INSERM U 1104; Francia. CNRS UMR 7280; Francia. Université Claude Bernard Lyon 1; Francia
Fil: Marchesini, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
Fil: Degos, Clara. Centre d’Immunologie de Marseille-Luminy; Francia. INSERM U 1104; Francia. CNRS UMR 7280; Francia
Fil: Terwagne, Matthiew. University of Namur; Bélgica
Fil: Von Bargen, Kristine. Centre d’Immunologie de Marseille-Luminy; Francia. INSERM U 1104; Francia. CNRS UMR 7280; Francia
Fil: Lepidi, Hubert. Aix-Marseille Université; Francia
Fil: Herrmann, Claudia Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
Fil: Santos Lacerda, Thais L.. Centre d’Immunologie de Marseille-Luminy; Francia. INSERM U 1104; Francia. CNRS UMR 7280; Francia. Université Claude Bernard Lyon 1; Francia
Fil: Imbert, Paul R. C.. Université Claude Bernard Lyon 1; Francia
Fil: Pierre, Philippe. Centre d’Immunologie de Marseille-Luminy; Francia. INSERM U 1104; Francia. CNRS UMR 7280; Francia
Fil: Alexopoulou, Lena. Centre d’Immunologie de Marseille-Luminy; Francia. INSERM U 1104; Francia. CNRS UMR 7280; Francia
Fil: Letesson, Jean Jacques. University of Namur; Bélgica
Fil: Comerci, Diego José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
Fil: Gorvel, Jean Pierre. Centre d’Immunologie de Marseille-Luminy; Francia. INSERM U 1104; Francia. CNRS UMR 7280; Francia
Materia
BRUCELLA
TIR DOMAIN
TLR
DENDRITIC CELLS
Btp1/BtpA
DC
NF-κB
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/24837

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oai_identifier_str oai:ri.conicet.gov.ar:11336/24837
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions.Salcedo, Suzana P.Marchesini, Maria InesDegos, ClaraTerwagne, MatthiewVon Bargen, KristineLepidi, HubertHerrmann, Claudia KarinaSantos Lacerda, Thais L.Imbert, Paul R. C.Pierre, PhilippeAlexopoulou, LenaLetesson, Jean JacquesComerci, Diego JoséGorvel, Jean PierreBRUCELLATIR DOMAINTLRDENDRITIC CELLSBtp1/BtpADCNF-κBhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Several bacterial pathogens have TIR domain-containing proteins that contribute to their pathogenesis. We identified a second TIR-containing protein in Brucella spp. that we have designated BtpB. We show it is a potent inhibitor of TLR signaling, probably via MyD88. BtpB is a novel Brucella effector that is translocated into host cells and interferes with activation of dendritic cells. In vivo mouse studies revealed that BtpB is contributing to virulence and control of local inflammatory responses with relevance in the establishment of chronic brucellosis. Together, our results show that BtpB is a novel Brucella effector that plays a major role in the modulation of host innate immune response during infection.Fil: Salcedo, Suzana P.. Centre d’Immunologie de Marseille-Luminy; Francia. INSERM U 1104; Francia. CNRS UMR 7280; Francia. Université Claude Bernard Lyon 1; FranciaFil: Marchesini, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Degos, Clara. Centre d’Immunologie de Marseille-Luminy; Francia. INSERM U 1104; Francia. CNRS UMR 7280; FranciaFil: Terwagne, Matthiew. University of Namur; BélgicaFil: Von Bargen, Kristine. Centre d’Immunologie de Marseille-Luminy; Francia. INSERM U 1104; Francia. CNRS UMR 7280; FranciaFil: Lepidi, Hubert. Aix-Marseille Université; FranciaFil: Herrmann, Claudia Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Santos Lacerda, Thais L.. Centre d’Immunologie de Marseille-Luminy; Francia. INSERM U 1104; Francia. CNRS UMR 7280; Francia. Université Claude Bernard Lyon 1; FranciaFil: Imbert, Paul R. C.. Université Claude Bernard Lyon 1; FranciaFil: Pierre, Philippe. Centre d’Immunologie de Marseille-Luminy; Francia. INSERM U 1104; Francia. CNRS UMR 7280; FranciaFil: Alexopoulou, Lena. Centre d’Immunologie de Marseille-Luminy; Francia. INSERM U 1104; Francia. CNRS UMR 7280; FranciaFil: Letesson, Jean Jacques. University of Namur; BélgicaFil: Comerci, Diego José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Gorvel, Jean Pierre. Centre d’Immunologie de Marseille-Luminy; Francia. INSERM U 1104; Francia. CNRS UMR 7280; FranciaFrontiers Media S. A.2013-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/24837Salcedo, Suzana P.; Marchesini, Maria Ines; Degos, Clara; Terwagne, Matthiew; Von Bargen, Kristine; et al.; BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions.; Frontiers Media S. A.; Frontiers in Cellular and Infection Microbiology; 3; 28; 7-2013; 1-132235-2988CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://journal.frontiersin.org/Journal/10.3389/fcimb.2013.00028/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fcimb.2013.00028info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:15:02Zoai:ri.conicet.gov.ar:11336/24837instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:15:03.188CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions.
title BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions.
spellingShingle BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions.
Salcedo, Suzana P.
BRUCELLA
TIR DOMAIN
TLR
DENDRITIC CELLS
Btp1/BtpA
DC
NF-κB
title_short BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions.
title_full BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions.
title_fullStr BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions.
title_full_unstemmed BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions.
title_sort BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions.
dc.creator.none.fl_str_mv Salcedo, Suzana P.
Marchesini, Maria Ines
Degos, Clara
Terwagne, Matthiew
Von Bargen, Kristine
Lepidi, Hubert
Herrmann, Claudia Karina
Santos Lacerda, Thais L.
Imbert, Paul R. C.
Pierre, Philippe
Alexopoulou, Lena
Letesson, Jean Jacques
Comerci, Diego José
Gorvel, Jean Pierre
author Salcedo, Suzana P.
author_facet Salcedo, Suzana P.
Marchesini, Maria Ines
Degos, Clara
Terwagne, Matthiew
Von Bargen, Kristine
Lepidi, Hubert
Herrmann, Claudia Karina
Santos Lacerda, Thais L.
Imbert, Paul R. C.
Pierre, Philippe
Alexopoulou, Lena
Letesson, Jean Jacques
Comerci, Diego José
Gorvel, Jean Pierre
author_role author
author2 Marchesini, Maria Ines
Degos, Clara
Terwagne, Matthiew
Von Bargen, Kristine
Lepidi, Hubert
Herrmann, Claudia Karina
Santos Lacerda, Thais L.
Imbert, Paul R. C.
Pierre, Philippe
Alexopoulou, Lena
Letesson, Jean Jacques
Comerci, Diego José
Gorvel, Jean Pierre
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BRUCELLA
TIR DOMAIN
TLR
DENDRITIC CELLS
Btp1/BtpA
DC
NF-κB
topic BRUCELLA
TIR DOMAIN
TLR
DENDRITIC CELLS
Btp1/BtpA
DC
NF-κB
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Several bacterial pathogens have TIR domain-containing proteins that contribute to their pathogenesis. We identified a second TIR-containing protein in Brucella spp. that we have designated BtpB. We show it is a potent inhibitor of TLR signaling, probably via MyD88. BtpB is a novel Brucella effector that is translocated into host cells and interferes with activation of dendritic cells. In vivo mouse studies revealed that BtpB is contributing to virulence and control of local inflammatory responses with relevance in the establishment of chronic brucellosis. Together, our results show that BtpB is a novel Brucella effector that plays a major role in the modulation of host innate immune response during infection.
Fil: Salcedo, Suzana P.. Centre d’Immunologie de Marseille-Luminy; Francia. INSERM U 1104; Francia. CNRS UMR 7280; Francia. Université Claude Bernard Lyon 1; Francia
Fil: Marchesini, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
Fil: Degos, Clara. Centre d’Immunologie de Marseille-Luminy; Francia. INSERM U 1104; Francia. CNRS UMR 7280; Francia
Fil: Terwagne, Matthiew. University of Namur; Bélgica
Fil: Von Bargen, Kristine. Centre d’Immunologie de Marseille-Luminy; Francia. INSERM U 1104; Francia. CNRS UMR 7280; Francia
Fil: Lepidi, Hubert. Aix-Marseille Université; Francia
Fil: Herrmann, Claudia Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
Fil: Santos Lacerda, Thais L.. Centre d’Immunologie de Marseille-Luminy; Francia. INSERM U 1104; Francia. CNRS UMR 7280; Francia. Université Claude Bernard Lyon 1; Francia
Fil: Imbert, Paul R. C.. Université Claude Bernard Lyon 1; Francia
Fil: Pierre, Philippe. Centre d’Immunologie de Marseille-Luminy; Francia. INSERM U 1104; Francia. CNRS UMR 7280; Francia
Fil: Alexopoulou, Lena. Centre d’Immunologie de Marseille-Luminy; Francia. INSERM U 1104; Francia. CNRS UMR 7280; Francia
Fil: Letesson, Jean Jacques. University of Namur; Bélgica
Fil: Comerci, Diego José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
Fil: Gorvel, Jean Pierre. Centre d’Immunologie de Marseille-Luminy; Francia. INSERM U 1104; Francia. CNRS UMR 7280; Francia
description Several bacterial pathogens have TIR domain-containing proteins that contribute to their pathogenesis. We identified a second TIR-containing protein in Brucella spp. that we have designated BtpB. We show it is a potent inhibitor of TLR signaling, probably via MyD88. BtpB is a novel Brucella effector that is translocated into host cells and interferes with activation of dendritic cells. In vivo mouse studies revealed that BtpB is contributing to virulence and control of local inflammatory responses with relevance in the establishment of chronic brucellosis. Together, our results show that BtpB is a novel Brucella effector that plays a major role in the modulation of host innate immune response during infection.
publishDate 2013
dc.date.none.fl_str_mv 2013-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/24837
Salcedo, Suzana P.; Marchesini, Maria Ines; Degos, Clara; Terwagne, Matthiew; Von Bargen, Kristine; et al.; BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions.; Frontiers Media S. A.; Frontiers in Cellular and Infection Microbiology; 3; 28; 7-2013; 1-13
2235-2988
CONICET Digital
CONICET
url http://hdl.handle.net/11336/24837
identifier_str_mv Salcedo, Suzana P.; Marchesini, Maria Ines; Degos, Clara; Terwagne, Matthiew; Von Bargen, Kristine; et al.; BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions.; Frontiers Media S. A.; Frontiers in Cellular and Infection Microbiology; 3; 28; 7-2013; 1-13
2235-2988
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://journal.frontiersin.org/Journal/10.3389/fcimb.2013.00028/full
info:eu-repo/semantics/altIdentifier/doi/10.3389/fcimb.2013.00028
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media S. A.
publisher.none.fl_str_mv Frontiers Media S. A.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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