Arabidopsis HAP2/GCS1 is a gamete fusion protein homologous to somatic and viral fusogens
- Autores
- Valansi, Clari; Moi, David; Leikina, Evgenia; Matveev, Elena; Graña, Martín; Chernomordik, Leonid V.; Romero, Héctor; Aguilar, Pablo Sebastián; Podbilewicz, Benjamin
- Año de publicación
- 2017
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Cell-cell fusion is inherent to sexual reproduction. Loss of HAP LESS 2/GEN ERA TIVE CELL SPE CIF IC 1 (HAP2/GCS1) proteins results in gamete fusion failure in diverse organisms, but their exact role is unclear. In this study, we show that Arabidopsis thaliana HAP2/GCS1 is sufficient to promote mammalian cell-cell fusion. Hemifusion and complete fusion depend on HAP2/GCS1 presence in both fusing cells. Furthermore, expression of HAP2 on the surface of pseudotyped vesicular stomatitis virus results in homotypic virus-cell fusion. We demonstrate that the Caenorhabditis elegans Epithelial Fusion Failure 1 (EFF-1) somatic cell fusogen can replace HAP2/GCS1 in one of the fusing membranes, indicating that HAP2/GCS1 and EFF-1 share a similar fusion mechanism. Structural modeling of the HAP2/GCS1 protein family predicts that they are homologous to EFF-1 and viral class II fusion proteins (e.g., Zika virus). We name this superfamily Fusexins: fusion proteins essential for sexual reproduction and exoplasmic merger of plasma membranes. We suggest a common origin and evolution of sexual reproduction, enveloped virus entry into cells, and somatic cell fusion.
Fil: Valansi, Clari. Technion- Israel Institute of Technology; Israel
Fil: Moi, David. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
Fil: Leikina, Evgenia. National Institutes of Health; Estados Unidos
Fil: Matveev, Elena. Technion- Israel Institute of Technology; Israel
Fil: Graña, Martín. Instituto Pasteur de Montevideo; Uruguay
Fil: Chernomordik, Leonid V.. National Institutes of Health; Estados Unidos
Fil: Romero, Héctor. Universidad de la República; Uruguay
Fil: Aguilar, Pablo Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
Fil: Podbilewicz, Benjamin. Technion- Israel Institute of Technology; Israel - Materia
-
FUSION
FERTILIZATION
VIRAL
GAMETE - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/53425
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spelling |
Arabidopsis HAP2/GCS1 is a gamete fusion protein homologous to somatic and viral fusogensValansi, ClariMoi, DavidLeikina, EvgeniaMatveev, ElenaGraña, MartínChernomordik, Leonid V.Romero, HéctorAguilar, Pablo SebastiánPodbilewicz, BenjaminFUSIONFERTILIZATIONVIRALGAMETEhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Cell-cell fusion is inherent to sexual reproduction. Loss of HAP LESS 2/GEN ERA TIVE CELL SPE CIF IC 1 (HAP2/GCS1) proteins results in gamete fusion failure in diverse organisms, but their exact role is unclear. In this study, we show that Arabidopsis thaliana HAP2/GCS1 is sufficient to promote mammalian cell-cell fusion. Hemifusion and complete fusion depend on HAP2/GCS1 presence in both fusing cells. Furthermore, expression of HAP2 on the surface of pseudotyped vesicular stomatitis virus results in homotypic virus-cell fusion. We demonstrate that the Caenorhabditis elegans Epithelial Fusion Failure 1 (EFF-1) somatic cell fusogen can replace HAP2/GCS1 in one of the fusing membranes, indicating that HAP2/GCS1 and EFF-1 share a similar fusion mechanism. Structural modeling of the HAP2/GCS1 protein family predicts that they are homologous to EFF-1 and viral class II fusion proteins (e.g., Zika virus). We name this superfamily Fusexins: fusion proteins essential for sexual reproduction and exoplasmic merger of plasma membranes. We suggest a common origin and evolution of sexual reproduction, enveloped virus entry into cells, and somatic cell fusion.Fil: Valansi, Clari. Technion- Israel Institute of Technology; IsraelFil: Moi, David. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Leikina, Evgenia. National Institutes of Health; Estados UnidosFil: Matveev, Elena. Technion- Israel Institute of Technology; IsraelFil: Graña, Martín. Instituto Pasteur de Montevideo; UruguayFil: Chernomordik, Leonid V.. National Institutes of Health; Estados UnidosFil: Romero, Héctor. Universidad de la República; UruguayFil: Aguilar, Pablo Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Podbilewicz, Benjamin. Technion- Israel Institute of Technology; IsraelRockefeller University Press2017-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/53425Valansi, Clari; Moi, David; Leikina, Evgenia; Matveev, Elena; Graña, Martín; et al.; Arabidopsis HAP2/GCS1 is a gamete fusion protein homologous to somatic and viral fusogens; Rockefeller University Press; Journal of Cell Biology; 216; 3; 1-2017; 1-110021-9525CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1083/jcb.201610093info:eu-repo/semantics/altIdentifier/url/http://jcb.rupress.org/content/216/3/571info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:52:41Zoai:ri.conicet.gov.ar:11336/53425instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:52:41.78CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Arabidopsis HAP2/GCS1 is a gamete fusion protein homologous to somatic and viral fusogens |
title |
Arabidopsis HAP2/GCS1 is a gamete fusion protein homologous to somatic and viral fusogens |
spellingShingle |
Arabidopsis HAP2/GCS1 is a gamete fusion protein homologous to somatic and viral fusogens Valansi, Clari FUSION FERTILIZATION VIRAL GAMETE |
title_short |
Arabidopsis HAP2/GCS1 is a gamete fusion protein homologous to somatic and viral fusogens |
title_full |
Arabidopsis HAP2/GCS1 is a gamete fusion protein homologous to somatic and viral fusogens |
title_fullStr |
Arabidopsis HAP2/GCS1 is a gamete fusion protein homologous to somatic and viral fusogens |
title_full_unstemmed |
Arabidopsis HAP2/GCS1 is a gamete fusion protein homologous to somatic and viral fusogens |
title_sort |
Arabidopsis HAP2/GCS1 is a gamete fusion protein homologous to somatic and viral fusogens |
dc.creator.none.fl_str_mv |
Valansi, Clari Moi, David Leikina, Evgenia Matveev, Elena Graña, Martín Chernomordik, Leonid V. Romero, Héctor Aguilar, Pablo Sebastián Podbilewicz, Benjamin |
author |
Valansi, Clari |
author_facet |
Valansi, Clari Moi, David Leikina, Evgenia Matveev, Elena Graña, Martín Chernomordik, Leonid V. Romero, Héctor Aguilar, Pablo Sebastián Podbilewicz, Benjamin |
author_role |
author |
author2 |
Moi, David Leikina, Evgenia Matveev, Elena Graña, Martín Chernomordik, Leonid V. Romero, Héctor Aguilar, Pablo Sebastián Podbilewicz, Benjamin |
author2_role |
author author author author author author author author |
dc.subject.none.fl_str_mv |
FUSION FERTILIZATION VIRAL GAMETE |
topic |
FUSION FERTILIZATION VIRAL GAMETE |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Cell-cell fusion is inherent to sexual reproduction. Loss of HAP LESS 2/GEN ERA TIVE CELL SPE CIF IC 1 (HAP2/GCS1) proteins results in gamete fusion failure in diverse organisms, but their exact role is unclear. In this study, we show that Arabidopsis thaliana HAP2/GCS1 is sufficient to promote mammalian cell-cell fusion. Hemifusion and complete fusion depend on HAP2/GCS1 presence in both fusing cells. Furthermore, expression of HAP2 on the surface of pseudotyped vesicular stomatitis virus results in homotypic virus-cell fusion. We demonstrate that the Caenorhabditis elegans Epithelial Fusion Failure 1 (EFF-1) somatic cell fusogen can replace HAP2/GCS1 in one of the fusing membranes, indicating that HAP2/GCS1 and EFF-1 share a similar fusion mechanism. Structural modeling of the HAP2/GCS1 protein family predicts that they are homologous to EFF-1 and viral class II fusion proteins (e.g., Zika virus). We name this superfamily Fusexins: fusion proteins essential for sexual reproduction and exoplasmic merger of plasma membranes. We suggest a common origin and evolution of sexual reproduction, enveloped virus entry into cells, and somatic cell fusion. Fil: Valansi, Clari. Technion- Israel Institute of Technology; Israel Fil: Moi, David. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina Fil: Leikina, Evgenia. National Institutes of Health; Estados Unidos Fil: Matveev, Elena. Technion- Israel Institute of Technology; Israel Fil: Graña, Martín. Instituto Pasteur de Montevideo; Uruguay Fil: Chernomordik, Leonid V.. National Institutes of Health; Estados Unidos Fil: Romero, Héctor. Universidad de la República; Uruguay Fil: Aguilar, Pablo Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina Fil: Podbilewicz, Benjamin. Technion- Israel Institute of Technology; Israel |
description |
Cell-cell fusion is inherent to sexual reproduction. Loss of HAP LESS 2/GEN ERA TIVE CELL SPE CIF IC 1 (HAP2/GCS1) proteins results in gamete fusion failure in diverse organisms, but their exact role is unclear. In this study, we show that Arabidopsis thaliana HAP2/GCS1 is sufficient to promote mammalian cell-cell fusion. Hemifusion and complete fusion depend on HAP2/GCS1 presence in both fusing cells. Furthermore, expression of HAP2 on the surface of pseudotyped vesicular stomatitis virus results in homotypic virus-cell fusion. We demonstrate that the Caenorhabditis elegans Epithelial Fusion Failure 1 (EFF-1) somatic cell fusogen can replace HAP2/GCS1 in one of the fusing membranes, indicating that HAP2/GCS1 and EFF-1 share a similar fusion mechanism. Structural modeling of the HAP2/GCS1 protein family predicts that they are homologous to EFF-1 and viral class II fusion proteins (e.g., Zika virus). We name this superfamily Fusexins: fusion proteins essential for sexual reproduction and exoplasmic merger of plasma membranes. We suggest a common origin and evolution of sexual reproduction, enveloped virus entry into cells, and somatic cell fusion. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-01 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/53425 Valansi, Clari; Moi, David; Leikina, Evgenia; Matveev, Elena; Graña, Martín; et al.; Arabidopsis HAP2/GCS1 is a gamete fusion protein homologous to somatic and viral fusogens; Rockefeller University Press; Journal of Cell Biology; 216; 3; 1-2017; 1-11 0021-9525 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/53425 |
identifier_str_mv |
Valansi, Clari; Moi, David; Leikina, Evgenia; Matveev, Elena; Graña, Martín; et al.; Arabidopsis HAP2/GCS1 is a gamete fusion protein homologous to somatic and viral fusogens; Rockefeller University Press; Journal of Cell Biology; 216; 3; 1-2017; 1-11 0021-9525 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1083/jcb.201610093 info:eu-repo/semantics/altIdentifier/url/http://jcb.rupress.org/content/216/3/571 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Rockefeller University Press |
publisher.none.fl_str_mv |
Rockefeller University Press |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.13397 |