Mechanical heart valve prostheses and persistent lupus anticoagulant: Is the thrombotic risk increased?

Autores
Casais, Patricia; Meschengieser, Susana S.; Gennari, Laura C.; Alberto, Maria Fabiana; Lazzari, María Ángela
Año de publicación
2005
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The risk of thrombosis in patients with mechanical heart valve prostheses in spite of life-long adequate anticoagulation is 1–2% per year. Current recommendations for anticoagulation take into account the prosthesis itself and the co-morbid conditions that enhance the thrombotic risk. Lupus anticoagulant is diagnosed in many thrombotic recurrences. We designed an ambispective case–control study to evaluate thrombotic events in patients with mechanical heart valve prostheses and persistent lupus anticoagulant. Our objectives were to determine whether persistent lupus anticoagulant increased the risk of embolism in that population and thus, if a more intense anticoagulation would be recommended, even at the risk of increasing bleeding episodes. We included 16 patients and 16 controls with more than 80 patient-years of follow-up and with other risk factors for embolism. We observed no increased rate of thromboembolic events in patients than in controls, even during high-risk situations (i.e. bacterial endocarditis). Our population spent most of the time within the intended anticoagulation range. We conclude that adequate anticoagulation is the most important issue to prevent events, protecting against thrombosis without increasing the bleeding risk.
Fil: Casais, Patricia. Academia Nacional de Medicina de Buenos Aires; Argentina
Fil: Meschengieser, Susana S.. Academia Nacional de Medicina de Buenos Aires; Argentina
Fil: Gennari, Laura C.. Academia Nacional de Medicina de Buenos Aires; Argentina
Fil: Alberto, Maria Fabiana. Academia Nacional de Medicina de Buenos Aires; Argentina
Fil: Lazzari, María Ángela. Academia Nacional de Medicina de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Materia
Lupus Antiocoagulant
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/240903
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Mechanical heart valve prostheses and persistent lupus anticoagulant: Is the thrombotic risk increased?Casais, PatriciaMeschengieser, Susana S.Gennari, Laura C.Alberto, Maria FabianaLazzari, María ÁngelaLupus Antiocoagulanthttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3The risk of thrombosis in patients with mechanical heart valve prostheses in spite of life-long adequate anticoagulation is 1–2% per year. Current recommendations for anticoagulation take into account the prosthesis itself and the co-morbid conditions that enhance the thrombotic risk. Lupus anticoagulant is diagnosed in many thrombotic recurrences. We designed an ambispective case–control study to evaluate thrombotic events in patients with mechanical heart valve prostheses and persistent lupus anticoagulant. Our objectives were to determine whether persistent lupus anticoagulant increased the risk of embolism in that population and thus, if a more intense anticoagulation would be recommended, even at the risk of increasing bleeding episodes. We included 16 patients and 16 controls with more than 80 patient-years of follow-up and with other risk factors for embolism. We observed no increased rate of thromboembolic events in patients than in controls, even during high-risk situations (i.e. bacterial endocarditis). Our population spent most of the time within the intended anticoagulation range. We conclude that adequate anticoagulation is the most important issue to prevent events, protecting against thrombosis without increasing the bleeding risk.Fil: Casais, Patricia. Academia Nacional de Medicina de Buenos Aires; ArgentinaFil: Meschengieser, Susana S.. Academia Nacional de Medicina de Buenos Aires; ArgentinaFil: Gennari, Laura C.. Academia Nacional de Medicina de Buenos Aires; ArgentinaFil: Alberto, Maria Fabiana. Academia Nacional de Medicina de Buenos Aires; ArgentinaFil: Lazzari, María Ángela. Academia Nacional de Medicina de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaLippincott Williams2005-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/240903Casais, Patricia; Meschengieser, Susana S.; Gennari, Laura C.; Alberto, Maria Fabiana; Lazzari, María Ángela; Mechanical heart valve prostheses and persistent lupus anticoagulant: Is the thrombotic risk increased?; Lippincott Williams; Blood Coagulation & Fibrinolysis : An International Journal In Haemostasis And Thrombosis.; 16; 3; 4-2005; 183-1850957-5235CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://journals.lww.com/bloodcoagulation/abstract/2005/04000/mechanical_heart_valve_prostheses_and_persistent.4.aspxinfo:eu-repo/semantics/altIdentifier/doi/10.1097/01.mbc.0000164426.75298.c6info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:55:47Zoai:ri.conicet.gov.ar:11336/240903instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:55:48.117CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Mechanical heart valve prostheses and persistent lupus anticoagulant: Is the thrombotic risk increased?
title Mechanical heart valve prostheses and persistent lupus anticoagulant: Is the thrombotic risk increased?
spellingShingle Mechanical heart valve prostheses and persistent lupus anticoagulant: Is the thrombotic risk increased?
Casais, Patricia
Lupus Antiocoagulant
title_short Mechanical heart valve prostheses and persistent lupus anticoagulant: Is the thrombotic risk increased?
title_full Mechanical heart valve prostheses and persistent lupus anticoagulant: Is the thrombotic risk increased?
title_fullStr Mechanical heart valve prostheses and persistent lupus anticoagulant: Is the thrombotic risk increased?
title_full_unstemmed Mechanical heart valve prostheses and persistent lupus anticoagulant: Is the thrombotic risk increased?
title_sort Mechanical heart valve prostheses and persistent lupus anticoagulant: Is the thrombotic risk increased?
dc.creator.none.fl_str_mv Casais, Patricia
Meschengieser, Susana S.
Gennari, Laura C.
Alberto, Maria Fabiana
Lazzari, María Ángela
author Casais, Patricia
author_facet Casais, Patricia
Meschengieser, Susana S.
Gennari, Laura C.
Alberto, Maria Fabiana
Lazzari, María Ángela
author_role author
author2 Meschengieser, Susana S.
Gennari, Laura C.
Alberto, Maria Fabiana
Lazzari, María Ángela
author2_role author
author
author
author
dc.subject.none.fl_str_mv Lupus Antiocoagulant
topic Lupus Antiocoagulant
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The risk of thrombosis in patients with mechanical heart valve prostheses in spite of life-long adequate anticoagulation is 1–2% per year. Current recommendations for anticoagulation take into account the prosthesis itself and the co-morbid conditions that enhance the thrombotic risk. Lupus anticoagulant is diagnosed in many thrombotic recurrences. We designed an ambispective case–control study to evaluate thrombotic events in patients with mechanical heart valve prostheses and persistent lupus anticoagulant. Our objectives were to determine whether persistent lupus anticoagulant increased the risk of embolism in that population and thus, if a more intense anticoagulation would be recommended, even at the risk of increasing bleeding episodes. We included 16 patients and 16 controls with more than 80 patient-years of follow-up and with other risk factors for embolism. We observed no increased rate of thromboembolic events in patients than in controls, even during high-risk situations (i.e. bacterial endocarditis). Our population spent most of the time within the intended anticoagulation range. We conclude that adequate anticoagulation is the most important issue to prevent events, protecting against thrombosis without increasing the bleeding risk.
Fil: Casais, Patricia. Academia Nacional de Medicina de Buenos Aires; Argentina
Fil: Meschengieser, Susana S.. Academia Nacional de Medicina de Buenos Aires; Argentina
Fil: Gennari, Laura C.. Academia Nacional de Medicina de Buenos Aires; Argentina
Fil: Alberto, Maria Fabiana. Academia Nacional de Medicina de Buenos Aires; Argentina
Fil: Lazzari, María Ángela. Academia Nacional de Medicina de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
description The risk of thrombosis in patients with mechanical heart valve prostheses in spite of life-long adequate anticoagulation is 1–2% per year. Current recommendations for anticoagulation take into account the prosthesis itself and the co-morbid conditions that enhance the thrombotic risk. Lupus anticoagulant is diagnosed in many thrombotic recurrences. We designed an ambispective case–control study to evaluate thrombotic events in patients with mechanical heart valve prostheses and persistent lupus anticoagulant. Our objectives were to determine whether persistent lupus anticoagulant increased the risk of embolism in that population and thus, if a more intense anticoagulation would be recommended, even at the risk of increasing bleeding episodes. We included 16 patients and 16 controls with more than 80 patient-years of follow-up and with other risk factors for embolism. We observed no increased rate of thromboembolic events in patients than in controls, even during high-risk situations (i.e. bacterial endocarditis). Our population spent most of the time within the intended anticoagulation range. We conclude that adequate anticoagulation is the most important issue to prevent events, protecting against thrombosis without increasing the bleeding risk.
publishDate 2005
dc.date.none.fl_str_mv 2005-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/240903
Casais, Patricia; Meschengieser, Susana S.; Gennari, Laura C.; Alberto, Maria Fabiana; Lazzari, María Ángela; Mechanical heart valve prostheses and persistent lupus anticoagulant: Is the thrombotic risk increased?; Lippincott Williams; Blood Coagulation & Fibrinolysis : An International Journal In Haemostasis And Thrombosis.; 16; 3; 4-2005; 183-185
0957-5235
CONICET Digital
CONICET
url http://hdl.handle.net/11336/240903
identifier_str_mv Casais, Patricia; Meschengieser, Susana S.; Gennari, Laura C.; Alberto, Maria Fabiana; Lazzari, María Ángela; Mechanical heart valve prostheses and persistent lupus anticoagulant: Is the thrombotic risk increased?; Lippincott Williams; Blood Coagulation & Fibrinolysis : An International Journal In Haemostasis And Thrombosis.; 16; 3; 4-2005; 183-185
0957-5235
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://journals.lww.com/bloodcoagulation/abstract/2005/04000/mechanical_heart_valve_prostheses_and_persistent.4.aspx
info:eu-repo/semantics/altIdentifier/doi/10.1097/01.mbc.0000164426.75298.c6
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Lippincott Williams
publisher.none.fl_str_mv Lippincott Williams
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083093281112064
score 13.22299

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