Effect of undernutrition on cranial components and somatotroph-lactotroph pituitary populations in the squirrel monkey (Saimiri sciureus boliviensis)

Autores
Console de Avegliano, Gloria Miriam; Oyhenart, Evelia Edith; Jurado, Susana Beatriz; Riccillo, Fernando Luis; Pucciarelli, Hector Mario; Gomez Dumm, Cesar Leandro Alberto
Año de publicación
2001
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of the present study was to investigate in monkeys the effects of undernutrition on neurocranial and facial components, correlated with a histometric and ultrastructural analysis of somatotroph (growth hormone, GH) and lactotroph (prolactin, PRL) pituitary populations. Twenty Saimiri sciureus boliviensis (Cebidae) of both sexes were employed. The monkeys were born in captivity and when they reached 1 year of age, they were separated into two groups: control and undernourished animals. They were fed ad libitum a 20% and 10% protein diet, respectively. The monkeys were radiographed when they were 3 years old in order to measure the length, width and height of the anterior, middle and posterior components of the neurocranium, as well as those of the masticatory, respiratory and optic components of the face. The volumetric and morphometric indices were then calculated. After the sacrifice, pituitary glands were processed for light and electron microscopy. The quantitative immunohistochemistry revealed a decrease in the volume density and cell density of both GH and PRL cells from malnourished animals when compared to control ones. The ultrastructural study showed changes suggestive of cellular hyperfunction for both types of cells in the former experimental group. Undernutrition also affected the size of the cranial components, with males being more affected than females; brain weight was, however, nonmodified by stress, with the brain/body ratio difference being the same for both sexes. We conclude that in monkeys, experimental undernutrition produces a decrease in the pituitary GH and PRL cell populations, in some way related to changes in the cranio-facial morphometric patterns.
Fil: Console de Avegliano, Gloria Miriam. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; Argentina
Fil: Oyhenart, Evelia Edith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Centro de Investigaciones en Genética Básica y Aplicada; Argentina
Fil: Jurado, Susana Beatriz. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Riccillo, Fernando Luis. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; Argentina
Fil: Pucciarelli, Hector Mario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Centro de Investigaciones en Genética Básica y Aplicada; Argentina
Fil: Gomez Dumm, Cesar Leandro Alberto. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Materia
CRANIOLOGY, FUNCTIONAL
LACTOTROPHS
SOMATOTROPHS
SQUIRREL MONKEY
UNDERNUTRITION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/84818
Acceder
id CONICETDig_05595507ac942e9ba135f59e4f8b9585
oai_identifier_str oai:ri.conicet.gov.ar:11336/84818
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Effect of undernutrition on cranial components and somatotroph-lactotroph pituitary populations in the squirrel monkey (Saimiri sciureus boliviensis)Console de Avegliano, Gloria MiriamOyhenart, Evelia EdithJurado, Susana BeatrizRiccillo, Fernando LuisPucciarelli, Hector MarioGomez Dumm, Cesar Leandro AlbertoCRANIOLOGY, FUNCTIONALLACTOTROPHSSOMATOTROPHSSQUIRREL MONKEYUNDERNUTRITIONhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The aim of the present study was to investigate in monkeys the effects of undernutrition on neurocranial and facial components, correlated with a histometric and ultrastructural analysis of somatotroph (growth hormone, GH) and lactotroph (prolactin, PRL) pituitary populations. Twenty Saimiri sciureus boliviensis (Cebidae) of both sexes were employed. The monkeys were born in captivity and when they reached 1 year of age, they were separated into two groups: control and undernourished animals. They were fed ad libitum a 20% and 10% protein diet, respectively. The monkeys were radiographed when they were 3 years old in order to measure the length, width and height of the anterior, middle and posterior components of the neurocranium, as well as those of the masticatory, respiratory and optic components of the face. The volumetric and morphometric indices were then calculated. After the sacrifice, pituitary glands were processed for light and electron microscopy. The quantitative immunohistochemistry revealed a decrease in the volume density and cell density of both GH and PRL cells from malnourished animals when compared to control ones. The ultrastructural study showed changes suggestive of cellular hyperfunction for both types of cells in the former experimental group. Undernutrition also affected the size of the cranial components, with males being more affected than females; brain weight was, however, nonmodified by stress, with the brain/body ratio difference being the same for both sexes. We conclude that in monkeys, experimental undernutrition produces a decrease in the pituitary GH and PRL cell populations, in some way related to changes in the cranio-facial morphometric patterns.Fil: Console de Avegliano, Gloria Miriam. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; ArgentinaFil: Oyhenart, Evelia Edith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Centro de Investigaciones en Genética Básica y Aplicada; ArgentinaFil: Jurado, Susana Beatriz. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaFil: Riccillo, Fernando Luis. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; ArgentinaFil: Pucciarelli, Hector Mario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Centro de Investigaciones en Genética Básica y Aplicada; ArgentinaFil: Gomez Dumm, Cesar Leandro Alberto. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaKarger2001-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/84818Console de Avegliano, Gloria Miriam; Oyhenart, Evelia Edith; Jurado, Susana Beatriz; Riccillo, Fernando Luis; Pucciarelli, Hector Mario; et al.; Effect of undernutrition on cranial components and somatotroph-lactotroph pituitary populations in the squirrel monkey (Saimiri sciureus boliviensis); Karger; Cells Tissues Organs; 168; 4; 4-2001; 272-2841422-6405CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.karger.com/Article/FullText/47844info:eu-repo/semantics/altIdentifier/doi/10.1159/000047844info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:11:31Zoai:ri.conicet.gov.ar:11336/84818instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:11:32.246CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effect of undernutrition on cranial components and somatotroph-lactotroph pituitary populations in the squirrel monkey (Saimiri sciureus boliviensis)
title Effect of undernutrition on cranial components and somatotroph-lactotroph pituitary populations in the squirrel monkey (Saimiri sciureus boliviensis)
spellingShingle Effect of undernutrition on cranial components and somatotroph-lactotroph pituitary populations in the squirrel monkey (Saimiri sciureus boliviensis)
Console de Avegliano, Gloria Miriam
CRANIOLOGY, FUNCTIONAL
LACTOTROPHS
SOMATOTROPHS
SQUIRREL MONKEY
UNDERNUTRITION
title_short Effect of undernutrition on cranial components and somatotroph-lactotroph pituitary populations in the squirrel monkey (Saimiri sciureus boliviensis)
title_full Effect of undernutrition on cranial components and somatotroph-lactotroph pituitary populations in the squirrel monkey (Saimiri sciureus boliviensis)
title_fullStr Effect of undernutrition on cranial components and somatotroph-lactotroph pituitary populations in the squirrel monkey (Saimiri sciureus boliviensis)
title_full_unstemmed Effect of undernutrition on cranial components and somatotroph-lactotroph pituitary populations in the squirrel monkey (Saimiri sciureus boliviensis)
title_sort Effect of undernutrition on cranial components and somatotroph-lactotroph pituitary populations in the squirrel monkey (Saimiri sciureus boliviensis)
dc.creator.none.fl_str_mv Console de Avegliano, Gloria Miriam
Oyhenart, Evelia Edith
Jurado, Susana Beatriz
Riccillo, Fernando Luis
Pucciarelli, Hector Mario
Gomez Dumm, Cesar Leandro Alberto
author Console de Avegliano, Gloria Miriam
author_facet Console de Avegliano, Gloria Miriam
Oyhenart, Evelia Edith
Jurado, Susana Beatriz
Riccillo, Fernando Luis
Pucciarelli, Hector Mario
Gomez Dumm, Cesar Leandro Alberto
author_role author
author2 Oyhenart, Evelia Edith
Jurado, Susana Beatriz
Riccillo, Fernando Luis
Pucciarelli, Hector Mario
Gomez Dumm, Cesar Leandro Alberto
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv CRANIOLOGY, FUNCTIONAL
LACTOTROPHS
SOMATOTROPHS
SQUIRREL MONKEY
UNDERNUTRITION
topic CRANIOLOGY, FUNCTIONAL
LACTOTROPHS
SOMATOTROPHS
SQUIRREL MONKEY
UNDERNUTRITION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The aim of the present study was to investigate in monkeys the effects of undernutrition on neurocranial and facial components, correlated with a histometric and ultrastructural analysis of somatotroph (growth hormone, GH) and lactotroph (prolactin, PRL) pituitary populations. Twenty Saimiri sciureus boliviensis (Cebidae) of both sexes were employed. The monkeys were born in captivity and when they reached 1 year of age, they were separated into two groups: control and undernourished animals. They were fed ad libitum a 20% and 10% protein diet, respectively. The monkeys were radiographed when they were 3 years old in order to measure the length, width and height of the anterior, middle and posterior components of the neurocranium, as well as those of the masticatory, respiratory and optic components of the face. The volumetric and morphometric indices were then calculated. After the sacrifice, pituitary glands were processed for light and electron microscopy. The quantitative immunohistochemistry revealed a decrease in the volume density and cell density of both GH and PRL cells from malnourished animals when compared to control ones. The ultrastructural study showed changes suggestive of cellular hyperfunction for both types of cells in the former experimental group. Undernutrition also affected the size of the cranial components, with males being more affected than females; brain weight was, however, nonmodified by stress, with the brain/body ratio difference being the same for both sexes. We conclude that in monkeys, experimental undernutrition produces a decrease in the pituitary GH and PRL cell populations, in some way related to changes in the cranio-facial morphometric patterns.
Fil: Console de Avegliano, Gloria Miriam. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; Argentina
Fil: Oyhenart, Evelia Edith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Centro de Investigaciones en Genética Básica y Aplicada; Argentina
Fil: Jurado, Susana Beatriz. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Riccillo, Fernando Luis. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; Argentina
Fil: Pucciarelli, Hector Mario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Centro de Investigaciones en Genética Básica y Aplicada; Argentina
Fil: Gomez Dumm, Cesar Leandro Alberto. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
description The aim of the present study was to investigate in monkeys the effects of undernutrition on neurocranial and facial components, correlated with a histometric and ultrastructural analysis of somatotroph (growth hormone, GH) and lactotroph (prolactin, PRL) pituitary populations. Twenty Saimiri sciureus boliviensis (Cebidae) of both sexes were employed. The monkeys were born in captivity and when they reached 1 year of age, they were separated into two groups: control and undernourished animals. They were fed ad libitum a 20% and 10% protein diet, respectively. The monkeys were radiographed when they were 3 years old in order to measure the length, width and height of the anterior, middle and posterior components of the neurocranium, as well as those of the masticatory, respiratory and optic components of the face. The volumetric and morphometric indices were then calculated. After the sacrifice, pituitary glands were processed for light and electron microscopy. The quantitative immunohistochemistry revealed a decrease in the volume density and cell density of both GH and PRL cells from malnourished animals when compared to control ones. The ultrastructural study showed changes suggestive of cellular hyperfunction for both types of cells in the former experimental group. Undernutrition also affected the size of the cranial components, with males being more affected than females; brain weight was, however, nonmodified by stress, with the brain/body ratio difference being the same for both sexes. We conclude that in monkeys, experimental undernutrition produces a decrease in the pituitary GH and PRL cell populations, in some way related to changes in the cranio-facial morphometric patterns.
publishDate 2001
dc.date.none.fl_str_mv 2001-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/84818
Console de Avegliano, Gloria Miriam; Oyhenart, Evelia Edith; Jurado, Susana Beatriz; Riccillo, Fernando Luis; Pucciarelli, Hector Mario; et al.; Effect of undernutrition on cranial components and somatotroph-lactotroph pituitary populations in the squirrel monkey (Saimiri sciureus boliviensis); Karger; Cells Tissues Organs; 168; 4; 4-2001; 272-284
1422-6405
CONICET Digital
CONICET
url http://hdl.handle.net/11336/84818
identifier_str_mv Console de Avegliano, Gloria Miriam; Oyhenart, Evelia Edith; Jurado, Susana Beatriz; Riccillo, Fernando Luis; Pucciarelli, Hector Mario; et al.; Effect of undernutrition on cranial components and somatotroph-lactotroph pituitary populations in the squirrel monkey (Saimiri sciureus boliviensis); Karger; Cells Tissues Organs; 168; 4; 4-2001; 272-284
1422-6405
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.karger.com/Article/FullText/47844
info:eu-repo/semantics/altIdentifier/doi/10.1159/000047844
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Karger
publisher.none.fl_str_mv Karger
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842270161928716288
score 13.13397

Publicaciones similares