BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions.
- Autores
- Salcedo, Suzana P.; Marchesini, Maria Ines; Degos, Clara; Terwagne, Matthiew; Von Bargen, Kristine; Lepidi, Hubert; Herrmann, Claudia Karina; Santos Lacerda, Thais L.; Imbert, Paul R. C.; Pierre, Philippe; Alexopoulou, Lena; Letesson, Jean Jacques; Comerci, Diego José; Gorvel, Jean Pierre
- Año de publicación
- 2013
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Several bacterial pathogens have TIR domain-containing proteins that contribute to their pathogenesis. We identified a second TIR-containing protein in Brucella spp. that we have designated BtpB. We show it is a potent inhibitor of TLR signaling, probably via MyD88. BtpB is a novel Brucella effector that is translocated into host cells and interferes with activation of dendritic cells. In vivo mouse studies revealed that BtpB is contributing to virulence and control of local inflammatory responses with relevance in the establishment of chronic brucellosis. Together, our results show that BtpB is a novel Brucella effector that plays a major role in the modulation of host innate immune response during infection.
Fil: Salcedo, Suzana P.. Centre d’Immunologie de Marseille-Luminy; Francia. INSERM U 1104; Francia. CNRS UMR 7280; Francia. Université Claude Bernard Lyon 1; Francia
Fil: Marchesini, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
Fil: Degos, Clara. Centre d’Immunologie de Marseille-Luminy; Francia. INSERM U 1104; Francia. CNRS UMR 7280; Francia
Fil: Terwagne, Matthiew. University of Namur; Bélgica
Fil: Von Bargen, Kristine. Centre d’Immunologie de Marseille-Luminy; Francia. INSERM U 1104; Francia. CNRS UMR 7280; Francia
Fil: Lepidi, Hubert. Aix-Marseille Université; Francia
Fil: Herrmann, Claudia Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
Fil: Santos Lacerda, Thais L.. Centre d’Immunologie de Marseille-Luminy; Francia. INSERM U 1104; Francia. CNRS UMR 7280; Francia. Université Claude Bernard Lyon 1; Francia
Fil: Imbert, Paul R. C.. Université Claude Bernard Lyon 1; Francia
Fil: Pierre, Philippe. Centre d’Immunologie de Marseille-Luminy; Francia. INSERM U 1104; Francia. CNRS UMR 7280; Francia
Fil: Alexopoulou, Lena. Centre d’Immunologie de Marseille-Luminy; Francia. INSERM U 1104; Francia. CNRS UMR 7280; Francia
Fil: Letesson, Jean Jacques. University of Namur; Bélgica
Fil: Comerci, Diego José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
Fil: Gorvel, Jean Pierre. Centre d’Immunologie de Marseille-Luminy; Francia. INSERM U 1104; Francia. CNRS UMR 7280; Francia - Materia
-
BRUCELLA
TIR DOMAIN
TLR
DENDRITIC CELLS
Btp1/BtpA
DC
NF-κB - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/24837
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BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions.Salcedo, Suzana P.Marchesini, Maria InesDegos, ClaraTerwagne, MatthiewVon Bargen, KristineLepidi, HubertHerrmann, Claudia KarinaSantos Lacerda, Thais L.Imbert, Paul R. C.Pierre, PhilippeAlexopoulou, LenaLetesson, Jean JacquesComerci, Diego JoséGorvel, Jean PierreBRUCELLATIR DOMAINTLRDENDRITIC CELLSBtp1/BtpADCNF-κBhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Several bacterial pathogens have TIR domain-containing proteins that contribute to their pathogenesis. We identified a second TIR-containing protein in Brucella spp. that we have designated BtpB. We show it is a potent inhibitor of TLR signaling, probably via MyD88. BtpB is a novel Brucella effector that is translocated into host cells and interferes with activation of dendritic cells. In vivo mouse studies revealed that BtpB is contributing to virulence and control of local inflammatory responses with relevance in the establishment of chronic brucellosis. Together, our results show that BtpB is a novel Brucella effector that plays a major role in the modulation of host innate immune response during infection.Fil: Salcedo, Suzana P.. Centre d’Immunologie de Marseille-Luminy; Francia. INSERM U 1104; Francia. CNRS UMR 7280; Francia. Université Claude Bernard Lyon 1; FranciaFil: Marchesini, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Degos, Clara. Centre d’Immunologie de Marseille-Luminy; Francia. INSERM U 1104; Francia. CNRS UMR 7280; FranciaFil: Terwagne, Matthiew. University of Namur; BélgicaFil: Von Bargen, Kristine. Centre d’Immunologie de Marseille-Luminy; Francia. INSERM U 1104; Francia. CNRS UMR 7280; FranciaFil: Lepidi, Hubert. Aix-Marseille Université; FranciaFil: Herrmann, Claudia Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Santos Lacerda, Thais L.. Centre d’Immunologie de Marseille-Luminy; Francia. INSERM U 1104; Francia. CNRS UMR 7280; Francia. Université Claude Bernard Lyon 1; FranciaFil: Imbert, Paul R. C.. Université Claude Bernard Lyon 1; FranciaFil: Pierre, Philippe. Centre d’Immunologie de Marseille-Luminy; Francia. INSERM U 1104; Francia. CNRS UMR 7280; FranciaFil: Alexopoulou, Lena. Centre d’Immunologie de Marseille-Luminy; Francia. INSERM U 1104; Francia. CNRS UMR 7280; FranciaFil: Letesson, Jean Jacques. University of Namur; BélgicaFil: Comerci, Diego José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Gorvel, Jean Pierre. Centre d’Immunologie de Marseille-Luminy; Francia. INSERM U 1104; Francia. CNRS UMR 7280; FranciaFrontiers Media S. A.2013-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/24837Salcedo, Suzana P.; Marchesini, Maria Ines; Degos, Clara; Terwagne, Matthiew; Von Bargen, Kristine; et al.; BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions.; Frontiers Media S. A.; Frontiers in Cellular and Infection Microbiology; 3; 28; 7-2013; 1-132235-2988CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://journal.frontiersin.org/Journal/10.3389/fcimb.2013.00028/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fcimb.2013.00028info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:15:02Zoai:ri.conicet.gov.ar:11336/24837instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:15:03.188CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions. |
title |
BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions. |
spellingShingle |
BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions. Salcedo, Suzana P. BRUCELLA TIR DOMAIN TLR DENDRITIC CELLS Btp1/BtpA DC NF-κB |
title_short |
BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions. |
title_full |
BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions. |
title_fullStr |
BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions. |
title_full_unstemmed |
BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions. |
title_sort |
BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions. |
dc.creator.none.fl_str_mv |
Salcedo, Suzana P. Marchesini, Maria Ines Degos, Clara Terwagne, Matthiew Von Bargen, Kristine Lepidi, Hubert Herrmann, Claudia Karina Santos Lacerda, Thais L. Imbert, Paul R. C. Pierre, Philippe Alexopoulou, Lena Letesson, Jean Jacques Comerci, Diego José Gorvel, Jean Pierre |
author |
Salcedo, Suzana P. |
author_facet |
Salcedo, Suzana P. Marchesini, Maria Ines Degos, Clara Terwagne, Matthiew Von Bargen, Kristine Lepidi, Hubert Herrmann, Claudia Karina Santos Lacerda, Thais L. Imbert, Paul R. C. Pierre, Philippe Alexopoulou, Lena Letesson, Jean Jacques Comerci, Diego José Gorvel, Jean Pierre |
author_role |
author |
author2 |
Marchesini, Maria Ines Degos, Clara Terwagne, Matthiew Von Bargen, Kristine Lepidi, Hubert Herrmann, Claudia Karina Santos Lacerda, Thais L. Imbert, Paul R. C. Pierre, Philippe Alexopoulou, Lena Letesson, Jean Jacques Comerci, Diego José Gorvel, Jean Pierre |
author2_role |
author author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
BRUCELLA TIR DOMAIN TLR DENDRITIC CELLS Btp1/BtpA DC NF-κB |
topic |
BRUCELLA TIR DOMAIN TLR DENDRITIC CELLS Btp1/BtpA DC NF-κB |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Several bacterial pathogens have TIR domain-containing proteins that contribute to their pathogenesis. We identified a second TIR-containing protein in Brucella spp. that we have designated BtpB. We show it is a potent inhibitor of TLR signaling, probably via MyD88. BtpB is a novel Brucella effector that is translocated into host cells and interferes with activation of dendritic cells. In vivo mouse studies revealed that BtpB is contributing to virulence and control of local inflammatory responses with relevance in the establishment of chronic brucellosis. Together, our results show that BtpB is a novel Brucella effector that plays a major role in the modulation of host innate immune response during infection. Fil: Salcedo, Suzana P.. Centre d’Immunologie de Marseille-Luminy; Francia. INSERM U 1104; Francia. CNRS UMR 7280; Francia. Université Claude Bernard Lyon 1; Francia Fil: Marchesini, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina Fil: Degos, Clara. Centre d’Immunologie de Marseille-Luminy; Francia. INSERM U 1104; Francia. CNRS UMR 7280; Francia Fil: Terwagne, Matthiew. University of Namur; Bélgica Fil: Von Bargen, Kristine. Centre d’Immunologie de Marseille-Luminy; Francia. INSERM U 1104; Francia. CNRS UMR 7280; Francia Fil: Lepidi, Hubert. Aix-Marseille Université; Francia Fil: Herrmann, Claudia Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina Fil: Santos Lacerda, Thais L.. Centre d’Immunologie de Marseille-Luminy; Francia. INSERM U 1104; Francia. CNRS UMR 7280; Francia. Université Claude Bernard Lyon 1; Francia Fil: Imbert, Paul R. C.. Université Claude Bernard Lyon 1; Francia Fil: Pierre, Philippe. Centre d’Immunologie de Marseille-Luminy; Francia. INSERM U 1104; Francia. CNRS UMR 7280; Francia Fil: Alexopoulou, Lena. Centre d’Immunologie de Marseille-Luminy; Francia. INSERM U 1104; Francia. CNRS UMR 7280; Francia Fil: Letesson, Jean Jacques. University of Namur; Bélgica Fil: Comerci, Diego José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina Fil: Gorvel, Jean Pierre. Centre d’Immunologie de Marseille-Luminy; Francia. INSERM U 1104; Francia. CNRS UMR 7280; Francia |
description |
Several bacterial pathogens have TIR domain-containing proteins that contribute to their pathogenesis. We identified a second TIR-containing protein in Brucella spp. that we have designated BtpB. We show it is a potent inhibitor of TLR signaling, probably via MyD88. BtpB is a novel Brucella effector that is translocated into host cells and interferes with activation of dendritic cells. In vivo mouse studies revealed that BtpB is contributing to virulence and control of local inflammatory responses with relevance in the establishment of chronic brucellosis. Together, our results show that BtpB is a novel Brucella effector that plays a major role in the modulation of host innate immune response during infection. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-07 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/24837 Salcedo, Suzana P.; Marchesini, Maria Ines; Degos, Clara; Terwagne, Matthiew; Von Bargen, Kristine; et al.; BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions.; Frontiers Media S. A.; Frontiers in Cellular and Infection Microbiology; 3; 28; 7-2013; 1-13 2235-2988 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/24837 |
identifier_str_mv |
Salcedo, Suzana P.; Marchesini, Maria Ines; Degos, Clara; Terwagne, Matthiew; Von Bargen, Kristine; et al.; BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions.; Frontiers Media S. A.; Frontiers in Cellular and Infection Microbiology; 3; 28; 7-2013; 1-13 2235-2988 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://journal.frontiersin.org/Journal/10.3389/fcimb.2013.00028/full info:eu-repo/semantics/altIdentifier/doi/10.3389/fcimb.2013.00028 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers Media S. A. |
publisher.none.fl_str_mv |
Frontiers Media S. A. |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614083319431168 |
score |
13.070432 |